المؤلفون: Kuniyoshi N; Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan., Imazu H; Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Chiyoda-ku, Tokyo, Japan., Masuzaki R; Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan., Yamazaki M; Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan., Hamana S; Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan., Nomura S; Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan., Hayama J; Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan., Osawa R; Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Chiyoda-ku, Tokyo, Japan., Yamada K; Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Chiyoda-ku, Tokyo, Japan., Fujisawa M; Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan., Saito K; Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan., Kogure H; Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan.

المصدر: PloS one [PLoS One] 2023 Aug 10; Vol. 18 (8), pp. e0289537. Date of Electronic Publication: 2023 Aug 10 (Print Publication: 2023).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

مواضيع طبية MeSH: MicroRNAs*/genetics , Biliary Tract Neoplasms*/diagnosis , Cholestasis* , Bile Duct Neoplasms*/diagnosis, Humans ; Cholangiopancreatography, Endoscopic Retrograde ; Constriction, Pathologic/diagnosis ; Constriction, Pathologic/genetics ; Bile ; Retrospective Studies ; Sensitivity and Specificity

المؤلفون: Poudel SK; Department of Hematology and Medical Oncology, Corewell Health William Beaumont University Hospital, Royal Oak, Michigan, United States of America., Padmanabhan R; Department of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America., Dave H; Department of Hematology and Medical Oncology, Cleveland Clinic Taussig Cancer Institute, Cleveland, Ohio, United States of America., Guinta K; Department of Hematology and Medical Oncology, Cleveland Clinic Taussig Cancer Institute, Cleveland, Ohio, United States of America., Stevens T; Department of Gastroenterology, Hepatology and Nutrition, Cleveland Clinic, Cleveland, Ohio, United States of America., Sanaka MR; Department of Gastroenterology, Hepatology and Nutrition, Cleveland Clinic, Cleveland, Ohio, United States of America., Chahal P; Department of Gastroenterology, Hepatology and Nutrition, Cleveland Clinic, Cleveland, Ohio, United States of America., Sohal DPS; Division of Hematology/Oncology, Department of Medicine, University of Cincinnati, Cincinnati, Ohio, United States of America., Khorana AA; Department of Hematology and Medical Oncology, Cleveland Clinic Taussig Cancer Institute, Cleveland, Ohio, United States of America., Eng C; Department of Genomic Medicine, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio, United States of America.

المصدر: PloS one [PLoS One] 2023 Apr 18; Vol. 18 (4), pp. e0283021. Date of Electronic Publication: 2023 Apr 18 (Print Publication: 2023).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

مواضيع طبية MeSH: Pancreatic Neoplasms*/genetics , Pancreatic Neoplasms*/pathology , Cholangiocarcinoma*/genetics , Cholangiocarcinoma*/pathology , Bile Duct Neoplasms*/pathology, Humans ; Bile ; RNA, Ribosomal, 16S/genetics ; Cholangiopancreatography, Endoscopic Retrograde ; Bile Ducts, Intrahepatic/pathology ; Pancreatic Ducts/pathology ; Pancreatic Neoplasms

المؤلفون: Kerdkumthong K; Faculty of Science, Division of Health and Applied Sciences, Biochemistry Graduate Program, Prince of Songkla University, Hatyai, Songkhla, Thailand., Nanarong S; Faculty of Science, Division of Health and Applied Sciences, Biochemistry Graduate Program, Prince of Songkla University, Hatyai, Songkhla, Thailand.; Faculty of Pharmaceutical Sciences, Department of Pharmacognosy and Pharmaceutical Botany, Prince of Songkla University, Hatyai, Songkhla, Thailand., Roytrakul S; National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Pathumtani, Thailand., Pitakpornpreecha T; Faculty of Science, Division of Health and Applied Sciences, Biochemistry Graduate Program, Prince of Songkla University, Hatyai, Songkhla, Thailand.; Faculty of Science, Center of Excellence for Biochemistry, Prince of Songkla University, Hatyai, Songkhla, Thailand., Tantimetta P; Faculty of Science, Division of Health and Applied Sciences, Biochemistry Graduate Program, Prince of Songkla University, Hatyai, Songkhla, Thailand., Runsaeng P; Faculty of Science, Division of Health and Applied Sciences, Biochemistry Graduate Program, Prince of Songkla University, Hatyai, Songkhla, Thailand.; Faculty of Science, Center of Excellence for Biochemistry, Prince of Songkla University, Hatyai, Songkhla, Thailand., Obchoei S; Faculty of Science, Division of Health and Applied Sciences, Biochemistry Graduate Program, Prince of Songkla University, Hatyai, Songkhla, Thailand.; Faculty of Science, Center of Excellence for Biochemistry, Prince of Songkla University, Hatyai, Songkhla, Thailand.

المصدر: PloS one [PLoS One] 2024 Jun 26; Vol. 19 (6), pp. e0306060. Date of Electronic Publication: 2024 Jun 26 (Print Publication: 2024).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

مواضيع طبية MeSH: Cholangiocarcinoma*/drug therapy , Cholangiocarcinoma*/metabolism , Cholangiocarcinoma*/pathology , Proteomics*/methods , Deoxyadenosines*/pharmacology , Bile Duct Neoplasms*/drug therapy , Bile Duct Neoplasms*/pathology , Bile Duct Neoplasms*/metabolism , Apoptosis*/drug effects , Cell Movement*/drug effects, Humans ; Cell Line, Tumor ; Thionucleosides/pharmacology ; Antineoplastic Agents/pharmacology ; Gemcitabine ; Deoxycytidine/analogs & derivatives ; Deoxycytidine/pharmacology ; Cell Survival/drug effects ; Cell Proliferation/drug effects ; Drug Resistance, Neoplasm/drug effects

المؤلفون: Inoue T; Department of Gastroenterology, Aichi Medical University, Nagakute, Aichi, Japan., Kutsumi H; Center for Clinical Research and Advance Medicine, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga, Japan., Ibusuki M; Department of Gastroenterology, Aichi Medical University, Nagakute, Aichi, Japan., Yoneda M; Department of Gastroenterology, Aichi Medical University, Nagakute, Aichi, Japan.

المصدر: PloS one [PLoS One] 2023 Mar 31; Vol. 18 (3), pp. e0283733. Date of Electronic Publication: 2023 Mar 31 (Print Publication: 2023).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

مواضيع طبية MeSH: Cholangiocarcinoma*/surgery , Bile Duct Neoplasms*/surgery , Catheter Ablation*, Swine ; Animals ; Cholangiopancreatography, Endoscopic Retrograde/methods ; Feasibility Studies ; Constriction, Pathologic/surgery ; Ethanol ; Bile Ducts, Intrahepatic/surgery ; Catheters ; Stents ; Treatment Outcome

المؤلفون: Ye Y; Department of Surgery, School of Clinical Medicine, The University of Hong Kong, Hong Kong, China.; Faculty of Medicine, Macau University of Science and Technology, Macau SAR, China.; Department of General Surgery, Shenzhen Children's Hospital, Shenzhen, Guangdong, China., Lui VCH; Department of Surgery, School of Clinical Medicine, The University of Hong Kong, Hong Kong, China.; Dr. Li Dak-Sum Research Centre, The University of Hong Kong, Hong Kong, China., Babu RO; Department of Surgery, School of Clinical Medicine, The University of Hong Kong, Hong Kong, China., Wu Z; Department of Surgery, School of Clinical Medicine, The University of Hong Kong, Hong Kong, China., Wu W; Department of General Surgery, Shenzhen Children's Hospital, Shenzhen, Guangdong, China., Chung PHY; Department of Surgery, School of Clinical Medicine, The University of Hong Kong, Hong Kong, China.; Department of Surgery, University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong, China., Wong KKY; Department of Surgery, School of Clinical Medicine, The University of Hong Kong, Hong Kong, China.; Department of Surgery, University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong, China., Wang B; Department of General Surgery, Shenzhen Children's Hospital, Shenzhen, Guangdong, China., Tam PKH; Department of Surgery, School of Clinical Medicine, The University of Hong Kong, Hong Kong, China.; Faculty of Medicine, Macau University of Science and Technology, Macau SAR, China.; Dr. Li Dak-Sum Research Centre, The University of Hong Kong, Hong Kong, China.; Department of Surgery, University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong, China.

المصدر: PloS one [PLoS One] 2023 Mar 30; Vol. 18 (3), pp. e0283737. Date of Electronic Publication: 2023 Mar 30 (Print Publication: 2023).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

مواضيع طبية MeSH: Choledochal Cyst*/genetics , Hepatoblastoma*/pathology , Bile Duct Neoplasms*/genetics , Liver Neoplasms*/genetics , Liver Neoplasms*/pathology, Humans ; Bile Ducts, Intrahepatic/pathology ; Organoids/pathology ; Sequence Analysis, RNA ; Receptor, Fibroblast Growth Factor, Type 2/genetics ; CCAAT-Enhancer-Binding Protein-beta/genetics

المؤلفون: Gookin JL; Department of Clinical Sciences, College of Veterinary Medicine and Comparative Medicine Institute, North Carolina State University, Raleigh, North Carolina, United States of America., Hartley AN; Department of Clinical Sciences, College of Veterinary Medicine and Comparative Medicine Institute, North Carolina State University, Raleigh, North Carolina, United States of America., Aicher KM; Department of Clinical Sciences, College of Veterinary Medicine and Comparative Medicine Institute, North Carolina State University, Raleigh, North Carolina, United States of America., Mathews KG; Department of Clinical Sciences, College of Veterinary Medicine and Comparative Medicine Institute, North Carolina State University, Raleigh, North Carolina, United States of America., Cullen R; Department of Clinical Sciences, College of Veterinary Medicine and Comparative Medicine Institute, North Carolina State University, Raleigh, North Carolina, United States of America., Cullen JM; Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, United States of America., Callahan BJ; Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, United States of America., Stowe DM; Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, United States of America., Seiler GS; Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, United States of America., Jacob ME; Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, United States of America., Arnold JW; Department of Medicine, Division of Gastroenterology and Hepatology, and UNC Microbiome Core, Center for Gastrointestinal Biology and Disease, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, United States of America., Azcarate-Peril MA; Department of Medicine, Division of Gastroenterology and Hepatology, and UNC Microbiome Core, Center for Gastrointestinal Biology and Disease, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, United States of America., Stauffer SH; Department of Clinical Sciences, College of Veterinary Medicine and Comparative Medicine Institute, North Carolina State University, Raleigh, North Carolina, United States of America.

المصدر: PloS one [PLoS One] 2023 Feb 10; Vol. 18 (2), pp. e0281432. Date of Electronic Publication: 2023 Feb 10 (Print Publication: 2023).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

مواضيع طبية MeSH: Mucocele*/veterinary , Gallbladder Diseases*/veterinary , Microbiota*/genetics , Bile Duct Diseases* , Dog Diseases*/diagnosis, Dogs ; Animals ; Gallbladder/pathology ; RNA, Ribosomal, 16S/genetics ; Bile/microbiology

المؤلفون: Muhamad N; Graduate Program in Bioclinical Sciences, Chulabhorn International College of Medicine, Thammasat University (Rangsit Campus), Pathumthani, Thailand.; Center of Excellence in Pharmacology and Molecular Biology of Malaria and Cholangiocarcinoma, Thammasat University (Rangsit Campus), Pathumthani, Thailand., Plengsuriyakarn T; Graduate Program in Bioclinical Sciences, Chulabhorn International College of Medicine, Thammasat University (Rangsit Campus), Pathumthani, Thailand.; Center of Excellence in Pharmacology and Molecular Biology of Malaria and Cholangiocarcinoma, Thammasat University (Rangsit Campus), Pathumthani, Thailand., Na-Bangchang K; Graduate Program in Bioclinical Sciences, Chulabhorn International College of Medicine, Thammasat University (Rangsit Campus), Pathumthani, Thailand.; Center of Excellence in Pharmacology and Molecular Biology of Malaria and Cholangiocarcinoma, Thammasat University (Rangsit Campus), Pathumthani, Thailand.; Drug Discovery and Development Center, Office of Advanced Science and Technology, Thammasat University (Rangsit Campus), Pathumthani, Thailand.

المصدر: PloS one [PLoS One] 2022 Nov 14; Vol. 17 (11), pp. e0277614. Date of Electronic Publication: 2022 Nov 14 (Print Publication: 2022).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

مواضيع طبية MeSH: Atractylodes*/chemistry , Bile Duct Neoplasms*/drug therapy , Cholangiocarcinoma*/drug therapy , Cytochrome P-450 CYP1A2*/metabolism , Cytochrome P-450 CYP3A*/metabolism, Animals ; Female ; Male ; Mice ; Rats ; Bile Ducts, Intrahepatic ; Body Weight ; Tissue Distribution ; Plant Preparations/pharmacology

المؤلفون: Holm M; Transplantation Laboratory, Haartman Institute, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Joenväärä S; Transplantation Laboratory, Haartman Institute, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; HUSLAB, Helsinki University Hospital, Helsinki, Finland., Saraswat M; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America., Tohmola T; Transplantation Laboratory, Haartman Institute, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Saarela T; Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Tenca A; Clinic of Gastroenterology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Arola J; HUSLAB, Helsinki University Hospital, Helsinki, Finland., Renkonen R; Transplantation Laboratory, Haartman Institute, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; HUSLAB, Helsinki University Hospital, Helsinki, Finland., Färkkilä M; Clinic of Gastroenterology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

المصدر: PloS one [PLoS One] 2022 Aug 25; Vol. 17 (8), pp. e0272810. Date of Electronic Publication: 2022 Aug 25 (Print Publication: 2022).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

مواضيع طبية MeSH: Bile Duct Neoplasms*/metabolism , Cholangitis, Sclerosing*/pathology, Bile/metabolism ; Bile Ducts, Intrahepatic/pathology ; Biomarkers ; Diagnosis, Differential ; Humans ; Pilot Projects ; Proteomics

المؤلفون: Suksuratin P; Biomedical Engineering Program, Faculty of Engineering, Khon Kaen University, Khon Kaen, Thailand., Rodpai R; Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.; Mekong Health Science Research Institute, Khon Kaen University, Khon Kaen, Thailand., Luvira V; Department of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand., Intapan PM; Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.; Mekong Health Science Research Institute, Khon Kaen University, Khon Kaen, Thailand., Maleewong W; Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.; Mekong Health Science Research Institute, Khon Kaen University, Khon Kaen, Thailand., Chuchuen O; Biomedical Engineering Program, Faculty of Engineering, Khon Kaen University, Khon Kaen, Thailand.; Mekong Health Science Research Institute, Khon Kaen University, Khon Kaen, Thailand.; Department of Chemical Engineering, Faculty of Engineering, Khon Kaen University, Khon Kaen, Thailand.

المصدر: PloS one [PLoS One] 2022 Oct 13; Vol. 17 (10), pp. e0275362. Date of Electronic Publication: 2022 Oct 13 (Print Publication: 2022).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

مواضيع طبية MeSH: Bile Duct Neoplasms*/diagnosis , Cholangiocarcinoma*/diagnosis, Amides ; Bile Ducts, Intrahepatic ; Discriminant Analysis ; Humans ; Principal Component Analysis ; Spectrum Analysis, Raman/methods ; Tryptophan ; beta Carotene

المؤلفون: Zhou X; Division of Liver Surgery, Department of General Surgery and Laboratory of Liver Surgery, and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China., Huang T; Division of Liver Surgery, Department of General Surgery and Laboratory of Liver Surgery, and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China., Pan H; Division of Liver Surgery, Department of General Surgery and Laboratory of Liver Surgery, and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China., Du A; Division of Liver Surgery, Department of General Surgery and Laboratory of Liver Surgery, and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China., Wu T; NHC Key Laboratory of Transplant Engineering and Immunology, Regenerative Medicine Research Center, Frontiers Science Center for Disease-related Molecular Network, West China Hospital of Sichuan University, Chengdu, China., Lan J; Division of Liver Surgery, Department of General Surgery and Laboratory of Liver Surgery, and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China., Song Y; Division of Liver Surgery, Department of General Surgery and Laboratory of Liver Surgery, and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China., Lv Y; Division of Liver Surgery, Department of General Surgery and Laboratory of Liver Surgery, and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China., He F; Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China., Yuan K; Division of Liver Surgery, Department of General Surgery and Laboratory of Liver Surgery, and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.

المصدر: PloS one [PLoS One] 2024 Apr 22; Vol. 19 (4), pp. e0300441. Date of Electronic Publication: 2024 Apr 22 (Print Publication: 2024).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

مواضيع طبية MeSH: Cholangiocarcinoma*/genetics , Cholangiocarcinoma*/virology , COVID-19*/genetics , COVID-19*/virology , SARS-CoV-2*/genetics , Computational Biology*/methods , Bile Duct Neoplasms*/genetics , Bile Duct Neoplasms*/virology , Systems Biology*/methods, Humans ; Protein Interaction Maps/genetics ; Pandemics ; Coronavirus Infections/virology ; Coronavirus Infections/genetics ; Betacoronavirus/genetics ; Gene Expression Regulation, Neoplastic ; Gene Regulatory Networks