المؤلفون: DeBerge M; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.; Department of Anesthesiology, Critical Care and Pain Medicine, University of Texas Health Science Center, Houston, TX 77030., Schroth S; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611., Du F; Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208., Yeap XY; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611., Wang JJ; Department of Surgery, Comprehensive Transplant Center, Northwestern University, Chicago, IL 60611., Zhang ZJ; Department of Surgery, Comprehensive Transplant Center, Northwestern University, Chicago, IL 60611., Ansari MJ; Division of Nephrology and Hypertension, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611., Scott EA; Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208., Thorp EB; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Jun 25; Vol. 121 (26), pp. e2319623121. Date of Electronic Publication: 2024 Jun 18.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Heart Transplantation* , Macrophages*/metabolism , Macrophages*/immunology , Basic Helix-Loop-Helix Transcription Factors*/metabolism , Basic Helix-Loop-Helix Transcription Factors*/genetics , Transplantation Tolerance*/immunology , Monocytes*/immunology , Monocytes*/metabolism, Animals ; Mice ; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor/metabolism ; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor/genetics ; Graft Rejection/immunology ; Graft Rejection/prevention & control ; Graft Rejection/genetics ; Mice, Inbred C57BL ; Gene Expression Regulation/drug effects ; Graft Survival/immunology ; Graft Survival/drug effects ; Male

المؤلفون: Choi JY; Division of Renal Medicine, Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115., Eskandari SK; Division of Renal Medicine, Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.; Division of Nephrology, University Medical Center Groningen, University of Groningen, 9700 AB Groningen, The Netherlands., Cai S; Division of Renal Medicine, Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115., Sulkaj I; Division of Renal Medicine, Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115., Assaker JP; Division of Renal Medicine, Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115., Allos H; Division of Renal Medicine, Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115., AlHaddad J; Division of Renal Medicine, Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115., Muhsin SA; Division of Renal Medicine, Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115., Alhussain E; Division of Renal Medicine, Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115., Mansouri A; Division of Renal Medicine, Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115., Yeung MY; Division of Renal Medicine, Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115., Seelen MAJ; Division of Nephrology, University Medical Center Groningen, University of Groningen, 9700 AB Groningen, The Netherlands., Kim HJ; Department of Cancer Immunology & Virology, Dana-Farber Cancer Institute, Boston, MA 02215.; Department of Immunology, Harvard Medical School, Boston, MA 02115., Cantor H; Department of Cancer Immunology & Virology, Dana-Farber Cancer Institute, Boston, MA 02215; harvey_cantor@dfci.harvard.edu Jazzi@bwh.harvard.edu.; Department of Immunology, Harvard Medical School, Boston, MA 02115., Azzi JR; Division of Renal Medicine, Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115; harvey_cantor@dfci.harvard.edu Jazzi@bwh.harvard.edu.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Mar 17; Vol. 117 (11), pp. 6042-6046. Date of Electronic Publication: 2020 Feb 28.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Graft Rejection/*immunology , Heart Transplantation/*adverse effects , Histocompatibility Antigens Class I/*immunology , T-Lymphocytes, Helper-Inducer/*metabolism , T-Lymphocytes, Regulatory/*immunology, Allografts/immunology ; Allografts/metabolism ; Animals ; Disease Models, Animal ; Graft Rejection/blood ; Graft Rejection/genetics ; Graft Survival/immunology ; Histocompatibility Antigens Class I/genetics ; Histocompatibility Antigens Class I/metabolism ; Humans ; Immune Tolerance ; Isoantibodies/immunology ; Isoantibodies/metabolism ; Isoantigens/immunology ; Isoantigens/metabolism ; Mice ; Myocardium/immunology ; Myocardium/metabolism ; Point Mutation ; Receptors, Antigen, T-Cell/immunology ; Receptors, Antigen, T-Cell/metabolism ; T-Lymphocytes, Helper-Inducer/immunology ; Transplantation, Homologous/adverse effects

المؤلفون: Ishiyama K; Department of Microbiology and Immunology, University of California, San Francisco, CA 94143.; Parker Institute for Cancer Immunotherapy, University of California, San Francisco, CA 94143., Arakawa-Hoyt J; Department of Microbiology and Immunology, University of California, San Francisco, CA 94143.; Parker Institute for Cancer Immunotherapy, University of California, San Francisco, CA 94143., Aguilar OA; Department of Microbiology and Immunology, University of California, San Francisco, CA 94143.; Parker Institute for Cancer Immunotherapy, University of California, San Francisco, CA 94143., Damm I; Department of Surgery, University of California, San Francisco, CA 94143., Towfighi P; Department of Surgery, University of California, San Francisco, CA 94143., Sigdel T; Department of Surgery, University of California, San Francisco, CA 94143., Tamaki S; Parnassus Flow Cytometry Core, University of California, San Francisco, CA 94143., Babdor J; Department of Microbiology and Immunology, University of California, San Francisco, CA 94143.; Parker Institute for Cancer Immunotherapy, University of California, San Francisco, CA 94143.; Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, CA 94143., Spitzer MH; Department of Microbiology and Immunology, University of California, San Francisco, CA 94143.; Parker Institute for Cancer Immunotherapy, University of California, San Francisco, CA 94143.; Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, CA 94143.; Chan Zuckerberg Biohub, San Francisco, CA 94158., Reed EF; Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA 90095., Sarwal MM; Department of Surgery, University of California, San Francisco, CA 94143., Lanier LL; Department of Microbiology and Immunology, University of California, San Francisco, CA 94143; lewis.lanier@ucsf.edu.; Parker Institute for Cancer Immunotherapy, University of California, San Francisco, CA 94143.

مؤلفون مشاركون: CMV Systems Immunobiology Group

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 Feb 22; Vol. 119 (8).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Cytomegalovirus Infections/*immunology , Flow Cytometry/*methods , Killer Cells, Natural/*metabolism, Adult ; CD8-Positive T-Lymphocytes/metabolism ; Cell Separation/methods ; Cytomegalovirus/metabolism ; Cytomegalovirus/pathogenicity ; Cytomegalovirus Infections/virology ; Female ; Graft Rejection/immunology ; Humans ; Kidney Transplantation/adverse effects ; Kidney Transplantation/methods ; Killer Cells, Natural/immunology ; Kinetics ; Lymphocyte Activation/immunology ; Male ; Middle Aged ; NK Cell Lectin-Like Receptor Subfamily C/metabolism ; Single-Cell Analysis/methods ; Viremia/immunology ; Viremia/virology

المؤلفون: Harper SJ; School of Clinical Medicine, University of Cambridge, Cambridge, CB2 0QQ, United Kingdom., Ali JM; School of Clinical Medicine, University of Cambridge, Cambridge, CB2 0QQ, United Kingdom ja297@cam.ac.uk gjp25@cam.ac.uk., Wlodek E; School of Clinical Medicine, University of Cambridge, Cambridge, CB2 0QQ, United Kingdom., Negus MC; School of Clinical Medicine, University of Cambridge, Cambridge, CB2 0QQ, United Kingdom., Harper IG; School of Clinical Medicine, University of Cambridge, Cambridge, CB2 0QQ, United Kingdom., Chhabra M; School of Clinical Medicine, University of Cambridge, Cambridge, CB2 0QQ, United Kingdom., Qureshi MS; School of Clinical Medicine, University of Cambridge, Cambridge, CB2 0QQ, United Kingdom., Mallik M; School of Clinical Medicine, University of Cambridge, Cambridge, CB2 0QQ, United Kingdom., Bolton E; School of Clinical Medicine, University of Cambridge, Cambridge, CB2 0QQ, United Kingdom., Bradley JA; School of Clinical Medicine, University of Cambridge, Cambridge, CB2 0QQ, United Kingdom., Pettigrew GJ; School of Clinical Medicine, University of Cambridge, Cambridge, CB2 0QQ, United Kingdom ja297@cam.ac.uk gjp25@cam.ac.uk.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2015 Oct 13; Vol. 112 (41), pp. 12788-93. Date of Electronic Publication: 2015 Sep 29.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Heart Transplantation*, CD8-Positive T-Lymphocytes/*immunology , Graft Rejection/*immunology , Isoantigens/*immunology, Allografts ; Animals ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/pathology ; CD8-Positive T-Lymphocytes/pathology ; Dendritic Cells/immunology ; Dendritic Cells/pathology ; Graft Rejection/pathology ; Histocompatibility Antigens Class I/genetics ; Histocompatibility Antigens Class I/immunology ; Mice ; Mice, Inbred BALB C ; Mice, Knockout

المؤلفون: Sarraj B; Division of Nephrology, Department of Medicine,Division of Organ Transplantation, Department of Surgery, and., Ye J; Division of Organ Transplantation, Department of Surgery, andDepartment of Kidney Transplantation, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China., Akl AI; Division of Nephrology, Department of Medicine., Chen G; Division of Organ Transplantation, Department of Surgery, and., Wang JJ; Division of Organ Transplantation, Department of Surgery, and., Zhang Z; Division of Organ Transplantation, Department of Surgery, and., Abadja F; Division of Organ Transplantation, Department of Surgery, and., Abecassis M; Division of Organ Transplantation, Department of Surgery, and., Miller SD; Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611; and., Kansas GS; Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611; and., Ansari MJ; Division of Nephrology, Department of Medicine,Division of Organ Transplantation, Department of Surgery, and jansari@northwestern.edu.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2014 Aug 19; Vol. 111 (33), pp. 12145-50. Date of Electronic Publication: 2014 Aug 04.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Allografts* , Graft Rejection*, Blood Vessels/*pathology , CD4-Positive T-Lymphocytes/*immunology , Leukocytes/*cytology , Selectins/*physiology, Adoptive Transfer ; Cell Movement ; Flow Cytometry ; Fucosyltransferases/genetics ; Humans

المؤلفون: Miller ML; Department of Medicine, Section of Rheumatology, The University of Chicago, Chicago, IL 60637., McIntosh CM; Department of Medicine, Section of Rheumatology, The University of Chicago, Chicago, IL 60637., Wang Y; Department of Medicine, Section of Rheumatology, The University of Chicago, Chicago, IL 60637., Chen L; Department of Medicine, Section of Rheumatology, The University of Chicago, Chicago, IL 60637., Wang P; Department of Medicine, Section of Rheumatology, The University of Chicago, Chicago, IL 60637., Lei YM; Department of Medicine, Section of Rheumatology, The University of Chicago, Chicago, IL 60637., Daniels MD; Department of Surgery, Section of Transplantation, The University of Chicago, Chicago, IL 60637., Watkins E; Institute for Molecular Engineering, The University of Chicago, Chicago, IL 60637., Mora Solano C; Department of Surgery, Section of Transplantation, The University of Chicago, Chicago, IL 60637., Chong AS; Department of Surgery, Section of Transplantation, The University of Chicago, Chicago, IL 60637., Alegre ML; Department of Medicine, Section of Rheumatology, The University of Chicago, Chicago, IL 60637; malegre@midway.uchicago.edu.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2019 Nov 19; Vol. 116 (47), pp. 23682-23690. Date of Electronic Publication: 2019 Nov 04.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Transplantation Immunology*, Graft Survival/*immunology , Immune Tolerance/*immunology , T-Lymphocyte Subsets/*immunology, Allografts ; Animals ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/transplantation ; Forkhead Transcription Factors/analysis ; Genes, Reporter ; Graft Rejection/immunology ; H-2 Antigens/immunology ; Heart Transplantation ; Histocompatibility Antigens Class II/immunology ; Immunologic Memory ; Isoantigens/immunology ; Listeria monocytogenes ; Listeriosis/immunology ; Lymphocyte Transfusion ; Mice ; Mice, Congenic ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Postoperative Complications/immunology ; T-Lymphocytes, Regulatory/immunology ; Tissue Donors

المؤلفون: Snyder TM; Department of Applied Physics, Stanford University, Stanford, The Howard Hughes Medical Institute, CA 94305, USA., Khush KK, Valantine HA, Quake SR

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2011 Apr 12; Vol. 108 (15), pp. 6229-34. Date of Electronic Publication: 2011 Mar 28.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Heart Transplantation*, DNA/*blood , Graft Rejection/*diagnosis , High-Throughput Nucleotide Sequencing/*methods , Monitoring, Physiologic/*methods, Chromosomes, Human, Y/genetics ; DNA/genetics ; Graft Rejection/blood ; Graft Rejection/pathology ; Humans ; Polymorphism, Single Nucleotide ; Tissue Donors

المؤلفون: Khan MA; Medical Service, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA., Maasch C, Vater A, Klussmann S, Morser J, Leung LL, Atkinson C, Tomlinson S, Heeger PS, Nicolls MR

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2013 Apr 09; Vol. 110 (15), pp. 6061-6. Date of Electronic Publication: 2013 Mar 25.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Airway Remodeling* , Graft Rejection*, Complement C5a/*genetics , Thrombin/*metabolism, Animals ; Bronchiolitis Obliterans/diagnosis ; Complement C3/genetics ; Complement C5a/antagonists & inhibitors ; Fibrosis ; Hypoxia ; Immunosuppressive Agents/therapeutic use ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Knockout ; Microcirculation ; Oxygen/metabolism ; Perfusion ; Platelet Endothelial Cell Adhesion Molecule-1/metabolism ; Transplantation, Homologous

المؤلفون: Pieper GM; Department of Surgery, Division of Transplant Surgery, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA. gmpieper@mcw.edu, Halligan NL, Hilton G, Konorev EA, Felix CC, Roza AM, Adams MB, Griffith OW

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2003 Mar 18; Vol. 100 (6), pp. 3125-30. Date of Electronic Publication: 2003 Mar 06.

نوع المنشور: Journal Article; Research Support, U.S. Gov't, P.H.S.

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0027-8424 (Print) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Graft Rejection/*metabolism , Heart Transplantation/*physiology , Lysine/*analogs & derivatives , Nitric Oxide/*metabolism , Nonheme Iron Proteins/*metabolism, Aconitate Hydratase/metabolism ; Animals ; Cyclosporine/pharmacology ; Electron Spin Resonance Spectroscopy ; Enzyme Inhibitors/pharmacology ; Graft Rejection/drug therapy ; Graft Rejection/etiology ; Heart Transplantation/adverse effects ; Hemeproteins/chemistry ; Hemeproteins/metabolism ; Immunosuppressive Agents/pharmacology ; Lysine/pharmacology ; Nitric Oxide Synthase/antagonists & inhibitors ; Nitric Oxide Synthase/metabolism ; Nitric Oxide Synthase Type II ; Nonheme Iron Proteins/chemistry ; Rats ; Rats, Inbred Lew ; Rats, Inbred WF ; Rats, Sprague-Dawley ; Transplantation, Homologous ; Transplantation, Isogeneic

المؤلفون: Pilat N; Immunology Division, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.; St Vincent's Clinical School, University of New South Wales, Sydney, NSW 2010, Australia.; Department of Surgery, Medical University of Vienna, 1090 Vienna, Austria., Wiletel M; Department of Surgery, Medical University of Vienna, 1090 Vienna, Austria., Weijler AM; Department of Surgery, Medical University of Vienna, 1090 Vienna, Austria., Steiner R; Department of Surgery, Medical University of Vienna, 1090 Vienna, Austria., Mahr B; Department of Surgery, Medical University of Vienna, 1090 Vienna, Austria., Warren J; Immunology Division, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.; St Vincent's Clinical School, University of New South Wales, Sydney, NSW 2010, Australia., Corpuz TM; Immunology Division, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.; St Vincent's Clinical School, University of New South Wales, Sydney, NSW 2010, Australia., Wekerle T; Department of Surgery, Medical University of Vienna, 1090 Vienna, Austria., Webster KE; Immunology Division, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.; St Vincent's Clinical School, University of New South Wales, Sydney, NSW 2010, Australia., Sprent J; Immunology Division, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia; j.sprent@garvan.org.au.; St Vincent's Clinical School, University of New South Wales, Sydney, NSW 2010, Australia.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2019 Jul 02; Vol. 116 (27), pp. 13508-13516. Date of Electronic Publication: 2019 Jun 13.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Graft Survival*/immunology , Skin Transplantation*, Graft Rejection/*prevention & control , T-Lymphocytes, Regulatory/*immunology, Allografts ; Animals ; Antibodies, Monoclonal/immunology ; Female ; Flow Cytometry ; Immunosuppressive Agents/therapeutic use ; Interleukin-2/immunology ; Interleukin-6/antagonists & inhibitors ; Mice, Inbred BALB C ; Mice, Inbred C3H ; Mice, Inbred C57BL ; Sirolimus/therapeutic use