المؤلفون: Hua W; Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, China.; National Center for Neurological Disorders, Shanghai 200040, China.; Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration, Shanghai 200040, China.; Neurosurgical Institute of Fudan University, Shanghai 200040, China.; Shanghai Clinical Medical Center of Neurosurgery, Shanghai 200040, China., Zhang W; State Key Laboratory of Precision Measurement Technology and Instruments, Department of Precision Instrument, Tsinghua University, Beijing 100084, China., Brown H; Department of Chemistry, Purdue University, West Lafayette, IN 47907., Wu J; State Key Laboratory of Precision Measurement Technology and Instruments, Department of Precision Instrument, Tsinghua University, Beijing 100084, China., Fang X; Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, China.; National Center for Neurological Disorders, Shanghai 200040, China.; Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration, Shanghai 200040, China.; Neurosurgical Institute of Fudan University, Shanghai 200040, China.; Shanghai Clinical Medical Center of Neurosurgery, Shanghai 200040, China., Shahi M; Department of Chemistry, Purdue University, West Lafayette, IN 47907., Chen R; Department of Chemistry, Purdue University, West Lafayette, IN 47907., Zhang H; Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration, Shanghai 200040, China., Jiao B; Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration, Shanghai 200040, China., Wang N; PurSpecTechnologies, Beijing 100084, China., Xu H; Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, China.; National Center for Neurological Disorders, Shanghai 200040, China.; Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration, Shanghai 200040, China.; Neurosurgical Institute of Fudan University, Shanghai 200040, China.; Shanghai Clinical Medical Center of Neurosurgery, Shanghai 200040, China., Fu M; Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, China.; National Center for Neurological Disorders, Shanghai 200040, China.; Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration, Shanghai 200040, China.; Neurosurgical Institute of Fudan University, Shanghai 200040, China.; Shanghai Clinical Medical Center of Neurosurgery, Shanghai 200040, China., Wang X; Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, China.; National Center for Neurological Disorders, Shanghai 200040, China.; Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration, Shanghai 200040, China.; Neurosurgical Institute of Fudan University, Shanghai 200040, China.; Shanghai Clinical Medical Center of Neurosurgery, Shanghai 200040, China., Zhang J; Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, China.; National Center for Neurological Disorders, Shanghai 200040, China.; Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration, Shanghai 200040, China.; Neurosurgical Institute of Fudan University, Shanghai 200040, China.; Shanghai Clinical Medical Center of Neurosurgery, Shanghai 200040, China., Zhang X; Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, China.; National Center for Neurological Disorders, Shanghai 200040, China.; Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration, Shanghai 200040, China.; Neurosurgical Institute of Fudan University, Shanghai 200040, China.; Shanghai Clinical Medical Center of Neurosurgery, Shanghai 200040, China., Wang Q; Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, China.; National Center for Neurological Disorders, Shanghai 200040, China.; Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration, Shanghai 200040, China.; Neurosurgical Institute of Fudan University, Shanghai 200040, China.; Shanghai Clinical Medical Center of Neurosurgery, Shanghai 200040, China., Zhu W; Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, China.; National Center for Neurological Disorders, Shanghai 200040, China.; Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration, Shanghai 200040, China.; Neurosurgical Institute of Fudan University, Shanghai 200040, China.; Shanghai Clinical Medical Center of Neurosurgery, Shanghai 200040, China., Ye D; The Molecular and Cell Biology Lab, Institute of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai 200232, China., Garcia DM; Department of Neurosurgery, Mayo Clinic, Jacksonville, FL 32224., Chaichana K; Department of Neurosurgery, Mayo Clinic, Jacksonville, FL 32224., Cooks RG; Department of Chemistry, Purdue University, West Lafayette, IN 47907., Ouyang Z; State Key Laboratory of Precision Measurement Technology and Instruments, Department of Precision Instrument, Tsinghua University, Beijing 100084, China., Mao Y; Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, China.; National Center for Neurological Disorders, Shanghai 200040, China.; Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration, Shanghai 200040, China.; Neurosurgical Institute of Fudan University, Shanghai 200040, China.; Shanghai Clinical Medical Center of Neurosurgery, Shanghai 200040, China., Quinones-Hinojosa A; Department of Neurosurgery, Mayo Clinic, Jacksonville, FL 32224.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Jun 04; Vol. 121 (23), pp. e2318843121. Date of Electronic Publication: 2024 May 28.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Glioma*/genetics , Glioma*/surgery , Glioma*/pathology , Isocitrate Dehydrogenase*/genetics , Mutation* , Brain Neoplasms*/genetics , Brain Neoplasms*/surgery , Brain Neoplasms*/pathology, Humans ; Tandem Mass Spectrometry/methods ; Glutarates/metabolism ; Mass Spectrometry/methods ; Glutamic Acid/metabolism ; Glutamic Acid/genetics

المؤلفون: Wu R; Department of Pharmacology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China.; Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, China., Sun C; Department of Pharmacology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China.; Department of Neurology, Huashan hospital, Fudan University, Shanghai 200040, China., Chen X; Department of Pharmacology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China., Yang R; Department of Pharmacology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China.; Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai 200032, China., Luan Y; Department of Pharmacology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China.; Department of Microbiology, Key Laboratory of Medical Molecular Virology (Ministry of Education/ National Health Commission/ Chinese Academy of Medical Sciences), Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China., Zhao X; Department of Pharmacology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China., Yu P; Department of Pharmacology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China., Luo R; Department of Pathology, Zhongshan hospital, Fudan University, Shanghai 200032, China., Hou Y; Department of Pathology, Zhongshan hospital, Fudan University, Shanghai 200032, China., Tian R; Department of Pharmacology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China., Bian S; Department of Pharmacology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China.; Department of Microbiology, Key Laboratory of Medical Molecular Virology (Ministry of Education/ National Health Commission/ Chinese Academy of Medical Sciences), Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China., Li Y; Department of Pharmacology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China., Dong Y; Department of Pharmacology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China.; Department of Logistics, Dalian No.3 People's hospital Affiliated to Dalian Medical University, Dalian 116033, China., Liu Q; Department of Pharmacology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China., Dai W; Department of Pharmacology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China.; Department of Microbiology, Key Laboratory of Medical Molecular Virology (Ministry of Education/ National Health Commission/ Chinese Academy of Medical Sciences), Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China., Fan Z; Department of Pharmacology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China., Yan R; Department of Pharmacology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China., Pan B; Department of Pharmacology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China.; Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, China., Feng S; Department of Pharmacology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China., Wu J; Department of Pharmacology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China.; Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, China., Chen F; Department of Pharmacology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China.; Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, China., Yang C; Department of Pharmacology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China.; Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, China., Wang H; Department of Pharmacology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China., Dai H; Department of Pharmacology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China., Shu M; Department of Pharmacology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China.; Department of Microbiology, Key Laboratory of Medical Molecular Virology (Ministry of Education/ National Health Commission/ Chinese Academy of Medical Sciences), Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Apr 02; Vol. 121 (14), pp. e2321611121. Date of Electronic Publication: 2024 Mar 28.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: 5-Methylcytosine*/*analogs & derivatives, 5-Methylcytosine*/metabolism , Glioma*/pathology , DNA-Binding Proteins* , Muscle Proteins* , Dioxygenases*, Humans ; beta Catenin/metabolism ; Chromatin ; CD47 Antigen/genetics ; RNA ; Immune Evasion ; RNA, Messenger/metabolism ; Methyltransferases/metabolism ; RNA, Small Nuclear ; Tumor Microenvironment ; RNA Splicing Factors/genetics ; Repressor Proteins/metabolism

المؤلفون: Theorell J; Oxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, United Kingdom.; Department of Medicine Huddinge, Karolinska Institutet, Stockholm 17177, Sweden.; Department of Neurology, Karolinska University Hospital, Stockholm 17176, Sweden., Harrison R; Oxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, United Kingdom., Williams R; Oxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, United Kingdom.; Department of Neurology, John Radcliffe Hospital, Oxford University Hospitals, Oxford OX3 9DU, United Kingdom., Raybould MIJ; Department of Statistics, Oxford Protein Informatics Group, University of Oxford, Oxford OX1 3LB, United Kingdom., Zhao M; Oxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, United Kingdom., Fox H; Oxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, United Kingdom., Fower A; Oxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, United Kingdom., Miller G; Oxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, United Kingdom., Wu Z; Oxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, United Kingdom., Browne E; Oxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, United Kingdom., Mgbachi V; Oxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, United Kingdom., Sun B; Oxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, United Kingdom., Mopuri R; Department of Quantitative Health Sciences, Mayo Clinic, Jacksonville, FL 32224., Li Y; Department of Quantitative Health Sciences, Mayo Clinic, Jacksonville, FL 32224., Waters P; Oxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, United Kingdom., Deane CM; Department of Statistics, Oxford Protein Informatics Group, University of Oxford, Oxford OX1 3LB, United Kingdom., Handel A; Oxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, United Kingdom.; Department of Neurology, John Radcliffe Hospital, Oxford University Hospitals, Oxford OX3 9DU, United Kingdom., Makuch M; Oxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, United Kingdom., Irani SR; Oxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, United Kingdom.; Department of Neurology, John Radcliffe Hospital, Oxford University Hospitals, Oxford OX3 9DU, United Kingdom.; Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Feb 13; Vol. 121 (7), pp. e2311049121. Date of Electronic Publication: 2024 Feb 06.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Encephalitis* , Autoimmune Diseases of the Nervous System* , Glioma* , Hashimoto Disease*, Humans ; Leucine ; Intracellular Signaling Peptides and Proteins ; Neoplasm Recurrence, Local ; Autoantibodies ; Autoantigens

SCR Disease Name: Hashimoto's encephalitis

المؤلفون: Kikuchi M; Laboratory for Epigenetics Drug Discovery, RIKEN Center for Biosystems Dynamics Research, Yokohama 230-0045, Japan., Takase S; Laboratory of Cell Signaling, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0392, Japan., Konuma T; Structural Epigenetics Laboratory, Graduate School of Medical Life Science, Yokohama City University, Yokohama 230-0045, Japan., Noritsugu K; Laboratory of Cell Signaling, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0392, Japan., Sekine S; Laboratory of Cell Signaling, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0392, Japan., Ikegami T; Structural Epigenetics Laboratory, Graduate School of Medical Life Science, Yokohama City University, Yokohama 230-0045, Japan., Ito A; Laboratory of Cell Signaling, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0392, Japan., Umehara T; Laboratory for Epigenetics Drug Discovery, RIKEN Center for Biosystems Dynamics Research, Yokohama 230-0045, Japan.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Oct 24; Vol. 120 (43), pp. e2304103120. Date of Electronic Publication: 2023 Oct 16.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Histones*/metabolism , Glioma*, Humans ; Protein Domains ; Chromatin ; Arginine

المؤلفون: Mota M; Laboratory of Brain Tumor Metabolism and Epigenetics, Department of Pathology, University of Michigan, Ann Arbor, MI 48109.; Chad Carr Pediatric Tumor Center, Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109., Sweha SR; Laboratory of Brain Tumor Metabolism and Epigenetics, Department of Pathology, University of Michigan, Ann Arbor, MI 48109.; Chad Carr Pediatric Tumor Center, Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109., Pun M; Laboratory of Brain Tumor Metabolism and Epigenetics, Department of Pathology, University of Michigan, Ann Arbor, MI 48109.; Chad Carr Pediatric Tumor Center, Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109.; Cellular and Molecular Biology Program, University of Michigan Medical School, Ann Arbor, MI 48109.; Medical Scientist Training Program, University of Michigan Medical School, Ann Arbor, MI 48109., Natarajan SK; Laboratory of Brain Tumor Metabolism and Epigenetics, Department of Pathology, University of Michigan, Ann Arbor, MI 48109.; Chad Carr Pediatric Tumor Center, Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109., Ding Y; Laboratory of Brain Tumor Metabolism and Epigenetics, Department of Pathology, University of Michigan, Ann Arbor, MI 48109.; Chad Carr Pediatric Tumor Center, Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109., Chung C; Department of New Biology, Daegu Gyeongbuk Institute of Science and Technology, Daegu 42988, Korea., Hawes D; Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Keck School of Medicine University of Southern California, Los Angeles, CA 90027., Yang F; Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Keck School of Medicine University of Southern California, Los Angeles, CA 90027., Judkins AR; Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Keck School of Medicine University of Southern California, Los Angeles, CA 90027., Samajdar S; Aurigene Discovery Technologies, Bengaluru, Karnataka 560100, India., Cao X; Michigan Center for Translational Pathology, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109., Xiao L; Michigan Center for Translational Pathology, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109., Parolia A; Michigan Center for Translational Pathology, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109., Chinnaiyan AM; Michigan Center for Translational Pathology, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109.; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109.; Department of Urology, University of Michigan Medical School, Ann Arbor, MI 48109.; HHMI, University of Michigan Medical School, Ann Arbor, MI 48109., Venneti S; Laboratory of Brain Tumor Metabolism and Epigenetics, Department of Pathology, University of Michigan, Ann Arbor, MI 48109.; Chad Carr Pediatric Tumor Center, Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109.; Cellular and Molecular Biology Program, University of Michigan Medical School, Ann Arbor, MI 48109.; Michigan Center for Translational Pathology, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109.; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 May 02; Vol. 120 (18), pp. e2221175120. Date of Electronic Publication: 2023 Apr 24.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Diffuse Intrinsic Pontine Glioma* , Glioma*/genetics , Brain Neoplasms*/genetics, Humans ; Child ; Histones/genetics ; Adenosine Triphosphatases/metabolism ; Lysine/genetics ; Chromatin ; Mutation ; DNA Helicases/metabolism ; Nuclear Proteins/metabolism ; Transcription Factors/metabolism

المؤلفون: Yu D; Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, MD 20892.; CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 116023 Dalian, China.; University of Chinese Academy of Sciences, 100049 Beijing, China., Liu Y; Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, MD 20892., Zhou Y; Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, MD 20892., Ruiz-Rodado V; Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, MD 20892., Larion M; Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, MD 20892., Xu G; CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 116023 Dalian, China; xugw@dicp.ac.cn yangc2@nih.gov., Yang C; Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, MD 20892; xugw@dicp.ac.cn yangc2@nih.gov.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 May 05; Vol. 117 (18), pp. 9964-9972. Date of Electronic Publication: 2020 Apr 20.

نوع المنشور: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Diterpenes/*pharmacology , Glioma/*drug therapy , Isocitrate Dehydrogenase/*genetics , NF-E2-Related Factor 2/*genetics , Phenanthrenes/*pharmacology, Amino Acid Transport System y+/genetics ; Animals ; Biosynthetic Pathways/drug effects ; Cell Line, Tumor ; Epoxy Compounds/pharmacology ; Gene Expression Regulation, Neoplastic/drug effects ; Glioma/genetics ; Glioma/pathology ; Glutamate-Cysteine Ligase/genetics ; Glutathione/metabolism ; Humans ; Mice ; Mutation/genetics ; Reactive Oxygen Species/metabolism ; Synthetic Lethal Mutations/genetics ; Xenograft Model Antitumor Assays

المؤلفون: Flores-Toro JA; Department of Pharmacology & Therapeutics, College of Medicine, University of Florida, Gainesville, FL 32610., Luo D; Department of Pharmacology & Therapeutics, College of Medicine, University of Florida, Gainesville, FL 32610., Gopinath A; Department of Pharmacology & Therapeutics, College of Medicine, University of Florida, Gainesville, FL 32610., Sarkisian MR; Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL 32610., Campbell JJ; ChemoCentryx, Mountain View, CA 94043., Charo IF; ChemoCentryx, Mountain View, CA 94043., Singh R; ChemoCentryx, Mountain View, CA 94043., Schall TJ; ChemoCentryx, Mountain View, CA 94043., Datta M; Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114., Jain RK; Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114; jain@steele.mgh.harvard.edu jharriso@ufl.edu., Mitchell DA; Department of Neurosurgery, College of Medicine, University of Florida, Gainesville, FL 32610.; Preston A. Wells Jr. Center for Brain Tumor Therapy, University of Florida, Gainesville, FL 32610., Harrison JK; Department of Pharmacology & Therapeutics, College of Medicine, University of Florida, Gainesville, FL 32610; jain@steele.mgh.harvard.edu jharriso@ufl.edu.; Preston A. Wells Jr. Center for Brain Tumor Therapy, University of Florida, Gainesville, FL 32610.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Jan 14; Vol. 117 (2), pp. 1129-1138. Date of Electronic Publication: 2019 Dec 26.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: B7-H1 Antigen/*antagonists & inhibitors , Glioma/*drug therapy , Myeloid Cells/*metabolism , Receptors, CCR2/*drug effects , Receptors, CCR2/*metabolism, Animals ; CD4-Positive T-Lymphocytes ; CD8-Positive T-Lymphocytes ; CX3C Chemokine Receptor 1/genetics ; CX3C Chemokine Receptor 1/metabolism ; Chemokine CCL2 ; Disease Models, Animal ; Gene Knock-In Techniques ; Glioblastoma/drug therapy ; Glioblastoma/pathology ; Glioma/pathology ; Humans ; Immunotherapy ; Lymphocytes, Tumor-Infiltrating/drug effects ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Myeloid Cells/drug effects ; Myeloid-Derived Suppressor Cells/metabolism ; Programmed Cell Death 1 Receptor ; Receptors, CCR2/genetics ; Survival Analysis ; Tumor Microenvironment/drug effects

المؤلفون: Phillips RE; Department of Neurology and Brain Tumor Center, Memorial Sloan Kettering Cancer Center, New York, NY 10065.; Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, NY 10065., Yang Y; Department of Neurosurgery, Center for Stem Cell Biology and Brain Tumor Center, Memorial Sloan Kettering Cancer Center, New York, NY 10065., Smith RC; Department of Neurosurgery, Center for Stem Cell Biology and Brain Tumor Center, Memorial Sloan Kettering Cancer Center, New York, NY 10065., Thompson BM; Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390., Yamasaki T; Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology, 305-8566 Tsukuba, Japan., Soto-Feliciano YM; Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, NY 10065., Funato K; Department of Neurosurgery, Center for Stem Cell Biology and Brain Tumor Center, Memorial Sloan Kettering Cancer Center, New York, NY 10065., Liang Y; Center for Clinical and Translational Science, The Rockefeller University, New York, NY 10065., Garcia-Bermudez J; Laboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY 10065., Wang X; Epigenetics Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104., Garcia BA; Epigenetics Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104., Yamasaki K; Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology, 305-8566 Tsukuba, Japan., McDonald JG; Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390., Birsoy K; Laboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY 10065., Tabar V; Department of Neurosurgery, Center for Stem Cell Biology and Brain Tumor Center, Memorial Sloan Kettering Cancer Center, New York, NY 10065., Allis CD; Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, NY 10065; alliscd@rockefeller.edu.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2019 Apr 16; Vol. 116 (16), pp. 7957-7962. Date of Electronic Publication: 2019 Mar 28.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Brain Stem Neoplasms*/enzymology , Brain Stem Neoplasms*/metabolism , Glioma*/enzymology , Glioma*/metabolism, Antineoplastic Agents/*pharmacology , Intramolecular Transferases/*metabolism , Proto-Oncogene Proteins/*antagonists & inhibitors, Cholesterol/metabolism ; Humans ; Metabolic Networks and Pathways/drug effects ; Proto-Oncogene Proteins/metabolism

المؤلفون: Zhang Y; Beijing Key Laboratory of Gene Resource and Molecular Development, Laboratory of Neuroscience and Brain Development, Beijing Normal University, 100875 Beijing, China., Li J; Beijing Key Laboratory of Gene Resource and Molecular Development, Laboratory of Neuroscience and Brain Development, Beijing Normal University, 100875 Beijing, China., Yi K; Laboratory of Neuro-Oncology, Tianjin Neurological Institute, Department of Neurosurgery, Tianjin Medical University General Hospital, 300052 Tianjin, China.; Key Laboratory of Neurotrauma, Variation, and Regeneration, Ministry of Education and Tianjin Municipal Government, 300052 Tianjin, China., Feng J; Beijing Key Laboratory of Gene Resource and Molecular Development, Laboratory of Neuroscience and Brain Development, Beijing Normal University, 100875 Beijing, China., Cong Z; Beijing Key Laboratory of Gene Resource and Molecular Development, Laboratory of Neuroscience and Brain Development, Beijing Normal University, 100875 Beijing, China., Wang Z; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, 100070 Beijing, China.; Beijing Neurosurgical Institute, 100070 Beijing, China., Wei Y; Beijing Key Laboratory of Gene Resource and Molecular Development, Laboratory of Neuroscience and Brain Development, Beijing Normal University, 100875 Beijing, China., Wu F; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, 100070 Beijing, China.; Beijing Neurosurgical Institute, 100070 Beijing, China., Cheng W; Department of Neurosurgery, The First Hospital of China Medical University, 110001 Shenyang, China., Samo AA; Beijing Key Laboratory of Gene Resource and Molecular Development, Laboratory of Neuroscience and Brain Development, Beijing Normal University, 100875 Beijing, China., Salomoni P; Nuclear Function Group, German Center for Neurodegenerative Diseases, 53127 Bonn, Germany., Yang Q; Beijing Key Laboratory of Gene Resource and Molecular Development, Laboratory of Neuroscience and Brain Development, Beijing Normal University, 100875 Beijing, China., Huang Y; Department of Medical Genetics, School of Basic Medical Sciences, Peking University Health Science Center, 100191 Beijing, China., Kang C; Laboratory of Neuro-Oncology, Tianjin Neurological Institute, Department of Neurosurgery, Tianjin Medical University General Hospital, 300052 Tianjin, China; kang97061@tmu.edu.cn taojiang1964@163.com xfan@bnu.edu.cn.; Key Laboratory of Neurotrauma, Variation, and Regeneration, Ministry of Education and Tianjin Municipal Government, 300052 Tianjin, China.; Chinese Glioma Genome Atlas Network and Asian Glioma Genome Atlas Network, Fengtai District, 100070 Beijing, China., Jiang T; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, 100070 Beijing, China; kang97061@tmu.edu.cn taojiang1964@163.com xfan@bnu.edu.cn.; Beijing Neurosurgical Institute, 100070 Beijing, China.; Chinese Glioma Genome Atlas Network and Asian Glioma Genome Atlas Network, Fengtai District, 100070 Beijing, China., Fan X; Beijing Key Laboratory of Gene Resource and Molecular Development, Laboratory of Neuroscience and Brain Development, Beijing Normal University, 100875 Beijing, China; kang97061@tmu.edu.cn taojiang1964@163.com xfan@bnu.edu.cn.; Chinese Glioma Genome Atlas Network and Asian Glioma Genome Atlas Network, Fengtai District, 100070 Beijing, China.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2019 Apr 02; Vol. 116 (14), pp. 6975-6984. Date of Electronic Publication: 2019 Mar 15.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Gene Expression Regulation, Neoplastic* , Genomic Instability*, Biomarkers, Tumor/*biosynthesis , Cdc20 Proteins/*biosynthesis , Glioma/*metabolism , Neoplasm Proteins/*biosynthesis, Animals ; Biomarkers, Tumor/genetics ; Cdc20 Proteins/genetics ; Chemotherapy, Adjuvant ; Female ; Gene Expression Profiling ; Glioma/drug therapy ; Glioma/genetics ; Glioma/pathology ; Humans ; Male ; Mice ; Mice, Nude ; Neoplasm Proteins/genetics ; Temozolomide/pharmacology ; Xenograft Model Antitumor Assays

المؤلفون: Shankar GM; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114., Kirtane AR; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139., Miller JJ; Stephen E. and Catherine Pappas Center for Neuro-Oncology, Division of Hematology/Oncology, Department of Neurology, Massachusetts General Hospital, Boston, MA 02114., Mazdiyasni H; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139., Rogner J; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139., Tai T; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139., Williams EA; Department of Pathology, Massachusetts General Hospital, Boston, MA 02114., Higuchi F; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114., Juratli TA; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114., Tateishi K; Department of Neurosurgery, Yokohama City University, Yokohama, Kanagawa Prefecture, Japan 236-0027., Koerner MVA; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114., Tummala SS; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114., Fink AL; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114., Penson T; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114., Schmidt SP; Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114., Wojtkiewicz GR; Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114., Baig A; Department of Pathology, Massachusetts General Hospital, Boston, MA 02114., Francis JM; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston MA 02215.; Cancer Program, Broad Institute, Cambridge MA 02142., Rinne ML; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston MA 02215.; Cancer Program, Broad Institute, Cambridge MA 02142., Batten JM; Department of Pathology, Massachusetts General Hospital, Boston, MA 02114., Batchelor TT; Stephen E. and Catherine Pappas Center for Neuro-Oncology, Division of Hematology/Oncology, Department of Neurology, Massachusetts General Hospital, Boston, MA 02114., Brastianos PK; Stephen E. and Catherine Pappas Center for Neuro-Oncology, Division of Hematology/Oncology, Department of Neurology, Massachusetts General Hospital, Boston, MA 02114., Curry WT Jr; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114., Barker FG 2nd; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114., Jordan JT; Stephen E. and Catherine Pappas Center for Neuro-Oncology, Division of Hematology/Oncology, Department of Neurology, Massachusetts General Hospital, Boston, MA 02114., Iafrate AJ; Department of Pathology, Massachusetts General Hospital, Boston, MA 02114., Chi AS; Laura and Isaac Perlmutter Cancer Center, New York University School of Medicine and New York University Langone Health, New York, NY 10016., Lennerz JK; Department of Pathology, Massachusetts General Hospital, Boston, MA 02114., Meyerson M; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston MA 02215.; Cancer Program, Broad Institute, Cambridge MA 02142., Langer R; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139; rlanger@mit.edu ctraverso@bwh.harvard.edu cahill@mgh.harvard.edu.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139., Wakimoto H; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114., Traverso G; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139; rlanger@mit.edu ctraverso@bwh.harvard.edu cahill@mgh.harvard.edu.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139.; Division of Gastroenterology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115., Cahill DP; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114; rlanger@mit.edu ctraverso@bwh.harvard.edu cahill@mgh.harvard.edu.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2018 Sep 04; Vol. 115 (36), pp. E8388-E8394. Date of Electronic Publication: 2018 Aug 06.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Brain Neoplasms*/drug therapy , Brain Neoplasms*/enzymology , Brain Neoplasms*/genetics , Genotype* , Glioma*/drug therapy , Glioma*/enzymology , Glioma*/genetics , Mutation*, Cyanides/*pharmacology , Guanidines/*pharmacology , Isocitrate Dehydrogenase/*genetics , Molecular Targeted Therapy/*methods , Neoplasm Proteins/*genetics, Animals ; Drug Delivery Systems/methods ; Female ; Humans ; Male ; Mice ; Mice, SCID ; Xenograft Model Antitumor Assays