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المؤلفون: Russo TA; Department of Medicine, Veterans Administration Western New York Healthcare System, Buffalo, NY 14215.; The Department of Medicine, University at Buffalo-State University of New York, Buffalo, NY 14203.; Department of Microbiology and Immunology, University at Buffalo-State University of New York, Buffalo, NY 14203.; The Witebsky Center for Microbial Pathogenesis, University at Buffalo-State University of New York, Buffalo, NY 14203., Umland TC; Department of Structural Biology, University at Buffalo State University of New York, Buffalo, NY 14203.; Hauptman Woodward Medical Research Institute, Buffalo, NY 14203., Deng X; Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390., El Mazouni F; Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390., Kokkonda S; Department of Chemistry, University of Washington, Seattle, WA 98195.; Department of Global Health, University of Washington, Seattle, WA 98195., Olson R; Department of Medicine, Veterans Administration Western New York Healthcare System, Buffalo, NY 14215.; The Department of Medicine, University at Buffalo-State University of New York, Buffalo, NY 14203., Carlino-MacDonald U; Department of Medicine, Veterans Administration Western New York Healthcare System, Buffalo, NY 14215.; The Department of Medicine, University at Buffalo-State University of New York, Buffalo, NY 14203., Beanan J; Department of Medicine, Veterans Administration Western New York Healthcare System, Buffalo, NY 14215.; The Department of Medicine, University at Buffalo-State University of New York, Buffalo, NY 14203., Alvarado CL; Department of Medicine, Veterans Administration Western New York Healthcare System, Buffalo, NY 14215.; The Department of Medicine, University at Buffalo-State University of New York, Buffalo, NY 14203., Tomchick DR; Department of Biophysics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390., Hutson A; Department of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14203., Chen H; Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390., Posner B; Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390., Rathod PK; Department of Chemistry, University of Washington, Seattle, WA 98195.; Department of Global Health, University of Washington, Seattle, WA 98195., Charman SA; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052 Australia., Phillips MA; Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 Dec 20; Vol. 119 (51), pp. e2213116119. Date of Electronic Publication: 2022 Dec 13.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Acinetobacter baumannii*, Humans ; Mice ; Animals ; Dihydroorotate Dehydrogenase ; Microbial Sensitivity Tests ; Meropenem ; Enzyme Inhibitors/pharmacology ; Enzyme Inhibitors/chemistry ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use

المؤلفون: Zhong X; Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505., Su L; Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505., Yang Y; Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505., Nair-Gill E; Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505., Tang M; Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505., Anderton P; Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505., Li X; Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505., Wang J; Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505., Zhan X; Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505., Tomchick DR; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390.; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390., Brautigam CA; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390.; Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390., Moresco EMY; Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505., Choi JH; Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505; Jin.Choi@UTSouthwestern.edu Bruce.Beutler@UTSouthwestern.edu.; Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390., Beutler B; Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505; Jin.Choi@UTSouthwestern.edu Bruce.Beutler@UTSouthwestern.edu.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Apr 14; Vol. 117 (15), pp. 8563-8572. Date of Electronic Publication: 2020 Mar 27.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Lymphopoiesis*, B-Lymphocytes/*immunology , Mutant Proteins/*metabolism , Receptors, G-Protein-Coupled/*metabolism , T-Lymphocytes/*immunology , rab GTP-Binding Proteins/*chemistry , rab GTP-Binding Proteins/*physiology, Animals ; B-Lymphocytes/metabolism ; B-Lymphocytes/pathology ; Crystallography, X-Ray ; Female ; Herpesviridae Infections/immunology ; Herpesviridae Infections/virology ; Killer Cells, Natural/immunology ; Killer Cells, Natural/metabolism ; Killer Cells, Natural/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Muromegalovirus/immunology ; Mutant Proteins/chemistry ; Mutant Proteins/genetics ; Mutation ; Protein Conformation ; T-Lymphocytes/metabolism ; T-Lymphocytes/pathology

المؤلفون: Voleti R; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390.; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390.; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390., Tomchick DR; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390.; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390., Südhof TC; Department of Molecular and Cellular Physiology, Stanford University Medical School, Stanford, CA 94305; tcs1@stanford.edu jose.rizo-rey@UTSouthwestern.edu.; Howard Hughes Medical Institute, Stanford University Medical School, Stanford, CA 94305., Rizo J; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390; tcs1@stanford.edu jose.rizo-rey@UTSouthwestern.edu.; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390.; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2017 Oct 03; Vol. 114 (40), pp. E8518-E8527. Date of Electronic Publication: 2017 Sep 18.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Calcium/*metabolism , Cell Membrane/*metabolism , Neurotransmitter Agents/*metabolism , Synaptotagmin I/*metabolism , Synaptotagmins/*metabolism, Animals ; Crystallography, X-Ray ; Liposomes ; Protein Binding ; Protein Domains ; Rats ; Synaptic Transmission ; Synaptotagmin I/chemistry ; Synaptotagmin I/genetics ; Synaptotagmins/chemistry ; Synaptotagmins/genetics

المؤلفون: Kikuchi S; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390.; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390., Borek DM; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390., Otwinowski Z; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390., Tomchick DR; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390., Yu H; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390; hongtao.yu@utsouthwestern.edu.; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2016 Nov 01; Vol. 113 (44), pp. 12444-12449. Date of Electronic Publication: 2016 Oct 18.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Cell Cycle Proteins/*metabolism , Chaetomium/*metabolism , Chromosomal Proteins, Non-Histone/*metabolism , Fungal Proteins/*metabolism, Amino Acid Sequence ; Cell Cycle Proteins/chemistry ; Cell Cycle Proteins/genetics ; Chaetomium/genetics ; Chromatids ; Chromosomal Proteins, Non-Histone/chemistry ; Chromosomal Proteins, Non-Histone/genetics ; Chromosome Segregation ; Crystallography, X-Ray ; Fungal Proteins/chemistry ; Fungal Proteins/genetics ; Models, Molecular ; Protein Binding ; Protein Domains ; Protein Structure, Secondary ; Sequence Homology, Amino Acid ; Cohesins

المؤلفون: Nguyen KB; Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093;, Sreelatha A; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390;, Durrant ES; Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093;, Lopez-Garrido J; Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093;, Muszewska A; Department of Microbial Biochemistry, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, 02106 Warsaw, Poland;, Dudkiewicz M; Department of Experimental Design and Bioinformatics, Warsaw University of Life Sciences, 02787 Warsaw, Poland;, Grynberg M; Department of Biophysics, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, 02106 Warsaw, Poland;, Yee S; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390;, Pogliano K; Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093;, Tomchick DR; Departments of Biophysics and Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390;, Pawłowski K; Department of Experimental Design and Bioinformatics, Warsaw University of Life Sciences, 02787 Warsaw, Poland;, Dixon JE; Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093 jedixon@ucsd.edu vincent.tagliabracci@utsouthwestern.edu., Tagliabracci VS; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390; jedixon@ucsd.edu vincent.tagliabracci@utsouthwestern.edu.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2016 Jun 21; Vol. 113 (25), pp. E3482-91. Date of Electronic Publication: 2016 May 16.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Comment

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Protein Kinases*, Spores, Bacterial/*genetics, Bacillus subtilis/genetics ; Bacterial Proteins/chemistry ; Capsid Proteins ; Phosphorylation

المؤلفون: Rivera-Cancel G; Departments of Biophysics and Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390-8816;, Ko WH; Departments of Biophysics and Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390-8816;, Tomchick DR; Departments of Biophysics and Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390-8816;, Correa F; Departments of Biophysics and Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390-8816; Structural Biology Initiative, City University of New York Advanced Science Research Center, New York, NY 10031; and., Gardner KH; Departments of Biophysics and Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390-8816; Structural Biology Initiative, City University of New York Advanced Science Research Center, New York, NY 10031; and Department of Chemistry, City College of New York, New York, NY 10031 Kevin.Gardner@asrc.cuny.edu.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2014 Dec 16; Vol. 111 (50), pp. 17839-44. Date of Electronic Publication: 2014 Dec 02.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Models, Molecular*, Protein Kinases/*chemistry , Signal Transduction/*physiology , Sphingomonadaceae/*enzymology, Chromatography, Gel ; Chromatography, Liquid ; Computational Biology ; Crystallization ; Dimerization ; Escherichia coli ; Histidine Kinase ; Magnetic Resonance Spectroscopy ; Mass Spectrometry ; Protein Conformation ; Signal Transduction/genetics ; X-Ray Diffraction

المؤلفون: Ouyang Z; Howard Hughes Medical Institute, Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Zheng G, Song J, Borek DM, Otwinowski Z, Brautigam CA, Tomchick DR, Rankin S, Yu H

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2013 Jul 09; Vol. 110 (28), pp. 11355-60. Date of Electronic Publication: 2013 Jun 17.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Carrier Proteins/*chemistry , Cell Cycle Proteins/*antagonists & inhibitors , Chromosomal Proteins, Non-Histone/*antagonists & inhibitors , Nuclear Proteins/*chemistry , Proto-Oncogene Proteins/*chemistry, Carrier Proteins/genetics ; Cell Cycle Proteins/metabolism ; Chromosomal Proteins, Non-Histone/metabolism ; Humans ; Models, Molecular ; Mutation ; Nuclear Proteins/genetics ; Protein Conformation ; Proto-Oncogene Proteins/genetics ; Cohesins

المؤلفون: Tian W; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Li B, Warrington R, Tomchick DR, Yu H, Luo X

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2012 Nov 06; Vol. 109 (45), pp. 18419-24. Date of Electronic Publication: 2012 Oct 22.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Proteolysis*, Cell Cycle Proteins/*chemistry , Cell Cycle Proteins/*metabolism , Ubiquitin-Protein Ligase Complexes/*metabolism, Anaphase-Promoting Complex-Cyclosome ; Binding Sites ; Carrier Proteins/chemistry ; Carrier Proteins/metabolism ; Cdc20 Proteins ; Conserved Sequence ; Humans ; Models, Molecular ; Mutagenesis/genetics ; Protein Binding ; Protein Serine-Threonine Kinases/chemistry ; Protein Serine-Threonine Kinases/metabolism ; Protein Structure, Tertiary ; Substrate Specificity ; Ubiquitination