المؤلفون: Ruscetti M; Department of Cancer Biology and Genetics, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Leibold J; Department of Cancer Biology and Genetics, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Bott MJ; Department of Cancer Biology and Genetics, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Fennell M; Department of Cancer Biology and Genetics, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Kulick A; Department of Molecular Pharmacology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Salgado NR; Department of Cancer Biology and Genetics, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Chen CC; Department of Cancer Biology and Genetics, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Ho YJ; Department of Cancer Biology and Genetics, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Sanchez-Rivera FJ; Department of Cancer Biology and Genetics, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Feucht J; Center for Cell Engineering and Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Baslan T; Department of Cancer Biology and Genetics, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Tian S; Department of Cancer Biology and Genetics, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Chen HA; Department of Cancer Biology and Genetics, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Romesser PB; Department of Cancer Biology and Genetics, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Poirier JT; Department of Molecular Pharmacology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Rudin CM; Department of Molecular Pharmacology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., de Stanchina E; Department of Molecular Pharmacology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Manchado E; Department of Cancer Biology and Genetics, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Sherr CJ; Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA., Lowe SW; Department of Cancer Biology and Genetics, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. lowes@mskcc.org.; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.

المصدر: Science (New York, N.Y.) [Science] 2018 Dec 21; Vol. 362 (6421), pp. 1416-1422.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE

مواضيع طبية MeSH: Cytotoxicity, Immunologic* , Immunologic Surveillance*, Antineoplastic Combined Chemotherapy Protocols/*therapeutic use , Cyclin-Dependent Kinase 4/*antagonists & inhibitors , Cyclin-Dependent Kinase 6/*antagonists & inhibitors , Cytostatic Agents/*therapeutic use , Killer Cells, Natural/*immunology , Lung Neoplasms/*drug therapy, Aminopyridines/pharmacology ; Aminopyridines/therapeutic use ; Animals ; Apoptosis ; Benzimidazoles/pharmacology ; Benzimidazoles/therapeutic use ; Cellular Senescence ; Cytostatic Agents/pharmacology ; Humans ; Intercellular Adhesion Molecule-1/metabolism ; Lung Neoplasms/pathology ; Mice ; Mice, Inbred C57BL ; Mitogen-Activated Protein Kinases ; Molecular Targeted Therapy ; Mutation ; Piperazines/pharmacology ; Piperazines/therapeutic use ; Proto-Oncogene Proteins p21(ras)/genetics ; Purines/pharmacology ; Purines/therapeutic use ; Pyridines/pharmacology ; Pyridines/therapeutic use ; Pyridones/pharmacology ; Pyridones/therapeutic use ; Pyrimidinones/pharmacology ; Pyrimidinones/therapeutic use ; Retinoblastoma Protein/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Xenograft Model Antitumor Assays