المؤلفون: Campbell T; Valley Hospital Medical Center, Las Vegas, USA. jawoflehi@gmail.com.; Las Vegas Neurology Center, 2020 Wellness Way Ste. 300, Las Vegas, NV, 89106, USA. jawoflehi@gmail.com., Diuguid C; Kirk Kerkorian School of Medicine at University of Nevada Las Vegas, 1650 W Charleston Blvd, NV, 89016, Las Vegas, USA., Vasaya S; Valley Hospital Medical Center, Las Vegas, USA.; Las Vegas Neurology Center, 2020 Wellness Way Ste. 300, Las Vegas, NV, 89106, USA., Janda P; Valley Hospital Medical Center, Las Vegas, USA.; Las Vegas Neurology Center, 2020 Wellness Way Ste. 300, Las Vegas, NV, 89106, USA.; Neurology, Touro University Nevada, Henderson, USA., Vickers A; Valley Hospital Medical Center, Las Vegas, USA.; Las Vegas Neurology Center, 2020 Wellness Way Ste. 300, Las Vegas, NV, 89106, USA.; Neurology and Neuro-Ophthalmology, Touro University Nevada, Henderson, USA.; Neuro-Ophthalmology Department, Las Vegas Neurology Center, Las Vegas, USA.

المصدر: Cerebellum (London, England) [Cerebellum] 2024 Feb; Vol. 23 (1), pp. 255-259. Date of Electronic Publication: 2023 Jan 23.

نوع المنشور: Case Reports; Journal Article

بيانات الدورية: Publisher: Springer Country of Publication: United States NLM ID: 101089443 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-4230 (Electronic) Linking ISSN: 14734222 NLM ISO Abbreviation: Cerebellum Subsets: MEDLINE

مواضيع طبية MeSH: Aphasia*/etiology , Cerebellar Diseases*/complications , Cerebellar Diseases*/diagnostic imaging , Brain Ischemia*, Humans ; Language ; Cerebellum/physiology ; Infarction

مستخلص: Although neuroanatomical and physiological understanding of the cerebellum has evolved over recent decades and continues to develop, there is much that remains to be expounded upon, especially with regard to nonmotor roles. Neurocognitive and language processing is one area where involvement of the cerebellum is no longer in question, but the extent and mechanism of this relationship have yet to be defined. For example, which of the cerebellar hemispheres is involved continues to be debated. We present a case wherein a thrombus in the basilar artery led to bihemispheric cerebellar strokes with profound mixed effects on the patient's language and cognition. To the authors' knowledge, this is the first reported case of bilateral cerebellar strokes resulting in a mixed aphasia reported in scientific literature. This demonstrates the importance of continued research into a model for cerebellar function and the clinical impact of lesions to various cerebellar regions.
(© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)

المؤلفون: Kakinuma K; Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, 2-1 Seiryo, Aoba-ku, Sendai, 980-8575, Japan. kazuo.kakinuma.c1@tohoku.ac.jp., Osawa SI; Department of Neurosurgery, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan., Katsuse K; Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, 2-1 Seiryo, Aoba-ku, Sendai, 980-8575, Japan.; Department of Neurology, The University of Tokyo Graduate School of Medicine Faculty of Medicine, Bunkyo-ku, Tokyo, Japan., Hosokawa H; Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, 2-1 Seiryo, Aoba-ku, Sendai, 980-8575, Japan.; Department of Rehabilitation, National Hospital Organization Sendai Nishitaga Hospital, Taihaku-ku, Sendai, Japan., Ukishiro K; Department of Epileptology, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan., Jin K; Department of Epileptology, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan., Niizuma K; Department of Neurosurgery, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan.; Department of Neurosurgical Engineering and Translational Neuroscience, Tohoku University Graduate School of Biomedical Engineering, Aoba-ku, Sendai, Japan.; Department of Neurosurgical Engineering and Translational Neuroscience, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan., Tominaga T; Department of Neurosurgery, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan., Endo H; Department of Neurosurgery, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan., Nakasato N; Department of Epileptology, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan., Suzuki K; Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, 2-1 Seiryo, Aoba-ku, Sendai, 980-8575, Japan.

المصدر: Acta neurochirurgica [Acta Neurochir (Wien)] 2024 Feb 10; Vol. 166 (1), pp. 77. Date of Electronic Publication: 2024 Feb 10.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Country of Publication: Austria NLM ID: 0151000 Publication Model: Electronic Cited Medium: Internet ISSN: 0942-0940 (Electronic) Linking ISSN: 00016268 NLM ISO Abbreviation: Acta Neurochir (Wien) Subsets: MEDLINE

مواضيع طبية MeSH: Epilepsy*/diagnosis , Aphasia* , Anesthetics*/pharmacology, Humans ; Retrospective Studies ; Amobarbital/pharmacology ; Dominance, Cerebral ; Magnetic Resonance Imaging ; Functional Laterality ; Brain Mapping/methods

مستخلص: Background: The classical Wada test (cWada), performed by injecting a short-acting anesthetic through the intracarotid route, helps determine language dominance. In the cWada, adverse effects are observed in 10-30% of trials, hindering accurate assessments. In this study, we assessed the effectiveness of the super-selective Wada test (ssWada), a more selective approach for anesthetic infusion into the middle cerebral artery (MCA).
Methods: We retrospectively examined the data of 17 patients with epilepsy who underwent ssWada via anesthetic injection into one M1 segment of the MCA and at least one contralateral trial.
Results: The ssWada identified 12 patients with left language dominance, 3 with right language dominance, and 2 with bilateral language distribution. Nine trials on the language dominant side resulted in global aphasia for patients with left- or right language dominance. Of the 13 trials conducted on the non-dominant language side, 12 revealed intact language function and one resulted in confusion. Among these, the outcomes of global aphasia or no language impairment were confirmed in the contralateral trials. Among the 22 trials of unilateral M1 injections in patients with unilateral language dominance, 21 (95.5%) showed either global aphasia or no language impairment, indicating language dominance.
Conclusions: The ssWada yields clear results, with a high rate of over 90% in determining the language dominant hemisphere with few side effects.
(© 2024. The Author(s).)

المؤلفون: Perković R; Department of Neurology, University Hospital Center Zagreb, Zagreb, Croatia. romana.per@gmail.com., Jerčić KG; Department of Neurology, University Hospital Center Zagreb, Zagreb, Croatia.; Department of Functional Genomics, Center for Translational and Clinical Research, University of Zagreb School of Medicine, Zagreb, Croatia., Frančić M; University of Zagreb School of Medicine, Zagreb, Croatia., Ozretić D; Department of Radiology, University Hospital Center Zagreb, Zagreb, Croatia., Borovečki F; Department of Neurology, University Hospital Center Zagreb, Zagreb, Croatia.; Department of Functional Genomics, Center for Translational and Clinical Research, University of Zagreb School of Medicine, Zagreb, Croatia.

المصدر: Acta neurologica Belgica [Acta Neurol Belg] 2023 Apr; Vol. 123 (2), pp. 727-729. Date of Electronic Publication: 2022 Aug 18.

نوع المنشور: Letter

بيانات الدورية: Publisher: Springer Country of Publication: Italy NLM ID: 0247035 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2240-2993 (Electronic) Linking ISSN: 03009009 NLM ISO Abbreviation: Acta Neurol Belg Subsets: MEDLINE

مواضيع طبية MeSH: Parkinsonian Disorders*/diagnostic imaging , Parkinsonian Disorders*/genetics , Aphasia, Primary Progressive*/diagnostic imaging , Aphasia, Primary Progressive*/genetics , Frontotemporal Dementia*, Humans ; Mutation/genetics ; Progranulins/genetics

المؤلفون: Fyndanis V; Department of Rehabilitation Sciences, Cyprus University of Technology, Limassol, Cyprus. c.fyndanis@cut.ac.cy.; MultiLing/Department of Linguistics and Scandinavian Studies, University of Oslo, Oslo, Norway. c.fyndanis@cut.ac.cy.; Department of Linguistics, University of Potsdam, Potsdam, Germany. c.fyndanis@cut.ac.cy., Miceli G; Department of Psychology and Cognitive Science, University of Trento, Trento/Rovereto, Italy., Capasso R; SCA Associates, Rome, Italy., Killmer H; MultiLing/Department of Linguistics and Scandinavian Studies, University of Oslo, Oslo, Norway.; Department of Linguistics, University of Potsdam, Potsdam, Germany., Malefaki S; Department of Mechanical Engineering and Aeronautics, University of Patras, Rio Patras, Greece., Grohmann KK; Department of English Studies, University of Cyprus, Nicosia, Cyprus.

المصدر: Journal of psycholinguistic research [J Psycholinguist Res] 2023 Apr; Vol. 52 (2), pp. 497-524. Date of Electronic Publication: 2022 Jun 25.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Country of Publication: United States NLM ID: 0333506 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-6555 (Electronic) Linking ISSN: 00906905 NLM ISO Abbreviation: J Psycholinguist Res Subsets: MEDLINE

مواضيع طبية MeSH: Semantics* , Aphasia*, Humans ; Comprehension ; Memory, Short-Term ; Italy

مستخلص: The ability of persons with non-fluent aphasia (PWAs) to produce sentential negation has been investigated in several languages, but only in small samples. Accounts of (morpho)syntactic impairment in PWAs have emphasized various factors, such as whether the negative marker blocks or interferes with verb movement, the position of the Negation Phrase in the syntactic hierarchy or the interpretability of negation. This study investigates the ability of German- and Italian-speaking PWAs to construct negative sentences, as well as the role of verbal working memory (WM) capacity and education in task performance and production of sentential negation. German and Italian differ in the syntactic properties of the negative markers that are relevant here (nicht and non, respectively). A sentence anagram task tapping into the construction of negative and affirmative declarative sentences was administered to 9 German- and 7 Italian-speaking PWAs, and to 14 German- and 11 Italian-speaking age- and education-matched healthy volunteers. We fitted generalized linear mixed-effects models to the datasets. There was no significant difference between negative and affirmative sentences in either group of PWAs. There was a main effect of verbal WM capacity on task performance, but no interaction between verbal WM capacity and production of negative vs. affirmative sentences. Education did not affect task performance. The results are discussed in light of different linguistically-informed accounts of (morpho)syntactic impairment in non-fluent aphasia.
(© 2022. The Author(s).)

المؤلفون: Özdemir Ş; Department of Speech and Language Therapy, Faculty of Health Sciences, Muğla Sıtkı Koçman University, Kötekli, Menteşe, 48000, Muğla, Turkey. sevketozdemir@mu.edu.tr., Maviş İ; Department of Speech and Language Therapy, Faculty of Health Sciences, Anadolu University, Eskişehir, Turkey., Tunçer AM; Department of Speech and Language Therapy, Faculty of Health Sciences, Muğla Sıtkı Koçman University, Kötekli, Menteşe, 48000, Muğla, Turkey.

المصدر: Journal of psycholinguistic research [J Psycholinguist Res] 2022 Aug; Vol. 51 (4), pp. 789-802. Date of Electronic Publication: 2022 Mar 02.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Country of Publication: United States NLM ID: 0333506 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-6555 (Electronic) Linking ISSN: 00906905 NLM ISO Abbreviation: J Psycholinguist Res Subsets: MEDLINE

مواضيع طبية MeSH: Aphasia*/diagnosis , Language*, Humans ; Language Tests ; Reproducibility of Results ; Turkey

مستخلص: Aphasia assessment is the initial step of a well-structured language therapy. Therefore, it is reasonable to underline that the assessment tools need to consider the typological and cultural characteristics of the language. A group of international researchers in the Collaboration of Aphasia Trialists have been adapting the Comprehensive Aphasia Test (CAT) into 14 languages spoken in Europe including Turkish. Thus, the aim of this study was to perform the validity and reliability analyses of the Language Battery section of CAT-TR to ensure the assessment of Turkish-speaking people with aphasia (PWA). The test included 21 sub-tests and yielded six modality scores (spoken language comprehension, written language comprehension, repetition, naming, reading, writing). Ninety PWA (Mean AGE = 61.07) and 200 controls (Mean AGE = 54.89) involved in the analyses. The participants were stratified into two education and three age groups. The analyses belonging to content, construct and criterion validity were performed, while the reliability analyses included internal consistency, test-retest and inter-rater reliability. Education influenced all the modality scores of the controls, while age-related differences were significant among all the modality scores except reading. It has to be underlined that Education did not hold any significant effects on the language performance of PWA, whereas those younger than 60 showed statistically better performance in the Spoken and Written Language Comprehension modality scores. The cut-off scores for each modality and Language Battery were presented with high sensitivity and specificity values. Compared to the psychometric characteristics of the adapted versions of CAT and aphasia tests utilized in Turkey, CAT-TR is an appropriate test for the language assessment of Turkish-speaking adults with aphasia.
(© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)

المؤلفون: Nigro S; Institute of Nanotechnology (NANOTEC), National Research Council, Lecce, Italy.; Center for Neurodegenerative Diseases and the Aging Brain, Department of Clinical Research in Neurology, University of Bari Aldo Moro, Pia Fondazione Cardinale G. Panico, Tricase, Lecce, Italy., Tafuri B; Center for Neurodegenerative Diseases and the Aging Brain, Department of Clinical Research in Neurology, University of Bari Aldo Moro, Pia Fondazione Cardinale G. Panico, Tricase, Lecce, Italy.; Department of Basic Medicine, Neuroscience, and Sense Organs, University of Bari Aldo Moro, Bari, Italy., Urso D; Center for Neurodegenerative Diseases and the Aging Brain, Department of Clinical Research in Neurology, University of Bari Aldo Moro, Pia Fondazione Cardinale G. Panico, Tricase, Lecce, Italy.; Department of Neurosciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, De Crespigny Park, London, SE5 8AF, UK., De Blasi R; Center for Neurodegenerative Diseases and the Aging Brain, Department of Clinical Research in Neurology, University of Bari Aldo Moro, Pia Fondazione Cardinale G. Panico, Tricase, Lecce, Italy.; Department of Radiology, Pia Fondazione Cardinale G. Panico, Tricase, Lecce, Italy., Cedola A; Institute of Nanotechnology (NANOTEC), National Research Council, Lecce, Italy., Gigli G; Institute of Nanotechnology (NANOTEC), National Research Council, Lecce, Italy.; Department of Mathematics and Physics Ennio De Giorgi, University of Salento, Campus Ecotekne, Lecce, Italy., Logroscino G; Center for Neurodegenerative Diseases and the Aging Brain, Department of Clinical Research in Neurology, University of Bari Aldo Moro, Pia Fondazione Cardinale G. Panico, Tricase, Lecce, Italy. giancarlo.logroscino@uniba.it.; Department of Basic Medicine, Neuroscience, and Sense Organs, University of Bari Aldo Moro, Bari, Italy. giancarlo.logroscino@uniba.it.

مؤلفون مشاركون: Frontotemporal Lobar Degeneration Neuroimaging Initiative*

المصدر: Brain imaging and behavior [Brain Imaging Behav] 2022 Jun; Vol. 16 (3), pp. 1113-1122. Date of Electronic Publication: 2021 Nov 10.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Country of Publication: United States NLM ID: 101300405 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1931-7565 (Electronic) Linking ISSN: 19317557 NLM ISO Abbreviation: Brain Imaging Behav Subsets: MEDLINE

مواضيع طبية MeSH: Aphasia, Primary Progressive*/diagnostic imaging , Frontotemporal Dementia*/diagnostic imaging, Brain/diagnostic imaging ; Humans ; Magnetic Resonance Imaging ; Semantics

مستخلص: Semantic (svPPA) and nonfluent (nfvPPA) variants of primary progressive aphasia (PPA) have recently been associated with distinct patterns of white matter and functional network alterations in left frontoinsular and anterior temporal regions, respectively. Little information exists, however, about the topological characteristics of gray matter covariance networks in these two PPA variants. In the present study, we used a graph theory approach to describe the structural covariance network organization in 34 patients with svPPA, 34 patients with nfvPPA and 110 healthy controls. All participants underwent a 3 T structural MRI. Next, we used cortical thickness values and subcortical volumes to define subject-specific connectivity networks. Patients with svPPA and nfvPPA were characterized by higher values of normalized characteristic path length compared with controls. Moreover, svPPA patients had lower values of normalized clustering coefficient relative to healthy controls. At a regional level, patients with svPPA showed a reduced connectivity and impaired information processing in temporal and limbic brain areas relative to controls and nfvPPA patients. By contrast, local network changes in patients with nfvPPA were focused on frontal brain regions such as the pars opercularis and the middle frontal cortex. Of note, a predominance of local metric changes was observed in the left hemisphere in both nfvPPA and svPPA brain networks. Taken together, these findings provide new evidences of a suboptimal topological organization of the structural covariance networks in svPPA and nfvPPA patients. Moreover, we further confirm that distinct patterns of structural network alterations are related to neurodegenerative mechanisms underlying each PPA variant.
(© 2021. The Author(s).)

المؤلفون: Meulemans C; Department of Management, University of Antwerp, Antwerp, Belgium. catherine.meulemans@uantwerpen.be., De Maeyer S; Department of Training and Education Sciences, University of Antwerp, Antwerp, Belgium., Leijten M; Department of Management, University of Antwerp, Antwerp, Belgium.

المصدر: Behavior research methods [Behav Res Methods] 2022 Aug; Vol. 54 (4), pp. 1976-1988. Date of Electronic Publication: 2021 Nov 23.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Springer Country of Publication: United States NLM ID: 101244316 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-3528 (Electronic) Linking ISSN: 1554351X NLM ISO Abbreviation: Behav Res Methods Subsets: MEDLINE

مواضيع طبية MeSH: Aphasia* , Language*, Adult ; Humans ; Writing

مستخلص: Researchers often decide on the number of trials included in an experiment without adhering to an empirical method or framework. This might compromise generalizability and unnecessarily increase participant burden. In this article we want to put forward generalizability theory as a guide for task reduction. We will use a sentence production task to demonstrate how a generalizability and a decision study can help researchers to estimate the minimum number of trials and of items per trial that are necessary to generalize over trials. We obtained writing process data for 116 participants. Each of them completed a sentence production task that had 40 trials. Pause times between and within all words, target nouns and target verbs were logged with the keystroke logging tool ScriptLog. Results demonstrate that generalizability theory can serve as an empirical framework to ensure generalizable measurements on the one hand, and reduce participant burden to a minimum on the other. This finding is particularly valuable for studies with vulnerable target groups, such as participants suffering from aphasia, dyslexia or Alzheimer's disease.
(© 2021. The Psychonomic Society, Inc.)

المؤلفون: Mueller-Sarnowski F; Department of Psychiatry and Psychotherapy, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675, Munich, Germany.; Department of Medical Information Science, School of Medicine, Augsburg University, Augsburg, Germany., Sollmann N; Department of Diagnostic and Interventional Neuroradiology, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.; TUM-Neuroimaging Center, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.; Department of Diagnostic and Interventional Radiology, University Hospital Ulm, Ulm, Germany., Schröder A; Department of Neurosurgery, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany., Houri L; Department of Psychiatry and Psychotherapy, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675, Munich, Germany., Ille S; Department of Neurosurgery, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany., Grimmer T; Department of Psychiatry and Psychotherapy, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675, Munich, Germany., Krieg SM; TUM-Neuroimaging Center, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.; Department of Neurosurgery, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany., Diehl-Schmid J; Department of Psychiatry and Psychotherapy, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675, Munich, Germany. janine.diehl-schmid@tum.de.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. janine.diehl-schmid@tum.de.

المصدر: Brain imaging and behavior [Brain Imaging Behav] 2022 Jun; Vol. 16 (3), pp. 1208-1216. Date of Electronic Publication: 2021 Dec 28.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Country of Publication: United States NLM ID: 101300405 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1931-7565 (Electronic) Linking ISSN: 19317557 NLM ISO Abbreviation: Brain Imaging Behav Subsets: MEDLINE

مواضيع طبية MeSH: Aphasia, Primary Progressive*/diagnostic imaging , Transcranial Magnetic Stimulation*/methods, Aged ; Brain Mapping/methods ; Humans ; Language ; Magnetic Resonance Imaging ; Male ; Pilot Projects

مستخلص: Navigated repetitive transcranial magnetic stimulation (nrTMS) is an innovative technique that provides insight into language function with high accuracy in time and space. So far, nrTMS has mainly been applied in presurgical language mapping of patients with intracranial neoplasms. For the present study, nrTMS was used for language mapping in primary progressive aphasia (PPA). Seven patients (median age: 70 years, 4 males) with the non-fluent variant of PPA (nfvPPA) were included in this pilot study. Trains of nrTMS (5 Hz, 100% resting motor threshold) caused virtual lesions at 46 standardized cortical stimulation targets per hemisphere. Patients' errors in a naming task during stimulation were counted. The majority of errors induced occurred during frontal lobe stimulation (34.3%). Timing errors and non-responses were most frequent. More errors were induced in the right hemisphere (58%) than in the left hemisphere (42%). Mapping was tolerated by all patients, however, discomfort or pain was reported for stimulation of frontal areas. The elevated right-hemispheric error rate in our study could be due to a partial shift of language function to the right hemisphere in neurodegenerative aphasia during the course of disease and therefore points to the existence of neuronal plasticity in nfvPPA. While this is an interesting finding for neurodegenerative disorders per se, its promotion might also harbor future therapeutic targets.
(© 2021. The Author(s).)

المؤلفون: Meier EL; Department of Communication Sciences and Disorders, Northeastern University, 360 Huntington Avenue, 228C FR, Boston, MA, 02215, USA. e.meier@northeastern.edu., Kelly CR; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA., Goldberg EB; Department of Communication Science and Disorders, University of Pittsburgh, Pittsburgh, PA, USA., Hillis AE; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA.; Department of Cognitive Science, Johns Hopkins University, Baltimore, MD, USA.; Department of Physical Medicine and Rehabilitation, Johns Hopkins School of Medicine, Baltimore, MD, USA.

المصدر: Brain imaging and behavior [Brain Imaging Behav] 2022 Apr; Vol. 16 (2), pp. 868-877. Date of Electronic Publication: 2021 Oct 14.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Country of Publication: United States NLM ID: 101300405 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1931-7565 (Electronic) Linking ISSN: 19317557 NLM ISO Abbreviation: Brain Imaging Behav Subsets: MEDLINE

مواضيع طبية MeSH: Aphasia*/diagnostic imaging , Aphasia*/etiology , Aphasia*/pathology , Stroke*/complications , Stroke*/diagnostic imaging , Stroke*/pathology, Brain Mapping ; Executive Function/physiology ; Humans ; Magnetic Resonance Imaging/methods ; Survivors

مستخلص: In contrast to the traditional definition of the disorder, many individuals with aphasia exhibit non-linguistic cognitive impairments, including executive control deficits. Classic lesion studies cite frontal lobe damage in executive dysfunction, but more recent lesion symptom-mapping studies in chronic aphasia present mixed results. In this study, we compared executive control abilities of acute stroke survivors with and without aphasia and investigated lesion correlates of linguistic and non-linguistic cognitive tasks. Twenty-nine participants with acute left hemisphere stroke resulting in aphasia (n = 14) or no aphasia (n = 15) completed clinical MRI and testing, including three NIH Toolbox Cognition Batteries (Pattern Comparison Processing Speed, Flanker Inhibitory Control and Attention, and Dimensional Change Card Sort Tests) and the Boston Naming Test. We compared performance between groups using Wilcoxon rank sum tests. We used Least Absolute Shrinkage and Selection Operator Regression to identify neural markers (percent regional damage, hypoperfusion within vascular territories, and total lesion volume) of executive control deficits and anomia. Group performance was comparable on the Pattern Comparison Processing Speed Test, but people with aphasia had poorer standard scores, lower accuracy, and slower response times on the Dimensional Change Card Sort Test than people without aphasia. Damage to extrasylvian regions (dorsolateral prefrontal cortex, intraparietal sulcus) was related to executive control deficits, whereas language network damage (to inferior frontal and superior and posterior middle temporal gyri) was linked to naming impairments. These results suggest people with aphasia can exhibit comorbid executive control impairments linked to damage outside classic language network areas.
(© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)

المؤلفون: Louppe E; Department of Neurosurgery, Montpellier University Medical Center, 34295, Montpellier, France.; Institute of Functional Genomics, INSERM U-1191, University of Montpellier, 34298, Montpellier, France., Moritz-Gasser S; Department of Neurosurgery, Montpellier University Medical Center, 34295, Montpellier, France.; Institute of Functional Genomics, INSERM U-1191, University of Montpellier, 34298, Montpellier, France., Duffau H; Department of Neurosurgery, Montpellier University Medical Center, 34295, Montpellier, France. h-duffau@chu-montpellier.fr.; Institute of Functional Genomics, INSERM U-1191, University of Montpellier, 34298, Montpellier, France. h-duffau@chu-montpellier.fr.; Department of Neurosurgery, Gui de Chauliac Hospital, CHU Montpellier, 80 Avenue Augustin Fliche, 34295, Montpellier, France. h-duffau@chu-montpellier.fr.

المصدر: Acta neurochirurgica [Acta Neurochir (Wien)] 2021 Nov; Vol. 163 (11), pp. 3115-3119. Date of Electronic Publication: 2021 Jul 18.

نوع المنشور: Case Reports; Journal Article

بيانات الدورية: Publisher: Springer Country of Publication: Austria NLM ID: 0151000 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 0942-0940 (Electronic) Linking ISSN: 00016268 NLM ISO Abbreviation: Acta Neurochir (Wien) Subsets: MEDLINE

مواضيع طبية MeSH: Aphasia* , Brain Neoplasms*/complications , Brain Neoplasms*/surgery , Glioma*/complications , Glioma*/surgery, Adult ; Brain Mapping ; Humans ; Quality of Life ; Wakefulness

مستخلص: Awake surgery is difficult in glioma patients with preoperative aphasia. A 29-year-old right-handed bilingual (Spanish/English) patient experienced intractable seizures with severe language disorders due to a voluminous left fronto-temporo-insular tumor. We performed awake procedure with initial laborious language mapping, but with real-time improvement throughout the debulking, allowing preservation of the connectivity. A substantial residue was left. Postoperative cognitive rehabilitation resulted in a dramatic functional improvement, in both languages, permitting a complementary awake surgery, this time with a perfect collaboration of the patient. This multistep strategy enabled 92% of resection while enhancing quality of life with language recovery and epilepsy control.
(© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.)