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المؤلفون: Mary Ellen Gray, David Martin, Fareed N. Ali, Jonathan S. Silver, Matthew F Yuyun, G. Muqtada Chaudhry
المصدر: JACC Case Reports
JACC: Case Reports, Vol 2, Iss 5, Pp 796-801 (2020)مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, CRT, cardiac resynchronization therapy, medicine.medical_treatment, health care facilities, manpower, and services, education, Cardiomyopathy, Case Report, macromolecular substances, 030105 genetics & heredity, LVEF - Left ventricular ejection fraction, 03 medical and health sciences, 0302 clinical medicine, implantable cardioverter-defibrillator, Clinical Case, Internal medicine, Primary prevention, LVEF, left ventricular ejection fraction, VT, ventricular tachycardia, Diseases of the circulatory (Cardiovascular) system, Medicine, elective replacement indicator, health care economics and organizations, VF - Ventricular fibrillation, EOL, end of life, business.industry, AV, atrioventricular, ventricular arrhythmias, Implantable cardioverter-defibrillator, medicine.disease, ICD, implantable cardioverter-defibrillator, LAD, left anterior descending coronary artery, ERI, elective replacement indicator, Nonischemic cardiomyopathy, NSVT, nonsustained ventricular tachycardia, RC666-701, Cardiology, VF, ventricular fibrillation, VT - Ventricular tachycardia, Cardiology and Cardiovascular Medicine, business, cardiomyopathy, 030217 neurology & neurosurgery
الوصف: We present the case of a 57-year-old man with a primary prevention internal cardioverter-defibrillator for severe nonischemic cardiomyopathy. At the time of elective replacement indicator, systolic function had fully recovered, and his generator was not changed. Nearly 5 years post–elective replacement indicator he received appropriate internal cardioverter-defibrillator therapies during a myocardial infarction. (Level of Difficulty: Intermediate.)
Graphical abstract
We present the case of a 57-year-old man with a primary prevention internal cardioverter-defibrillator for severe nonischemic cardiomyopathy… -
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المؤلفون: Lucia Hämmerl, Rosemary Rochford, David Martin Ogwang, Donald Maxwell Parkin, Murielle Colombet
المصدر: Infectious Agents and Cancer, Vol 14, Iss 1, Pp 1-6 (2019)
Infectious Agents and Cancerمصطلحات موضوعية: Cancer Research, medicine.medical_specialty, Epidemiology, medicine.disease_cause, lcsh:RC254-282, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, 0302 clinical medicine, hemic and lymphatic diseases, parasitic diseases, medicine, lcsh:RC109-216, business.industry, Incidence (epidemiology), Incidence, Cancer, Burkitt lymphoma, Epstein Barr virus, medicine.disease, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Epstein–Barr virus, Lymphoma, Geographic distribution, Infectious Diseases, Oncology, 030220 oncology & carcinogenesis, Tropical medicine, Africa, business, Malaria, Research Article, Demography
الوصف: Background Burkitt lymphoma (BL) is a relatively common cancer of childhood in tropical Africa, although its precise incidence and continent-wide geographic distribution have not been previously systematically studied. Methods Using the methods employed to produce national estimates of cancer incidence for the “Globocan” series of the International Agency for Research on Cancer, along with detailed information on cancer incidence by histological subtype from cancer registries in Africa, we estimate the numbers and rates of incidence by sex, age group, country and region of Africa. Results We estimate that the number of new cases that occurred in 2018 to be about 3900, two thirds in males, and 81% in children aged 0–14. On a national basis, the geographic distribution of incidence rates among children in sub-Saharan Africa resembles that of the prevalence of infection with Falciparum malaria. An estimated 81% of cases are associated with infection with Epstein Barr virus (EBV). Conclusions BL comprises almost 50% of childhood of non-Hodgkin lymphoma in Africa, almost all of which are associated with EBV, with the geographic distribution – at least in sub Saharan Africa - mediated by infection with malaria.
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المؤلفون: Al-Riyami, Arwa, Burnouf, Thierry, Yazer, Mark, Triulzi, Darrell, Kumaş, Levent Tufan, Sağdur, Levent, Pelit, Nil Banu, Bazin, Renée, Hindawi, Salwa, Badawi, Maha, Patidar, Gopal, Pandey, Hem Chandra, Chaurasia, Rahul, Fachini, Roberta Maria, Scuracchio, Patrícia, Wendel, Silvano, Ang, Ai Leen, Ong, Kiat Hoe, Young, Pampee, Ihalainen, Jarkko, Vierikko, Antti, Qiu, Yan, Yang, Ru, Xu, Hua, Rahimi-Levene, Naomi, Shinar, Eilat, Izak, Marina, Gonzalez, Carlos Alberto, Ferrari, David Martin, Cini, Paula Verónica, Aditya, Robby Nur, Sharma, Ratti Ram, Sachdev, Suchet, Hans, Rekha, Lamba, Divjot Singh, Nissen-Meyer, Lise Sofie H, Devine, Dana, Lee, Cheuk Kwong, Leung, Jennifer Nga-Sze, Hung, Ivan Fan Ngai, Tiberghien, Pierre, Gallian, Pierre, Morel, Pascal, Al Maamari, Khuloud, Al-Hinai, Zaid, Vrielink, Hans, So-Osman, Cynthia, De Angelis, Vincenzo, Berti, Pierluigi, Ostuni, Angelo, Marano, Giuseppe, Nevessignsky, Michel Toungouz, El Ekiaby, Magdy, Daly, James, Hoad, Veronica, Kim, Sinyoung, van den Berg, Karin, Vermeulen, Marion, Glatt, Tanya Nadia, Schäfer, Richard, Reik, Rita, Gammon, Richard, Lopez, Melissa, Estcourt, Lise, MacLennan, Sheila, Roberts, David, Louw, Vernon, Dunbar, Nancy, Al‐Riyami, Arwa, Rahimi‐Levene, Naomi, Nissen‐Meyer, Lise Sofie H., Leung, Jennifer Nga‐Sze, Al‐Hinai, Zaid, So‐Osman, Cynthia, Berg, Karin
المساهمون: Institut Hospitalier Universitaire Méditerranée Infection (IHU Marseille)
المصدر: Vox Sanguinis
Vox Sanguinis, Wiley, 2021, ⟨10.1111/vox.13113⟩مصطلحات موضوعية: 0303 health sciences, 2019-20 coronavirus outbreak, Convalescent plasma, Coronavirus disease 2019 (COVID-19), business.industry, SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), [SDV]Life Sciences [q-bio], Immunization, Passive, COVID-19, Hematology, General Medicine, 030204 cardiovascular system & hematology, Virology, 03 medical and health sciences, 0302 clinical medicine, Medicine, Humans, business, Coronavirus Infections, International Forum, COVID-19 Serotherapy, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology
الوصف: International audience
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المؤلفون: Tom Richard Okello, Irene Pecorella, David Martin Ogwang, Gaia Ciardi
مصطلحات موضوعية: medicine.medical_specialty, Duodenum, Biopsy, strongyloides stercoralis, Gastroenterology, roundworm, Strongyloides stercoralis, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, intestinal nematode, medicine, Gastric mucosa, Animals, Humans, Duodenal Infection, Gastric Infection, biology, medicine.diagnostic_test, Stomach, biology.organism_classification, medicine.disease, medicine.anatomical_structure, Strongyloidiasis, Gastric pits, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, Parasitology
الوصف: PurposeGastric infection withStrongyloides stercoralis(SS) usually occurs in immunocompromised patients. The unexpected observation of this parasite in an otherwise healthy young lady who had undergone upper endoscopy and biopsy sampling of the gastro-duodenal mucosa, prompted us to review the literature to ascertain the conditions favouring gastric colonization bySS.MethodsPathology files of gastroduodenal biopsies received at St. Mary’s hospital, Northern Uganda, between 2007 and 2017 were reviewed. Pubmed search was performed under the headings “Strongyloides stercoralis”, “Gastric parasitosis”.ResultsHistology of the only gastroduodenal biopsy with SS infection showed parasite eggs, immature rhabditiform larvae, and numerous adult worms in gastric pits and rhabditiform larvae in interepithelial parasitic tunnels, causing reactive changes of the glandular epithelium. There was no significant acute inflammatory cell infiltrate surrounding the parasites. Literature review showed that gastricSSinfection appears to be very uncommon and was, as expected, largely prevalent in immunodeficient individuals (84.2% of published cases). The rare gastricSSinfection is a complication of systemic strongyloidiasis, either hyperinfective, or disseminated form. It is also commonly associated with duodenal infection at microscopical examination.ConclusionInvolvement of gastric mucosa in the absence of duodenal strongyloidiasis appears to be quite rare and false-negative histopathological exams are reported if only the stomach is biopsied.
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94de2ebc2ad2acf4245921a546758881
http://hdl.handle.net/11573/1565065 -
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المؤلفون: Jonathan Davies, Christoph Teufel, Jazz Croft, Paul Madley-Dowd, David Martin, Jon Heron, Daniela Strelchuk, Stanley Zammit
المصدر: PLoS ONE, Vol 16, Iss 2, p e0246948 (2021)
Croft, J, Martin, D, Madley-Dowd, P, Strelchuk, D, Davies, J, Heron, J, Teufel, C & Zammit, S 2021, ' Childhood trauma and cognitive biases associated with psychosis : A systematic review and meta-analysis ', PLoS ONE, vol. 16, no. 2, e0246948 . https://doi.org/10.1371/journal.pone.0246948
PLoS ONEمصطلحات موضوعية: Child abuse, Epidemiology, Social Sciences, Criminology, Pediatrics, Database and Informatics Methods, 0302 clinical medicine, Mathematical and Statistical Techniques, Cognition, Sociology, Risk Factors, Medicine and Health Sciences, Psychology, Public and Occupational Health, Child Abuse, Database Searching, Child, Problem Solving, media_common, Multidisciplinary, Schools, Statistics, Traumatic Injury Risk Factors, Metaanalysis, Research Assessment, Cognitive bias, Locus of control, Meta-analysis, Physical Sciences, Research Reporting Guidelines, Medicine, Crime, Clinical psychology, Research Article, Psychosis, media_common.quotation_subject, Science, Research and Analysis Methods, Education, 03 medical and health sciences, Bias, Perception, Mental Health and Psychiatry, medicine, Humans, Statistical Methods, Association (psychology), Cognitive Psychology, Psychoses, Biology and Life Sciences, medicine.disease, 030227 psychiatry, Psychotic Disorders, Medical Risk Factors, Cognitive Science, Attribution, 030217 neurology & neurosurgery, Mathematics, Neuroscience
الوصف: Childhood trauma is associated with an increased risk of psychosis, but the mechanisms that mediate this relationship are unknown. Exposure to trauma has been hypothesised to lead to cognitive biases that might have causal effects on psychotic symptoms. The literature on whether childhood trauma is associated with psychosis-related cognitive biases has not been comprehensively reviewed. A systematic review and meta-analysis or narrative synthesis of studies examining the association between childhood trauma and the following biases: external locus of control (LOC), external attribution, probabilistic reasoning, source monitoring, top-down processing, and bias against disconfirmatory evidence. Studies were assessed for quality, and sources of heterogeneity were explored. We included 25 studies from 3,465 studies identified. Individuals exposed to childhood trauma reported a more external LOC (14 studies: SMD Median = 0.40, Interquartile range 0.07 to 0.52), consistent with a narrative synthesis of 11 other studies of LOC. There was substantial heterogeneity in the meta-analysis (I2 = 93%) not explained by study characteristics examined. Narrative syntheses for other biases showed weaker, or no evidence of association with trauma. The quality of included studies was generally low. Our review provides some evidence of an association between childhood trauma and a more external LOC, but not with the other biases examined. The low quality and paucity of studies for most of the cognitive biases examined highlights the need for more rigorous studies to determine which biases occur after trauma, and whether they mediate an effect of childhood trauma on psychosis.
وصف الملف: application/pdf
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المؤلفون: Robert Inga, Angel Farro, Daniel Mantuani, Sayuri Enríquez, Arun Nagdev, David Martin, Andrea Dreyfuss
المصدر: Western Journal of Emergency Medicine, Vol 21, Iss 4 (2020)
Western Journal of Emergency Medicineمصطلحات موضوعية: Educational Advances, Low resource, Point-of-Care Systems, MEDLINE, lcsh:Medicine, 03 medical and health sciences, 0302 clinical medicine, Physicians, Peru, Humans, Medicine, 030212 general & internal medicine, Fellowships and Scholarships, Curriculum, Schools, Medical, Ultrasonography, Medical education, Education, Medical, business.industry, Teaching, Point of care ultrasound, lcsh:R, lcsh:Medical emergencies. Critical care. Intensive care. First aid, Internship and Residency, 030208 emergency & critical care medicine, Multimodal therapy, General Medicine, Limiting, lcsh:RC86-88.9, Telemedicine, Scalability, Emergency Medicine, Health Resources, Technology in Emergency Medicine, Educational interventions, business
الوصف: Point-of-care ultrasound (POCUS) enables physicians to make critical diagnosis and treatment decisions at the bedside. However, access to and expertise with this technology remain limited in Peru. Establishing longitudinal POCUS educational curriculums in remote, low-resource settings can be challenging due to geographical distances, encumbering the ability to provide ongoing hands-on support. Previously described educational interventions have focused on training individual users on clinical applications of POCUS, rather than training physicians how to teach POCUS, thereby limiting scalability and sustainable impact. We therefore describe our experiences establishing the first ultrasound fellowship curriculum in Peru, which incorporates tele-ultrasonography to circumvent traditional geographical barriers.
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المؤلفون: Victoria Cj Wallace, Mahinda Yogarajah, David Martin-Lopez, Silas Webb
المصدر: BMJ Case Reports
مصطلحات موضوعية: 0301 basic medicine, Male, Pediatrics, Neurology, medicine.medical_treatment, infectious diseases, 0302 clinical medicine, Intubation, Respiratory function, Lung, intensive care, Neurologic Examination, Guillain-Barre syndrome, Immunoglobulins, Intravenous, General Medicine, Middle Aged, Treatment Outcome, medicine.symptom, Coronavirus Infections, medicine.medical_specialty, Neuromuscular disease, Pneumonia, Viral, Guillain-Barre Syndrome, Malaise, 03 medical and health sciences, Betacoronavirus, Intensive care, medicine, Humans, Immunologic Factors, Pandemics, Mechanical ventilation, business.industry, SARS-CoV-2, neurology, COVID-19, neuromuscular disease, medicine.disease, Respiration, Artificial, 030104 developmental biology, Early Diagnosis, business, Tomography, X-Ray Computed, 030217 neurology & neurosurgery, New Disease
الوصف: A 57-year-old man presented with a progressive flaccid symmetrical motor and sensory neuropathy following a 1-week history of cough and malaise. He was diagnosed with Guillain-Barré syndrome secondary to COVID-19 and started on intravenous immunoglobulin. He proceeded to have worsening respiratory function and needed intubation and mechanical ventilation. This is the first reported case of this rare neurological complication of COVID-19 in the UK, but it adds to a small but growing body of international evidence to suggest a significant association between these two conditions. Increasing appreciation of this by clinicians will ensure earlier diagnosis, monitoring and treatment of patients presenting with this.
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المؤلفون: David Martin, Prajakta Bajad, Konstantin Licht, Utkarsh Kapoor, Michael F. Jantsch, Ernesto Picardi, Fabian Amman
مصطلحات موضوعية: Transcription, Genetic, Adenosine Deaminase, Computational biology, Biology, 03 medical and health sciences, Exon, Mice, 0302 clinical medicine, Transcription (biology), Genetics, RNA Precursors, Animals, Genetics (clinical), 030304 developmental biology, Repetitive Sequences, Nucleic Acid, 0303 health sciences, Sequence Analysis, RNA, Research, Gene Expression Profiling, Alternative splicing, Intron, RNA, Brain, Chromosome Mapping, RNA-Binding Proteins, Alternative Splicing, RNA editing, Organ Specificity, RNA splicing, ADAR, RNA Editing, 030217 neurology & neurosurgery
الوصف: Pre-mRNA-splicing and adenosine to inosine (A-to-I) RNA-editing occur mostly cotranscriptionally. During A-to-I editing, a genomically encoded adenosine is deaminated to inosine by adenosine deaminases acting on RNA (ADARs). Editing-competent stems are frequently formed between exons and introns. Consistently, studies using reporter assays have shown that splicing efficiency can affect editing levels. Here, we use Nascent-seq and identify ∼90,000 novel A-to-I editing events in the mouse brain transcriptome. Most novel sites are located in intronic regions. Unlike previously assumed, we show that both ADAR (ADAR1) and ADARB1 (ADAR2) can edit repeat elements and regular transcripts to the same extent. We find that inhibition of splicing primarily increases editing levels at hundreds of sites, suggesting that reduced splicing efficiency extends the exposure of intronic and exonic sequences to ADAR enzymes. Lack of splicing factors NOVA1 or NOVA2 changes global editing levels, demonstrating that alternative splicing factors can modulate RNA editing. Finally, we show that intron retention rates correlate with editing levels across different brain tissues. We therefore demonstrate that splicing efficiency is a major factor controlling tissue-specific differences in editing levels.
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5abeda702e763ff0915b370620552ec8
https://europepmc.org/articles/PMC6724681/ -
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المؤلفون: Hajime Utsunomiya, Marc J. Philippon, Yoichi Murata, Soshi Uchida, Alex W. Brady, Samuel I Rosenberg, Patrick Quinn, Naomasa Fukase, Hal David Martin
المصدر: Journal of Hip Preservation Surgery
مصطلحات موضوعية: 030222 orthopedics, business.industry, 030229 sport sciences, Anatomy, Ischiofemoral impingement, Ischium, 03 medical and health sciences, Femoral head, Clinical Vignette, 0302 clinical medicine, medicine.anatomical_structure, Lesser Trochanter, Cadaver, Medicine, AcademicSubjects/MED00960, Femur, business, Range of motion, Pelvis
الوصف: Ischiofemoral impingement (IFI) occurs due to the diminishing of space between the ischium and lesser trochanter. During a robotic hip study, one hip presented with indications of IFI, an opportunity to explore the pathophysiology and treatment strategies for this unusual condition. This specimen underwent kinematic tests in two states: (i) native lesser trochanter and (ii) resected lesser trochanter. The ‘Resected lesser trochanter’ state was found to increase the hip range of motion and decrease femoral head translation by eliminating contact between the femur and pelvis. These results suggest that lesser trochanteric resection would provide physical benefit for IFI patients.
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41de05bfa945e6934c297c3bc515811d
http://europepmc.org/articles/PMC8081431 -
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المصدر: Clinical Case Reports, Vol 8, Iss 12, Pp 3631-3632 (2020)
Clinical Case Reportsمصطلحات موضوعية: medicine.medical_specialty, Medicine (General), Cardiac Neoplasm, Chest ct, chest CT, 030204 cardiovascular system & hematology, Asymptomatic, 03 medical and health sciences, 0302 clinical medicine, R5-920, Clinical Images, medicine, cardiac MRI, lipomatous hypertrophy of the atrial septum, cardiac neoplasm, business.industry, food and beverages, General Medicine, Atrial septum, TEE, Lipomatous hypertrophy, Right atrial mass, Clinical Image, 030220 oncology & carcinogenesis, cardiovascular system, Medicine, Radiology, medicine.symptom, business
الوصف: Asymptomatic cardiac masses are often diagnosed incidentally. Massive lipomatous hypertrophy can be confused for other cardiac masses and need careful evaluation including multimodality imaging to manage appropriately.
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