المؤلفون: Piero Alberti, David Martin, Georgios Gemenetzis, Rowan Parks

المصدر: Laparoscopic, Endoscopic and Robotic Surgery, Vol 6, Iss 3, Pp 83-90 (2023)

مصطلحات موضوعية: Pancreatic neuroendocrine neoplasms, Non-functional pancreatic neuroendocrine tumours, Functional pancreatic neuroendocrine tumours, Lymphadenectomy, Minimally invasive surgery, Pancreas preserving techniques, Surgery, RD1-811

الوصف: Pancreatic neuroendocrine neoplasms are a rare and complex group of neoplastic lesions that develop from pancreatic islet cells. Their incidence has dramatically increased during the last two decades. Due to its complex nature and pathophysiological behaviour, surgical management continues to evolve. Surgery remains the cornerstone of treatment for most non-functional and functional pancreatic neuroendocrine tumours, while lymphadenectomy remains a controversial subject. Different techniques, such as pancreas-preserving and minimally invasive approaches, continue to evolve and offer the same overall outcomes as open surgery. This comprehensive review describes in detail the current and most up-to-date classification and staging of pancreatic neuroendocrine tumours, explores the rationale for non-surgical and surgical management, and focuses on surgical treatment and more specifically, on minimally invasive approaches.

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2468900923000397; https://doaj.org/toc/2468-9009

URL الوصول: https://doaj.org/article/e1cc76ff108d451ca898c1d213826b25

المؤلفون: Junjun Wu, Chi Sun, Enliang Li, Jiakun Wang, Xianping He, Rongfa Yuan, Chenghao Yi, Wenjun Liao, Linquan Wu

المصدر: BMC Cancer, Vol 19, Iss 1, Pp 1-10 (2019)

مصطلحات موضوعية: Non-functional pancreatic neuroendocrine tumours, Epidemiology, Incidence-based mortality, APC, SEER., Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

الوصف: Abstract Background Our aim was to determine the epidemiology and recent changes in the trends of non-functional pancreatic neuroendocrine tumours (NF-pNETs) at the population level. In addition, we explored the risk factors that are associated with survival duration. Methods Cases were identified form the Surveillance, Epidemiology, and End Results (SEER) Programme database from 2000 to 2014. Data on incidence and incidence-based (IB) mortality for NF-pNET were obtained from this database. Secular trends in age-adjusted incidence and IB mortality were determined by using the Joinpoint Regression program. Data analyses were performed using chi-square tests, Kaplan-Meier curves and Cox proportional hazards regression. Results Overall, 4766 patients diagnosed with NF-pNET with a median age of 59 years were identified through our descriptive criteria. Caucasian patients accounted for the majority of the study population, and the proportion of patients with distant disease significantly decreased during our study period. Overall, there was an increase in incidence and IB mortality for NF-pNET; however, the rate of increase decreased during the recent years. In addition, the incidence trends of NF-pNET located in the pancreatic head significantly increased, and rates fo increase in IB mortality for NF-pNET in the pancreatic tail decreased in recent years. Additionally, the 1-, 5-, and 10-year survival rates were 79.0, 51.8, 38.1%, respectively. Furthermore, patient age, tumour grade, stage at diagnosis, tumour size, tumour site and resection were associated with mortality. Conclusion Despite increases in incidence and IB mortality, the rate of change in IB mortality for NF-pNET has decreased in recent years. Survival duration displayed a secular increase during the overall period, and the prognosis and survival duration of patients were closely related to the time of diagnosis, age of the patients and size and location of the tumour. Appropriate treatment adjustments based on tumour stage may thus facilitate improvements in patient outcomes.

وصف الملف: electronic resource

Relation: http://link.springer.com/article/10.1186/s12885-019-5543-2; https://doaj.org/toc/1471-2407

URL الوصول: https://doaj.org/article/094bd873aabd4effb0a1df62195a1661

المؤلفون: Wu, Junjun, Sun, Chi, Li, Enliang, Wang, Jiakun, He, Xianping, Yuan, Rongfa, Yi, Chenghao, Liao, Wenjun^Aff1, Wu, Linquan^Aff1

المصدر: BMC Cancer. 19(1)

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