المؤلفون: Elena V. Tsallagova, Vasily O. Generalov, Timur R. Sadykov

المصدر: Гинекология, Vol 21, Iss 6, Pp 12-15 (2020)

مصطلحات موضوعية: anticonvulsant therapy, Pregnancy, medicine.diagnostic_test, pregnancy management, business.industry, medicine.medical_treatment, Progesterone therapy, Obstetrics and Gynecology, Electroencephalography, Dydrogesterone, medicine.disease, lcsh:Gynecology and obstetrics, Anticonvulsant therapy, Epilepsy, Anticonvulsant, Anesthesia, Recurrent seizures, medicine, epilepsy, business, lcsh:RG1-991, medicine.drug

الوصف: Pregnancy is the most dangerous period in terms of interruption of even persistent and long-term remission. At the same time increasing the dose of anticonvulsant increases the risk of teratogenic effects. Aim. to assess the possibility of using progesterone to prevent relapse of epileptic seizures during pregnancy. Materials and methods. 38 pregnant patients with epilepsy with clinical remission before pregnancy, with relapse of epileptic seizures in I trimester of pregnancy, age 31.81.4 years. Dydrogesterone in a dose of 10 to 60 mg/day was prescribed after the relapse of remission. Anticonvulsant dosage was not changed. The blood progesterone concentration and EEG control was carried out. Results. During pregnancy, the level of progesterone in the blood gradually increased from 77.8 nmol/l at 78 weeks of pregnancy to 521.1 nmol/l at 3637 weeks of pregnancy, without exceeding the limits. EEG results did not deteriorate. None of the patients had seizures during pregnancy. Conclusion. Progesterone therapy is an adequate and safe alternative to increasing the dose of anticonvulsants in case of recurrent seizures during pregnancy.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b7d19cd57db11610f2f29042a6e3e16
https://gynecology.orscience.ru/2079-5831/article/viewFile/33945/21557

المؤلفون: Evgeniya Polushkina, Roman G. Shmakov

المصدر: Медицинский совет, Vol 0, Iss 3, Pp 74-77 (2020)

مصطلحات موضوعية: medicine.medical_specialty, 030219 obstetrics & reproductive medicine, habitual miscarriage, business.industry, Obstetrics, General Medicine, habitual abortion, progestogens, Dydrogesterone, progesterone, medicine.disease, dydrogesterone, Miscarriage, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, Medicine, pregnancy, business, medicine.drug

الوصف: Habitual miscarriage is a fairly common complication of early pregnancy. In the opinion of most authors, the term habitual miscarriage is used to describe a loss of two or more pregnancies during the first 22 weeks of pregnancy. Issues of terminology and management continue to be relevant and debatable in medical professional communities and need further discussion. In addition to the medical sides of the issue, habitual miscarriage has a significant psychological impact on women and their partners. Regardless of the gestational age, the loss of pregnancy for most couples is similar in importance to the loss of a newborn and is associated with the loss of hope and plans that future parents connected with a baby who has not yet been born. After repeated losses, bereavement and emotional upheaval are further exacerbated irrespective of the term of abortion. Repeated pregnancy loss is a significant negative event in the life of a couple both from a medical and psychological point of view, that’s why the provision of adequate medical care is one of the objectives of a specialist managing pregnancy. This also involves the choice of effective disease management. Previously it was shown that luteal phase deficiency might be the cause of this phenomenon, and that hormonal deficiency had to be replenished. Many modern publications confirm that progesterone and its derivatives have an important immunomodulatory role in the habitual miscarriage. The article describes the role of progesterone in maintaining pregnancy and the results of studies devoted to the role of dydrogesterone. It also presents data of international studies on the treatment of women with habitual miscarriage.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a589860b181589ef5ebff998d89edb96
https://www.med-sovet.pro/jour/article/view/5573

المؤلفون: N. K. Tetruashvili, A. A. Agadzhanova

المصدر: Медицинский совет, Vol 0, Iss 13, Pp 68-72 (2018)

مصطلحات موضوعية: medicine.medical_specialty, Threatened miscarriage, gestagens, miscarriage, 030209 endocrinology & metabolism, Early pregnancy factor, Dydrogesterone, progesterone, Comparative evaluation, Miscarriage, 03 medical and health sciences, 0302 clinical medicine, threatened miscarriage, Medicine, Pregnancy, 030219 obstetrics & reproductive medicine, habitual miscarriage, biology, business.industry, Obstetrics, General Medicine, medicine.disease, dydrogesterone, Threatened species, biology.protein, pregnancy, business, medicine.drug

الوصف: The article presents the findings of the studies evaluating the efficacy of gestagens in the treatment of the threatened and habitual miscarriage. It summarizes a number of meta-analysis related to the comparative evaluation of the use of various gestagens during pregnancy. The foreign societies’ guidelines for the treatment of reproductive disorders and the management of early pregnancy in women with the threatened and habitual miscarriage are outlined.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d813f5d8b5a4d6bb7d6c7350bc92ba6e
https://www.med-sovet.pro/jour/article/view/2607

المؤلفون: L. V. Krechetova, A A Agadzhanova, N K Tetruashvili, V. A. Saribegova

المصدر: Гинекология, Vol 19, Iss 1, Pp 51-55 (2017)

مصطلحات موضوعية: medicine.medical_specialty, habitual miscarriage, natural killer cells, business.industry, medicine.medical_treatment, Obstetrics and Gynecology, Immunotherapy, Dydrogesterone, Abortion, progesterone, medicine.disease, immunocytotherapy, dydrogesterone, lcsh:Gynecology and obstetrics, cytokines, tolerogenic molecule cd200, Recurrent miscarriage, medicine, Intensive care medicine, business, t-regulatory cells, lcsh:RG1-991, medicine.drug

الوصف: The article presents the current understanding of the pathogenetic mechanisms of habitual abortion realization of alloimmune genesis and proposed methods of immunotherapy. The mechanisms of the impact and effectiveness of various drugs and cell therapies.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1977eb2f2d0a908c20d5c9420befac3c
https://gynecology.orscience.ru/2079-5831/article/viewFile/28611/pdf