نتائج البحث - "Protein-Serine-Threonine Kinases/*metabolism"

1

The ULK3 Kinase Is Critical for Convergent Control of Cancer-Associated Fibroblast Activation by CSL and GLI

المؤلفون: Victor A. Neel, Seung-Hee Jo, G. Paolo Dotto, Maria-Giuseppina Procopio, Sandro Goruppi, Andrea Clocchiatti

المصدر: Cell Reports, Vol 20, Iss 10, Pp 2468-2479 (2017)
Cell reports, vol. 20, no. 10, pp. 2468-2479

مصطلحات موضوعية: squamous cell carcinoma, 0301 basic medicine, autophagy, Stromal cell, cancer-associated fibroblast, Notch signaling pathway, Fluorescent Antibody Technique, Protein Serine-Threonine Kinases, Biology, Zinc Finger Protein GLI1, Article, General Biochemistry, Genetics and Molecular Biology, Mice, ULK3, 03 medical and health sciences, Cancer-Associated Fibroblasts, Downregulation and upregulation, GLI2, Animals, Humans, tumor microenvironment, Gene silencing, CAF, Autophagy/physiology, Cancer-Associated Fibroblasts/metabolism, Female, Fibroblasts/metabolism, Immunoglobulin J Recombination Signal Sequence-Binding Protein/metabolism, Protein-Serine-Threonine Kinases/genetics, Protein-Serine-Threonine Kinases/metabolism, Signal Transduction/genetics, Signal Transduction/physiology, Zinc Finger Protein GLI1/genetics, Zinc Finger Protein GLI1/metabolism, CSL/RBPJ, GLI, SCC, cancer stroma, lcsh:QH301-705.5, RBPJ, Autophagy, Fibroblasts, 030104 developmental biology, lcsh:Biology (General), Immunoglobulin J Recombination Signal Sequence-Binding Protein, Cancer research, Signal transduction, Signal Transduction

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https://doi.org/10.1016/j.celrep.2017.08.048

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2

Protein Phosphatase 1 inactivates Mps1 to ensure efficient Spindle Assembly Checkpoint silencing

المؤلفون: Mariana Osswald, Claudio E. Sunkel, João Barbosa, Helder Maiato, Nelson Leça, Carlos Conde, Margarida Moura, António J. Pereira

المساهمون: Instituto de Investigação e Inovação em Saúde

المصدر: eLife
eLife, Vol 6 (2017)
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

مصطلحات موضوعية: 0301 basic medicine, Cell cycle checkpoint, Drosophila Proteins/metabolism, QH301-705.5, Science, Drosophila/physiology, Cell Cycle Proteins, Protein Serine-Threonine Kinases, Biology, General Biochemistry, Genetics and Molecular Biology, spindle assembly checkpoint, 03 medical and health sciences, Protein Phosphatase 1, Chromosome Segregation, Drosophila Proteins, Animals, Biology (General), Mps1, Metaphase, Mitosis, Anaphase, D. melanogaster, Cell Cycle Proteins/metabolism, General Immunology and Microbiology, Kinetochore, General Neuroscience, Cell Biology, Protein-Serine-Threonine Kinases/metabolism, General Medicine, PP1, Protein Phosphatase 1/metabolism, kinetochore, Spindle apparatus, Cell biology, Spindle checkpoint, 030104 developmental biology, Mitotic exit, embryonic structures, M Phase Cell Cycle Checkpoints, Medicine, Drosophila, cell cycle, cytosol, Cell Division, Research Article

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3

Higher-Order Looping and Nuclear Organization of Tcra Facilitate Targeted RAG Cleavage and Regulated Rearrangement in Recombination Centers

المؤلفون: David G. Schatz, Iannis Aifantis, Panagiotis Ntziachristos, Mariann Micsinai, Joy M. H. Wang, Ludovic Deriano, Yuval Kluger, Jeffrey A. Jeddeloh, Elphège P. Nora, Matthew Rodesch, Julie Chaumeil, Yanhong Ji, Jane A. Skok

المساهمون: New York University School of Medicine (NYU), New York University School of Medicine, NYU System (NYU)-NYU System (NYU), Développement lymphocytaire et Oncogénèse, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Génétique et Biologie du Développement, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Roche NimbleGen Inc., Yale Cancer Center, Yale School of Medicine [New Haven, Connecticut] (YSM), Yale University [New Haven], Howard Hughes Medical Institute (HHMI), This work is supported by the National Institute ofHealth: R01GM086852 (to J.A.S.), R37AI32524 (to D.G.S.), RO1CA133379,RO1CA105129, RO1CA149655, and RO1GM088847 (to I.A.). J.A.S. is aLeukemia & Lymphoma Society (LLS) scholar. J.C. is an Irvington Institute Fellow of the Cancer Research Institute. M.M. was supported by an NSFIGERT 0333389. L.D. was an LLS Fellow. E.P.N. was supported by the FrenchMinistry of Research and the Association pour la Recherche sur le Cancer(France). I.A. is also supported by the Leukemia & Lymphoma Society (TRPgrant), The V Foundation for Cancer Research, and the Dana Foundation.D.G.S. is an Investigator, and I.A. is an Early Career Scientist of the HowardHughes Medical Institute. The authors from Roche NimbleGen, Inc. (M.J.R.and J.A.J.) recognize a competing interest in this publication as employeesof the company., Lassailly-Bondaz, Anne, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), Yale University School of Medicine

المصدر: Cell Reports
Cell Reports, 2013, 3 (2), pp.359-70. ⟨10.1016/j.celrep.2013.01.024⟩
CELL REPORTS
Cell Reports, Vol 3, Iss 2, Pp 359-370 (2013)
Cell Reports, Elsevier Inc, 2013, 3 (2), pp.359-70. ⟨10.1016/j.celrep.2013.01.024⟩

مصطلحات موضوعية: Genome instability, MESH: V(D)J Recombination, Ataxia Telangiectasia Mutated Proteins, Inbred C57BL, MESH: Mice, Knockout, Tumor Suppressor Proteins/metabolism, Mice, 0302 clinical medicine, Transcription (biology), Receptors, Recombinase, Medicine and Health Sciences, MESH: Animals, MESH: Ataxia Telangiectasia Mutated Proteins, lcsh:QH301-705.5, DNA-Binding Proteins/genetics/*metabolism, Genetics, MESH: Histones, 0303 health sciences, MESH: Mice, Inbred CBA, MESH: Receptors, Antigen, T-Cell, alpha-beta, biology, MESH: Genomic Instability, V(D)J recombination, Protein-Serine-Threonine Kinases/metabolism, Chromatin, alpha-beta/genetics/*metabolism, Histone, Antigen, [SDV.IMM]Life Sciences [q-bio]/Immunology, MESH: Cell Nucleus, [SDV.IMM] Life Sciences [q-bio]/Immunology, Knockout, Cleavage (embryo), DNA-binding protein, MESH: Genetic Loci, General Biochemistry, Genetics and Molecular Biology, Genomic Instability, MESH: Protein-Serine-Threonine Kinases, 03 medical and health sciences, MESH: Cell Cycle Proteins, MESH: Mice, Inbred C57BL, MESH: Homeodomain Proteins, Homeodomain Proteins/genetics/*metabolism, Animals, MESH: Tumor Suppressor Proteins, MESH: Mice, Alleles, 030304 developmental biology, MESH: DNA Damage, Histones/genetics, Cell Cycle Proteins/metabolism, MESH: Alleles, Inbred CBA, Biology and Life Sciences, T-Cell, lcsh:Biology (General), Genetic Loci, Cell Nucleus/metabolism, biology.protein, 030217 neurology & neurosurgery, MESH: DNA-Binding Proteins, V(D)J Recombination, DNA Damage

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4

Internalization and vacuolar targeting of the brassinosteroid hormone receptor BRI1 are regulated by ubiquitination

المؤلفون: Anne Cayrel, Niko Geldner, Wolfgang H. Fischer, Esther M. N. Dohmann, Sara Martins, Béatrice Satiat-Jeunemaitre, Florence Pojer, Alexander W. Johnson, Joanne Chory, Yvon Jaillais, Grégory Vert

المساهمون: Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Dynamique de la Compartimentation cellulaire dans les cellules de plantes supérieures (DYNBSJ), Département Biologie Cellulaire (BioCell), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Signalisation Cellulaire et Ubiquitination chez les plantes (UBINET), 'Infrastructures en Biologie Sante et Agronomie' (IBiSA), French National Research Agency under Investments for the Future programmes 'France-BioImaging infrastructure' [ANR-10-INSB-04-01], Saclay Plant Sciences initiative [ANR-10-LABX-0040-SPS], 'Conseil General de l'Essonne', Saclay Plant Sciences LabEx initiative - French government [ANR-10-LABX-0040-SPS], Agence Nationale de la Recherche [ANR-11-IDEX-0003-02, ANR-13-JSV2-0004-01], EMBO long-term fellowship, National Institutes of Health [5 R01 GM094428], Howard Hughes Medical Institute, Swiss National Science Foundation [31003A_120558], Marie Curie Action [PCIG-GA-2012-334021]

المصدر: Nature Communications
Nature Communications, 2015, 6, pp.6151. ⟨10.1038/ncomms7151⟩
Nature Communications, vol. 6, pp. 6151-6151
Nature Communications, Nature Publishing Group, 2015, 6, pp.6151. ⟨10.1038/ncomms7151⟩

مصطلحات موضوعية: 0106 biological sciences, [SDV]Life Sciences [q-bio], Endocytic cycle, Arabidopsis, General Physics and Astronomy, 01 natural sciences, UBINET, chemistry.chemical_compound, Ubiquitin, Gene Expression Regulation, Plant, Brassinosteroid, Phosphorylation, Internalization, Receptor, Polyubiquitin, media_common, 0303 health sciences, Microscopy, Multidisciplinary, biology, Atomic and molecular interactions with photons, Plants, Protein-Serine-Threonine Kinases, Plants, Genetically Modified, Cell biology, Transport protein, Protein Transport, Signal transduction, Signal Transduction, trans-Golgi Network, DYNBSJ, Endosome, media_common.quotation_subject, Genetically Modified, Endosomes, Protein Serine-Threonine Kinases, Article, General Biochemistry, Genetics and Molecular Biology, Fluorescence, 03 medical and health sciences, Arabidopsis/genetics, Arabidopsis/metabolism, Arabidopsis Proteins/genetics, Arabidopsis Proteins/metabolism, Brassinosteroids/metabolism, Cell Membrane/metabolism, Cell Membrane/ultrastructure, Endosomes/metabolism, Endosomes/ultrastructure, Lysine/metabolism, Microscopy, Fluorescence/methods, Polyubiquitin/genetics, Polyubiquitin/metabolism, Protein Kinases/genetics, Protein Kinases/metabolism, Protein-Serine-Threonine Kinases/genetics, Protein-Serine-Threonine Kinases/metabolism, Vacuoles/metabolism, Vacuoles/ultrastructure, trans-Golgi Network/metabolism, trans-Golgi Network/ultrastructure, Brassinosteroids, Author Correction, Protein Processing, 030304 developmental biology, Attosecond science, Arabidopsis Proteins, Lysine, fungi, Cell Membrane, Post-Translational, Ubiquitination, General Chemistry, Plant, chemistry, Gene Expression Regulation, Microscopy, Fluorescence, Mutation, Proteolysis, Vacuoles, biology.protein, High-harmonic generation, Protein Kinases, Protein Processing, Post-Translational, 010606 plant biology & botany