المؤلفون: Hilde Van Esch, Joris Vermeesch, Louise Gallagher, Eric Legius, Griet Van Buggenhout, Thomy de Ravel, Laura Vandenhove, Peter Aerssens, Nele Cosemans, Koenraad Devriendt, Annick Vogels, Sanbing Shen, Hilde Olivié, Jacqueline Fitzgerald, Hilde Peeters, Jeroen Breckpot, Els Ortibus

المساهمون: Medical Genetics

المصدر: Journal of Medical Genetics. 57:347-355

مصطلحات موضوعية: Male, Proband, Neural Cell Adhesion Molecules/genetics, Schizophrenia/epidemiology, Exon, Intellectual disability, Genetics, Humans, Medicine, Genetic Predisposition to Disease, Intellectual Disability/epidemiology, Clinical significance, Genetics (clinical), Calcium-Binding Proteins/genetics, business.industry, Breakpoint, Intron, Exons, Neurodevelopmental Disorders/epidemiology, medicine.disease, Penetrance, Schizophrenia, Abnormalities, Multiple/epidemiology, Female, business, Gene Deletion

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24c857a9e8bca50014a388e16fe900e5
https://doi.org/10.1136/jmedgenet-2019-106448

المؤلفون: Arvind Y. M. Sundaram, Camilla Maria Falch, Kjersti Ringvoll Normann, Marianne Andersen, Ivars Silamikelis, Tove Lekva, Nicoleta Cristina Olarescu, Jens Bollerslev, Kristin Astrid Berland Øystese, Alexander Eieland

المصدر: Falch, C M, Sundaram, A Y M, Øystese, K A, Normann, K R, Lekva, T, Silamikelis, I, Eieland, A K, Andersen, M S, Bollerslev, J & Olarescu, N C 2018, ' Gene expression profiling of fast-and slow-growing non-functioning gonadotroph pituitary adenomas ', European Journal of Endocrinology, vol. 178, no. 3, pp. 295-307 . https://doi.org/10.1530/EJE-17-0702

مصطلحات موضوعية: Male, Receptors, Cell Surface/genetics, 0301 basic medicine, Time Factors, Endocrinology, Diabetes and Metabolism, RNA, Messenger/metabolism, Adaptor Proteins, Signal Transducing/genetics, Endocrinology, Cell Movement, Gene expression, Nerve Tissue Proteins/genetics, Myosin Type I/genetics, Regulation of gene expression, Membrane Glycoproteins, Reverse Transcriptase Polymerase Chain Reaction, Intracellular Signaling Peptides and Proteins, RNA-Binding Proteins, Follicle Stimulating Hormone/metabolism, MTDH, General Medicine, Middle Aged, Cadherins, Gene Expression Regulation, Neoplastic, Female, Luteinizing Hormone/metabolism, Cell Adhesion Molecules/genetics, Microtubule-Associated Proteins, Adenoma, Adult, medicine.medical_specialty, Epithelial-Mesenchymal Transition, Sialoglycoproteins, Cyclic AMP-Dependent Protein Kinase Catalytic Subunits/genetics, Nerve Tissue Proteins, Receptors, Cell Surface, In Vitro Techniques, Biology, Ribonucleases/genetics, Sialoglycoproteins/genetics, Myosin Type I, 03 medical and health sciences, Ribonucleases, Downregulation and upregulation, Epithelial-Mesenchymal Transition/genetics, Proto-Oncogene Proteins, Internal medicine, Cell Movement/genetics, medicine, Humans, Gene silencing, Pituitary Neoplasms, RNA, Messenger, Gene Silencing, Gene, Adaptor Proteins, Signal Transducing, Aged, Cyclic AMP-Dependent Protein Kinase Catalytic Subunits, Cadherins/genetics, Gene Expression Profiling, Membrane Proteins, Luteinizing Hormone, Membrane Glycoproteins/genetics, Microtubule-Associated Proteins/genetics, medicine.disease, Adenoma/genetics, Pituitary Neoplasms/genetics, Protocadherins, Gene expression profiling, Proto-Oncogene Proteins/genetics, 030104 developmental biology, Cancer research, Follicle Stimulating Hormone, Intracellular Signaling Peptides and Proteins/genetics, Cell Adhesion Molecules

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::126a05ef8be51edb939b724d5fc8fbb4
https://doi.org/10.1530/eje-17-0702

المؤلفون: Tamas L. Horvath, Louise van der Weyden, Chun-Xia Yi, Xin Yan, Valentina Tarallo, Andreas L. Birkenfeld, Dmytro Puchkov, Min Chi Ku, Anne Sophie Carlo, Sonja C. Schriever, Jan Siemens, Volker Haucke, Kun Song, Arnd Heuser, Luis Varela, Sudhir Gopal Tattikota, James F.A. Poulet, Mirko Moroni, Matthew N. Poy, Mirko Trajkovski, Matthias H. Tschöp, Natalia L. Kononenko, Thoralf Niendorf, Leiron Ferrarese, Gaga Kochlamazashvili, Matthias Heinig, Thomas Rathjen, Klara Szigeti-Buck, Sebastian Brachs

المساهمون: AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, APH - Aging & Later Life, ANS - Cellular & Molecular Mechanisms, Endocrinology Laboratory, Endocrinology, ACS - Diabetes & metabolism

المصدر: Nature neuroscience
Nature Neuroscience
Nat. Neurosci. 20, 1096-1103 (2017)
Nature neuroscience, 20(8), 1096-1103. Nature Publishing Group
Nature neuroscience, Vol. 20, No 8 (2017) pp. 1096-1103
Rathjen, T, Yan, X, Kononenko, N L, Ku, M-C, Song, K, Ferrarese, L, Tarallo, V, Puchkov, D, Kochlamazashvili, G, Brachs, S, Varela, L, Szigeti-Buck, K, Yi, C-X, Schriever, S C, Tattikota, S G, Carlo, A S, Moroni, M, Siemens, J, Heuser, A, van der Weyden, L, Birkenfeld, A L, Niendorf, T, Poulet, J F A, Horvath, T L, Tschöp, M H, Heinig, M, Trajkovski, M, Haucke, V & Poy, M N 2017, ' Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule 1 ', Nature Neuroscience, vol. 20, no. 8, pp. 1096-1103 . https://doi.org/10.1038/nn.4590

مصطلحات موضوعية: 0301 basic medicine, Pro-Opiomelanocortin, Neurons/metabolism, Obesity/genetics, Energy homeostasis, Cell Adhesion Molecules, Neuronal/genetics, 0302 clinical medicine, Homeostasis, 2. Zero hunger, Neurons, Pro-Opiomelanocortin/metabolism, Cell adhesion molecule, General Neuroscience, Hypothalamus, Arcuate Nucleus of Hypothalamus/metabolism, Cell Adhesion Molecules/genetics, medicine.medical_specialty, Transgene, Cell Adhesion Molecules, Neuronal, Immunoglobulins, Mice, Transgenic, Neurotransmission, Biology, Energy Metabolism/physiology, Article, 03 medical and health sciences, Arcuate nucleus, Internal medicine, medicine, Animals, Obesity, ddc:612, Body Weight, Arcuate Nucleus of Hypothalamus, Cell Adhesion Molecule-1, Membrane Proteins, Homeostasis/genetics, Immunoglobulins/genetics, 030104 developmental biology, Endocrinology, Membrane protein, Body Weight/physiology, Membrane Proteins/metabolism, Energy Metabolism, Neuronal Cell Adhesion Molecule, Neuroscience, Cell Adhesion Molecules, 030217 neurology & neurosurgery, Genome-Wide Association Study

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b367621004e2f620bfe7fda4a58125a9
https://pubmed.ncbi.nlm.nih.gov/28628102

المؤلفون: Jozsef Zoltan Kiss, Dominique Muller, Thierry Steimer, Egbert Welker, Edgardo Troncoso, K. Korodi

المصدر: Cerebral Cortex, Vol. 14, No 3 (2004) pp. 332-341
Cerebral Cortex, vol. 14, no. 3, pp. 332-41

مصطلحات موضوعية: Male, Antimetabolites, Cognitive Neuroscience, Deoxyglucose, Biology, Somatosensory system, Evoked Potentials, Somatosensory/ physiology, Lesion, Mice, Cellular and Molecular Neuroscience, Antimetabolites/metabolism, Evoked Potentials, Somatosensory, Physical Stimulation, Somatosensory Cortex/ injuries/ metabolism/pathology, medicine, Animals, Evoked potential, Neural Cell Adhesion Molecules, Neural Cell Adhesion Molecules/genetics/ physiology, Psychomotor Performance/physiology, Mice, Knockout, Behavior, Animal, Deoxyglucose/metabolism, Somatosensory Cortex, Barrel cortex, ddc:616.8, Mice, Inbred C57BL, medicine.anatomical_structure, Somatosensory evoked potential, Vibrissae, Behavior, Animal/ physiology, Knockout mouse, Vibrissae/innervation, Neural cell adhesion molecule, medicine.symptom, Neuroscience, Psychomotor Performance, Animals Antimetabolites/metabolism Behavior, Animal/*physiology Deoxyglucose/metabolism Evoked Potentials, Somatosensory/*physiology Male Mice Mice, Inbred C57BL Mice, Knockout Neural Cell Adhesion Molecules/genetics/*physiology Physical Stimulation Psychomotor Performance/physiology Somatosensory Cortex/*injuries/*metabolism/pathology Vibrissae/innervation, Motor cortex

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::714bba7447989b1d5252c89a0dfc6b07
https://doi.org/10.1093/cercor/bhg131

المؤلفون: Christina Pfirschke, Tobias Meißner, Brigitte Gueckel, Simone Jünger, Philipp Beckhove, Kai Neben, Mathias Witzens-Harig, Hartmut Goldschmidt, Bernard Klein, Bettina Brackertz, Helga Bernhard, Thierry Rème, Ludmila Umansky, Dirk Hose, Anja Seckinger, Anthony D. Ho, Michael Hundemer, Heinke Conrad, Nisit Khandelwal, Jean-François Rossi

المساهمون: Hematology, Basic (bio-) Medical Sciences

المصدر: Blood. 121:4493-4503

مصطلحات موضوعية: Cytotoxicity, Immunologic, medicine.drug_class, T cell, Plasma Cells, Immunology, GPI-Linked Proteins/genetics, CD8-Positive T-Lymphocytes, GPI-Linked Proteins, CD8-Positive T-Lymphocytes/immunology, Monoclonal antibody, Biochemistry, Interleukin 21, Multiple Myeloma/immunology, Antigen, Antigens, CD, hemic and lymphatic diseases, Tumor Cells, Cultured, medicine, Humans, Cytotoxic T cell, MCF-7 cells, RNA, Small Interfering, Antigen-presenting cell, Multiple myeloma, RNA, Small Interfering/genetics, Signal Transduction/immunology, Chemistry, Antigens, CD/genetics, U937 Cells, Cell Biology, Hematology, T-Lymphocytes, Cytotoxic/immunology, medicine.disease, Coculture Techniques, medicine.anatomical_structure, Plasma Cells/immunology, Cytotoxicity, Immunologic/genetics, oncology, Immunotherapy/methods, Cancer research, Interleukin 12, Immunotherapy, Multiple Myeloma, Cell Adhesion Molecules/genetics, Cell Adhesion Molecules, Signal Transduction, T-Lymphocytes, Cytotoxic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aa59841972758ad3b9ece93ab26cb17
https://doi.org/10.1182/blood-2012-05-429415

المؤلفون: Tsun Leung Chan, Eugène T P Verwiel, Irma Kluijt, Diana Eccles, Rolf H. Sijmons, Egbert J.W. Redeker, Rachel S. van der Post, Encarna B. Gomez Garcia, Reinhard Büttner, Cora M. Aalfs, Roland P. Kuiper, Johan J.P. Gille, Bernadette P M van Nesselrooij, Frans B. L. Hogervorst, Marjolijn J L Ligtenberg, Tracy Graham, Julie O. Culver, Edith Olah, Monique Goossens, Carli M. J. Tops, Elke Holinski-Feder, David J. Bunyan, Marielle E. van Gijn, Frederik J. Hes, Suet Yi Leung, Pierre O. Chappuis, Monika Morak, Edward M Leter, Nils Rahner, Lea Velsher, János Papp, Renee C. Niessen, J. Han van Krieken, Lambertus A. Kiemeney, Ad Geurts van Kessel, Charlotte W. Ockeloen, Nicoline Hoogerbrugge, Marlies Kempers, Iris D. Nagtegaal, Verena Steinke, Hans K. Schackert, Matthias Kloor, Melanie R. Palomares, Sapna Syngal, Pierre Hutter, Elena M. Stoffel

المساهمون: Genetica & Celbiologie, RS: GROW - School for Oncology and Reproduction, Clinical sciences, Human Genetics, ACS - Amsterdam Cardiovascular Sciences, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Other Research, Guided Treatment in Optimal Selected Cancer Patients (GUTS), Human genetics, CCA - Oncogenesis

المصدر: Kempers, M J E, Kuiper, R P, Ockeloen, C W, Chappuis, P O, Hutter, P, Rahner, N, Schackert, H K, Steinke, V, Holinski-Feder, E, Morak, M, Kloor, M, Buttner, R, Verwiel, E T P, van Krieken, J H, Nagtegaal, I D, Goossens, M, van der Post, R S, Niessen, R C, Sijmons, RH, Kluijt, I, Hogervorst, F B L, Leter, E M, Gille, J J P, Aalfs, C M, Redeker, E J W, Hes, F J, Tops, C M J, van Nesselrooij, B P M, van Gijn, M E, Garcia, E B G, Eccles, D M, Bunyan, D J, Syngal, S, Stoffel, E M, Culver, J O, Palomares, M R, Graham, T, Velsher, L, Papp, J, Olah, E, Chan, T L, Leung, S Y, van Kessel, A G, Kiemeney, L A L M, Hoogerbrugge, N & Ligtenberg, M J L 2011, ' Risk of colorectal and endometrial cancers in EPCAM deletion-positive Lynch syndrome: a cohort study ', Lancet Oncology, vol. 12, no. 1, pp. 49-55 . https://doi.org/10.1016/S1470-2045(10)70265-5
The Lancet Oncology, 49-55
STARTPAGE=49;ENDPAGE=55;TITLE=The Lancet Oncology
Lancet Oncology, 12, 1, pp. 49-55
Lancet oncology, 12(1), 49-55. Elsevier Science
Lancet Oncology, 12, 49-55
lancet oncology, 12(1), 49-55. Lancet Publishing Group
Lancet Oncology, 12(1), 49-55. ELSEVIER SCIENCE INC
Lancet Oncology, 12(1), 49-55. Lancet Publishing Group

مصطلحات موضوعية: Male, Oncology, Genetics and epigenetic pathways of disease [NCMLS 6], REPAIR GENE HMSH2, Colorectal cancer, FAMILIES, chemistry.chemical_compound, Promoter Regions, Genetic, Colorectal Neoplasms/etiology, risk, Sequence Deletion, Medicine(all), METHYLATION, Epithelial cell adhesion molecule, Middle Aged, Epithelial Cell Adhesion Molecule, Translational research Tissue engineering and pathology [ONCOL 3], Lynch syndrome, Antigens, Neoplasm/genetics, Endometrial Neoplasms/etiology, MutS Homolog 2 Protein, Cohort studies, Female, Duodenal cancer, Colorectal Neoplasms, Cell Adhesion Molecules/genetics, STEM-CELLS, MutS Homolog 2 Protein/genetics, Adult, medicine.medical_specialty, congenital, hereditary, and neonatal diseases and abnormalities, Adolescent, TACSTD1, Hereditary cancer and cancer-related syndromes Genetics and epigenetic pathways of disease [ONCOL 1], MUTATION CARRIERS, MLH1, Genomic disorders and inherited multi-system disorders [IGMD 3], Molecular epidemiology [NCEBP 1], Antigens, Neoplasm, Translational research [ONCOL 3], Internal medicine, SURVEILLANCE, medicine, MANAGEMENT, Humans, Genetics and epigenetic pathways of disease Translational research [NCMLS 6], neoplasms, Aged, Molecular epidemiology Aetiology, screening and detection [NCEBP 1], Gynecology, Hereditary cancer and cancer-related syndromes [ONCOL 1], business.industry, Endometrial cancer, Cancer, nutritional and metabolic diseases, medicine.disease, HYPERMETHYLATION, digestive system diseases, Endometrial Neoplasms, MSH2, MSH6, chemistry, business, Cell Adhesion Molecules, Gene Deletion

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85f4a39c0f97e31d38f52cdcda56a8a1
https://hdl.handle.net/2066/97324

المؤلفون: Ralf Ludwig, Katja Hardt, Roland Kaufmann, Josef Pfeilschifter, Simone A. Rubant, Sandra Diehl, Wolf-Henning Boehncke

المصدر: Journal of Investigative Dermatology, Vol. 128, No 2 (2008) pp. 326-331

مصطلحات موضوعية: Male, Fumarates/*pharmacology, Dimethyl Fumarate, Lymphocyte, Biochemistry, Enterotoxins, Mice, chemistry.chemical_compound, Fumarates, Venules, Cells, Cultured, Enterotoxins/pharmacology, Mice, Knockout, Leukocytes, Mononuclear/cytology, Superantigens, Dimethyl fumarate, Chemistry, Cell adhesion molecule, Leukocyte extravasation, P-Selectin, medicine.anatomical_structure, Down-Regulation/drug effects/immunology, Cell Adhesion/*drug effects/immunology, E-Selectin, Immunosuppressive Agents, Superantigens/pharmacology, Intravital microscopy, Bacterial Toxins, E-Selectin/genetics/metabolism, Down-Regulation, Vascular Cell Adhesion Molecule-1, Cell Adhesion Molecules/genetics/*metabolism, Leukocyte Rolling, Dermatology, In Vitro Techniques, Immunosuppressive Agents/*pharmacology, In vivo, Cell Adhesion, medicine, Animals, Humans, Cell adhesion, Molecular Biology, Leukocyte Rolling/*drug effects/physiology, Bacterial Toxins/pharmacology, Venules/cytology, P-Selectin/genetics/metabolism, Cell Biology, Molecular biology, Mice, Inbred C57BL, Solubility, Immunology, Leukocytes, Mononuclear, Vascular Cell Adhesion Molecule-1/genetics/metabolism, Cell Adhesion Molecules

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3000a637071aa6996732dd2bd684f18b
https://doi.org/10.1038/sj.jid.5700996

المؤلفون: Bruce E. Magun, Anjali D. Dotson, David E. Purdy, Mihail S. Iordanov, Pascal Schneider, Sherry M. Farley, Aaron J. Sundholm

المصدر: Journal of Investigative Dermatology, vol. 126, no. 11, pp. 2438-2451

مصطلحات موضوعية: Keratinocytes, Fas Ligand Protein, Eczema, Gene Expression, Apoptosis, Dermatitis, Dermatology, Cysteine Proteinase Inhibitors, Biochemistry, Fas ligand, Cell Line, Proinflammatory cytokine, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Apoptosis/genetics, Caspase Inhibitors, Caspases/metabolism, Cell Adhesion Molecules/genetics, Cell Adhesion Molecules/metabolism, Chemokines/genetics, Chemokines/metabolism, Cysteine Proteinase Inhibitors/pharmacology, Cytokines/genetics, Cytokines/metabolism, Dermatitis/etiology, Dermatitis/genetics, Eczema/etiology, Eczema/genetics, Epidermis/drug effects, Epidermis/metabolism, Fas Ligand Protein/pharmacology, Fas Ligand Protein/physiology, Gene Expression/drug effects, Gene Expression Regulation, Intercellular Adhesion Molecule-1/genetics, Intercellular Adhesion Molecule-1/metabolism, Keratinocytes/chemistry, Keratinocytes/drug effects, NF-kappa B/antagonists & inhibitors, NF-kappa B/genetics, Protein Biosynthesis/genetics, RNA, Messenger/metabolism, RNA, Messenger, Molecular Biology, Caspase, 030304 developmental biology, 0303 health sciences, biology, Cell adhesion molecule, NF-kappa B, hemic and immune systems, Cell Biology, Intercellular Adhesion Molecule-1, medicine.disease, medicine.anatomical_structure, Caspases, Protein Biosynthesis, 030220 oncology & carcinogenesis, Immunology, Cancer research, biology.protein, Cytokines, Eczematous dermatitis, Chemokines, Epidermis, Keratinocyte, Cell Adhesion Molecules, Spongiosis

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcd186a0a394f66dbee56a15bf520a69
https://doi.org/10.1038/sj.jid.5700477

المؤلفون: Chrystelle Lamagna, Michel Aurrand-Lions, Toru Kita, Harunobu Ozaki, Beat A. Imhof, Caroline Johnson-Leger

المصدر: Cells Tissues Organs, Vol. 172, No 3 (2002) pp. 152-160

مصطلحات موضوعية: Intercellular Junctions/ metabolism, Histology, government.form_of_government, Molecular Sequence Data, High endothelial venules, Lymphocytes/cytology/metabolism, Immunoglobulins, Receptors, Cell Surface, Septate junctions, ddc:616.07, Endothelium, Vascular/cytology/metabolism, Cell junction, Cell Line, Adherens junction, Mice, Cell–cell interaction, Cell Movement, Leukocytes, Membrane Proteins/genetics/ metabolism, Animals, Humans, Tissue Distribution, Amino Acid Sequence, Lymphocytes, Tight junction, Chemistry, Cell Movement/physiology, Gap junction, Membrane Proteins, Immunoglobulins/genetics/ metabolism, Cell biology, Lymphatic Endothelium, Intercellular Junctions, Leukocytes/metabolism, government, Endothelium, Vascular, Anatomy, Cell Adhesion Molecules/genetics/ metabolism, Cell Adhesion Molecules, Sequence Alignment

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77223c8797ddf199835fa9c0075a6a08
https://doi.org/10.1159/000066967

المؤلفون: Christian Korff, Paul A. McGettigan, Thierry Deonna, Naisha Shah, Dara McCreary, Kevin Collins, Bronwyn Parry-Fielder, Sean Ennis, Sally Ann Lynch, Mary D. King, Judith Conroy, David Webb, Donncha Hanrahan, Margaret M. Moran

المصدر: Epilepsia, Vol. 55, No 6 (2014) pp. 858-65

مصطلحات موضوعية: Adult, Male, Candidate gene, Adolescent, Landau–Kleffner syndrome, Receptor, EphB2, Cell Adhesion Molecules, Neuronal, Serine Endopeptidases/genetics, Twins, Monozygotic/genetics, Nerve Tissue Proteins, Extracellular Matrix Proteins/genetics, Polymorphism, Single Nucleotide, Receptors, N-Methyl-D-Aspartate, Cell Adhesion Molecules, Neuronal/genetics, Young Adult, medicine, Landau-Kleffner Syndrome/genetics, Nerve Tissue Proteins/genetics, Humans, Genetic Predisposition to Disease, Child, Exome sequencing, Oligonucleotide Array Sequence Analysis, Genetics, Comparative Genomic Hybridization, Extracellular Matrix Proteins, Landau-Kleffner Syndrome, ddc:618, Receptors, N-Methyl-D-Aspartate/genetics, Genetic Predisposition to Disease/genetics, Calcium-Binding Proteins, Serine Endopeptidases, Twins, Monozygotic, medicine.disease, Polymorphism, Single Nucleotide/genetics, Receptor, EphB2/genetics, Rolandic epilepsy, Reelin Protein, Neurology, Female, Neurology (clinical), Psychology, Cell Adhesion Molecules/genetics, Cell Adhesion Molecules, Isolated cases

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b5ef3ad27c540ad5344fc1ba1b16b4b
https://pubmed.ncbi.nlm.nih.gov/24828792