المؤلفون: Bumsup Kwon, Austin Y. Ha, Kyohei Itamura, Henry W. Querfurth, Suzanne M. de la Monte, Han-Kyu Lee, Cynthia A. Lemere

المصدر: Journal of Alzheimer's Disease. 56:1015-1036

مصطلحات موضوعية: Male, 0301 basic medicine, medicine.medical_specialty, Cell Survival, medicine.medical_treatment, Mice, Transgenic, Mechanistic Target of Rapamycin Complex 2, mTORC1, Mechanistic Target of Rapamycin Complex 1, mTORC2, Article, Rats, Sprague-Dawley, 03 medical and health sciences, Insulin resistance, Alzheimer Disease, Internal medicine, Autophagy, medicine, Animals, Humans, Protein kinase B, Cells, Cultured, PI3K/AKT/mTOR pathway, Aged, Aged, 80 and over, Cerebral Cortex, Neurons, Amyloid beta-Peptides, Chemistry, Cell growth, General Neuroscience, Insulin, General Medicine, Middle Aged, medicine.disease, Peptide Fragments, Psychiatry and Mental health, Clinical Psychology, 030104 developmental biology, Endocrinology, Cell culture, Female, Insulin Resistance, biological phenomena, cell phenomena, and immunity, Geriatrics and Gerontology, Proto-Oncogene Proteins c-akt

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fec2b31c11029cc0d96405b98de93379
https://doi.org/10.3233/jad-161029

المؤلفون: Bumsup Kwon, Henry W. Querfurth, Han-Kyu Lee, Timothy R. Gamache

المصدر: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1852(9):1810-1823

مصطلحات موضوعية: Ceramide, biology, β-amyloid, Insulin resistance, Lipid signaling, Mitochondrion, Alzheimer's disease, medicine.disease, Insulin receptor, chemistry.chemical_compound, Mitochondrial respiratory chain, Biochemistry, mitochondrial fusion, chemistry, biology.protein, medicine, MFN1, Molecular Medicine, Mitochondrial dysfunction, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38d230c4ed580ede2b6c19dde7bf587f

المؤلفون: Paul S. Aisen, Sarah Walter, Kenneth M. Spicer, Stephanie Reeder, Nick C. Fox, Heather Anderson, Chuang Kuo Wu, Teresa Villena, Cynthia M. Carlsson, Paul Malloy, Bonnie S. Goldstein, Stacy Schneider, Po H. Lu, Jeffrey M. Burns, Balebail Ashok Raj, Stephanie Kielb, Adrian Preda, Pierre N. Tariot, Chet Mathis, Christopher H. van Dyck, Maria Carroll, Karen E. Smith, Lon S. Schneider, Velandai Srikanth, Daniel Varon, Nunzio Pomara, Michael Borrie, Eben S. Schwartz, Gaby Thai, Susan De Santi, Dana Nguyen, Daniel C. Marson, Gene E. Alexander, Thomas O. Obisesan, Steven Potkin, Kris A. Johnson, Henry Rusinek, Nigel J. Cairns, Gad A. Marshall, Scott C. Neu, Benita Mudge, Leyla deToledo-Morrell, Jeff D. Williamson, Helen Vanderswag, Howard Chertkow, Sandra W. Jacobson, Dana Mathews, Arthur W. Toga, Saba Wolday, Douglas W. Scharre, Lidia Glodzik, Rob Bartha, Anders M. Dale, Norbert Schuff, Ging-Yuek Robin Hsiung, Rachelle S. Doody, Richard D. King, Vernice Bates, Li Shen, Barton Lane, Kristin Fargher, Chris Moran, Greg Jicha, Dan Bandy, Sara Dolen, Andrew E. Budson, Martha G. MacAvoy, Daniel H.S. Silverman, Anton P. Porsteinsson, Kathleen R. Johnson, Michele L. Callisaya, Betty Lind, Michael D. Devous, Robert C. Green, P. Murali Doraiswamy, Andrew J. Saykin, Joseph F. Quinn, Kristina Lipowski, Raymundo Hernando, Catherine Mc-Adams-Ortiz, Ronald G. Thomas, Jeffrey Kaye, Irina Rachinsky, Donna Munic, Munir Chowdhury, Bruce L. Miller, Les Shaw, Brian R. Ott, Randall Griffith, Kristen Martin-Cook, Marwan N. Sabbagh, Crystal V. Flynn Longmire, Raymond Scott Turner, Karen Blank, Effie M. Mitsis, Charles Bernick, Marilyn S. Albert, John M Olichney, Earl A. Zimmerman, Jared R. Tinklenberg, Robert A. Koeppe, Dick Trost, Howard Feldman, Laura L. Boles Ponto, M. Saleem Ismail, Alan J. Lerner, Kelly M. Makino, Pradeep Garg, Jeffrey R. Petrella, Peter J. Snyder, Norman R. Relkin, Laurel A. Beckett, Allyson C. Rosen, Devon Gessert, MaryAnn Oakley, J. Q. Trojanowki, Lisa Raudin, Stephen Salloway, Paula Ogrocki, Bryan M. Spann, Susan K. Schultz, Adam S. Fleisher, Brigid Reynolds, Jason Karlawish, Michele Assaly, John Q. Trojanowki, Kewei Chen, Enchi Liu, Mary Quiceno, Kaycee M. Sink, Jerome A. Yesavage, Sterling C. Johnson, Curtis B. Caldwell, Heather E. Johnson, Neill R. Graff-Radford, Karen S. Anderson, Richard Frank, John C. Morris, Donna M. Simpson, Tatiana Foroud, Joel P. Felmlee, Zaven Kachaturian, Magdalena Korecka, George Bartzokis, Francine Parfitt, Henry W. Querfurth, Patricia Lynn Johnson, Raj C. Shah, M.-Marsel Mesulam, Howard J. Rosen, Ann Marie Hake, Danielle J Harvey, Hyungsub Shim, Dick J. Drost, Yaakov Stern, Charles DeCarli, Brandy R. Matthews, Geoffrey Tremont, Kim Martin, Robert B. Santulli, Aliza Romirowsky, Joy L. Taylor, Ramon Diaz-Arrastia, Godfrey D. Pearlson, Mark A. Mintun, James J. Lah, Norm Foster, Matt A. Bernstein, Diana R. Kerwin, Virginia M.-Y. Lee, Bojana Stefanovic, Joanne L. Lord, Chris Hosein, Susan E. Molchan, David J. Clark, Leon Hudson, Janet S. Cellar, Karen Crawford, Richard Beare, Franklin Watkins, T. J. Montine, Ronald C. Petersen, Carl H. Sadowsky, David A. Wolk, Steven E. Arnold, Nancy Collins Johnson, Ruth A. Mulnard, Antero Sarrael, John Kornak, Amanda Smith, Owen Carmichael, Beau M. Ances, Clifford R. Jack, Meghan Frey, Martin R. Farlow, William J. Jagust, Ronald J. Killiany, Mony J. de Leon, Sandra E. Black, Javier Villanueva-Meyer, Smita Kittur, Walter Martinez, Sue Leon, Anthony Gamst, James B. Brewer, Hillel Grossman, Eric M. Reiman, Jacobo Mintzer, Stephen Correia, Kyle B. Womack, Maria Kataki, Lawrence S. Honig, Liana G. Apostolova, Peggy Roberts, Christine Belden, Michelle Rainka, Alexander Norbash, R. Edward Coleman, Richard E. Carson, Dzintra Celmins, Lisa Taylor-Reinwald, Scott Herring, Oscar L. Lopez, Michael W. Weiner, Ranjan Duara, Elizabether Finger, Peter A. Hardy, Myron F. Weiner, Horacio Capote, Keith A. Johnson, Karen L. Bell, Allan I. Levey, Steven G. Potkin, Howard Bergman, John A. Rogers, Wei Wang, Connie Brand, Chiadi U. Onyike, Paul M. Thompson, Russell H. Swerdlow, Gloria Chaing, Judith L. Heidebrink, Salome K. Bwayo, Reisa A. Sperling, Michael C. Donohue, Sanjay Asthana, Alice D. Brown, Charles D. Smith, Neil W. Kowall, Andrew Kertesz, Tamie Sather, Evan Fletcher, Sonia Pawluczyk

المصدر: Neurology

مصطلحات موضوعية: Blood Glucose, Male, Pediatrics, medicine.medical_specialty, endocrine system diseases, Article, Alzheimer Disease, medicine, Dementia, Humans, Cognitive Dysfunction, Longitudinal Studies, Cognitive decline, Cognitive reserve, Aged, Aged, 80 and over, Cerebral Cortex, business.industry, Type 2 Diabetes Mellitus, nutritional and metabolic diseases, Brain, Cognition, Organ Size, medicine.disease, Magnetic Resonance Imaging, Cognitive test, Diabetes Mellitus, Type 2, Cohort, Female, Neurology (clinical), Alzheimer's disease, Atrophy, business, Factor Analysis, Statistical

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2468b73929ec8a8e70031760e42449f7
https://pubmed.ncbi.nlm.nih.gov/31889018

المؤلفون: Mary L. Hynes, Liberty Teodoro, John C. Brockington, Connie Brand, Paul Malloy, Russell H. Swerdlow, Ronald C. Petersen, Judith L. Heidebrink, Pierre N. Tariot, Curtis Caldwell, Clifford R. Jack, David G. Clark, Neill R. Graff-Radford, Charles D. Smith, Geoffrey Tremont, Ranjan Duara, Stephen Pasternack, T. Y. Lee, Owen Carmichael, Nadira Trncic, Irina Rachisky, Daniel D'Agostino, James J. Lah, Steven G. Potkin, Howard Bergman, Dana M. Pogorelec, Lon S. Schneider, Anna Burke, Sherye A. Sirrel, Henry W. Querfurth, Michael Lin, David Bachman, Edward Coleman, Michele Assaly, Allyson C. Rosen, Jeffrey M. Burns, Balebail Ashok Raj, Jared R. Brosch, Joanne L. Lord, William Brooks, Brigid Reynolds, Karen S. Anderson, Sandra Jacobson, Nunzio Pomara, Patricia Lynn Johnson, George Bartzokis, Parianne Fatica, Benita Mudge, Dana Nguyen, Carl H. Sadowsky, Michael Borrie, Qianjin Feng, Chiadi U. Onyike, Partha Sinha, Gloria Chaing, Howard Chertkow, Leyla deToledo-Morrell, Bojana Stefanovic, Richard E. Carson, Wufan Chen, Ronald J. Killiany, Mimi Dang, Thomas O. Obisesan, Christopher H. van Dyck, Maria Carroll, Gaby Thai, Arthur W. Toga, Chuang Kuo Wu, Erik D. Roberson, Effie M. Mitsis, Smita Kittur, Keith A. Johnson, Dana Mathews, Sara Dolen, Raj C. Shah, M.-Marsel Mesulam, Howard J. Rosen, Karen L. Bell, Ging-Yuek Robin Hsiung, Teresa Villena, Kris Johnson, Saba Wolday, Douglas W. Scharre, Kyle B. Womack, Maria Kataki, Barton Lane, Angela Oliver, Greg Jicha, Reisa A. Sperling, Wei Yang, David S. Geldmacher, Lawrence S. Honig, Sanjay Asthana, Janet S. Cellar, William J. Jagust, Dzintra Celmins, Susan Rountree, Christina A. Michel, Allan I. Levey, Tracy Kendall, Lisa D. Ravdin, Jared R. Tinklenberg, Brittany Cerbone, Alice D. Brown, Marilyn S. Albert, Andrew J. Saykin, Raymundo Hernando, Sandra Weintraub, John Q. Trojanowki, Raina Carter, Betty Lind, Kristin Fargher, Sterling C. Johnson, P. Murali Doraiswamy, Jeffrey R. Petrella, Neil W. Kowall, Sara S. Mason, Heather Johnson, Mary L. Creech, Stacy Schneider, Donna Munic, Liana G. Apostolova, Peter A. Hardy, Munir Chowdhury, Bruce L. Miller, Ruth A. Mulnard, Curtis Tatsuoka, Po H. Lu, Daniel C. Marson, Pauline Maillard, John C. Morris, Marwan N. Sabbagh, Jeffrey Kaye, Hillel Grossman, Gary R. Conrad, Karen Blank, Meiyan Huang, Stephanie Kielb, Andrew Kertesz, Jerome A. Yesavage, Leslie Shaw, Martin R. Farlow, Maria T. Greig, Jacobo Mintzer, Susan De Santi, David S. Knopman, Marc Seltzer, Scott Herring, Joy L. Taylor, Vernice Bates, Rob Bartha, Cynthia Hunt, Henry Rusinek, Randall Griffith, Cynthia M. Carlsson, Charles Bernick, Bonnie S. Goldstein, Rachelle S. Doody, Leslie Gordineer, Catherine Mc-Adams-Ortiz, Kim Martin, Howard Feldman, David C. Perry, Horacio Capote, Lidia Glodzik, Stephen Correia, James B. Brewer, Elizabeth Finger, Jeff D. Williamson, Franklin Watkins, Borna Bonakdarpour, Colleen S. Albers, M. Saleem Ismail, Alan J. Lerner, Daniel Varon, Christine M. Belden, Sonia Pawluczyk, Paul S. Aisen, Pradeep Garg, Kelly M. Makino, Laurel A. Beckett, Peggy Roberts, Nancy Johnson, Anahita Adeli, Terence Z. Wong, Michelle Rainka, Elizabeth Oates, Amanda Smith, Kenneth M. Spicer, Laura A. Flashman, Kristine Lipowski, Charles DeCarli, Stephanie Reeder, Mauricio Beccera, Dick Trost, Alexander Norbash, Lisa C. Silbert, Michael W. Weiner, Gad A. Marshall, Ann Marie Hake, Pradeep Varma, Francine Parfitt, Chris Hosein, Adam S. Fleisher, Marissa Natelson Love, Joanne S. Allard, Earl A. Zimmerman, Kathleen Tingus, Brian R. Ott, Joseph F. Quinn, Anton P. Porsteinsson, Paula Ogrocki, Raymond Scott Turner, Salvador Borges-Neto, James E. Galvin, Yaakov Stern, Andrew E. Budson, Martha G. MacAvoy, Daniel H.S. Silverman, Robert B. Santulli, Adrian Preda, Godfrey D. Pearlson, Mark A. Mintun, Stephen Salloway, Mary Quiceno, Kaycee M. Sink, John M Olichney, Antero Sarrael, Beau M. Ances, Javier Villanueva-Meyer, Mony J. de Leon, Sandra E. Black, Bryan M. Spann, Diana R. Kerwin, Ellen Woo, Helen Vanderswag, Erin E. Franklin, Robert C. Green, Norman R. Relkin

المصدر: Medical Biophysics Publications
Scientific Reports

مصطلحات موضوعية: Male, Computer science, Neuroimaging, Disease, computer.software_genre, Sensitivity and Specificity, Article, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Alzheimer Disease, Predictive Value of Tests, mental disorders, medicine, Dementia, Humans, Cognitive Dysfunction, Longitudinal Studies, Cognitive impairment, Aged, Aged, 80 and over, Multidisciplinary, medicine.diagnostic_test, business.industry, Brain, Pattern recognition, Magnetic resonance imaging, Middle Aged, medicine.disease, Magnetic Resonance Imaging, Early Diagnosis, Disease Progression, Female, Data mining, Artificial intelligence, business, computer, 030217 neurology & neurosurgery, Alzheimer's Disease Neuroimaging Initiative, Follow-Up Studies

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05f0222334c82f5a5e04dacd0e71b036
https://ir.lib.uwo.ca/biophysicspub/575

المؤلفون: Henry W. Querfurth, Bumsup Kwon, Han-Kyu Lee

المصدر: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1843(7):1402-1413

مصطلحات موضوعية: Ceramide, medicine.medical_specialty, Docosahexaenoic Acids, Cell Survival, medicine.medical_treatment, Palmitic Acid, Peroxisome proliferator-activated receptor, Inflammation, Biology, Palmitate, Linoleic Acid, Rats, Sprague-Dawley, chemistry.chemical_compound, Mice, Insulin resistance, Oleate, Internal medicine, Cell Line, Tumor, medicine, Animals, Protein kinase A, Molecular Biology, Diacylglycerol kinase, chemistry.chemical_classification, Cerebral Cortex, Neurons, Insulin, Transcription Factor RelA, Gene Expression Regulation, Developmental, Serum Albumin, Bovine, Cell Biology, medicine.disease, Embryo, Mammalian, Cyclic AMP-Dependent Protein Kinases, Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Mitochondria, Rats, Endocrinology, chemistry, Cattle, Signal transduction, medicine.symptom, Insulin Resistance, Mitogen-Activated Protein Kinases, Mitochondrial dysfunction, Oleic Acid, Signal Transduction, Transcription Factors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e2bfe72d234e0047bd3dcd65eabb132

المؤلفون: Robert Gross, Henry W. Querfurth, Julie L. Roth, Jennifer D. Davis

المصدر: Case Reports in Neurological Medicine
Case Reports in Neurological Medicine, Vol 2016 (2016)

مصطلحات موضوعية: medicine.medical_specialty, 030214 geriatrics, business.industry, Autoimmune limbic encephalitis, Cognition, Case Report, lcsh:RC346-429, Immune therapy, 03 medical and health sciences, Personality changes, 0302 clinical medicine, Voltage gated potassium channel complex, Memory impairment, Medicine, Neuropsychological testing, General Agricultural and Biological Sciences, business, Psychiatry, Cognitive impairment, Neuroscience, lcsh:Neurology. Diseases of the nervous system, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc9d031a0a9cadeb6082ebda03e2b73f
https://pubmed.ncbi.nlm.nih.gov/26881156

المؤلفون: R. Karunya, Kaveri Pradhan, Rashmi K. Ambasta, Henry W. Querfurth, Pravir Kumar

المصدر: Journal of Neurochemistry. 120:350-370

مصطلحات موضوعية: Amyloid, biology, Neurodegeneration, medicine.disease, Biochemistry, Parkin, nervous system diseases, Ubiquitin ligase, Cellular and Molecular Neuroscience, medicine.anatomical_structure, Proteasome, Lysosome, medicine, biology.protein, Tauopathy, Cognitive decline, Neuroscience

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f444ddaf6353c68b8c02c1968a14893a
https://doi.org/10.1111/j.1471-4159.2011.07588.x

المؤلفون: Henry W. Querfurth, Pravir Kumar, Gangjian Qin, Han-Kyu Lee, Qinghao Fu, Charbel Moussa, Tohru Kitada, Kenneth M. Rosen

المصدر: Journal of Neuroscience Research. 88:167-178

مصطلحات موضوعية: Amyloid, biology, Transfection, Molecular biology, Parkin, nervous system diseases, Cell biology, Ubiquitin ligase, Cellular and Molecular Neuroscience, Ubiquitin, Proteasome, mental disorders, biology.protein, Neprilysin, Intracellular

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::457326bec546c570f8b669a8f8cddea4
https://doi.org/10.1002/jnr.22178

المؤلفون: Henry W. Querfurth, Salvatore Oddo, Alvin Lyckman, Frank M. LaFerla, Alexander Shtifman, Jose R. Lopez

المصدر: Journal of Neurochemistry. 105:262-271

مصطلحات موضوعية: Amyloid, medicine.medical_specialty, Calcium Channels, L-Type, Mice, Transgenic, Neocortex, tau Proteins, Biology, Biochemistry, Amyloid beta-Protein Precursor, Mice, Cellular and Molecular Neuroscience, chemistry.chemical_compound, Alzheimer Disease, Internal medicine, Presenilin-1, medicine, Extracellular, Animals, Homeostasis, Humans, Channel blocker, Calcium Signaling, Cells, Cultured, Neurons, Voltage-dependent calcium channel, Ryanodine, Ryanodine receptor, Neurodegeneration, Inositol trisphosphate, Calcium Channel Blockers, medicine.disease, Resting potential, Disease Models, Animal, Endocrinology, medicine.anatomical_structure, chemistry, Calcium, Neuron

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51f37d67a5332ca63050420c1b5148b2
https://doi.org/10.1111/j.1471-4159.2007.05135.x

المؤلفون: Kenneth M. Rosen, Pravir Kumar, Ken Kosik, Vimal Veereshwarayya, Cam Patterson, Rashmi K. Ambasta, Hamid Band, Ruben Mestril, Henry W. Querfurth

المصدر: Human Molecular Genetics. 16:848-864

مصطلحات موضوعية: Proteasome Endopeptidase Complex, Cell Survival, Leupeptins, Ubiquitin-Protein Ligases, Blotting, Western, Cysteine Proteinase Inhibitors, Models, Biological, Cell Line, Amyloid beta-Protein Precursor, chemistry.chemical_compound, Ubiquitin, Heat shock protein, MG132, Genetics, medicine, Humans, Immunoprecipitation, HSP70 Heat-Shock Proteins, RNA, Small Interfering, Molecular Biology, Heat-Shock Proteins, Genetics (clinical), Analysis of Variance, Microscopy, Confocal, biology, Reverse Transcriptase Polymerase Chain Reaction, Hydrolysis, HEK 293 cells, General Medicine, Hsp70, Ubiquitin ligase, Cell biology, chemistry, Proteasome, Proteasome inhibitor, biology.protein, Amyloid Precursor Protein Secretases, Proteasome Inhibitors, Protein Binding, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::186a388b216ba15599b2f751b32ce1fb
https://doi.org/10.1093/hmg/ddm030