المؤلفون: Hu J; Center for Cell Death, Injury & Regeneration, Medical University of South Carolina, Charleston, SC, United States of America; Departments of Drug Discovery & Biomedical Sciences, Medical University of South Carolina, Charleston, SC, United States of America., Nieminen AL; Center for Cell Death, Injury & Regeneration, Medical University of South Carolina, Charleston, SC, United States of America; Departments of Drug Discovery & Biomedical Sciences, Medical University of South Carolina, Charleston, SC, United States of America; Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, United States of America., Weemhoff JL; Department of Pharmacology, Toxicology & Therapeutics, University of Kansas Medical Center, Kansas City, KS, United States of America., Jaeschke H; Department of Pharmacology, Toxicology & Therapeutics, University of Kansas Medical Center, Kansas City, KS, United States of America., Murphy LG; Center for Cell Death, Injury & Regeneration, Medical University of South Carolina, Charleston, SC, United States of America; Departments of Drug Discovery & Biomedical Sciences, Medical University of South Carolina, Charleston, SC, United States of America., Dent JA; Center for Cell Death, Injury & Regeneration, Medical University of South Carolina, Charleston, SC, United States of America; Departments of Drug Discovery & Biomedical Sciences, Medical University of South Carolina, Charleston, SC, United States of America., Lemasters JJ; Center for Cell Death, Injury & Regeneration, Medical University of South Carolina, Charleston, SC, United States of America; Departments of Drug Discovery & Biomedical Sciences, Medical University of South Carolina, Charleston, SC, United States of America; Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, SC, United States of America; Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, United States of America. Electronic address: JJLemasters@musc.edu.

المصدر: Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2023 Nov 15; Vol. 479, pp. 116722. Date of Electronic Publication: 2023 Oct 15.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 0416575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0333 (Electronic) Linking ISSN: 0041008X NLM ISO Abbreviation: Toxicol Appl Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Acetaminophen*/toxicity , Chemical and Drug Induced Liver Injury*/etiology , Chemical and Drug Induced Liver Injury*/metabolism, Mice ; Animals ; Mitochondria, Liver/metabolism ; Mitochondria/metabolism ; Hepatocytes/metabolism ; Necrosis/metabolism ; Mice, Inbred C57BL

المؤلفون: Adelusi OB; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA., Ramachandran A; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA., Lemasters JJ; Center for Cell Death, Injury & Regeneration, Departments of Drug Discovery & Biomedical Sciences and Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, SC, USA., Jaeschke H; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA. Electronic address: hjaeschke@kumc.edu.

المصدر: Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2022 Jun 15; Vol. 445, pp. 116043. Date of Electronic Publication: 2022 May 02.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 0416575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0333 (Electronic) Linking ISSN: 0041008X NLM ISO Abbreviation: Toxicol Appl Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Chemical and Drug Induced Liver Injury*/etiology , Chemical and Drug Induced Liver Injury*/metabolism , Chemical and Drug Induced Liver Injury*/prevention & control , Chemical and Drug Induced Liver Injury, Chronic*/metabolism, Acetaminophen/toxicity ; Animals ; Deferoxamine/pharmacology ; Hepatocytes ; Iron/metabolism ; Lipid Peroxidation ; Liver ; Male ; Mice ; Mice, Inbred C57BL ; Minocycline/pharmacology ; Mitochondria, Liver ; Oxidative Stress ; Peroxynitrous Acid/pharmacology

المؤلفون: Wimborne HJ; Center for Cell Death, Injury & Regeneration, Medical University of South Carolina, Charleston, SC, United States of America; Department of Drug Discovery & Biomedical Sciences, Medical University of South Carolina, Charleston, SC, United States of America., Hu J; Center for Cell Death, Injury & Regeneration, Medical University of South Carolina, Charleston, SC, United States of America; Department of Drug Discovery & Biomedical Sciences, Medical University of South Carolina, Charleston, SC, United States of America., Takemoto K; Center for Cell Death, Injury & Regeneration, Medical University of South Carolina, Charleston, SC, United States of America; Department of Drug Discovery & Biomedical Sciences, Medical University of South Carolina, Charleston, SC, United States of America., Nguyen NT; Department of Pharmacology, Toxicology, & Therapeutics, University of Kansas Medical Center, Kansas City, KS, United States of America., Jaeschke H; Department of Pharmacology, Toxicology, & Therapeutics, University of Kansas Medical Center, Kansas City, KS, United States of America., Lemasters JJ; Center for Cell Death, Injury & Regeneration, Medical University of South Carolina, Charleston, SC, United States of America; Department of Drug Discovery & Biomedical Sciences, Medical University of South Carolina, Charleston, SC, United States of America; Department of Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, SC, United States of America; Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, United States of America. Electronic address: JJLemasters@musc.edu., Zhong Z; Center for Cell Death, Injury & Regeneration, Medical University of South Carolina, Charleston, SC, United States of America; Department of Drug Discovery & Biomedical Sciences, Medical University of South Carolina, Charleston, SC, United States of America. Electronic address: zhong@musc.edu.

المصدر: Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2020 Jun 01; Vol. 396, pp. 114982. Date of Electronic Publication: 2020 Mar 30.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 0416575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0333 (Electronic) Linking ISSN: 0041008X NLM ISO Abbreviation: Toxicol Appl Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Acetaminophen/*toxicity , Aldehyde Dehydrogenase, Mitochondrial/*metabolism , Analgesics, Non-Narcotic/*toxicity , Chemical and Drug Induced Liver Injury/*etiology , Mitochondria, Liver/*drug effects, Alanine Transaminase/blood ; Animals ; Aspartate Aminotransferases/blood ; Benzamides/pharmacology ; Benzodioxoles/pharmacology ; Chemical and Drug Induced Liver Injury/prevention & control ; Enzyme Activation ; Liver/drug effects ; Liver/enzymology ; Liver/metabolism ; Liver/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Microscopy, Fluorescence, Multiphoton ; Mitochondria, Liver/metabolism

المؤلفون: Hu J; Center for Cell Death, Injury & Regeneration, Medical University of South Carolina, Charleston, SC 29425, United States of America; Department of Drug Discovery & Biomedical Sciences, Medical University of South Carolina, Charleston, SC 29425, United States of America., Lemasters JJ; Center for Cell Death, Injury & Regeneration, Medical University of South Carolina, Charleston, SC 29425, United States of America; Department of Drug Discovery & Biomedical Sciences, Medical University of South Carolina, Charleston, SC 29425, United States of America; Department of Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, United States of America. Electronic address: JJLemasters@musc.edu.

المصدر: Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2020 Apr 01; Vol. 392, pp. 114930. Date of Electronic Publication: 2020 Feb 25.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 0416575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0333 (Electronic) Linking ISSN: 0041008X NLM ISO Abbreviation: Toxicol Appl Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Acetaminophen/*toxicity , Chemical and Drug Induced Liver Injury/*metabolism , Iron/*metabolism , Lysosomes/*drug effects , Minocycline/*pharmacology , Mitochondria/*metabolism, Acetaminophen/administration & dosage ; Analgesics, Non-Narcotic/administration & dosage ; Analgesics, Non-Narcotic/toxicity ; Animals ; Anti-Bacterial Agents/pharmacology ; Cell Survival/drug effects ; Cells, Cultured ; Drug Overdose ; Hepatocytes/drug effects ; Humans ; Male ; Mice ; Mice, Inbred C57BL

المؤلفون: Herr DJ; Department of Medicine, Division of Cardiology, Medical University of South Carolina, Charleston, SC 29425, United States., Baarine M; Department of Medicine, Division of Cardiology, Medical University of South Carolina, Charleston, SC 29425, United States., Aune SE; Department of Medicine, Division of Cardiology, Medical University of South Carolina, Charleston, SC 29425, United States., Li X; Department of Drug Discovery and Biomedical Sciences, Medical University of South Carolina, Charleston, SC 29425, United States., Ball LE; Department of Cell and Molecular Pharmacology, Medical University of South Carolina, Charleston, SC 29425, United States., Lemasters JJ; Department of Drug Discovery and Biomedical Sciences, Medical University of South Carolina, Charleston, SC 29425, United States; Center for Cell Death, Injury & Regeneration, Medical University of South Carolina, Charleston, SC 29425, United States., Beeson CC; Department of Drug Discovery and Biomedical Sciences, Medical University of South Carolina, Charleston, SC 29425, United States., Chou JC; Department of Drug Discovery and Biomedical Sciences, Medical University of South Carolina, Charleston, SC 29425, United States., Menick DR; Department of Medicine, Division of Cardiology, Medical University of South Carolina, Charleston, SC 29425, United States; Ralph H. Johnson Veterans Affairs Medical Center, Charleston, SC 29425, United States. Electronic address: menickd@musc.edu.

المصدر: Journal of molecular and cellular cardiology [J Mol Cell Cardiol] 2018 Jan; Vol. 114, pp. 309-319. Date of Electronic Publication: 2017 Dec 07.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Academic Press Country of Publication: England NLM ID: 0262322 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-8584 (Electronic) Linking ISSN: 00222828 NLM ISO Abbreviation: J Mol Cell Cardiol Subsets: MEDLINE

مواضيع طبية MeSH: Mitochondria/*enzymology , Myocardial Reperfusion Injury/*enzymology , Myocytes, Cardiac/*enzymology, Animals ; Cell Survival/drug effects ; Endothelial Cells/drug effects ; Endothelial Cells/metabolism ; Fibroblasts/drug effects ; Fibroblasts/metabolism ; Histone Deacetylase 1/metabolism ; Histone Deacetylase Inhibitors/pharmacology ; Male ; Mitochondria/drug effects ; Myocardial Reperfusion Injury/pathology ; Myocardial Reperfusion Injury/physiopathology ; Myocardium/enzymology ; Myocardium/pathology ; Myocytes, Cardiac/pathology ; Oxygen Consumption/drug effects ; Rats, Sprague-Dawley ; Reactive Oxygen Species/metabolism ; Succinate Dehydrogenase/metabolism ; Ventricular Function/drug effects

المؤلفون: Schwartz J; Department of Drug Discovery & Biomedical Sciences, Medical University of South Carolina, Charleston, SC, USA., Holmuhamedov E, Zhang X, Lovelace GL, Smith CD, Lemasters JJ

المصدر: Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2013 Nov 15; Vol. 273 (1), pp. 172-9. Date of Electronic Publication: 2013 Sep 05.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 0416575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0333 (Electronic) Linking ISSN: 0041008X NLM ISO Abbreviation: Toxicol Appl Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Calcium Channels/*drug effects , Doxycycline/*pharmacology , Hepatocytes/*drug effects , Minocycline/*pharmacology , Reperfusion Injury/*prevention & control , Tetracycline/*pharmacology, Animals ; Anti-Bacterial Agents/pharmacology ; Calcium/pharmacokinetics ; Calcium Channels/metabolism ; Hepatocytes/metabolism ; Hypoxia/prevention & control ; Iron/pharmacokinetics ; Male ; Mitochondria, Liver/drug effects ; Mitochondria, Liver/metabolism ; Mitochondrial Membrane Transport Proteins/metabolism ; Mitochondrial Permeability Transition Pore ; Rats ; Rats, Sprague-Dawley

المؤلفون: Saito C; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA., Lemasters JJ, Jaeschke H

المصدر: Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2010 Jul; Vol. 246 (1-2), pp. 8-17. Date of Electronic Publication: 2010 Apr 25.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 0416575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0333 (Electronic) Linking ISSN: 0041008X NLM ISO Abbreviation: Toxicol Appl Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Acetaminophen/*pharmacology , Analgesics, Non-Narcotic/*pharmacology , JNK Mitogen-Activated Protein Kinases/*physiology , Liver/*drug effects , Nitric Oxide Synthase/*drug effects , Oxidative Stress/*drug effects , Peroxynitrous Acid/*biosynthesis, Acetaminophen/toxicity ; Alanine Transaminase/blood ; Analgesics, Non-Narcotic/toxicity ; Animals ; Anthracenes/pharmacology ; Apoptosis/drug effects ; Blotting, Western ; Enzyme Activation/drug effects ; Enzyme Induction/drug effects ; JNK Mitogen-Activated Protein Kinases/antagonists & inhibitors ; JNK Mitogen-Activated Protein Kinases/drug effects ; JNK Mitogen-Activated Protein Kinases/metabolism ; Liver/enzymology ; Liver/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Mitochondria, Liver/drug effects ; Nitric Oxide Synthase/biosynthesis ; Phosphorylation ; Reverse Transcriptase Polymerase Chain Reaction ; Subcellular Fractions/drug effects ; Translocation, Genetic/genetics ; bcl-2-Associated X Protein/metabolism

المؤلفون: Lemasters JJ; Center for Cell Death, Injury and Regeneration, and Departments of Pharmaceutical Sciences and Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA., Ramshesh VK

المصدر: Methods in cell biology [Methods Cell Biol] 2007; Vol. 80, pp. 283-95.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Review

بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 0373334 Publication Model: Print Cited Medium: Print ISSN: 0091-679X (Print) Linking ISSN: 0091679X NLM ISO Abbreviation: Methods Cell Biol Subsets: MEDLINE

مواضيع طبية MeSH: Membrane Potential, Mitochondrial*, Cations/*analysis , Fluorescence Polarization/*methods , Mitochondria/*physiology, Animals ; Fluorescence Resonance Energy Transfer ; Fluorescent Dyes/analysis ; Image Processing, Computer-Assisted