المؤلفون: White J; Departments of Chemistry and Global Health , University of Washington , 36 Bagley Hall, 400 15th Avenue NE , Seattle , Washington 98195 , United States., Dhingra SK; Department of Microbiology & Immunology , Columbia University Irving Medical Center , 701 West 168th Street, HHSC 1502 , New York , New York 10032 , United States., Deng X; Department of Biochemistry , University of Texas Southwestern Medical Center , 5323 Harry Hines Blvd , Dallas , Texas 75390 , United States., El Mazouni F; Department of Biochemistry , University of Texas Southwestern Medical Center , 5323 Harry Hines Blvd , Dallas , Texas 75390 , United States., Lee MCS; Department of Microbiology & Immunology , Columbia University Irving Medical Center , 701 West 168th Street, HHSC 1502 , New York , New York 10032 , United States.; Parasites and Microbes Programme , Wellcome Sanger Institute , Hinxton, Cambridgeshire CB10 1SA , U.K., Afanador GA; Department of Biochemistry , University of Texas Southwestern Medical Center , 5323 Harry Hines Blvd , Dallas , Texas 75390 , United States., Lawong A; Department of Biochemistry , University of Texas Southwestern Medical Center , 5323 Harry Hines Blvd , Dallas , Texas 75390 , United States., Tomchick DR; Department of Biophysics , University of Texas Southwestern Medical Center , 5323 Harry Hines Blvd , Dallas , Texas 75390 , United States., Ng CL; Department of Microbiology & Immunology , Columbia University Irving Medical Center , 701 West 168th Street, HHSC 1502 , New York , New York 10032 , United States., Bath J; Department of Microbiology & Immunology , Columbia University Irving Medical Center , 701 West 168th Street, HHSC 1502 , New York , New York 10032 , United States., Rathod PK; Departments of Chemistry and Global Health , University of Washington , 36 Bagley Hall, 400 15th Avenue NE , Seattle , Washington 98195 , United States., Fidock DA; Department of Microbiology & Immunology , Columbia University Irving Medical Center , 701 West 168th Street, HHSC 1502 , New York , New York 10032 , United States.; Division of Infectious Diseases, Department of Medicine , Columbia University Irving Medical Center , PH8-W, 630 West 168th Street, PH 8-West , New York , New York 10032 , United States., Phillips MA; Department of Biochemistry , University of Texas Southwestern Medical Center , 5323 Harry Hines Blvd , Dallas , Texas 75390 , United States.

المصدر: ACS infectious diseases [ACS Infect Dis] 2019 Jan 11; Vol. 5 (1), pp. 90-101. Date of Electronic Publication: 2018 Nov 13.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: ACS Publications Country of Publication: United States NLM ID: 101654580 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2373-8227 (Electronic) Linking ISSN: 23738227 NLM ISO Abbreviation: ACS Infect Dis Subsets: MEDLINE

مواضيع طبية MeSH: Point Mutation*, Antimalarials/*pharmacology , Drug Resistance/*genetics , Oxidoreductases Acting on CH-CH Group Donors/*genetics , Plasmodium falciparum/*drug effects , Plasmodium falciparum/*genetics , Pyrimidines/*pharmacology , Triazoles/*pharmacology, Amino Acid Sequence ; Animals ; Binding Sites ; CRISPR-Cas Systems ; Crystallography, X-Ray ; Dihydroorotate Dehydrogenase ; Gene Editing ; Humans ; Malaria, Falciparum ; Oxidoreductases Acting on CH-CH Group Donors/antagonists & inhibitors ; Plasmodium falciparum/enzymology

المؤلفون: Phillips MA, White KL; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University , Parkville, VIC 3052, Australia., Kokkonda S; Departments of Chemistry and Global Health, University of Washington , Seattle, Washington 98195, United States., Deng X, White J; Departments of Chemistry and Global Health, University of Washington , Seattle, Washington 98195, United States., El Mazouni F, Marsh K; AbbVie Inc. , 1 North Waukegan Road, North Chicago, Illinois 60064-6104, United States., Tomchick DR, Manjalanagara K; Syngene International Ltd. , 560 099 Bangalore, India., Rudra KR; Syngene International Ltd. , 560 099 Bangalore, India., Wirjanata G; Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University , P.O. Box 41096, Casuarina, NT 0811, Australia., Noviyanti R; Eijkman Institute for Molecular Biology , Jl. Diponegoro 69, 10430 Jakarta, Indonesia., Price RN; Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University , P.O. Box 41096, Casuarina, NT 0811, Australia.; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford , Oxford OX3 7LJ, U.K., Marfurt J; Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University , P.O. Box 41096, Casuarina, NT 0811, Australia., Shackleford DM; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University , Parkville, VIC 3052, Australia., Chiu FC; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University , Parkville, VIC 3052, Australia., Campbell M; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University , Parkville, VIC 3052, Australia., Jimenez-Diaz MB; GlaxoSmithKline , Tres Cantos Medicines Development Campus, Severo Ochoa, Madrid 28760, Spain., Bazaga SF; GlaxoSmithKline , Tres Cantos Medicines Development Campus, Severo Ochoa, Madrid 28760, Spain., Angulo-Barturen I; GlaxoSmithKline , Tres Cantos Medicines Development Campus, Severo Ochoa, Madrid 28760, Spain., Martinez MS; GlaxoSmithKline , Tres Cantos Medicines Development Campus, Severo Ochoa, Madrid 28760, Spain., Lafuente-Monasterio M; GlaxoSmithKline , Tres Cantos Medicines Development Campus, Severo Ochoa, Madrid 28760, Spain., Kaminsky W; Departments of Chemistry and Global Health, University of Washington , Seattle, Washington 98195, United States., Silue K; Centre Suisse de Recherches Scientifiques en Côte d'Ivoire , Km17, Route de Dabou, Adiopodoumé, BP 1303 Abidjan, Ivory Coast., Zeeman AM; Biomedical Primate Research Centre , 2288 GJ Rijswijk, The Netherlands., Kocken C; Biomedical Primate Research Centre , 2288 GJ Rijswijk, The Netherlands., Leroy D; Medicines for Malaria Venture , 1215 Geneva, Switzerland., Blasco B; Medicines for Malaria Venture , 1215 Geneva, Switzerland., Rossignol E; Medicines for Malaria Venture , 1215 Geneva, Switzerland., Rueckle T; Medicines for Malaria Venture , 1215 Geneva, Switzerland., Matthews D; Medicines for Malaria Venture , 1215 Geneva, Switzerland., Burrows JN; Medicines for Malaria Venture , 1215 Geneva, Switzerland., Waterson D; Medicines for Malaria Venture , 1215 Geneva, Switzerland., Palmer MJ; Medicines for Malaria Venture , 1215 Geneva, Switzerland., Rathod PK; Departments of Chemistry and Global Health, University of Washington , Seattle, Washington 98195, United States., Charman SA; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University , Parkville, VIC 3052, Australia.

المصدر: ACS infectious diseases [ACS Infect Dis] 2016 Dec 09; Vol. 2 (12), pp. 945-957. Date of Electronic Publication: 2016 Oct 04.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: ACS Publications Country of Publication: United States NLM ID: 101654580 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2373-8227 (Electronic) Linking ISSN: 23738227 NLM ISO Abbreviation: ACS Infect Dis Subsets: MEDLINE

مواضيع طبية MeSH: Enzyme Inhibitors/*administration & dosage , Malaria, Falciparum/*prevention & control , Oxidoreductases Acting on CH-CH Group Donors/*antagonists & inhibitors , Plasmodium falciparum/*drug effects , Plasmodium falciparum/*enzymology , Protozoan Proteins/*antagonists & inhibitors , Pyrimidines/*pharmacology, Animals ; Antimalarials/chemistry ; Antimalarials/pharmacokinetics ; Dihydroorotate Dehydrogenase ; Dogs ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/pharmacokinetics ; Humans ; Malaria, Falciparum/drug therapy ; Malaria, Falciparum/parasitology ; Mice ; Oxidoreductases Acting on CH-CH Group Donors/genetics ; Oxidoreductases Acting on CH-CH Group Donors/metabolism ; Plasmodium falciparum/genetics ; Protozoan Proteins/genetics ; Protozoan Proteins/metabolism ; Pyrimidines/chemistry ; Rats ; Structure-Activity Relationship