المؤلفون: Kaya P; Cancer Cell Biology and Drug Discovery Group, Department of Life Sciences and Medicine, University of Luxembourg, 4365 Esch-sur-Alzette, Luxembourg., Schaffner-Reckinger E; Cancer Cell Biology and Drug Discovery Group, Department of Life Sciences and Medicine, University of Luxembourg, 4365 Esch-sur-Alzette, Luxembourg., Manoharan GB; Cancer Cell Biology and Drug Discovery Group, Department of Life Sciences and Medicine, University of Luxembourg, 4365 Esch-sur-Alzette, Luxembourg., Vukic V; Faculty of Technology, University of Novi Sad, 21000 Novi Sad, Serbia., Kiriazis A; Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520 Turku, Finland., Ledda M; Luxembourg Center for Systems Biomedicine, University of Luxembourg, 4365 Esch-sur-Alzette, Luxembourg., Burgos Renedo M; Cancer Cell Biology and Drug Discovery Group, Department of Life Sciences and Medicine, University of Luxembourg, 4365 Esch-sur-Alzette, Luxembourg., Pavic K; Cancer Cell Biology and Drug Discovery Group, Department of Life Sciences and Medicine, University of Luxembourg, 4365 Esch-sur-Alzette, Luxembourg., Gaigneaux A; Bioinformatics Core, Department of Life Sciences and Medicine, University of Luxembourg, 4365 Esch-sur-Alzette, Luxembourg., Glaab E; Luxembourg Center for Systems Biomedicine, University of Luxembourg, 4365 Esch-sur-Alzette, Luxembourg., Abankwa DK; Cancer Cell Biology and Drug Discovery Group, Department of Life Sciences and Medicine, University of Luxembourg, 4365 Esch-sur-Alzette, Luxembourg.; Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520 Turku, Finland.

المصدر: Journal of medicinal chemistry [J Med Chem] 2024 Jun 13; Vol. 67 (11), pp. 8569-8584. Date of Electronic Publication: 2024 May 17.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Cyclic Nucleotide Phosphodiesterases, Type 6*/antagonists & inhibitors , Cyclic Nucleotide Phosphodiesterases, Type 6*/metabolism , Sildenafil Citrate*/pharmacology , Proto-Oncogene Proteins p21(ras)*/genetics , Proto-Oncogene Proteins p21(ras)*/antagonists & inhibitors , Proto-Oncogene Proteins p21(ras)*/metabolism , Cell Proliferation*/drug effects, Humans ; Cell Line, Tumor ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/chemical synthesis ; Mutation ; Animals ; Structure-Activity Relationship ; Phosphodiesterase Inhibitors/pharmacology ; Phosphodiesterase Inhibitors/chemistry ; Phosphodiesterase Inhibitors/chemical synthesis

المؤلفون: Zhao ZJ; Key Laboratory of Tropical Biological Resources of Ministry of Education and Hainan Engineering Research Center for Drug Screening and Evaluation, School of Pharmaceutical Sciences, Hainan University, Haikou, Hainan 570228, China.; State Key Laboratory of Anti-Infective Drug Discovery and Development, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, P. R. China., Jiang MY; State Key Laboratory of Anti-Infective Drug Discovery and Development, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, P. R. China., Huang MX; Key Laboratory of Tropical Biological Resources of Ministry of Education and Hainan Engineering Research Center for Drug Screening and Evaluation, School of Pharmaceutical Sciences, Hainan University, Haikou, Hainan 570228, China.; State Key Laboratory of Anti-Infective Drug Discovery and Development, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, P. R. China., Yang YY; State Key Laboratory of Anti-Infective Drug Discovery and Development, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, P. R. China., Feng LL; State Key Laboratory of Anti-Infective Drug Discovery and Development, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, P. R. China., Zhang C; School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, Zhongshan 528458, China., Huang YY; Key Laboratory of Tropical Biological Resources of Ministry of Education and Hainan Engineering Research Center for Drug Screening and Evaluation, School of Pharmaceutical Sciences, Hainan University, Haikou, Hainan 570228, China., Luo HB; Key Laboratory of Tropical Biological Resources of Ministry of Education and Hainan Engineering Research Center for Drug Screening and Evaluation, School of Pharmaceutical Sciences, Hainan University, Haikou, Hainan 570228, China.; Song Li' Academician Workstation of Hainan University (School of Pharmaceutical Sciences), Yazhou Bay, Sanya 572000, China., Wu Y; State Key Laboratory of Anti-Infective Drug Discovery and Development, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, P. R. China.

المصدر: Journal of medicinal chemistry [J Med Chem] 2024 May 23; Vol. 67 (10), pp. 8309-8322. Date of Electronic Publication: 2024 Apr 26.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Cyclic Nucleotide Phosphodiesterases, Type 1*/antagonists & inhibitors , Cyclic Nucleotide Phosphodiesterases, Type 1*/metabolism , Drug Design* , Liver Cirrhosis*/drug therapy , Liver Cirrhosis*/pathology , Pyrimidines*/chemical synthesis , Pyrimidines*/pharmacology , Pyrimidines*/chemistry , Pyrimidines*/therapeutic use , Phosphodiesterase Inhibitors*/pharmacology , Phosphodiesterase Inhibitors*/chemical synthesis , Phosphodiesterase Inhibitors*/therapeutic use , Phosphodiesterase Inhibitors*/chemistry, Animals ; Humans ; Rats ; Male ; Structure-Activity Relationship ; Rats, Sprague-Dawley ; Molecular Docking Simulation ; Molecular Structure

المؤلفون: Pérez O; Chemical Processes and Pharmaceutical Development Research Institutes of Sweden, Forskargatan 20 J, 15136 Södertälje, Sweden.; Faculty of Pharmaceutical Sciences, University of Iceland, Hofsvallagata 53, 107 Reykjavik, Iceland., Stanzani A; Department of Life Sciences, University of Modena and Reggio Emilia, via Campi 287, 41125 Modena, Italy., Huang L; Department of Life Sciences, University of Modena and Reggio Emilia, via Campi 287, 41125 Modena, Italy., Schipper N; Chemical Processes and Pharmaceutical Development Research Institutes of Sweden, Forskargatan 20 J, 15136 Södertälje, Sweden., Loftsson T; Faculty of Pharmaceutical Sciences, University of Iceland, Hofsvallagata 53, 107 Reykjavik, Iceland., Bollmark M; Chemical Processes and Pharmaceutical Development Research Institutes of Sweden, Forskargatan 20 J, 15136 Södertälje, Sweden., Marigo V; Department of Life Sciences, University of Modena and Reggio Emilia, via Campi 287, 41125 Modena, Italy.

المصدر: Journal of medicinal chemistry [J Med Chem] 2024 May 23; Vol. 67 (10), pp. 8396-8405. Date of Electronic Publication: 2024 Apr 30.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Cyclic GMP*/metabolism , Neuroprotective Agents*/pharmacology , Neuroprotective Agents*/chemical synthesis , Neuroprotective Agents*/chemistry , Neuroprotective Agents*/therapeutic use , Retinal Rod Photoreceptor Cells*/drug effects , Retinal Rod Photoreceptor Cells*/pathology , Retinal Rod Photoreceptor Cells*/metabolism, Cyclic Nucleotide Phosphodiesterases, Type 6/antagonists & inhibitors ; Cyclic Nucleotide Phosphodiesterases, Type 6/metabolism ; Guanosine Monophosphate/chemistry ; Guanosine Monophosphate/metabolism ; Retinal Degeneration/drug therapy ; Retinitis Pigmentosa/drug therapy ; Retinitis Pigmentosa/metabolism ; Structure-Activity Relationship

المؤلفون: Rowley AM; GSK, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., Yao G; GSK, Encoded Library Technologies, NCE Molecular Discovery, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States., Andrews L; 23andMe Inc, Therapeutics, 349 Oyster Point Boulevard, South San Francisco, California 94080, United States., Bedermann A; GSK, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., Biddulph R; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, Hertfordshire, U.K., Bingham R; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, Hertfordshire, U.K., Brady JJ; 23andMe Inc, Therapeutics, 349 Oyster Point Boulevard, South San Francisco, California 94080, United States., Buxton R; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, Hertfordshire, U.K., Cecconie T; GSK, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., Cooper R; GSK, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., Csakai A; GSK, Encoded Library Technologies, NCE Molecular Discovery, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States., Gao EN; GSK, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., Grenier-Davies MC; GSK, Encoded Library Technologies, NCE Molecular Discovery, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States., Lawler M; GSK, Encoded Library Technologies, NCE Molecular Discovery, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States., Lian Y; GSK, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., Macina J; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, Hertfordshire, U.K., Macphee C; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, Hertfordshire, U.K., Marcaurelle L; GSK, Encoded Library Technologies, NCE Molecular Discovery, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States., Martin J; GSK, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., McCormick P; GSK, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., Pindoria R; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, Hertfordshire, U.K., Rauch M; GSK, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., Rocque W; GSK, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., Shen Y; GSK, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., Shewchuk LM; GSK, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., Squire M; GSK, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., Stebbeds W; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, Hertfordshire, U.K., Tear W; GSK, Encoded Library Technologies, NCE Molecular Discovery, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States., Wang X; 23andMe Inc, Therapeutics, 349 Oyster Point Boulevard, South San Francisco, California 94080, United States., Ward P; GSK, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., Xiao S; 23andMe Inc, Therapeutics, 349 Oyster Point Boulevard, South San Francisco, California 94080, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2024 Feb 08; Vol. 67 (3), pp. 2049-2065. Date of Electronic Publication: 2024 Jan 29.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Heart* , DNA*, Humans ; Catalytic Domain ; Cyclic Nucleotide Phosphodiesterases, Type 3

المؤلفون: Jiang M; Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892-1003, United States., Lu S; Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892-1003, United States., Telu S; Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892-1003, United States., Pike VW; Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892-1003, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2023 Jan 26; Vol. 66 (2), pp. 1543-1561. Date of Electronic Publication: 2023 Jan 06.

نوع المنشور: Journal Article; Research Support, N.I.H., Intramural

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Phosphodiesterase Inhibitors*/metabolism , Cyclic Nucleotide Phosphodiesterases, Type 4*/metabolism, Humans ; Quantitative Structure-Activity Relationship ; Positron-Emission Tomography/methods ; Brain/metabolism ; Structure-Activity Relationship ; Ligands ; Radiopharmaceuticals/chemistry

المؤلفون: Mahmood SU; Department of Chemistry & Biochemistry, Montclair State University, Montclair, New Jersey 07043, United States.; Sokol Institute of Pharmaceutical Life Sciences, Montclair State University, Montclair, New Jersey 07043, United States., Lozano Gonzalez M; Department of Chemistry & Biochemistry, Montclair State University, Montclair, New Jersey 07043, United States.; Sokol Institute of Pharmaceutical Life Sciences, Montclair State University, Montclair, New Jersey 07043, United States., Tummalapalli S; Department of Chemistry & Biochemistry, Montclair State University, Montclair, New Jersey 07043, United States.; Sokol Institute of Pharmaceutical Life Sciences, Montclair State University, Montclair, New Jersey 07043, United States., Eberhard J; Biology Department, Boston College, Chestnut Hill, Massachusetts 02467, United States., Ly J; Biology Department, Boston College, Chestnut Hill, Massachusetts 02467, United States., Hoffman CS; Biology Department, Boston College, Chestnut Hill, Massachusetts 02467, United States., Kelly MP; Department of Anatomy & Neurobiology, School of Medicine, University of Maryland, Baltimore, Maryland 21201, United States., Gordon J; Moulder Center for Drug Discovery Research, Temple University, Philadelphia, Pennsylvania 19140, United States., Colussi D; Moulder Center for Drug Discovery Research, Temple University, Philadelphia, Pennsylvania 19140, United States., Childers W; Moulder Center for Drug Discovery Research, Temple University, Philadelphia, Pennsylvania 19140, United States., Rotella DP; Department of Chemistry & Biochemistry, Montclair State University, Montclair, New Jersey 07043, United States.; Sokol Institute of Pharmaceutical Life Sciences, Montclair State University, Montclair, New Jersey 07043, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2023 Nov 09; Vol. 66 (21), pp. 14597-14608. Date of Electronic Publication: 2023 Oct 20.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Phosphodiesterase Inhibitors*/pharmacology , Phosphodiesterase Inhibitors*/therapeutic use , Phosphodiesterase Inhibitors*/metabolism , Cognitive Dysfunction*/drug therapy , Cognitive Dysfunction*/metabolism, Humans ; Animals ; Mice ; 3',5'-Cyclic-GMP Phosphodiesterases/metabolism ; Phosphoric Diester Hydrolases/metabolism ; Brain/metabolism ; Mice, Knockout

المؤلفون: Teng M; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, United States., Lu W; Department of Chemical and Systems Biology, ChEM-H, Stanford Cancer Institute, School of Medicine, Stanford University, Stanford, California 94305, United States., Donovan KA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, United States.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, United States., Sun J; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, United States.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, United States., Krupnick NM; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, United States., Nowak RP; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, United States.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, United States., Li YD; Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, United States., Sperling AS; Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, United States., Zhang T; Department of Chemical and Systems Biology, ChEM-H, Stanford Cancer Institute, School of Medicine, Stanford University, Stanford, California 94305, United States., Ebert BL; Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, United States.; Howard Hughes Medical Institute, Boston, Massachusetts 02215, United States., Fischer ES; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, United States.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, United States., Gray NS; Department of Chemical and Systems Biology, ChEM-H, Stanford Cancer Institute, School of Medicine, Stanford University, Stanford, California 94305, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2022 Jan 13; Vol. 65 (1), pp. 747-756. Date of Electronic Publication: 2021 Dec 29.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Casein Kinase Ialpha*/antagonists & inhibitors , Cyclic Nucleotide Phosphodiesterases, Type 6*/antagonists & inhibitors , Phosphodiesterase Inhibitors*/chemical synthesis , Phosphodiesterase Inhibitors*/pharmacology, Humans ; Binding Sites ; Cell Line, Tumor ; Cell Proliferation ; Immunotherapy ; Kinetics

المؤلفون: Landucci E; Department of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Firenze, Firenze 50139, Italy., Ribaudo G; Department of Molecular and Translational Medicine, University of Brescia, Brescia 25123, Italy., Anyanwu M; Department of Molecular and Translational Medicine, University of Brescia, Brescia 25123, Italy., Oselladore E; Department of Molecular and Translational Medicine, University of Brescia, Brescia 25123, Italy., Giannangeli M; Department of Molecular and Translational Medicine, University of Brescia, Brescia 25123, Italy., Mazzantini C; Department of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Firenze, Firenze 50139, Italy., Lana D; Department of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Firenze, Firenze 50139, Italy., Giovannini MG; Department of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Firenze, Firenze 50139, Italy., Memo M; Department of Molecular and Translational Medicine, University of Brescia, Brescia 25123, Italy., Pellegrini-Giampietro DE; Department of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Firenze, Firenze 50139, Italy., Gianoncelli A; Department of Molecular and Translational Medicine, University of Brescia, Brescia 25123, Italy.

المصدر: ACS chemical neuroscience [ACS Chem Neurosci] 2023 Oct 18; Vol. 14 (20), pp. 3826-3838. Date of Electronic Publication: 2023 Sep 19.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101525337 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1948-7193 (Electronic) Linking ISSN: 19487193 NLM ISO Abbreviation: ACS Chem Neurosci Subsets: MEDLINE

مواضيع طبية MeSH: Phosphodiesterase Inhibitors*/pharmacology , Neuroprotective Agents*/pharmacology, 3',5'-Cyclic-AMP Phosphodiesterases ; Kainic Acid ; Ligands ; Phosphoric Diester Hydrolases/metabolism ; Hippocampus/metabolism

المؤلفون: Abdel-Halim M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, Egypt., Sigler S; Departments of Oncologic Sciences and Pharmacology, Mitchell Cancer Institute, University of South Alabama, 1660 Springhill Avenue, Mobile, Alabama 36604, United States., Racheed NAS; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, Egypt., Hefnawy A; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, Egypt., Fathalla RK; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, Egypt.; Pharmaceutical and Medicinal Chemistry, Saarland University, Campus C2.3, D-66123 Saarbrücken, Germany., Hammam MA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, Egypt., Maher A; Biochemistry Department, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), Giza 11266, Egypt., Maxuitenko Y; Departments of Oncologic Sciences and Pharmacology, Mitchell Cancer Institute, University of South Alabama, 1660 Springhill Avenue, Mobile, Alabama 36604, United States., Keeton AB; Departments of Oncologic Sciences and Pharmacology, Mitchell Cancer Institute, University of South Alabama, 1660 Springhill Avenue, Mobile, Alabama 36604, United States., Hartmann RW; Pharmaceutical and Medicinal Chemistry, Saarland University, Campus C2.3, D-66123 Saarbrücken, Germany., Engel M; Pharmaceutical and Medicinal Chemistry, Saarland University, Campus C2.3, D-66123 Saarbrücken, Germany., Piazza GA; Departments of Oncologic Sciences and Pharmacology, Mitchell Cancer Institute, University of South Alabama, 1660 Springhill Avenue, Mobile, Alabama 36604, United States., Abadi AH; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, Egypt.

المصدر: Journal of medicinal chemistry [J Med Chem] 2021 Apr 22; Vol. 64 (8), pp. 4462-4477. Date of Electronic Publication: 2021 Apr 01.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Celecoxib/*chemistry , Cyclic Nucleotide Phosphodiesterases, Type 5/*chemistry , Phosphodiesterase 5 Inhibitors/*chemistry , Pyrazoles/*chemistry, Animals ; Blood Proteins/chemistry ; Blood Proteins/metabolism ; Celecoxib/metabolism ; Cyclic Nucleotide Phosphodiesterases, Type 5/genetics ; Cyclic Nucleotide Phosphodiesterases, Type 5/metabolism ; Drug Design ; Female ; Half-Life ; Humans ; Isoenzymes/antagonists & inhibitors ; Isoenzymes/metabolism ; Mice ; Mice, Inbred C57BL ; Microsomes, Liver/metabolism ; Phosphodiesterase 5 Inhibitors/metabolism ; Protein Binding ; Pyrazoles/metabolism ; Recombinant Proteins/biosynthesis ; Recombinant Proteins/chemistry ; Stereoisomerism ; Structure-Activity Relationship

المؤلفون: Wu Y; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, P. R. China., Wang Q; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, P. R. China., Jiang MY; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, P. R. China., Huang YY; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, P. R. China.; Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Pharmaceutical Sciences, Hainan University, Haikou 570228, Hainan, China., Zhu Z; Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Pharmaceutical Sciences, Hainan University, Haikou 570228, Hainan, China., Han C; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, P. R. China., Tian YJ; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, P. R. China., Zhang B; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, P. R. China., Luo HB; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, P. R. China.; Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Pharmaceutical Sciences, Hainan University, Haikou 570228, Hainan, China.

المصدر: Journal of medicinal chemistry [J Med Chem] 2021 Jul 08; Vol. 64 (13), pp. 9537-9549. Date of Electronic Publication: 2021 Jun 18.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Drug Discovery*, 3',5'-Cyclic-AMP Phosphodiesterases/*antagonists & inhibitors , Fibrosis/*drug therapy , Phosphodiesterase Inhibitors/*pharmacology, 3',5'-Cyclic-AMP Phosphodiesterases/metabolism ; Animals ; Bile Ducts/metabolism ; Bile Ducts/surgery ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Fibrosis/metabolism ; Humans ; Molecular Structure ; Phosphodiesterase Inhibitors/chemical synthesis ; Phosphodiesterase Inhibitors/chemistry ; Rats ; Structure-Activity Relationship