المؤلفون: European Alzheimer’s & Dementia Biobank Mendelian Randomization (EADB-MR), Luo, Jiao, Thomassen, Jesper Qvist, Bellenguez, Celine, Grenier-Boley, Benjamin, Rojas, Itziar de, Castillo, Atahualpa, Parveen, Kayenat, Kucukali, Fahri, Nicolas, Aude, Peters, Oliver, Schneider, Anja, Dichgans, Martin, Rujescu, Dan, Scherbaum, Norbert, Jurgen, Deckert, Riedel-Heller, Steffi, Hausner, Lucrezia, Molina Porcel, Laura, Duzel, Emrah, Grimmer, Timo, Wiltfang, Jens, Heilmann-Heimbach, Stefanie, Moebus, Susanne, Tegos, Thomas, Scarmeas, Nikolaos, Clarimón, Jordi, Moreno, Fermín, Pérez-Tur, Jordi, Bullido, Maria J., Pastor, Pau, Sánchez-Valle, Raquel, Álvarez, Victoria, Boada, Mercè, García-González, Pablo, Puerta, Raquel, Mir, Pablo, Real, Luis M., Pinol-Ripoll, Gerard, García-Alberca, José María, Royo, José Luis, Rodríguez-Rodríguez, Eloy, Soininen, Hilkka, Kuulasmaa, Teemu, Mendonça, Alexandre de, Mehrabian, Shima, Hort, Jakub, Vyhnalek, Martin, van der Lee, Sven, Graff, Caroline, Papenberg, Goran, Giedraitis, Vilmantas, Boland, Anne, Bacq-Daian, Delphine, Deleuze, Jean-Francois, Nicolas, Gael, Dufouil, Carole, Pasquier, Florence, Hanon, Olivier, Debette, Stephanie, Grunblatt, Edna, Popp, Julius, Benussi, Luisa, Galimberti, Daniela, Arosio, Beatrice, Mecocci, Patrizia, Solfrizzi, Vincenzo, Parnetti, Lucilla, Squassina, Alessio, Tremolizzo, Lucio, Borroni, Barbara, Nacmias, Benedetta, Sorbi, Sandro, Caffarra, Paolo, Seripa, Davide, Rainero, Innocenzo, Daniele, Antonio, Masullo, Carlo, Spalletta, Gianfranco, Williams, Julie, Amouyel, Philippe, Jessen, Frank, Kehoe, Patrick, Magda, Tsolaki, Rossi, Giacomina, Sánchez-Juan, Pascual, Sleegers, Kristel, Ingelsson, Martin, Andreassen, Ole A., Hiltunen, Mikko, Van Duijn, Cornelia, Sims, Rebecca, van der Flier, Wiesje, Ruiz, Agustin, Ramírez, Alfredo, Lambert, Jean-Charles, Frikke-Schmidt, Ruth

المساهمون: European Research Council, Instituto de Salud Carlos III, Pérez-Tur, Jordi

المصدر: JAMA network open 6(5), e2313734 (2023). doi:10.1001/jamanetworkopen.2023.13734

مصطلحات موضوعية: Aged, 80 and over, Male, Causality, epidemiology [Alzheimer Disease], Risk Factors, Cholesterol, HDL, Humans, ethyl 4-azidophenyl-1,4-dithiobutyrimidate, Female, genetics [Alzheimer Disease], ddc:610, Aged

URL الوصول: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::a98ee718d67c4f02546d238d218e93af

المؤلفون: Luo, Jiao, Thomassen, Jesper Qvist, Bellenguez, Céline, Grenier-Boley, Benjamin, De Rojas, Itziar, Castillo, Atahualpa, Parveen, Kayenat, Küçükali, Fahri, Nicolas, Aude, Peters, Oliver, Schneider, Anja, Dichgans, Martin, Rujescu, Dan, Scherbaum, Norbert, Jürgen, Deckert, Riedel-Heller, Steffi, Hausner, Lucrezia, Porcel, Laura Molina, Düzel, Emrah, Grimmer, Timo, Wiltfang, Jens, Heilmann-Heimbach, Stefanie, Moebus, Susanne, Tegos, Thomas, Scarmeas, Nikolaos, Clarimon, Jordi, Moreno, Fermin, Pérez-Tur, Jordi, Bullido, María J., Pastor, Pau, Sánchez-Valle, Raquel, Álvarez, Victoria, Boada, Mercè, García-González, Pablo, Puerta, Raquel, Mir, Pablo, Real, Luis M., Piñol-Ripoll, Gerard, García-Alberca, Jose María, Royo, Jose Luís, Rodriguez-Rodriguez, Eloy, Soininen, Hilkka, Kuulasmaa, Teemu, De Mendonça, Alexandre, Mehrabian, Shima, Hort, Jakub, Vyhnalek, Martin, Van Der Lee, Sven, Graff, Caroline, Papenberg, Goran, Giedraitis, Vilmantas, Boland, Anne, Bacq-Daian, Delphine, Deleuze, Jean-François, Nicolas, Gael, Dufouil, Carole, Pasquier, Florence, Hanon, Olivier, Debette, Stéphanie, Grünblatt, Edna, Popp, Julius, Benussi, Luisa, Galimberti, Daniela, Arosio, Beatrice, Mecocci, Patrizia, Solfrizzi, Vincenzo, Parnetti, Lucilla, Squassina, Alessio, Tremolizzo, Lucio, Borroni, Barbara, Nacmias, Benedetta, Sorbi, Sandro, Caffarra, Paolo, Seripa, Davide, Rainero, Innocenzo, Daniele, Antonio, Masullo, Carlo, Spalletta, Gianfranco, Williams, Julie, Amouyel, Philippe, Jessen, Frank, Kehoe, Patrick, Magda, Tsolaki, Rossi, Giacomina, Sánchez-Juan, Pascual, Sleegers, Kristel, Ingelsson, Martin, Andreassen, Ole, Hiltunen, Mikko, Van Duijn, Cornelia, Sims, Rebecca, Van Der Flier, Wiesje, Ruiz, Agustín, Ramirez, Alfredo, Lambert, Jean-Charles, Frikke-Schmidt, Ruth

المصدر: Luo, Jiao Thomassen, Jesper Qvist Bellenguez, Céline Grenier-Boley, Benjamin De Rojas, Itziar Castillo, Atahualpa Parveen, Kayenat Küçükali, Fahri Nicolas, Aude Peters, Oliver Schneider, Anja Dichgans, Martin Rujescu, Dan Scherbaum, Norbert Jürgen, Deckert Riedel-Heller, Steffi Hausner, Lucrezia Porcel, Laura Molina Düzel, Emrah Grimmer, Timo Wiltfang, Jens Heilmann-Heimbach, Stefanie Moebus, Susanne Tegos, Thomas Scarmeas, Nikolaos Clarimon, Jordi Moreno, Fermin Pérez-Tur, Jordi Bullido, María J. Pastor, Pau Sánchez-Valle, Raquel Álvarez, Victoria Boada, Mercè García-González, Pablo Puerta, Raquel Mir, Pablo Real, Luis M. Piñol-Ripoll, Gerard García-Alberca, Jose María Royo, Jose Luís Rodriguez-Rodriguez, Eloy Soininen, Hilkka Kuulasmaa, Teemu De Mendonça, Alexandre Mehrabian, Shima Hort, Jakub Vyhnalek, Martin Van Der Lee, Sven Graff, Caroline Papenberg, Goran Giedraitis, Vilmantas Boland, Anne Bacq-Daian, Delphine Deleuze, Jean-François Nicolas, Gael Dufouil, Carole Pasquier, Florence Hanon, Olivier Debette, Stéphanie Grünblatt, Edna Popp, Julius Benussi, Luisa Galimberti, Daniela Arosio, Beatrice Mecocci, Patrizia Solfrizzi, Vincenzo Parnetti, Lucilla Squassina, Alessio Tremolizzo, Lucio Borroni, Barbara Nacmias, Benedetta Sorbi, Sandro Caffarra, Paolo Seripa, Davide Rainero, Innocenzo Daniele, Antonio Masullo, Carlo Spalletta, Gianfranco Williams, Julie Amouyel, Philippe Jessen, Frank Kehoe, Patrick Magda, Tsolaki Rossi, Giacomina Sánchez-Juan, Pascual Sleegers, Kristel Ingelsson, Martin Andreassen, Ole Hiltunen, Mikko Van Duijn, Cornelia Sims, Rebecca Van Der Flier, Wiesje Ruiz, Agustín Ramirez, Alfredo Lambert, Jean-Charles Frikke-Schmidt, Ruth . Genetic Associations between Modifiable Risk Factors and Alzheimer Disease. JAMA Network Open. 2023, 6(5)
JAMA Network Open

الإتاحة: http://hdl.handle.net/10852/105651

المؤلفون: Karch, Cm, Wen, N, Fan, Cc2, Yokoyama, Js, Kouri, N, Ross, Oa, Höglinger, G, Müller, U, Ferrari, R, Hardy, J, Schellenberg, Gd, Sleiman, Pm, Momeni, P, Hess, Cp, Miller, Bl, Sharma, M, Van Deerlin, V, Smeland, Ob, Andreassen, Oa, Dale, Am, Desikan, Rs, Rainero, Innocenzo, Rubino, Elisa, Pinessi, Lorenzo, Ekaterina Rogaeva, Peter St George-Hyslop, Giacomina, Rossi, Fabrizio Tagliavini, Giorgio, Giaccone

المصدر: JAMA neurology 75(7), 860 (2018). doi:10.1001/jamaneurol.2018.0372
JAMA neurology, vol 75, iss 7

مصطلحات موضوعية: 0301 basic medicine, Aging, ERGIC1 protein, human, genetics [Basal Ganglia Diseases], Vesicular Transport Proteins, Genome-wide association study, genetics [Alzheimer Disease], Disease, Neurodegenerative, 0302 clinical medicine, Superoxide Dismutase-1, Progressive Supranuclear Palsy (PSP) Genetics Consortium, C9orf72, genetics [Parkinson Disease], Corticobasal degeneration, 2.1 Biological and endogenous factors, Supranuclear Palsy, BNIP1 protein, human, Amyotrophic lateral sclerosis, Aetiology, genetics [Proto-Oncogene Proteins c-bcl-2], and International Parkinson’s Disease Genomics Consortium, genetics [Frontotemporal Dementia], genetics [Nerve Tissue Proteins], Genetics, genetics [Supranuclear Palsy, Progressive], SOD1 protein, human, Parkinson Disease, genetics [Superoxide Dismutase-1], genetics [Amyotrophic Lateral Sclerosis], Proto-Oncogene Proteins c-bcl-2, International Collaboration for Frontotemporal Dementia, Frontotemporal Dementia, Neurological, International Frontotemporal Dementia (FTD)–Genomics Consortium, Cognitive Sciences, Supranuclear Palsy, Progressive, Alzheimer's disease, Frontotemporal dementia, Clinical Sciences, MAPT protein, human, Nerve Tissue Proteins, tau Proteins, Article, Progressive supranuclear palsy, 03 medical and health sciences, Rare Diseases, Basal Ganglia Diseases, Progressive, genetics [Vesicular Transport Proteins], Alzheimer Disease, medicine, Acquired Cognitive Impairment, Humans, Genetic Predisposition to Disease, ddc:610, genetics [C9orf72 Protein], Neurology & Neurosurgery, UNC13B protein, human, C9orf72 Protein, business.industry, Amyotrophic Lateral Sclerosis, Neurosciences, genetics [TDP-43 Proteinopathies], Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), medicine.disease, Brain Disorders, genetics [tau Proteins], 030104 developmental biology, TDP-43 Proteinopathies, Dementia, Neurology (clinical), ALS, C9orf72 protein, human, business, 030217 neurology & neurosurgery, Genome-Wide Association Study

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5144cd809c5ecbb53e7f59ac1e490cd
https://pub.dzne.de/record/140070

المؤلفون: Zhengrui Xi, Zinman, Lorne, Grinberg, Yakov, Moreno, Danielle, Christine Sato, Bilbao, Juan M., Ghani, Mahdi, Hernández, Isabel, Ruiz, Agustín, Boada, Mercè, Morón, Francisco J., Lang, Anthony E., Marras, Connie, Bruni, Amalia, Colao, Rosanna, Maletta, Raffaele G., Puccio, Gianfranco, Rainero, Innocenzo, Pinessi, Lorenzo, Galimberti, Daniela

المصدر: Archives of Neurology; Dec2012, Vol. 69 Issue 12, p1583-1590, 8p

المؤلفون: Luo J; Department of Clinical Biochemistry, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark., Thomassen JQ; Department of Clinical Biochemistry, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark., Bellenguez C; Univ. Lille, Inserm, CHU Lille, Institut Pasteur Lille, U1167-RID-AGE-Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France., Grenier-Boley B; Univ. Lille, Inserm, CHU Lille, Institut Pasteur Lille, U1167-RID-AGE-Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France., de Rojas I; Research Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Castillo A; Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Wales, United Kingdom., Parveen K; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Department of Neurodegenerative diseases and Geriatric Psychiatry, University Hospital Bonn, Medical Faculty, Bonn, Germany., Küçükali F; Complex Genetics of Alzheimer's Disease Group, VIB Center for Molecular Neurology, Antwerp, Belgium.; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium., Nicolas A; Univ. Lille, Inserm, CHU Lille, Institut Pasteur Lille, U1167-RID-AGE-Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France., Peters O; German Center for Neurodegenerative Diseases, Berlin, Germany.; Institute of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Psychiatry and Psychotherapy, Berlin, Germany., Schneider A; German Center for Neurodegenerative Diseases, Bonn, Germany.; Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany., Dichgans M; Institute for Stroke and Dementia Research, University Hospital, LMU Munich, Munich, Germany.; German Center for Neurodegenerative Diseases, Munich, Germany.; Munich Cluster for Systems Neurology, Munich, Germany., Rujescu D; Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.; Comprehensive Centre for Clinical Neurosciences and Mental Health, Medical University of Vienna, Vienna, Austria., Scherbaum N; LVR-Hospital Essen, Department of Psychiatry and Psychotherapy, Medical Faculty, University of Duisburg-Essen, Essen, Germany., Jürgen D; Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Würzburg, Germany., Riedel-Heller S; Institute of Social Medicine, Occupational Health and Public Health (ISAP), University of Leipzig, Leipzig, Germany., Hausner L; Department of Geriatric Psychiatry, Central Institute for Mental Health Mannheim, Faculty Mannheim, University of Heidelberg, Heidelberg, Germany., Porcel LM; Neurological Tissue Bank, Biobanc Hospital Clinic, Instituto de Investigaciones Biomédicas August Pi i Sunyer, Barcelona, Spain.; Alzheimer's Disease and Other Cognitive Disorders Unit, Neurology Department, Hospital Clinic, Barcelona, Spain., Düzel E; German Center for Neurodegenerative Diseases, Magdeburg, Germany.; Institute of Cognitive Neurology and Dementia Research, Otto-von-Guericke University, Magdeburg, Germany., Grimmer T; Technical University of Munich, School of Medicine, Klinikum rechts der Isar, Department of Psychiatry and Psychotherapy, Munich, Germany., Wiltfang J; Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, Goettingen, Germany.; German Center for Neurodegenerative Diseases, Goettingen, Germany.; Medical Science Department, Instituto de Biomedicina, Aveiro, Portugal., Heilmann-Heimbach S; Institute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany., Moebus S; Institute for Urban Public Health, University Hospital of University Duisburg-Essen, Essen, Germany., Tegos T; First Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece., Scarmeas N; First Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece.; Taub Institute for Research in Alzheimer's Disease and the Aging Brain, The Gertrude H. Sergievsky Center, Department of Neurology, Columbia University, New York, New York., Clarimon J; Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Department of Neurology, II B Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain., Moreno F; Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Department of Neurology, Hospital Universitario Donostia, San Sebastian, Spain.; Neurosciences Area, Instituto Biodonostia, San Sebastian, Spain., Pérez-Tur J; Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Unitat de Genètica Molecular, Institut de Biomedicina de València, Consejo Superior de Investigaciones Científicas, Valencia, Spain.; Unidad Mixta de Neurologia Genètica, Instituto de Investigación Sanitaria La Fe, Valencia, Spain., Bullido MJ; Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Centro de Biología Molecular Severo Ochoa, UAM-CSIC, Madrid, Spain.; Instituto de Investigacion Sanitaria Hospital la Paz, Madrid, Spain., Pastor P; Unit of Neurodegenerative Diseases, Department of Neurology, University Hospital Germans Trias i Pujol and The Germans Trias i Pujol Research Institute (IGTP) Badalona, Barcelona, Spain., Sánchez-Valle R; Alzheimer's Disease and Other Cognitive Disorders Unit, Service of Neurology, Hospital Clínic of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain., Álvarez V; Laboratorio de Genética, Hospital Universitario Central de Asturias, Oviedo, Spain.; Instituto de Investigación Sanitaria del Principado de Asturias, Asturias, Spain., Boada M; Research Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., García-González P; Research Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain., Puerta R; Research Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain., Mir P; Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío, Consejo Superior de Investigaciones Científicas, Universidad de Sevilla, Seville, Spain., Real LM; Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain.; Depatamento de Especialidades Quirúrgicas, Bioquímica e Inmunología, Facultad de Medicina, Universidad de Málaga, Málaga, Spain., Piñol-Ripoll G; Unitat Trastorns Cognitius, Hospital Universitari Santa Maria de Lleida, Lleida, Spain.; Institut de Recerca Biomedica de Lleida, Lleida, Spain., García-Alberca JM; Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Alzheimer Research Center & Memory Clinic, Instituto Andaluz de Neurociencia, Málaga, Spain., Royo JL; Depatamento de Especialidades Quirúrgicas, Bioquímica e Inmunología, Facultad de Medicina, Universidad de Málaga, Málaga, Spain., Rodriguez-Rodriguez E; Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Neurology Service, Marqués de Valdecilla University Hospital, University of Cantabria and IDIVAL, Santander, Spain., Soininen H; Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland., Kuulasmaa T; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland., de Mendonça A; Faculty of Medicine, University of Lisbon, Portugal., Mehrabian S; Clinic of Neurology, UH 'Alexandrovska,' Medical University-Sofia, Sofia, Bulgaria., Hort J; Memory Clinic, Department of Neurology, Charles University, Second Faculty of Medicine and Motol University Hospital, Prague, Czech Republic.; International Clinical Research Center, St Anne's University Hospital Brno, Brno, Czech Republic., Vyhnalek M; Memory Clinic, Department of Neurology, Charles University, Second Faculty of Medicine and Motol University Hospital, Prague, Czech Republic.; International Clinical Research Center, St Anne's University Hospital Brno, Brno, Czech Republic., van der Lee S; Genomics of Neurodegenerative Diseases and Aging, Human Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC, locatie VUmc, Amsterdam, the Netherlands.; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC, locatie VUmc, Amsterdam, the Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, the Netherlands., Graff C; Unit for Hereditary Dementias, Theme Aging, Karolinska University Hospital-Solna, Stockholm, Sweden., Papenberg G; Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden., Giedraitis V; Department of Public Health and Caring Sciences/ and Geriatrics, Uppsala University, Uppsala, Sweden., Boland A; Université Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine, Evry, France., Bacq-Daian D; Université Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine, Evry, France., Deleuze JF; Université Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine, Evry, France., Nicolas G; Normandie Univ, Université de Rouen Normandie, Inserm U1245 and CHU Rouen, Department of Genetics and Centre national de référence pour les malades Alzheimer jeunes, Rouen, France., Dufouil C; Inserm, Bordeaux Population Health Research Center, UMR 1219, University of Bordeaux, ISPED, CIC 1401-EC, Bordeaux, France.; CHU de Bordeaux, Pole santé publique, Bordeaux, France., Pasquier F; University of Lille, Inserm, CHU Lille, UMR1172, Resources and Research Memory Center of Distalz, Licend, Lille, France., Hanon O; Université de Paris, EA 4468, Assistance Publique - Hôpitaux de Paris, Hôpital Broca, Paris, France., Debette S; University Bordeaux, Inserm, Bordeaux Population Health Research Center, France.; Department of Neurology, Bordeaux University Hospital, Bordeaux, France., Grünblatt E; Department of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich, University of Zurich, Zurich, Switzerland.; Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland.; Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland., Popp J; Old Age Psychiatry, Department of Psychiatry, Lausanne University Hospital, Lausanne, Switzerland.; Department of Geriatric Psychiatry, University Hospital of Psychiatry Zürich, Zürich, Switzerland.; Department of Psychiatry, Psychotherapy and Psychosomatics, University of Zürich, Zurich, Switzerland., Benussi L; Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy., Galimberti D; Neurodegenerative Diseases Unit, Fondazione IRCCS Ca' Granda, Ospedale Policlinico, Milan, Italy.; Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy., Arosio B; Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.; Geriatric Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Mecocci P; Institute of Gerontology and Geriatrics, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.; Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden., Solfrizzi V; Interdisciplinary Department of Medicine, Geriatric Medicine and Memory Unit, University of Bari Aldo Moro, Bari, Italy., Parnetti L; Centre for Memory Disturbances, Lab of Clinical Neurochemistry, Section of Neurology, University of Perugia, Perugia, Italy., Squassina A; Department of Biomedical Sciences, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, Cagliari, Italy., Tremolizzo L; Neurology Unit, Hospital San Gerardo, Monza and University of Milano-Bicocca, Milan, Italy., Borroni B; Centre for Neurodegenerative Disorders, Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy., Nacmias B; Department of Neuroscience, Psychology, Drug Research and Child Health University of Florence, Florence, Italy.; IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy., Sorbi S; Department of Neuroscience, Psychology, Drug Research and Child Health University of Florence, Florence, Italy.; IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy., Caffarra P; Unit of Neurology, University of Parma, Parma, Italy., Seripa D; Laboratory for Advanced Hematological Diagnostics, Department of Hematology and Stem Cell Transplant, Vito Fazzi Hospital, Lecce, Italy., Rainero I; Department of Neuroscience Rita Levi Montalcini, University of Torino, Torino, Italy., Daniele A; Department of Neuroscience, Università Cattolica del Sacro Cuore, Rome, Italy.; Neurology Unit, IRCCS Fondazione Policlinico Universitario A. Gemelli, Rome, Italy., Masullo C; Institute of Neurology, Università Cattolica del Sacro Cuore, Rome, Italy., Spalletta G; Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy.; Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas., Williams J; UK Dementia Research Institute at Cardiff, School of Medicine, Cardiff University, Cardiff, United Kingdom., Amouyel P; Univ. Lille, Inserm, CHU Lille, Institut Pasteur Lille, U1167-RID-AGE-Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France., Jessen F; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; German Center for Neurodegenerative Diseases, Bonn, Germany.; Cluster of Excellence Cellular Stress Responses in Aging-Associated Diseases, University of Cologne, Cologne, Germany., Kehoe P; Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom., Tsolaki M; First Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece., Rossi G; Unit of Neurology V - Neuropathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy., Sánchez-Juan P; Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Alzheimer's Centre Reina Sofia-CIEN Foundation-ISCIII, Madrid, Spain., Sleegers K; Complex Genetics of Alzheimer's Disease Group, VIB Center for Molecular Neurology, Antwerp, Belgium.; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium., Ingelsson M; Université Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine, Evry, France.; Krembil Brain Institute, University Health Network, Toronto, Canada.; Department of Medicine and Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Canada., Andreassen OA; NORMENT Centre, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Hiltunen M; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland., Van Duijn C; Department of Epidemiology, ErasmusMC, Rotterdam, the Netherlands.; Nuffield Department of Population Health, Oxford University, Oxford, United Kingdom., Sims R; Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Wales, United Kingdom., van der Flier W; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC, locatie VUmc, Amsterdam, the Netherlands., Ruiz A; Research Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Ramirez A; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Department of Neurodegenerative diseases and Geriatric Psychiatry, University Hospital Bonn, Medical Faculty, Bonn, Germany.; German Center for Neurodegenerative Diseases, Bonn, Germany.; Cluster of Excellence Cellular Stress Responses in Aging-Associated Diseases, University of Cologne, Cologne, Germany.; Department of Psychiatry and Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, Texas., Lambert JC; Univ. Lille, Inserm, CHU Lille, Institut Pasteur Lille, U1167-RID-AGE-Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France., Frikke-Schmidt R; Department of Clinical Biochemistry, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.

مؤلفون مشاركون: European Alzheimer’s & Dementia Biobank Mendelian Randomization (EADB-MR) Collaboration

المصدر: JAMA network open [JAMA Netw Open] 2023 May 01; Vol. 6 (5), pp. e2313734. Date of Electronic Publication: 2023 May 01.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Medical Association Country of Publication: United States NLM ID: 101729235 Publication Model: Electronic Cited Medium: Internet ISSN: 2574-3805 (Electronic) Linking ISSN: 25743805 NLM ISO Abbreviation: JAMA Netw Open Subsets: MEDLINE

مواضيع طبية MeSH: Alzheimer Disease*/epidemiology , Alzheimer Disease*/genetics, Humans ; Female ; Aged ; Aged, 80 and over ; Male ; Cholesterol, HDL ; Risk Factors ; Causality

المؤلفون: Le Guen Y; Department of Neurology and Neurological Sciences, Stanford University, Palo Alto, California.; Institut du Cerveau, Paris Brain Institute, Paris, France., Belloy ME; Department of Neurology and Neurological Sciences, Stanford University, Palo Alto, California., Grenier-Boley B; University of Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France., de Rojas I; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain., Castillo-Morales A; UKDRI@Cardiff, School of Medicine, Cardiff University, Cardiff, United Kingdom., Jansen I; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije University, Amsterdam, the Netherlands., Nicolas A; University of Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France., Bellenguez C; University of Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France., Dalmasso C; Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Estudios en Neurociencias y Sistemas Complejos (ENyS) CONICET-HEC-UNAJ, Universidad Nacional Arturo Jauretche, Florencio Varela, Argentina., Küçükali F; Complex Genetics of Alzheimer's Disease Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.; Laboratory of Neurogenetics, Born-Bunge Institute, Antwerp, Belgium.; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium., Eger SJ; Department of Neurology and Neurological Sciences, Stanford University, Palo Alto, California., Rasmussen KL; Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Thomassen JQ; Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Deleuze JF; Université Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine, Evry, France., He Z; Department of Neurology and Neurological Sciences, Stanford University, Palo Alto, California.; Quantitative Sciences Unit, Department of Medicine, Stanford University, Palo Alto, California., Napolioni V; School of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Italy., Amouyel P; University of Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France., Jessen F; Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Cluster of Excellence Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany., Kehoe PG; Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom., van Duijn C; Department of Epidemiology, ErasmusMC, Rotterdam, the Netherlands.; Nuffield Department of Population Health Oxford University, Oxford, United Kingdom., Tsolaki M; 1st Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece., Sánchez-Juan P; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Alzheimer's Centre Reina Sofia-CIEN Foundation, Madrid, Spain., Sleegers K; Complex Genetics of Alzheimer's Disease Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.; Laboratory of Neurogenetics, Born-Bunge Institute, Antwerp, Belgium.; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium., Ingelsson M; Department of Public Health and Caring Sciences / Geriatrics, Uppsala University, Uppsala, Sweden.; Krembil Brain Institute, University Health Network, Toronto, Ontario, Canada.; Department of Medicine and Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada., Rossi G; Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy., Hiltunen M; Institute of Biomedicine, University of Eastern Finland, Joensuu, Kuopio, Finland., Sims R; Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff, United Kingdom., van der Flier WM; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands., Ramirez A; Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Cluster of Excellence Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.; Department of Psychiatry and Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, UT Health San Antonio, The University of Texas Health Science Center at San Antonio., Andreassen OA; NORMENT Centre, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Frikke-Schmidt R; Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Williams J; UKDRI@Cardiff, School of Medicine, Cardiff University, Cardiff, United Kingdom.; Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff, United Kingdom., Ruiz A; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain., Lambert JC; University of Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France., Greicius MD; Department of Neurology and Neurological Sciences, Stanford University, Palo Alto, California., Arosio B; Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy., Benussi L; Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy., Boland A; Université Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine, Evry, France., Borroni B; Centre for Neurodegenerative Disorders, Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy., Caffarra P; Unit of Neurology, University of Parma, Parma, Italy., Daian D; Université Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine, Evry, France., Daniele A; Department of Neuroscience, Università Cattolica del Sacro Cuore, Rome, Italy.; Neurology Unit, IRCCS Fondazione Policlinico Universitario A. Gemelli, Rome, Italy., Debette S; University Bordeaux, Inserm, Bordeaux Population Health Research Center, Bordeaux, France.; Department of Neurology, Bordeaux University Hospital, Bordeaux, France., Dufouil C; Inserm, Bordeaux Population Health Research Center, UMR 1219, University of Bordeaux, ISPED, CIC 1401-EC, Université de Bordeaux, Bordeaux, France.; CHU de Bordeaux, Pole santé publique, Bordeaux, France., Düzel E; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.; Institute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University, Magdeburg, Germany., Galimberti D; Neurodegenerative Diseases Unit, Fondazione IRCCS Ca' Granda, Ospedale Policlinico, Milan, Italy.; Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy., Giedraitis V; Department of Public Health and Caring Sciences / Geriatrics, Uppsala University, Uppsala, Sweden., Grimmer T; Technical University of Munich, School of Medicine, Klinikum rechts der Isar, Department of Psychiatry and Psychotherapy, Munich, Germany., Graff C; Unit for Hereditary Dementias, Theme Aging, Karolinska University Hospital-Solna, Stockholm, Sweden., Grünblatt E; Department of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich, University of Zurich, Zurich, Switzerland.; Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland.; Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland., Hanon O; Université de Paris, EA 4468, APHP, Hôpital Broca, Paris, France., Hausner L; Department of Geriatric Psychiatry, Central Institute of Mental Health Mannheim, Faculty Mannheim, University of Heidelberg, Heidelberg, Germany., Heilmann-Heimbach S; Institute of Human Genetics, University of Bonn, School of Medicine, University Hospital Bonn, Bonn, Germany., Holstege H; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.; Department of Clinical Genetics, VU University Medical Centre, Amsterdam, the Netherlands., Hort J; Memory Clinic, Department of Neurology, Charles University, 2nd Faculty of Medicine and Motol University Hospital, Prague, Czech Republic.; International Clinical Research Center, St Anne's University Hospital Brno, Brno, Czech Republic., Jürgen D; Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Würzburg, Germany., Kuulasmaa T; Institute of Biomedicine, University of Eastern Finland, Joensuu, Kuopio, Finland., van der Lugt A; Department of Radiology and Nuclear Medicine, ErasmusMC, Rotterdam, the Netherlands., Masullo C; Institute of Neurology, Catholic University of the Sacred Heart, Rome, Italy., Mecocci P; Institute of Gerontology and Geriatrics, Department of Medicine and Surgery, University of Perugia, Perugia, Italy., Mehrabian S; Clinic of Neurology, UH Alexandrovska, Medical University Sofia, Sofia, Bulgaria., de Mendonça A; Faculty of Medicine, University of Lisbon, Lisbon, Portugal., Moebus S; Institute for Urban Public Health, University Hospital of University Duisburg-Essen, Essen, Germany., Nacmias B; Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.; IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy., Nicolas G; Normandie Université, UNIROUEN, Inserm U1245 and CHU Rouen, Department of Genetics and CNR-MAJ, Rouen, France., Olaso R; Université Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine, Evry, France., Papenberg G; Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden., Parnetti L; Centre for Memory Disturbances, Lab of Clinical Neurochemistry, Section of Neurology, University of Perugia, Perugia, Italy., Pasquier F; Université de Lille, Inserm 1172, CHU Clinical and Research Memory Research Centre (CMRR) of Distalz, Lille, France., Peters O; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Charité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Psychiatry and Psychotherapy, Berlin, Germany., Pijnenburg YAL; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands., Popp J; Old Age Psychiatry, Department of Psychiatry, Lausanne University Hospital, Lausanne, Switzerland.; Department of Geriatric Psychiatry, University Hospital of Psychiatry Zürich, Zurich, Switzerland.; Institute for Regenerative Medicine, University of Zürich, Zurich, Switzerland., Rainero I; Department of Neuroscience 'Rita Levi Montalcini,' University of Torino, Torino, Italy., Ramakers I; Maastricht University, Department of Psychiatry and Neuropsychologie, Alzheimer Center Limburg, Maastricht, the Netherlands., Riedel-Heller S; Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Leipzig, Germany., Scarmeas N; 1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece.; Taub Institute for Research in Alzheimer's Disease and the Aging Brain, The Gertrude H. Sergievsky Center, Department of Neurology, Columbia University, New York, New York., Scheltens P; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands., Scherbaum N; LVR-Hospital Essen, Department of Psychiatry and Psychotherapy, Medical Faculty, University of Duisburg-Essen, Essen, Germany., Schneider A; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany., Seripa D; Laboratory for Advanced Hematological Diagnostics, Department of Hematology and Stem Cell Transplant, 'Vito Fazzi' Hospital, Lecce, Italy., Soininen H; Institute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, Finland., Solfrizzi V; Interdisciplinary Department of Medicine, Geriatric Medicine and Memory Unit, University of Bari Aldo Moro, Bari, Italy., Spalletta G; Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy.; Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas., Squassina A; Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy., van Swieten J; Department of Neurology, ErasmusMC, Rotterdam, the Netherlands., Tegos TJ; 1st Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece., Tremolizzo L; Neurology, 'San Gerardo' Hospital, Monza and University of Milano-Bicocca, Milan, Italy., Verhey F; Maastricht University, Department of Psychiatry and Neuropsychologie, Alzheimer Center Limburg, Maastricht, the Netherlands., Vyhnalek M; Memory Clinic, Department of Neurology, Charles University, 2nd Faculty of Medicine and Motol University Hospital, Prague, Czech Republic.; International Clinical Research Center, St Anne's University Hospital Brno, Brno, Czech Republic., Wiltfang J; Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, Goettingen, Germany.; German Center for Neurodegenerative Diseases (DZNE), Goettingen, Germany.; Neurosciences and Signaling Group, Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Aveiro, Portugal., Boada M; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain., García-González P; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain., Puerta R; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain., Real LM; Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain.; Depatamento de Especialidades Quirúrgicas, Bioquímica e Inmunología, Facultad de Medicina, Universidad de Málaga, Málaga, Spain., Álvarez V; Laboratorio de Genética, Hospital Universitario Central de Asturias, Oviedo, Spain.; Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain., Bullido MJ; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Centro de Biología Molecular Severo Ochoa (UAM-CSIC), Universidad Autónoma de Madrid, Madrid, Spain.; Instituto de Investigacion Sanitaria 'Hospital la Paz' (IdIPaz), Madrid, Spain., Clarimon J; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Department of Neurology, II B Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain., García-Alberca JM; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Alzheimer Research Center & Memory Clinic, Andalusian Institute for Neuroscience, Málaga, Spain., Mir P; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain., Moreno F; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Department of Neurology, Hospital Universitario Donostia, San Sebastian, Spain.; Neurosciences Area, Instituto Biodonostia, San Sebastian, Spain., Pastor P; Fundació Docència i Recerca MútuaTerrassa, Terrassa, Spain.; Memory Disorders Unit, Department of Neurology, Hospital Universitari Mutua de Terrassa, Terrassa, Spain., Piñol-Ripoll G; Unitat Trastorns Cognitius, Hospital Universitari Santa Maria de Lleida, Lleida, Spain.; Institut de Recerca Biomedica de Lleida (IRBLLeida), Lleida, Spain., Molina-Porcel L; Neurological Tissue Bank (Biobanc), Hospital Clinic IDIBAPS, Barcelona, Spain.; Alzheimer's Disease and Other Cognitive Disorders Unit, Neurology Department, Hospital Clinic, Barcelona, Spain., Pérez-Tur J; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Unitat de Genètica Molecular, Institut de Biomedicina de València-CSIC, Valencia, Spain.; Unidad Mixta de Neurologia Genètica, Instituto de Investigación Sanitaria La Fe, Valencia, Spain., Rodríguez-Rodríguez E; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Neurology Service, Marqués de Valdecilla University Hospital (University of Cantabria and IDIVAL), Santander, Spain., Royo JL; Depatamento de Especialidades Quirúrgicas, Bioquímica e Inmunología, Facultad de Medicina, Universidad de Málaga, Málaga, Spain., Sánchez-Valle R; Alzheimer's Disease and Other Cognitive Disorders Unit, Service of Neurology, Hospital Clínic of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain., Dichgans M; Institute for Stroke and Dementia Research (ISD), University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Rujescu D; Medical University of Vienna, Department of Psychiatry and Psychotherapy, Vienna, Austria.

مؤلفون مشاركون: Members of the EADB, GR@ACE, DEGESCO, DemGene, GERAD, and EADI Groups

المصدر: JAMA neurology [JAMA Neurol] 2022 Jul 01; Vol. 79 (7), pp. 652-663.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: American Medical Association Country of Publication: United States NLM ID: 101589536 Publication Model: Print Cited Medium: Internet ISSN: 2168-6157 (Electronic) Linking ISSN: 21686149 NLM ISO Abbreviation: JAMA Neurol Subsets: MEDLINE

مواضيع طبية MeSH: Alzheimer Disease*/epidemiology , Alzheimer Disease*/genetics, Age of Onset ; Alleles ; Apolipoprotein E2/genetics ; Apolipoprotein E4/genetics ; Apolipoproteins E/genetics ; Female ; Genotype ; Humans ; Male