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المؤلفون: Andrea L. Frump, François Potus, Diana M. Tabima, Bakhtiyor Yakubov, Steeve Provencher, Junichi Omura, Kurt R. Stenmark, Valérie Nadeau, Kathy J. Krentz, Marjorie Albrecht, Todd G. Cook, Rongbo Li, Eve Tremblay, R. Dale Brown, Sébastien Bonnet, Tim Lahm, Amanda Fisher, Brooke H Rodriguez, Xin Sun, Sandra Breuils-Bonnet, Naomi C. Chesler, C. Dustin Rubinstein
المصدر: The Journal of clinical investigation, vol 131, iss 6
J Clin Investمصطلحات موضوعية: Male, 0301 basic medicine, Pulmonology, Molecular biology, Estrogen receptor, Cardiovascular, Medical and Health Sciences, Mice, 0302 clinical medicine, Models, Ventricular Function, Sex hormones, Myocytes, Cardiac, Lung, Mice, Knockout, Estradiol, Models, Cardiovascular, Pulmonary, General Medicine, Apelin, Mutant Strains, Right, 030220 oncology & carcinogenesis, Hypertension, Female, Cardiac, Research Article, Agonist, medicine.medical_specialty, Cardiotonic Agents, medicine.drug_class, Knockout, Hypertension, Pulmonary, Immunology, Heart failure, Bone Morphogenetic Protein Receptors, Type II, Type II, Rats, Mutant Strains, 03 medical and health sciences, Rare Diseases, Downregulation and upregulation, Vascular Biology, In vivo, Internal medicine, medicine, Animals, Humans, Myocytes, Animal, business.industry, Estrogen Receptor alpha, Endothelial Cells, Bone Morphogenetic Protein Receptors, medicine.disease, Estrogen, Pulmonary hypertension, Rats, BMPR2, Disease Models, Animal, 030104 developmental biology, Endocrinology, Disease Models, Ventricular Function, Right, business
وصف الملف: application/pdf
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المؤلفون: Shuyun Wang, Alan L Wineman, Li Shen, Dingding Xiong, Anne Eichmann, Lianghui Gong, Stephen J. Weiss, Catherine Z. Liu, Xiaoxiao Liu, Sylvia M. Evans, Ming-Sing Si, Baolei Li, Mena Shenouda, John A. Shaw, Yifeng Yang
المصدر: JCI Insight
مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, Cardiac fibrosis, Hypertension, Pulmonary, 03 medical and health sciences, 0302 clinical medicine, Afterload, Fibrosis, Internal medicine, medicine, Animals, Heart Failure, Mice, Knockout, Pressure overload, Ventricular Remodeling, business.industry, Myocardium, Membrane Proteins, Heart, General Medicine, medicine.disease, Pulmonary hypertension, 030104 developmental biology, Endocrinology, Echocardiography, 030220 oncology & carcinogenesis, Heart failure, Ventricular pressure, Myocardial fibrosis, Collagen, business, Research Article
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a49bbfb4eeaefefe5beabd69105ec44
https://doi.org/10.1172/jci.insight.136852 -
3
المؤلفون: Deping Kong, Colin D. Funk, Ying Yu, Caojian Zuo, Yunchao Su, Ankang Lu, Michael Lazarus, Richard M. Breyer, Bing Xiao, Juan Tang, Sheng-Zhong Duan, Di Chen, Fei Yuan, Sara Alberti, Yujun Shen, Lingjuan Piao, Yuhu He, Bin Zhou, Xiaochun Fei, Guilin Chen, Yu Yu, Shenkai Zuo, Qianqian Zhang, Shuai Yan, Jian Zhang
المصدر: Journal of Clinical Investigation. 125:1228-1242
مصطلحات موضوعية: Male, rho GTP-Binding Proteins, medicine.medical_specialty, Hypertension, Pulmonary, Prostacyclin, Pulmonary Artery, Vascular Remodeling, Biology, Matrix metalloproteinase, Rats, Sprague-Dawley, Transforming Growth Factor beta1, Downregulation and upregulation, Internal medicine, medicine.artery, medicine, Animals, Receptor, Cells, Cultured, Mice, Knockout, Extracellular Matrix Proteins, Sulfonamides, General Medicine, Hypoxia (medical), medicine.disease, Pulmonary hypertension, Cell Hypoxia, Extracellular Matrix, Mice, Inbred C57BL, Endocrinology, Receptors, Prostaglandin E, EP3 Subtype, Pulmonary artery, lipids (amino acids, peptides, and proteins), medicine.symptom, Signal transduction, rhoA GTP-Binding Protein, Signal Transduction, Research Article, medicine.drug
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المؤلفون: Sruti Shiva, Quyen Nguyen, Mark T. Gladwin, Pamela White, Catherine Corey, Marc A. Simon, Annie M. Watson
المصدر: JCI insight, vol 2, iss 5
مصطلحات موضوعية: Blood Platelets, Male, 0301 basic medicine, medicine.medical_specialty, Bioenergetics, Hypertension, Pulmonary, Oxidative phosphorylation, 030204 cardiovascular system & hematology, Cardiovascular, Oxidative Phosphorylation, 03 medical and health sciences, Oxygen Consumption, 0302 clinical medicine, Clinical Research, Internal medicine, medicine.artery, medicine, Humans, 2.1 Biological and endogenous factors, Platelet, Carnitine, Aetiology, Respiratory system, Lung, Chemistry, Pulmonary, General Medicine, Middle Aged, medicine.disease, Pulmonary hypertension, Mitochondria, 030104 developmental biology, medicine.anatomical_structure, Endocrinology, Hypertension, Pulmonary artery, Vascular resistance, Cardiology, Female, Energy Metabolism, Glycolysis, Research Article, medicine.drug
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8f2ddeb79e26dbe4db02bd0027e4128
https://doi.org/10.1172/jci.insight.91415 -
5
المؤلفون: Rubin M. Tuder, Kevin K.W. Wang, Haroldo A. Toque, Weihong Han, Peter A. Greer, Yunchao Su, Wanli Ma, R. William Caldwell
المصدر: Journal of Clinical Investigation. 121:4548-4566
مصطلحات موضوعية: Male, medicine.medical_specialty, Intracrine, Hypertension, Pulmonary, Becaplermin, Smad Proteins, Cysteine Proteinase Inhibitors, Biology, Collagen Type I, Rats, Sprague-Dawley, Transforming Growth Factor beta1, Gene Knockout Techniques, Mice, Right ventricular hypertrophy, medicine.artery, Internal medicine, medicine, Animals, Humans, Familial Primary Pulmonary Hypertension, Pulmonary pathology, RNA, Small Interfering, Lung, Cell Proliferation, Mice, Knockout, Platelet-Derived Growth Factor, Epidermal Growth Factor, Calpain, Dipeptides, Proto-Oncogene Proteins c-sis, General Medicine, Hypoxia (medical), medicine.disease, Pulmonary hypertension, Rats, Mice, Inbred C57BL, Arterioles, Disease Models, Animal, Endocrinology, medicine.anatomical_structure, Pulmonary artery, biology.protein, medicine.symptom, Research Article
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المؤلفون: Yassine Sassi, Yannis Hara, Marc Humbert, Anne-Marie Lompré, Saadia Eddahibi, Peter Dorfmüller, Jean-Sébastien Hulot, Christelle Guibert, Natacha Gambaryan
المساهمون: Institute of pharmacology and toxicology, Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM), Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] (CRCTB), Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux]-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Pathology, University Hospital of Giessen and Marburg (UKGM), Giessen, Germany., Hypertension arterielle pulmonaire physiopathologie et innovation thérapeutique, Centre chirurgical Marie Lannelongue-Institut National de la Santé et de la Recherche Médicale (INSERM), Physiopathologie, génétique et pharmacologie du remodelage cardiovasculaire, Université Pierre et Marie Curie - Paris 6 (UPMC)-IFR14-Institut National de la Santé et de la Recherche Médicale (INSERM), Inserm, UMR_S 999 – LabEx LERMIT, Centre Chirurgical Marie-Lannelongue, Le Plessis-Robinson 5Université Paris-Sud, Faculté de Médecine, Le Kremlin-Bicêtre, France, Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition (ICAN), Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre Chirurgical Marie Lannelongue (CCML)-Institut National de la Santé et de la Recherche Médicale (INSERM), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)
المصدر: Journal of Clinical Investigation
Journal of Clinical Investigation, American Society for Clinical Investigation, 2011, 121 (7), pp.2888-2897. ⟨10.1172/JCI45023⟩
Journal of Clinical Investigation, 2011, 121 (7), pp.2888-2897. ⟨10.1172/JCI45023⟩مصطلحات موضوعية: Elevated pulmonary artery pressure, [SDV]Life Sciences [q-bio], Vasodilation, 030204 cardiovascular system & hematology, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, Muscle, Smooth, Vascular, Mice, 0302 clinical medicine, Cyclic AMP, Medicine, Familial Primary Pulmonary Hypertension, Enzyme Inhibitors, Hypoxia, Cyclic GMP, Lung, ComputingMilieux_MISCELLANEOUS, Cells, Cultured, Mice, Knockout, 0303 health sciences, biology, General Medicine, 3. Good health, Quinolines, RNA Interference, Multidrug Resistance-Associated Proteins, medicine.symptom, Intracellular, Research Article, medicine.medical_specialty, Hypertension, Pulmonary, ABCC4, Pulmonary Artery, 03 medical and health sciences, Internal medicine, Cyclic GMP-Dependent Protein Kinases, Animals, Humans, Pulmonary pathology, 030304 developmental biology, business.industry, Hypoxia (medical), medicine.disease, Cyclic AMP-Dependent Protein Kinases, Pulmonary hypertension, Endocrinology, Vasoconstriction, biology.protein, Leukotriene Antagonists, Propionates, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
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المؤلفون: Kaori Ihida-Stansbury, Min Min Lu, Ethan D. Cohen, Peter L. Jones, Edward E. Morrisey, Reynold A. Panettieri
المصدر: Journal of Clinical Investigation. 119:2538-2549
مصطلحات موضوعية: medicine.medical_specialty, Receptor, Platelet-Derived Growth Factor alpha, Vascular smooth muscle, Beta-catenin, Hypertension, Pulmonary, Mesenchyme, Myocytes, Smooth Muscle, Mice, Transgenic, Biology, Models, Biological, Receptor, Platelet-Derived Growth Factor beta, Mice, Paracrine signalling, Pregnancy, Proto-Oncogene Proteins, Internal medicine, medicine, Animals, Humans, Lung, Embryonic Stem Cells, beta Catenin, Cell Proliferation, Mice, Knockout, Mice, Inbred BALB C, Tenascin C, Wnt signaling pathway, Tenascin, General Medicine, respiratory system, musculoskeletal system, Asthma, Mice, Mutant Strains, respiratory tract diseases, Cell biology, Mice, Inbred C57BL, Wnt Proteins, medicine.anatomical_structure, Endocrinology, biology.protein, Female, Signal transduction, Signal Transduction, Research Article
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8
المؤلفون: Leopold Stiebellehner, Georg-Christian Funk, Karin Vonbank, Bernhard Burian, Rolf Ziesche, Gerhard Hamilton, Lutz-Henning Block, Ventzislav Petkov, Markus Raderer, Wilhelm Mosgoeller, Clemens Novotny
المصدر: Journal of Clinical Investigation. 111:1339-1346
مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Receptors, Vasoactive Intestinal Polypeptide, Type I, Hypertension, Pulmonary, Myocytes, Smooth Muscle, Vasoactive intestinal peptide, Neuropeptide, Hemodynamics, Gastroenterology, Article, Muscle, Smooth, Vascular, Radioligand Assay, Western blot, Internal medicine, medicine.artery, medicine, Humans, Receptor, Exercise, Lung, Cells, Cultured, medicine.diagnostic_test, business.industry, General Medicine, Middle Aged, medicine.disease, Immunohistochemistry, Pulmonary hypertension, medicine.anatomical_structure, Endocrinology, Pulmonary artery, Receptors, Vasoactive Intestinal Peptide, Receptors, Vasoactive Intestinal Peptide, Type II, Female, business, Cell Division, Vasoactive Intestinal Peptide
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المؤلفون: David Shepherd, Rubin M. Tuder, Jay Y. Westcott, Norbert F. Voelkel, Mark D. Moore, Mark W. Geraci, Karen A. Fagan, Lori Alger, Bifeng Gao
المصدر: Journal of Clinical Investigation. 103:1509-1515
مصطلحات موضوعية: Male, medicine.medical_specialty, Pathology, DNA, Complementary, Hypertension, Pulmonary, Molecular Sequence Data, Gene Expression, Prostaglandin, Mice, Transgenic, Prostacyclin, Polycythemia, Pulmonary Artery, Biology, Article, Epithelium, Prostacyclin synthase, Pathogenesis, Mice, chemistry.chemical_compound, Cytochrome P-450 Enzyme System, Internal medicine, medicine.artery, medicine, Animals, Humans, Hypoxia, Lung, Base Sequence, General Medicine, Hypoxia (medical), medicine.disease, Pulmonary hypertension, Rats, Intramolecular Oxidoreductases, medicine.anatomical_structure, Endocrinology, chemistry, Pulmonary artery, biology.protein, Female, medicine.symptom, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83223e465a5be1267e2c4820b05d9e22
https://doi.org/10.1172/jci5911 -
10
المؤلفون: David M. Rodman, Lisa K. Hepler, Kenneth G. Morris, Karen A. Fagan, Robert C. Tyler, Ivan F. McMurtry, Koichi Sato, Paul L. Huang, Steven H. Abman, Howard D. Weinberger, Brian Fouty, Timothy D. LeCras
المصدر: Journal of Clinical Investigation. 103:291-299
مصطلحات موضوعية: Heterozygote, Pulmonary Circulation, medicine.medical_specialty, Hypertension, Pulmonary, Nitric Oxide, Article, Nitric oxide, Mice, chemistry.chemical_compound, Enos, Internal medicine, Hypoxic pulmonary vasoconstriction, Administration, Inhalation, Ventricular Pressure, medicine, Animals, RNA, Messenger, Hypoxia, Lung, Mice, Knockout, Dose-Response Relationship, Drug, Hypertrophy, Right Ventricular, biology, business.industry, Homozygote, General Medicine, Hypoxia (medical), medicine.disease, biology.organism_classification, Pulmonary hypertension, Nitric oxide synthase, Endocrinology, medicine.anatomical_structure, Hematocrit, chemistry, Vasoconstriction, Anesthesia, biology.protein, Blood Gas Analysis, Nitric Oxide Synthase, medicine.symptom, business
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::048631a5cb5168e44ee76f3dc378d075
https://doi.org/10.1172/jci3862
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