المؤلفون: Andreas Lindqvist, Olof Asplund, Emma Ahlqvist, Esa Laurila, Nils Wierup, Tiinamaija Tuomi, Peter Almgren, Jens J. Holst, Emily Sonestedt, Marju Orho-Melander, Ulrika Krus, Leif Groop, Peter M. Nilsson, Liisa Hakaste, Emilia Ottosson-Laakso, Rashmi B. Prasad, Olle Melander

المساهمون: Endokrinologian yksikkö, Department of Medicine, Clinicum, University of Helsinki, Institute for Molecular Medicine Finland, HUS Abdominal Center

المصدر: Almgren, P, Lindqvist, A, Krus, U, Hakaste, L, Ottosson-Laakso, E, Asplund, O, Sonestedt, E, Prasad, R B, Laurila, E, Orho-Melander, M, Melander, O, Tuomi, T, Holst, J J, Nilsson, P M, Wierup, N, Groop, L & Ahlqvist, E 2017, ' Genetic determinants of circulating GIP and GLP-1 concentrations ', JCI insight, vol. 2, no. 21, e93306 . https://doi.org/10.1172/jci.insight.93306

مصطلحات موضوعية: Male, 0301 basic medicine, medicine.medical_treatment, LOCI, Enteroendocrine cell, 0302 clinical medicine, Glucagon-Like Peptide 1, Insulin-Secreting Cells, Insulin, Glucose homeostasis, Prospective Studies, Aged, 80 and over, INSULIN-RESISTANCE, GLUCAGON-LIKE PEPTIDE-1, MOLECULAR-MECHANISMS, digestive, oral, and skin physiology, General Medicine, Middle Aged, CHOLESTEROL ABSORPTION, Glucagon-like peptide-1, 3. Good health, medicine.anatomical_structure, Glucagon-Like Peptide-2 Receptor, GLUCOSE-ABSORPTION, Female, hormones, hormone substitutes, and hormone antagonists, Research Article, endocrine system, medicine.medical_specialty, Dipeptidyl Peptidase 4, Enteroendocrine Cells, Incretin, 030209 endocrinology & metabolism, Gastric Inhibitory Polypeptide, Biology, Incretins, Glucagon, ABO Blood-Group System, Receptors, Gastrointestinal Hormone, Gastrointestinal Hormones, Islets of Langerhans, 03 medical and health sciences, Sodium-Glucose Transporter 1, Insulin resistance, Internal medicine, Journal Article, medicine, Humans, RNA, Messenger, GENOME-WIDE ASSOCIATION, Aged, Homeodomain Proteins, Pancreatic islets, Genetic Variation, Glucose Tolerance Test, medicine.disease, Gastrointestinal Tract, BODY-MASS INDEX, Glucose, 030104 developmental biology, Endocrinology, Diabetes Mellitus, Type 2, 3111 Biomedicine, MALMO DIET, FASTING GLUCOSE

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e9730492c0d028350d4ca7aab1fcb81
https://doi.org/10.1172/jci.insight.93306

المؤلفون: Charlotte Ling, Pernille Poulsen, Emma Carlsson, Martin Ridderstråle, Peter Almgren, Jørgen Wojtaszewski, Henning Beck-Nielsen, Leif Groop, Allan Vaag

المصدر: Journal of Clinical Investigation. 114:1518-1526

مصطلحات موضوعية: Adult, Blood Glucose, Polymorphism, Genetic, Age Factors, Gene Expression, Genetic Variation, General Medicine, Middle Aged, Models, Biological, Oxidative Phosphorylation, Body Mass Index, Fats, Diabetes Mellitus, Type 2, Commentary, Humans, Insulin, Body Weights and Measures, RNA, Messenger, Muscle, Skeletal, Oxidation-Reduction, Transcription Factors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3c80a3c6642db1f4ae14a460ecbc1a3
https://doi.org/10.1172/jci21889

المؤلفون: Kimmo Kontula, Päivi Pajukanta, Elina Suviolahti, Pekka Jousilahti, Jaakko Kaprio, Erkki Vartiainen, Leif Groop, Aila Rissanen, Veikko Salomaa, Rita M. Cantor, Miina Öhman, Leena Peltonen, Kaisa Silander, L Oksanen, Riika Kilpikari, Pertti Mustajoki, Martin Ridderstråle, Tiinamaija Tuomi

المصدر: University of Helsinki

مصطلحات موضوعية: Adult, Genetic Markers, Male, Linkage disequilibrium, Candidate gene, Genotype, Single-nucleotide polymorphism, Biology, Polymorphism, Single Nucleotide, Linkage Disequilibrium, Humans, SNP, Obesity, Allele, Allele frequency, Gene, Alleles, Aged, Genetics, Sex Characteristics, Haplotype, Membrane Transport Proteins, General Medicine, Middle Aged, Haplotypes, Commentary, Female

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3504d640739133e90c36e1e9bd79bfff
https://doi.org/10.1172/jci200317491

المؤلفون: R. Gitzelmann, Leif Groop, Albert Aynsley-Green, Frank Q. Nuttall, Nils U. Bosshard, Marju Orho, Peter Blümel, Neil R. M. Buist, Mary C. Gannon

المصدر: Journal of Clinical Investigation. 102:507-515

مصطلحات موضوعية: Male, medicine.medical_specialty, DNA, Complementary, Genetic Linkage, RNA Splicing, Blotting, Western, DNA Mutational Analysis, Hypoglycemia, Biology, Eating, chemistry.chemical_compound, Internal medicine, medicine, Animals, Humans, Point Mutation, Glycogen storage disease type 0, Glycogen storage disease, Missense mutation, Glycogen synthase, Polymorphism, Single-Stranded Conformational, Chromosomes, Human, Pair 12, Glycogen, Point mutation, Exons, General Medicine, Glycogen Storage Disease, medicine.disease, Ketotic hypoglycemia, Molecular biology, Introns, Pedigree, Glycogen Synthase, Phenotype, Endocrinology, Liver, chemistry, Child, Preschool, COS Cells, Mutagenesis, Site-Directed, biology.protein, Female, Polymorphism, Restriction Fragment Length, Research Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::922f3e9fe0456e1af8a2d2ef282d5302
https://doi.org/10.1172/jci2890

المؤلفون: Laura J. Scott, Natascia Sestu, Serena Sanna, Karen L. Mohlke, Gitte Andersen, Nicholas J. Timpson, Richard M. Watanabe, Marco Orrù, Braxton D. Mitchell, Manuela Uda, Valeriya Lyssenko, Torben Jørgensen, Wei-Min Chen, Heather M. Stringham, Amy J. Swift, Thomas A. Buchanan, Nazario Olla, Jouko Saramies, Samer S. Najjar, Jaakko Tuomilehto, Haiqing Shen, Alan R. Shuldiner, David Schlessinger, Anne U. Jackson, Richard N. Bergman, Oluf Pedersen, Torben Hansen, William L. Duren, Michael Boehnke, Antonio Cao, George Davey Smith, Maria Cristina Spada, Edward G. Lakatta, Knut Borch-Johnsen, Leif Groop, Johanna Kuusisto, David Altshuler, Francis S. Collins, Cristen J. Willer, Kristi D. Silver, Markku Laakso, Yoav Ben-Shlomo, Michael R. Erdos, Angelo Scuteri, Timo T. Valle, Maria Grazia Piras, Gonçalo R. Abecasis, Lori L. Bonnycastle, Debbie A Lawlor, Richa Saxena, Shah Ebrahim

المصدر: Journal of Clinical Investigation.

مصطلحات موضوعية: Adult, Blood Glucose, medicine.medical_specialty, Genotype, G6PC2, 030209 endocrinology & metabolism, Single-nucleotide polymorphism, Polymorphism, Single Nucleotide, Linkage Disequilibrium, White People, 03 medical and health sciences, 0302 clinical medicine, Gene Frequency, Diabetes mellitus, Internal medicine, medicine, Humans, SNP, ABCB11, Allele, Allele frequency, ATP Binding Cassette Transporter, Subfamily B, Member 11, Finland, Aged, 030304 developmental biology, Analysis of Variance, 0303 health sciences, biology, Fasting, General Medicine, Middle Aged, medicine.disease, Endocrinology, Italy, Glucose-6-Phosphatase, biology.protein, ATP-Binding Cassette Transporters, Glucose 6-phosphatase, Research Article, Follow-Up Studies

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13a3530f484823105df72b5f415e0238
https://doi.org/10.1172/jci34566

المؤلفون: Stina Simonsson, Amanda G. Mabey, Peter M. Nilsson, Allan Vaag, Tina Rönn, Pernille Poulsen, Per Hagert, Peter Almgren, Emma Nilsson, Leif Groop, Charlotte Ling, Johan Holmkvist

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Respiratory chain, Twins, Biology, Epigenesis, Genetic, Electron Transport, Insulin resistance, Internal medicine, Gene expression, Genotype, medicine, Humans, Insulin, Genetic Predisposition to Disease, NADH, NADPH Oxidoreductases, Epigenetics, Muscle, Skeletal, Promoter Regions, Genetic, Aged, Electron Transport Complex I, Polymorphism, Genetic, Age Factors, Skeletal muscle, General Medicine, Middle Aged, medicine.disease, medicine.anatomical_structure, Endocrinology, Diabetes Mellitus, Type 2, DNA methylation, Glucose Clamp Technique, Female, Epigenetics of diabetes Type 2, Research Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::240ed64448b2c1f66d3545e14b4181e2
https://europepmc.org/articles/PMC2030455/

المؤلفون: ÅsaLinda Lethagen, Peter Almgren, Göran Berglund, Karl-Fredrik Eriksson, Silvia Del Guerra, Leif Groop, Valeriya Lyssenko, Rita Mancarella, Tiinamaija Tuomi, Stefano Del Prato, Piero Marchetti, Peter M. Nilsson, Charlotte Ling, Marketa Sjögren, Roberto Lupi, Marju Orho-Melander

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, endocrine system, endocrine system diseases, medicine.medical_treatment, Single-nucleotide polymorphism, Type 2 diabetes, Biology, Polymorphism, Single Nucleotide, Islets of Langerhans, Risk Factors, Diabetes mellitus, Internal medicine, Genotype, Insulin Secretion, medicine, SNP, Humans, Insulin, Genetic Predisposition to Disease, Prospective Studies, Allele, Alleles, Aged, nutritional and metabolic diseases, General Medicine, Middle Aged, medicine.disease, Europe, Endocrinology, Glucose, Diabetes Mellitus, Type 2, Liver, Female, TCF Transcription Factors, TCF7L2, Transcription Factor 7-Like 2 Protein, Research Article, Follow-Up Studies

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::340096c32ae23a828369f58313381a3c
https://europepmc.org/articles/PMC1934596/

المؤلفون: Riccardo C. Bonadonna, Eleuterio Ferrannini, Stefano DelPrato, Kathy Zyck, Leif Groop, Ralph A. DeFronzo, Klaus Ratheiser

المصدر: Journal of Clinical Investigation. 84:205-213

مصطلحات موضوعية: Blood Glucose, Male, medicine.medical_specialty, Basal rate, medicine.medical_treatment, 030209 endocrinology & metabolism, Fatty Acids, Nonesterified, Carbohydrate metabolism, Randle's cycle, 03 medical and health sciences, 0302 clinical medicine, Insulin resistance, Lipid oxidation, Internal medicine, Diabetes mellitus, medicine, Hyperinsulinemia, Humans, Insulin, "insulin resistance, adipose tissue, free fatty acids, type 2 diabetes mellitus", 030304 developmental biology, 2. Zero hunger, 0303 health sciences, C-Peptide, Chemistry, General Medicine, Middle Aged, Lipid Metabolism, medicine.disease, Glucose, Endocrinology, Diabetes Mellitus, Type 2, Liver, Basal (medicine), Female, lipids (amino acids, peptides, and proteins), Insulin Resistance, Oxidation-Reduction, hormones, hormone substitutes, and hormone antagonists, Research Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3071323e91617e77881ffc696961640
https://doi.org/10.1172/jci114142