المؤلفون: Reyes NA; Department of Pathology, University of California, San Francisco, San Francisco, California 94143-0511, USA., Fisher JK, Austgen K, VandenBerg S, Huang EJ, Oakes SA

المصدر: The Journal of clinical investigation [J Clin Invest] 2010 Oct; Vol. 120 (10), pp. 3673-9. Date of Electronic Publication: 2010 Sep 20.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE

مواضيع طبية MeSH: Apoptosis*, Amyotrophic Lateral Sclerosis/*physiopathology , Mitochondria/*physiology , Motor Neurons/*physiology , bcl-2 Homologous Antagonist-Killer Protein/*physiology , bcl-2-Associated X Protein/*physiology, Amyotrophic Lateral Sclerosis/therapy ; Animals ; Disease Models, Animal ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Signal Transduction ; Superoxide Dismutase/physiology ; Superoxide Dismutase-1 ; bcl-2 Homologous Antagonist-Killer Protein/antagonists & inhibitors ; bcl-2-Associated X Protein/antagonists & inhibitors

المؤلفون: Dang CV; Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA. cvdang@jhmi.edu

المصدر: The Journal of clinical investigation [J Clin Invest] 2008 Jan; Vol. 118 (1), pp. 15-7.

نوع المنشور: Journal Article; Comment

بيانات الدورية: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Print Cited Medium: Print ISSN: 0021-9738 (Print) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE

مواضيع طبية MeSH: Antimalarials/*pharmacology , Apoptosis/*drug effects , Ataxia Telangiectasia/*prevention & control , Autophagy/*drug effects , Burkitt Lymphoma/*prevention & control , Cell Transformation, Neoplastic/*metabolism , Chloroquine/*pharmacology , Lysosomes/*metabolism , Tumor Suppressor Protein p53/*metabolism, Animals ; Antimalarials/therapeutic use ; Apoptosis/genetics ; Ataxia Telangiectasia/genetics ; Ataxia Telangiectasia/metabolism ; Ataxia Telangiectasia/pathology ; Ataxia Telangiectasia Mutated Proteins ; Autophagy/genetics ; B-Lymphocytes/metabolism ; B-Lymphocytes/pathology ; Burkitt Lymphoma/genetics ; Burkitt Lymphoma/metabolism ; Burkitt Lymphoma/pathology ; Caspases/genetics ; Caspases/metabolism ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/pathology ; Cells, Cultured ; Chloroquine/therapeutic use ; Cyclin-Dependent Kinase Inhibitor p16/genetics ; Cyclin-Dependent Kinase Inhibitor p16/metabolism ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Embryo, Mammalian/metabolism ; Embryo, Mammalian/pathology ; Female ; Fibroblasts/metabolism ; Fibroblasts/pathology ; Humans ; Lysosomes/pathology ; Male ; Mice ; Mice, Mutant Strains ; Neoplasms, Experimental/genetics ; Neoplasms, Experimental/metabolism ; Neoplasms, Experimental/pathology ; Neoplasms, Experimental/prevention & control ; Protein Serine-Threonine Kinases/genetics ; Protein Serine-Threonine Kinases/metabolism ; Proto-Oncogene Proteins c-myc/genetics ; Proto-Oncogene Proteins c-myc/metabolism ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Proteins/genetics ; Tumor Suppressor Proteins/metabolism ; bcl-2 Homologous Antagonist-Killer Protein/genetics ; bcl-2 Homologous Antagonist-Killer Protein/metabolism ; bcl-2-Associated X Protein/genetics ; bcl-2-Associated X Protein/metabolism

المؤلفون: Maclean KH; Division of Molecular Therapeutics, Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA., Dorsey FC, Cleveland JL, Kastan MB

المصدر: The Journal of clinical investigation [J Clin Invest] 2008 Jan; Vol. 118 (1), pp. 79-88.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Print Cited Medium: Print ISSN: 0021-9738 (Print) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE

مواضيع طبية MeSH: Antirheumatic Agents/*pharmacology , Apoptosis/*drug effects , Ataxia Telangiectasia/*prevention & control , Autophagy/*drug effects , Burkitt Lymphoma/*prevention & control , Cell Transformation, Neoplastic/*metabolism , Chloroquine/*pharmacology , Lysosomes/*metabolism , Tumor Suppressor Protein p53/*metabolism, Animals ; Antirheumatic Agents/therapeutic use ; Apoptosis/genetics ; Ataxia Telangiectasia/genetics ; Ataxia Telangiectasia/metabolism ; Ataxia Telangiectasia/pathology ; Ataxia Telangiectasia Mutated Proteins ; Autophagy/genetics ; B-Lymphocytes/metabolism ; B-Lymphocytes/pathology ; Burkitt Lymphoma/genetics ; Burkitt Lymphoma/metabolism ; Burkitt Lymphoma/pathology ; Caspases/genetics ; Caspases/metabolism ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/pathology ; Cells, Cultured ; Chloroquine/therapeutic use ; Cyclin-Dependent Kinase Inhibitor p16/genetics ; Cyclin-Dependent Kinase Inhibitor p16/metabolism ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Embryo, Mammalian/metabolism ; Embryo, Mammalian/pathology ; Female ; Fibroblasts/metabolism ; Fibroblasts/pathology ; Humans ; Lysosomes/pathology ; Male ; Mice ; Mice, Mutant Strains ; Neoplasms, Experimental/genetics ; Neoplasms, Experimental/metabolism ; Neoplasms, Experimental/pathology ; Neoplasms, Experimental/prevention & control ; Protein Serine-Threonine Kinases/genetics ; Protein Serine-Threonine Kinases/metabolism ; Proto-Oncogene Proteins c-myc/genetics ; Proto-Oncogene Proteins c-myc/metabolism ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Proteins/genetics ; Tumor Suppressor Proteins/metabolism ; bcl-2 Homologous Antagonist-Killer Protein/genetics ; bcl-2 Homologous Antagonist-Killer Protein/metabolism ; bcl-2-Associated X Protein/genetics ; bcl-2-Associated X Protein/metabolism

المؤلفون: Samudio I; Section of Molecular Hematology and Therapy, Department of Stem Cell Transplantation and Cellular Therapy, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA., Harmancey R, Fiegl M, Kantarjian H, Konopleva M, Korchin B, Kaluarachchi K, Bornmann W, Duvvuri S, Taegtmeyer H, Andreeff M

المصدر: The Journal of clinical investigation [J Clin Invest] 2010 Jan; Vol. 120 (1), pp. 142-56. Date of Electronic Publication: 2009 Dec 21.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE

مواضيع طبية MeSH: Apoptosis/*drug effects , Fatty Acids/*metabolism , Leukemia/*drug therapy, Adenosine Triphosphate/biosynthesis ; Animals ; Biphenyl Compounds/therapeutic use ; Cell Proliferation ; Cytarabine/therapeutic use ; Fatty Acid Synthases/physiology ; Humans ; Ion Channels/physiology ; Leukemia/pathology ; Mice ; Mitochondrial Membrane Transport Proteins ; Mitochondrial Permeability Transition Pore ; Mitochondrial Proteins/physiology ; Nitrophenols/therapeutic use ; Oxidation-Reduction ; Piperazines/therapeutic use ; Reactive Oxygen Species ; Sulfonamides/therapeutic use ; Uncoupling Protein 2 ; bcl-2 Homologous Antagonist-Killer Protein/chemistry ; bcl-2-Associated X Protein/chemistry

المؤلفون: Hendrickson AW; Department of Oncology, Mayo Clinic, Rochester, Minnesota, USA., Meng XW, Kaufmann SH

المصدر: The Journal of clinical investigation [J Clin Invest] 2008 Nov; Vol. 118 (11), pp. 3582-4. Date of Electronic Publication: 2008 Oct 23.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Comment

بيانات الدورية: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0021-9738 (Print) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE

مواضيع طبية MeSH: Apoptosis Regulatory Proteins/*antagonists & inhibitors , Melanoma/*genetics , Membrane Proteins/*antagonists & inhibitors , Mitogen-Activated Protein Kinase Kinases/*antagonists & inhibitors , Proto-Oncogene Proteins/*antagonists & inhibitors , Proto-Oncogene Proteins B-raf/*antagonists & inhibitors , Skin Neoplasms/*genetics, Animals ; Apoptosis Regulatory Proteins/genetics ; Bcl-2-Like Protein 11 ; Biphenyl Compounds ; Humans ; Melanoma/pathology ; Membrane Proteins/genetics ; Mice ; Mitogen-Activated Protein Kinase Kinases/genetics ; Models, Biological ; Nitrophenols ; Piperazines ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins B-raf/genetics ; Skin Neoplasms/pathology ; Sulfonamides ; Xenograft Model Antitumor Assays ; bcl-2 Homologous Antagonist-Killer Protein/genetics

المؤلفون: Borys Korchin, Ismael Samudio, Michael Andreeff, Hagop M. Kantarjian, Heinrich Taegtmeyer, Kumar Kaluarachchi, Michael Fiegl, Marina Konopleva, William G. Bornmann, Romain Harmancey, Seshagiri Duvvuri

المصدر: Journal of Clinical Investigation. 120:142-156

مصطلحات موضوعية: Apoptosis, Mitochondrial Membrane Transport Proteins, Ion Channels, Piperazines, Mitochondrial Proteins, Nitrophenols, Mice, chemistry.chemical_compound, Adenosine Triphosphate, medicine, Animals, Humans, Uncoupling Protein 2, Glycolysis, Beta oxidation, Cell Proliferation, bcl-2-Associated X Protein, Sulfonamides, Leukemia, biology, Mitochondrial Permeability Transition Pore, Biphenyl Compounds, Fatty Acids, Cytarabine, Myeloid leukemia, General Medicine, medicine.disease, Fatty acid synthase, bcl-2 Homologous Antagonist-Killer Protein, chemistry, Biochemistry, Cancer cell, biology.protein, Cancer research, Fatty Acid Synthases, Reactive Oxygen Species, Oxidation-Reduction, Etomoxir, Bcl-2 Homologous Antagonist-Killer Protein, Research Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::705e4ef51b3fb739adc02fdbee51e17c
https://doi.org/10.1172/jci38942

المؤلفون: Chi V. Dang

مصطلحات موضوعية: Male, Apoptosis, Cell Cycle Proteins, Ataxia Telangiectasia Mutated Proteins, Protein Serine-Threonine Kinases, medicine.disease_cause, Proto-Oncogene Proteins c-myc, Antimalarials, Ataxia Telangiectasia, Mice, Bcl-2-associated X protein, Chloroquine, medicine, Autophagy, Animals, Humans, Cells, Cultured, Cyclin-Dependent Kinase Inhibitor p16, bcl-2-Associated X Protein, B-Lymphocytes, biology, Tumor Suppressor Proteins, General Medicine, Neoplasms, Experimental, Fibroblasts, medicine.disease, Embryo, Mammalian, Burkitt Lymphoma, Mice, Mutant Strains, Lymphoma, DNA-Binding Proteins, Cell Transformation, Neoplastic, bcl-2 Homologous Antagonist-Killer Protein, Antirheumatic Agents, Caspases, biology.protein, Cancer research, Commentary, Female, Tumor Suppressor Protein p53, Carcinogenesis, Lysosomes, Bcl-2 Homologous Antagonist-Killer Protein, Research Article, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f8e2fcbb71602959339e7e31866d032
https://europepmc.org/articles/PMC2147675/

المؤلفون: Michael B. Kastan, John L. Cleveland, Frank C. Dorsey, Kirsteen H. Maclean

مصطلحات موضوعية: Genetically modified mouse, Programmed cell death, biology, Cancer, General Medicine, medicine.disease, Cell biology, Ataxia Telangiectasia Mutated Proteins, Bcl-2-associated X protein, Apoptosis, Ataxia-telangiectasia, medicine, Cancer research, biology.protein, Corrigendum, Bcl-2 Homologous Antagonist-Killer Protein

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a012fb4b4ce1040d1e65d42bfb4be69
https://europepmc.org/articles/PMC2276782/