المؤلفون: So J; Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA., Sudlow S; Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA., Sayeed A; Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA., Grudda T; Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA., Deborggraeve S; Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium., Ngoyi DM; Department of Parasitology, Institut National de Recherche Biomédicale, Kinshasa, Democratic Republic of the Congo., Desamber DK; Programme Nationale de Lutte contre la Trypanosomiase Humaine Africaine (PNLTHA), Ministry of Health, Kinshasa, Democratic Republic of the Congo., Wickstead B; School of Life Sciences, Queen's Medical Centre, University of Nottinghamgrid.4563.4, Nottingham, United Kingdom., Lejon V; UMR-177 Intertryp, Institut de Recherche pour le Développement, Centre de Coopération Internationale en Recherche Agronomique pour le Développement, University of Montpellier, Montpellier, France., Mugnier MR; Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

المصدر: MBio [mBio] 2022 Dec 20; Vol. 13 (6), pp. e0255322. Date of Electronic Publication: 2022 Nov 10.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101519231 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-7511 (Electronic) NLM ISO Abbreviation: mBio Subsets: MEDLINE

مواضيع طبية MeSH: Trypanosomiasis, African*/parasitology , Trypanosoma brucei brucei*/genetics, Humans ; Animals ; Mice ; Variant Surface Glycoproteins, Trypanosoma/genetics ; Trypanosoma brucei gambiense/genetics ; Membrane Glycoproteins

المؤلفون: Wenzler T; Medical Parasitology & Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland University of Basel, Basel, Switzerland Tanja.Wenzler@unibas.ch., Yang S; Department of Pharmaceutical Chemistry, School of Pharmacy, The University of Kansas, Lawrence, Kansas, USA., Patrick DA; Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA., Braissant O; University of Basel, Basel, Switzerland Department of Urology, University Hospital of Basel, Basel, Switzerland., Ismail MA; Department of Chemistry, Georgia State University, Atlanta, Georgia, USA., Tidwell RR; Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA., Boykin DW; Department of Chemistry, Georgia State University, Atlanta, Georgia, USA., Wang MZ; Department of Pharmaceutical Chemistry, School of Pharmacy, The University of Kansas, Lawrence, Kansas, USA., Brun R; Medical Parasitology & Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland University of Basel, Basel, Switzerland.

المصدر: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2014 Aug; Vol. 58 (8), pp. 4452-63. Date of Electronic Publication: 2014 May 27.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-6596 (Electronic) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE

مواضيع طبية MeSH: Amidines/*pharmacology , Pyridines/*pharmacology , Trypanocidal Agents/*pharmacology , Trypanosoma brucei gambiense/*drug effects , Trypanosoma brucei rhodesiense/*drug effects , Trypanosomiasis, African/*drug therapy, Amidines/chemical synthesis ; Amidines/pharmacokinetics ; Animals ; Dose-Response Relationship, Drug ; Female ; Humans ; Melarsoprol/pharmacokinetics ; Melarsoprol/pharmacology ; Mice ; Pentamidine/pharmacokinetics ; Pentamidine/pharmacology ; Pyridines/chemical synthesis ; Pyridines/pharmacokinetics ; Structure-Activity Relationship ; Trypanocidal Agents/chemical synthesis ; Trypanocidal Agents/pharmacokinetics ; Trypanosoma brucei gambiense/growth & development ; Trypanosoma brucei gambiense/pathogenicity ; Trypanosoma brucei rhodesiense/growth & development ; Trypanosoma brucei rhodesiense/pathogenicity ; Trypanosomiasis, African/parasitology

المؤلفون: Giordani F; Department of Chemistry, Georgia State University, Atlanta, Georgia, USA., Munde M, Wilson WD, Ismail MA, Kumar A, Boykin DW, Barrett MP

المصدر: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2014; Vol. 58 (3), pp. 1793-6. Date of Electronic Publication: 2013 Dec 23.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-6596 (Electronic) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE

مواضيع طبية MeSH: Fluorescent Dyes* , Pentamidine*/analogs & derivatives , Pentamidine*/pharmacology, Microscopy, Fluorescence/*methods , Trypanosoma brucei gambiense/*metabolism , Trypanosomiasis, African/*diagnosis, Humans ; Trypanocidal Agents/pharmacology ; Trypanosoma brucei gambiense/drug effects

المؤلفون: Wenzler T; Medical Parasitology & Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland., Yang S, Braissant O, Boykin DW, Brun R, Wang MZ

المصدر: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2013 Nov; Vol. 57 (11), pp. 5330-43. Date of Electronic Publication: 2013 Aug 19.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-6596 (Electronic) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE

مواضيع طبية MeSH: Amidines/*pharmacology , Trypanocidal Agents/*pharmacology , Trypanosoma brucei gambiense/*drug effects , Trypanosoma brucei rhodesiense/*drug effects , Trypanosomiasis, African/*drug therapy, Amidines/pharmacokinetics ; Animals ; Drug Administration Schedule ; Drug Evaluation, Preclinical ; Female ; Humans ; Injections, Intraperitoneal ; Melarsoprol/pharmacology ; Mice ; Parasitic Sensitivity Tests ; Pentamidine/pharmacology ; Time Factors ; Trypanocidal Agents/pharmacokinetics ; Trypanosoma brucei gambiense/growth & development ; Trypanosoma brucei rhodesiense/growth & development ; Trypanosomiasis, African/parasitology

المؤلفون: Garzón E; UMR 177, IRD-CIRAD, Montpellier, France., Holzmuller P, Bras-Gonçalves R, Vincendeau P, Cuny G, Lemesre JL, Geiger A

المصدر: Infection and immunity [Infect Immun] 2013 Sep; Vol. 81 (9), pp. 3300-8. Date of Electronic Publication: 2013 Jun 24.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0246127 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-5522 (Electronic) Linking ISSN: 00199567 NLM ISO Abbreviation: Infect Immun Subsets: MEDLINE

مواضيع طبية MeSH: Dendritic Cells/*immunology , Interleukin-10/*immunology , Interleukin-6/*immunology , Lipopolysaccharides/*immunology , Trypanosoma brucei gambiense/*immunology , Tumor Necrosis Factor-alpha/*immunology, Animals ; Antigens, CD/immunology ; Female ; Genes, MHC Class II/genetics ; Genes, MHC Class II/immunology ; Interleukin-10/genetics ; Interleukin-6/genetics ; Lymphocytes/immunology ; Male ; Mice ; Mice, Inbred BALB C ; Protein Array Analysis/methods ; Rats, Wistar ; Th1 Cells/immunology ; Th2 Cells/immunology ; Trypanosoma brucei gambiense/genetics ; Trypanosomiasis, African/genetics ; Trypanosomiasis, African/immunology

المؤلفون: Mathis AM; Division of Molecular Pharmaceutics, School of Pharmacy, University of North Carolina, Chapel Hill, Chapel 27599, USA., Holman JL, Sturk LM, Ismail MA, Boykin DW, Tidwell RR, Hall JE

المصدر: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2006 Jun; Vol. 50 (6), pp. 2185-91.

نوع المنشور: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Print Cited Medium: Print ISSN: 0066-4804 (Print) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE

مواضيع طبية MeSH: Benzamidines/*pharmacokinetics , Furans/*pharmacokinetics , Pentamidine/*analogs & derivatives , Pentamidine/*pharmacokinetics , Trypanocidal Agents/*pharmacokinetics , Trypanosoma brucei gambiense/*metabolism, Animals ; Benzamidines/blood ; Benzamidines/pharmacology ; Cell Nucleus/metabolism ; Cytoplasm/metabolism ; Dose-Response Relationship, Drug ; Fluorescence ; Furans/blood ; Furans/pharmacology ; In Vitro Techniques ; Kinetics ; Male ; Mice ; Molecular Structure ; Organelles/metabolism ; Pentamidine/pharmacology ; Tissue Distribution ; Trypanocidal Agents/blood ; Trypanocidal Agents/pharmacology ; Trypanosoma brucei gambiense/cytology ; Trypanosoma brucei gambiense/drug effects

المؤلفون: Njiru ZK; School of Veterinary Sciences, University of Queensland, Gatton, QLD 4343, Australia. z.njiru@uq.edu.au, Traub R, Ouma JO, Enyaru JC, Matovu E

المصدر: Journal of clinical microbiology [J Clin Microbiol] 2011 Apr; Vol. 49 (4), pp. 1530-6. Date of Electronic Publication: 2011 Feb 09.

نوع المنشور: Comparative Study; Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 7505564 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-660X (Electronic) Linking ISSN: 00951137 NLM ISO Abbreviation: J Clin Microbiol Subsets: MEDLINE

مواضيع طبية MeSH: Molecular Diagnostic Techniques/*methods , Nucleic Acid Amplification Techniques/*methods , Parasitology/*methods , Trypanosoma brucei gambiense/*isolation & purification , Trypanosomiasis, African/*diagnosis, Blood/parasitology ; Bone Marrow/parasitology ; Cerebrospinal Fluid/parasitology ; Humans ; Sensitivity and Specificity ; Trypanosoma brucei gambiense/genetics

المؤلفون: Chappuis F; Travel and Migration Medicine Unit, Geneva University Hospital, 24 rue Micheli-du-Crest, 1211 Geneva 14, Switzerland. francois.chappuis@hcuge.ch, Loutan L, Simarro P, Lejon V, Büscher P

المصدر: Clinical microbiology reviews [Clin Microbiol Rev] 2005 Jan; Vol. 18 (1), pp. 133-46.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 8807282 Publication Model: Print Cited Medium: Print ISSN: 0893-8512 (Print) Linking ISSN: 08938512 NLM ISO Abbreviation: Clin Microbiol Rev Subsets: MEDLINE

مواضيع طبية MeSH: Trypanosoma brucei gambiense*/genetics , Trypanosoma brucei gambiense*/immunology , Trypanosoma brucei gambiense*/isolation & purification , Trypanosoma brucei rhodesiense*/genetics , Trypanosoma brucei rhodesiense*/immunology , Trypanosoma brucei rhodesiense*/isolation & purification, Trypanosomiasis, African/*diagnosis, Animals ; Antibodies, Protozoan/blood ; Antigens, Protozoan/blood ; Cerebrospinal Fluid/parasitology ; Humans ; Polymerase Chain Reaction ; Trypanosomiasis, African/parasitology

المؤلفون: Watson JA; Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand jwatowatson@gmail.com nickw@tropmedres.ac.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Strub-Wourgraft N; Drugs for Neglected Diseases initiative (DNDi), Geneva, Switzerland., Tarral A; Drugs for Neglected Diseases initiative (DNDi), Geneva, Switzerland., Ribeiro I; Drugs for Neglected Diseases initiative (DNDi), Geneva, Switzerland., Tarning J; Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., White NJ; Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand jwatowatson@gmail.com nickw@tropmedres.ac.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.

المصدر: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2019 Mar 27; Vol. 63 (4). Date of Electronic Publication: 2019 Mar 27 (Print Publication: 2019).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1098-6596 (Electronic) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE

مواضيع طبية MeSH: Bone Marrow/*drug effects , Liver/*drug effects , Nitroimidazoles/*adverse effects , Nitroimidazoles/*pharmacokinetics , Trypanocidal Agents/*adverse effects , Trypanocidal Agents/*pharmacokinetics, Administration, Oral ; Animals ; Bayes Theorem ; Bone Marrow/metabolism ; Chagas Disease/drug therapy ; Chagas Disease/metabolism ; Clinical Trials as Topic ; Disease Models, Animal ; Double-Blind Method ; Humans ; Liver/metabolism ; Male ; Nitroimidazoles/pharmacology ; Randomized Controlled Trials as Topic ; Sulfones/adverse effects ; Sulfones/pharmacokinetics ; Sulfones/pharmacology ; Treatment Outcome ; Trypanocidal Agents/pharmacology ; Trypanosoma brucei gambiense/drug effects ; Trypanosomiasis, African/drug therapy ; Trypanosomiasis, African/metabolism

المؤلفون: Lejon V; Institute of Tropical Medicine, Department of Parasitology, Nationalestraat 155, B-2000 Antwerp, Belgium. vlejon@itg.be, Robays J, N'Siesi FX, Mumba D, Hoogstoel A, Bisser S, Reiber H, Boelaert M, Büscher P

المصدر: Clinical and vaccine immunology : CVI [Clin Vaccine Immunol] 2007 Jun; Vol. 14 (6), pp. 732-7. Date of Electronic Publication: 2007 Apr 11.

نوع المنشور: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101252125 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1556-6811 (Print) Linking ISSN: 1556679X NLM ISO Abbreviation: Clin Vaccine Immunol Subsets: MEDLINE

مواضيع طبية MeSH: Immunoglobulin M/*biosynthesis , Immunoglobulin M/*cerebrospinal fluid , Interleukin-10/*cerebrospinal fluid , Trypanosoma brucei gambiense/*immunology , Trypanosomiasis, African/*cerebrospinal fluid, Adolescent ; Adult ; Aged ; Animals ; Antibodies, Protozoan/blood ; Biomarkers/blood ; Biomarkers/cerebrospinal fluid ; Central Nervous System Protozoal Infections/immunology ; Central Nervous System Protozoal Infections/parasitology ; Female ; Humans ; Interleukin-10/blood ; Interleukin-10/genetics ; Latex Fixation Tests ; Male ; Middle Aged ; Nephelometry and Turbidimetry ; Recombinant Proteins/blood ; Recombinant Proteins/cerebrospinal fluid ; Recurrence ; Retrospective Studies ; Sensitivity and Specificity ; Suramin/therapeutic use ; Treatment Failure ; Trypanocidal Agents/therapeutic use ; Trypanosoma brucei gambiense/drug effects ; Trypanosomiasis, African/drug therapy ; Trypanosomiasis, African/immunology ; Trypanosomiasis, African/parasitology ; Trypanosomiasis, African/pathology