المؤلفون: Dias MV; Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QA, UK; Laboratório Nacional de Biociências (LNBio), Centro de Nacional de Pesquisa em Energia e Materiais, Campinas, (CNPEM), São Paulo 13083-100, Brazil. Electronic address: bertacine@gmail.com., Tyrakis P; Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QA, UK., Domingues RR; Laboratório Nacional de Biociências (LNBio), Centro de Nacional de Pesquisa em Energia e Materiais, Campinas, (CNPEM), São Paulo 13083-100, Brazil., Paes Leme AF; Laboratório Nacional de Biociências (LNBio), Centro de Nacional de Pesquisa em Energia e Materiais, Campinas, (CNPEM), São Paulo 13083-100, Brazil., Blundell TL; Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QA, UK.

المصدر: Structure (London, England : 1993) [Structure] 2014 Jan 07; Vol. 22 (1), pp. 94-103. Date of Electronic Publication: 2013 Nov 07.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101087697 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-4186 (Electronic) Linking ISSN: 09692126 NLM ISO Abbreviation: Structure Subsets: MEDLINE

مواضيع طبية MeSH: Bacterial Proteins/*chemistry , Enzyme Inhibitors/*chemistry , Folic Acid Antagonists/*chemistry , Mycobacterium tuberculosis/*chemistry , Tetrahydrofolate Dehydrogenase/*chemistry, Bacterial Proteins/antagonists & inhibitors ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Calorimetry ; Crystallography, X-Ray ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Ligands ; Molecular Docking Simulation ; Mutagenesis, Site-Directed ; Mycobacterium tuberculosis/enzymology ; Mycobacterium tuberculosis/genetics ; Proguanil/chemistry ; Protein Conformation ; Pyrimethamine/chemistry ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Structure-Activity Relationship ; Tetrahydrofolate Dehydrogenase/genetics ; Tetrahydrofolate Dehydrogenase/metabolism ; Thermodynamics ; Triazines/chemistry ; Trimethoprim/chemistry

المؤلفون: Martin J. Llewelyn, Derrick W. Crook, A. Sarah Walker, Tim E. A. Peto, Philip W. Fowler, N. Claire Gordon, Kevin Cole, Angela Kearns

مصطلحات موضوعية: 0301 basic medicine, Modern medicine, Staphylococcus aureus, medicine.drug_class, 030106 microbiology, Clinical Biochemistry, Antibiotics, Computational biology, Microbial Sensitivity Tests, medicine.disease_cause, Biochemistry, Genome, Trimethoprim, 03 medical and health sciences, Antibiotic resistance, Bacterial Proteins, Drug Discovery, Dihydrofolate reductase, Drug Resistance, Bacterial, medicine, Molecular Biology, Pharmacology, biology, Anti-Bacterial Agents, Tetrahydrofolate Dehydrogenase, Mutation (genetic algorithm), Mutation, biology.protein, Molecular Medicine, Thermodynamics, medicine.drug

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b8e0ec15326d24e56b2cffb4e7b0da0
https://doi.org/10.1016/j.chembiol.2017.12.009