المؤلفون: Zhang J; International Cancer Center, Guangdong Key Laboratory of Genome Instability and Human Disease Prevention, Department of Biochemistry and Molecular Biology, Shenzhen University Medical School, Shenzhen 518055, China., Chen F; International Cancer Center, Guangdong Key Laboratory of Genome Instability and Human Disease Prevention, Department of Biochemistry and Molecular Biology, Shenzhen University Medical School, Shenzhen 518055, China., Tang M; Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai 200092, China., Xu W; International Cancer Center, Guangdong Key Laboratory of Genome Instability and Human Disease Prevention, Department of Biochemistry and Molecular Biology, Shenzhen University Medical School, Shenzhen 518055, China., Tian Y; International Cancer Center, Guangdong Key Laboratory of Genome Instability and Human Disease Prevention, Department of Biochemistry and Molecular Biology, Shenzhen University Medical School, Shenzhen 518055, China., Liu Z; Sir William Dunn School of Pathology, South Parks Road, Oxford OX1 3RE, UK., Shu Y; International Cancer Center, Guangdong Key Laboratory of Genome Instability and Human Disease Prevention, Department of Biochemistry and Molecular Biology, Shenzhen University Medical School, Shenzhen 518055, China., Yang H; International Cancer Center, Guangdong Key Laboratory of Genome Instability and Human Disease Prevention, Department of Biochemistry and Molecular Biology, Shenzhen University Medical School, Shenzhen 518055, China., Zhu Q; International Cancer Center, Guangdong Key Laboratory of Genome Instability and Human Disease Prevention, Department of Biochemistry and Molecular Biology, Shenzhen University Medical School, Shenzhen 518055, China., Lu X; International Cancer Center, Guangdong Key Laboratory of Genome Instability and Human Disease Prevention, Department of Biochemistry and Molecular Biology, Shenzhen University Medical School, Shenzhen 518055, China., Peng B; International Cancer Center, Guangdong Key Laboratory of Genome Instability and Human Disease Prevention, Department of Cell Biology and Medical Genetics, Shenzhen University Medical School, Shenzhen 518055, China., Liu X; International Cancer Center, Guangdong Key Laboratory of Genome Instability and Human Disease Prevention, Department of Biochemistry and Molecular Biology, Shenzhen University Medical School, Shenzhen 518055, China., Xu X; International Cancer Center, Guangdong Key Laboratory of Genome Instability and Human Disease Prevention, Department of Cell Biology and Medical Genetics, Shenzhen University Medical School, Shenzhen 518055, China., Gullerova M; Sir William Dunn School of Pathology, South Parks Road, Oxford OX1 3RE, UK., Zhu WG; International Cancer Center, Guangdong Key Laboratory of Genome Instability and Human Disease Prevention, Department of Biochemistry and Molecular Biology, Shenzhen University Medical School, Shenzhen 518055, China; Marshall Laboratory of Biomedical Engineering, Shenzhen University Medical School, Shenzhen 518055, China; School of Basic Medical Sciences, Wannan Medical College, Wuhu, Anhui 241002, China; Department of Biochemistry and Molecular Biology, Peking University Health Science Centre, Beijing 100191, China. Electronic address: zhuweiguo@szu.edu.cn.

المصدر: Cell reports [Cell Rep] 2024 Feb 27; Vol. 43 (2), pp. 113779. Date of Electronic Publication: 2024 Feb 13.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE

مواضيع طبية MeSH: R-Loop Structures* , RNA* , Ribonuclease H*, Adenine/*analogs & derivatives, Humans ; Genomic Instability ; DNA-Binding Proteins/genetics ; Transcription Factors/genetics ; Methyltransferases/genetics

المؤلفون: Cho SI; Center for Genome Engineering, Institute for Basic Science, Daejeon 34126, Republic of Korea; Department of Chemistry, Seoul National University, Seoul 08826, Republic of Korea; Department of Pharmacology, Yonsei University College of Medicine, Seoul 03722, Republic of Korea., Lim K; Center for Genome Engineering, Institute for Basic Science, Daejeon 34126, Republic of Korea; Brain Science Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea; Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology, Seoul 02792, Republic of Korea., Hong S; Laboratory Animal Resource and Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju 28116, Republic of Korea; Department of Medicine, Korea University College of Medicine, Seoul 02708, Republic of Korea., Lee J; Center for Genome Engineering, Institute for Basic Science, Daejeon 34126, Republic of Korea; Department of Chemistry, Seoul National University, Seoul 08826, Republic of Korea., Kim A; Center for Genome Engineering, Institute for Basic Science, Daejeon 34126, Republic of Korea., Lim CJ; Edgene, Inc., Seoul 08790, Republic of Korea., Ryou S; Edgene, Inc., Seoul 08790, Republic of Korea., Lee JM; Center for Genome Engineering, Institute for Basic Science, Daejeon 34126, Republic of Korea; Department of Chemistry, Seoul National University, Seoul 08826, Republic of Korea., Mok YG; Center for Genome Engineering, Institute for Basic Science, Daejeon 34126, Republic of Korea; GreenGene Inc., Seoul 08790, Republic of Korea., Chung E; Center for Genome Engineering, Institute for Basic Science, Daejeon 34126, Republic of Korea., Kim S; Laboratory Animal Resource and Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju 28116, Republic of Korea; College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Republic of Korea., Han S; Laboratory Animal Resource and Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju 28116, Republic of Korea; Department of Biochemistry, College of Natural Sciences, Chungbuk National University, Cheongju 28644, Republic of Korea., Cho SM; Laboratory Animal Resource and Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju 28116, Republic of Korea., Kim J; Laboratory Animal Resource and Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju 28116, Republic of Korea; Department of Medicine, Korea University College of Medicine, Seoul 02708, Republic of Korea., Kim EK; Laboratory Animal Resource and Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju 28116, Republic of Korea., Nam KH; Laboratory Animal Resource and Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju 28116, Republic of Korea., Oh Y; Laboratory Animal Resource and Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju 28116, Republic of Korea., Choi M; Center for Genome Engineering, Institute for Basic Science, Daejeon 34126, Republic of Korea., An TH; Metabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea; Department of Functional Genomics, KRIBB School of Bioscience, University of Science and Technology (UST), Daejeon, Republic of Korea., Oh KJ; Metabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea; Department of Functional Genomics, KRIBB School of Bioscience, University of Science and Technology (UST), Daejeon, Republic of Korea., Lee S; Center for Genome Engineering, Institute for Basic Science, Daejeon 34126, Republic of Korea; Edgene, Inc., Seoul 08790, Republic of Korea; Department of MetaBioHealth, Sungkyunkwan University (SKKU), Suwon, Republic of Korea; Department of Precision Medicine, School of Medicine, Sungkyunkwan University (SKKU), Suwon, Republic of Korea. Electronic address: shlee9@skku.edu., Lee H; Laboratory Animal Resource and Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju 28116, Republic of Korea; Department of Medicine, Korea University College of Medicine, Seoul 02708, Republic of Korea. Electronic address: hjlee102@korea.ac.kr., Kim JS; Edgene, Inc., Seoul 08790, Republic of Korea; NUS Synthetic Biology for Clinical & Technological Innovation (SynCTI) and Department of Biochemistry, National University of Singapore, Singapore, Singapore. Electronic address: jskim01@snu.ac.kr.

المصدر: Cell [Cell] 2024 Jan 04; Vol. 187 (1), pp. 95-109.e26.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

مواضيع طبية MeSH: DNA, Mitochondrial*/genetics , Transcription Activator-Like Effectors*/metabolism, Animals ; Humans ; Mice ; Adenine ; Cytosine ; Gene Editing ; RNA ; Protein Engineering

المؤلفون: Tu T; School of Ophthalmology and Optometry, Eye Hospital, State Key Laboratory and Key Laboratory of Vision Science, Ministry of Health and Zhejiang Provincial Key Laboratory of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China., Song Z; Henan Eye Hospital, Henan Eye Institute, Henan Provincial People's Hospital and People's Hospital of Zhengzhou University and People's Hospital of Henan University, Zhengzhou, Henan, China., Liu X; School of Ophthalmology and Optometry, Eye Hospital, State Key Laboratory and Key Laboratory of Vision Science, Ministry of Health and Zhejiang Provincial Key Laboratory of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China., Wang S; State Key Laboratory of Plant Cell and Chromosome Engineering, Center for Genome Editing, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China., He X; School of Ophthalmology and Optometry, Eye Hospital, State Key Laboratory and Key Laboratory of Vision Science, Ministry of Health and Zhejiang Provincial Key Laboratory of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China., Xi H; The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China., Wang J; School of Ophthalmology and Optometry, Eye Hospital, State Key Laboratory and Key Laboratory of Vision Science, Ministry of Health and Zhejiang Provincial Key Laboratory of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China., Yan T; School of Ophthalmology and Optometry, Eye Hospital, State Key Laboratory and Key Laboratory of Vision Science, Ministry of Health and Zhejiang Provincial Key Laboratory of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China., Chen H; School of Ophthalmology and Optometry, Eye Hospital, State Key Laboratory and Key Laboratory of Vision Science, Ministry of Health and Zhejiang Provincial Key Laboratory of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China., Zhang Z; School of Life Science and Technology, ShanghaiTech University, Shanghai, China., Lv X; School of Ophthalmology and Optometry, Eye Hospital, State Key Laboratory and Key Laboratory of Vision Science, Ministry of Health and Zhejiang Provincial Key Laboratory of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China., Lv J; School of Ophthalmology and Optometry, Eye Hospital, State Key Laboratory and Key Laboratory of Vision Science, Ministry of Health and Zhejiang Provincial Key Laboratory of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China., Huang XF; The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China., Zhao J; The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China., Lin CP; School of Life Science and Technology, ShanghaiTech University, Shanghai, China., Gao C; State Key Laboratory of Plant Cell and Chromosome Engineering, Center for Genome Editing, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China. Electronic address: cxgao@genetics.ac.cn., Zhang J; Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA. Electronic address: jinwei.zhang@nih.gov., Gu F; School of Ophthalmology and Optometry, Eye Hospital, State Key Laboratory and Key Laboratory of Vision Science, Ministry of Health and Zhejiang Provincial Key Laboratory of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China. Electronic address: gufenguw@gmail.com.

المصدر: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2022 Sep 07; Vol. 30 (9), pp. 2933-2941. Date of Electronic Publication: 2022 Jul 12.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Intramural

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE

مواضيع طبية MeSH: Adenine* , Gene Editing*, CRISPR-Cas Systems ; Humans ; Mutation

المؤلفون: Gopala Krishna V; MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK., Gautsch VG; MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK., D'Angiolella V; MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK. Electronic address: vincenzo.dangiolella@oncology.ox.ac.uk.

المصدر: Molecular cell [Mol Cell] 2023 Dec 21; Vol. 83 (24), pp. 4442-4444.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE

مواضيع طبية MeSH: Gene Editing* , CRISPR-Cas Systems*, Adenine

المؤلفون: Hidaka T; Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8501, Japan., Hashiya K; Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8501, Japan., Bando T; Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8501, Japan., Pandian GN; Institute for Integrated Cell-Material Science (WPI-iCeMS), Kyoto University, Sakyo, Kyoto 606-8501, Japan. Electronic address: namasivayam.ganeshpandian.5z@kyoto-u.ac.jp., Sugiyama H; Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8501, Japan; Institute for Integrated Cell-Material Science (WPI-iCeMS), Kyoto University, Sakyo, Kyoto 606-8501, Japan. Electronic address: hs@kuchem.kyoto-u.ac.jp.

المصدر: Cell chemical biology [Cell Chem Biol] 2022 Apr 21; Vol. 29 (4), pp. 690-695.e5. Date of Electronic Publication: 2021 Aug 26.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101676030 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2451-9448 (Electronic) Linking ISSN: 24519448 NLM ISO Abbreviation: Cell Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: Adenine* , DNA, Mitochondrial*/genetics, Alkylation ; Chlorambucil/chemistry ; Humans ; Mitochondria ; Mutation ; Nylons/chemistry

المؤلفون: Dang L; Department of Obstetrics and Gynecology, Center of Reproductive Medicine, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China., Zhou X; Department of Obstetrics and Gynecology, Center of Reproductive Medicine, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Key Laboratory for Reproductive Medicine of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China., Zhong X; Department of Reproductive Center, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China., Yu W; Gene Editing Center, School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China., Huang S; Gene Editing Center, School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China., Liu H; Department of Obstetrics and Gynecology, Center of Reproductive Medicine, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Key Laboratory for Reproductive Medicine of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China., Chen Y; Department of Reproductive Center, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China., Zhang W; Department of Reproductive Center, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China., Yuan L; Department of Reproductive Center, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China., Li L; Department of Obstetrics and Gynecology, Center of Reproductive Medicine, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Key Laboratory for Reproductive Medicine of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China., Huang X; Gene Editing Center, School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China., Li G; Gene Editing Center, School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China. Electronic address: ligl@shanghaitech.edu.cn., Liu J; Department of Obstetrics and Gynecology, Center of Reproductive Medicine, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Key Laboratory for Reproductive Medicine of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. Electronic address: liujqssz@gzhmu.edu.cn., Tong G; Department of Reproductive Center, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address: drivftongguoqing@shutcm.edu.cn.

المصدر: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2022 Jan 05; Vol. 30 (1), pp. 175-183. Date of Electronic Publication: 2021 May 08.

نوع المنشور: Case Reports; Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE

مواضيع طبية MeSH: Adenine* , Gene Editing*/methods , Transglutaminases*/genetics, Heterozygote ; Humans ; Mutation ; RNA, Guide, CRISPR-Cas Systems

المؤلفون: Kweon SM; Department of Pathology, Keck School of Medicine of USC, Los Angeles, CA 90033, USA., Chen Y; Bioinformatics Service, Department of Health Sciences Libraries, Keck School of Medicine of USC, Los Angeles, CA 90033, USA., Moon E; Department of Pathology, Keck School of Medicine of USC, Los Angeles, CA 90033, USA., Kvederaviciutė K; Institute of Biotechnology, Life Sciences Center, Vilnius University, Vilnius LT-10257, Lithuania., Klimasauskas S; Institute of Biotechnology, Life Sciences Center, Vilnius University, Vilnius LT-10257, Lithuania., Feldman DE; Department of Pathology, Keck School of Medicine of USC, Los Angeles, CA 90033, USA. Electronic address: defeldma@usc.edu.

المصدر: Molecular cell [Mol Cell] 2019 Jun 20; Vol. 74 (6), pp. 1138-1147.e6. Date of Electronic Publication: 2019 Apr 11.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE

مواضيع طبية MeSH: Adenine/*analogs & derivatives , AlkB Homolog 4, Lysine Demethylase/*genetics , Craniofacial Abnormalities/*genetics , DNA/*genetics , Methyltransferases/*genetics , Repressor Proteins/*genetics, Adenine/metabolism ; AlkB Homolog 4, Lysine Demethylase/metabolism ; Animals ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Craniofacial Abnormalities/metabolism ; Craniofacial Abnormalities/pathology ; DNA/metabolism ; DNA Methylation ; Deubiquitinating Enzymes/genetics ; Deubiquitinating Enzymes/metabolism ; Female ; Gene Silencing ; Genes, Lethal ; Histones/genetics ; Histones/metabolism ; Inbreeding ; Male ; Methyltransferases/deficiency ; Mice ; Mice, Knockout ; Proteolysis ; Repressor Proteins/metabolism ; Signal Transduction ; Site-Specific DNA-Methyltransferase (Adenine-Specific)/genetics ; Site-Specific DNA-Methyltransferase (Adenine-Specific)/metabolism ; Transcription, Genetic ; Ubiquitin/genetics ; Ubiquitin/metabolism

المؤلفون: Wilson WH; Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Wright GW; Biometric Research Branch, Division of Cancer Diagnosis and Treatment, National Cancer Institute, National Institutes of Health, Bethesda, MD 20850, USA., Huang DW; Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Hodkinson B; Johnson & Johnson, 1 Johnson & Johnson Plaza, New Brunswick, NJ 08933, USA., Balasubramanian S; Johnson & Johnson, 1 Johnson & Johnson Plaza, New Brunswick, NJ 08933, USA., Fan Y; Johnson & Johnson, 1 Johnson & Johnson Plaza, New Brunswick, NJ 08933, USA., Vermeulen J; Johnson & Johnson, 1 Johnson & Johnson Plaza, New Brunswick, NJ 08933, USA., Shreeve M; Johnson & Johnson, 1 Johnson & Johnson Plaza, New Brunswick, NJ 08933, USA., Staudt LM; Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA; Center for Cancer Genomics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: lstaudt@mail.nih.gov.

المصدر: Cancer cell [Cancer Cell] 2021 Dec 13; Vol. 39 (12), pp. 1643-1653.e3. Date of Electronic Publication: 2021 Nov 04.

نوع المنشور: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101130617 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-3686 (Electronic) Linking ISSN: 15356108 NLM ISO Abbreviation: Cancer Cell Subsets: MEDLINE

مواضيع طبية MeSH: Adenine/*analogs & derivatives , Antineoplastic Combined Chemotherapy Protocols/*therapeutic use , Lymphoma, Large B-Cell, Diffuse/*drug therapy , Piperidines/*therapeutic use, Adenine/pharmacology ; Adenine/therapeutic use ; Aged ; Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Cyclophosphamide/pharmacology ; Cyclophosphamide/therapeutic use ; Doxorubicin/pharmacology ; Doxorubicin/therapeutic use ; Female ; Humans ; Male ; Middle Aged ; Piperidines/pharmacology ; Prednisone/pharmacology ; Prednisone/therapeutic use ; Rituximab/pharmacology ; Rituximab/therapeutic use ; Vincristine/pharmacology ; Vincristine/therapeutic use

المؤلفون: Werder RB; Center for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA 02118, USA; The Pulmonary Center and Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA; QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia., Kaserman JE; Center for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA 02118, USA; The Pulmonary Center and Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA., Packer MS; Beam Therapeutics, Cambridge, MA 02139, USA., Lindstrom-Vautrin J; Center for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA 02118, USA., Villacorta-Martin C; Center for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA 02118, USA., Young LE; Beam Therapeutics, Cambridge, MA 02139, USA., Aratyn-Schaus Y; Beam Therapeutics, Cambridge, MA 02139, USA., Gregoire F; Beam Therapeutics, Cambridge, MA 02139, USA., Wilson AA; Center for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA 02118, USA; The Pulmonary Center and Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA. Electronic address: awilson@bu.edu.

المصدر: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2021 Nov 03; Vol. 29 (11), pp. 3219-3229. Date of Electronic Publication: 2021 Jul 02.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE

مواضيع طبية MeSH: Adenine* , CRISPR-Cas Systems* , Gene Editing*, Hepatocytes/*metabolism , Induced Pluripotent Stem Cells/*metabolism , alpha 1-Antitrypsin/*genetics , alpha 1-Antitrypsin Deficiency/*genetics , alpha 1-Antitrypsin Deficiency/*therapy, Biomarkers ; Cell Differentiation/genetics ; Cells, Cultured ; Endoplasmic Reticulum Stress ; Gene Expression ; Hepatocytes/cytology ; Humans ; Induced Pluripotent Stem Cells/cytology ; Mutation ; alpha 1-Antitrypsin/chemistry

المؤلفون: Kim Y; Department of Surgery, Hanyang University College of Medicine, Seoul 04763, Republic of Korea; HY Indang Center of Regenerative Medicine and Stem Cell Research, Hanyang University, Seoul 04763, Republic of Korea., Hong SA; Department of Chemistry and Research Institute for Convergence of Basic Sciences, Hanyang University, Seoul 04763, Republic of Korea., Yu J; Department of Chemistry and Research Institute for Convergence of Basic Sciences, Hanyang University, Seoul 04763, Republic of Korea., Eom J; Department of Pathology, Hanyang University College of Medicine, Seoul 04763, Republic of Korea., Jang K; Department of Pathology, Hanyang University College of Medicine, Seoul 04763, Republic of Korea., Yoon S; Department of Surgery, Hanyang University College of Medicine, Seoul 04763, Republic of Korea; HY Indang Center of Regenerative Medicine and Stem Cell Research, Hanyang University, Seoul 04763, Republic of Korea., Hong DH; Department of Surgery, Hanyang University College of Medicine, Seoul 04763, Republic of Korea; HY Indang Center of Regenerative Medicine and Stem Cell Research, Hanyang University, Seoul 04763, Republic of Korea., Seo D; Psomagen, Inc., 1330 Piccard Drive, Suite 103, Rockville, MD 20850, USA., Lee SN; Department of Life Sciences, Korea University, Seoul 02841, Republic of Korea., Woo JS; Department of Life Sciences, Korea University, Seoul 02841, Republic of Korea., Jeong J; Department of Surgery, Hanyang University College of Medicine, Seoul 04763, Republic of Korea; HY Indang Center of Regenerative Medicine and Stem Cell Research, Hanyang University, Seoul 04763, Republic of Korea. Electronic address: jmj1103@gmail.com., Bae S; Department of Chemistry and Research Institute for Convergence of Basic Sciences, Hanyang University, Seoul 04763, Republic of Korea. Electronic address: sangsubae@hanyang.ac.kr., Choi D; Department of Surgery, Hanyang University College of Medicine, Seoul 04763, Republic of Korea; HY Indang Center of Regenerative Medicine and Stem Cell Research, Hanyang University, Seoul 04763, Republic of Korea; Department of HY-KIST Bio-convergence, Hanyang University, Seoul 04763, Republic of Korea. Electronic address: crane87@hanyang.ac.kr.

المصدر: Cell stem cell [Cell Stem Cell] 2021 Sep 02; Vol. 28 (9), pp. 1614-1624.e5. Date of Electronic Publication: 2021 May 04.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101311472 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-9777 (Electronic) Linking ISSN: 18759777 NLM ISO Abbreviation: Cell Stem Cell Subsets: MEDLINE

مواضيع طبية MeSH: Adenine*/pharmacology , Liver Diseases*/therapy, Animals ; Gene Editing ; Hepatocytes ; Mice