المؤلفون: Fröhling S; Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Scholl C, Levine RL, Loriaux M, Boggon TJ, Bernard OA, Berger R, Döhner H, Döhner K, Ebert BL, Teckie S, Golub TR, Jiang J, Schittenhelm MM, Lee BH, Griffin JD, Stone RM, Heinrich MC, Deininger MW, Druker BJ, Gilliland DG

المصدر: Cancer cell [Cancer Cell] 2007 Dec; Vol. 12 (6), pp. 501-13.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101130617 Publication Model: Print Cited Medium: Print ISSN: 1535-6108 (Print) Linking ISSN: 15356108 NLM ISO Abbreviation: Cancer Cell Subsets: MEDLINE

مواضيع طبية MeSH: Alleles*, Mutation/*genetics , fms-Like Tyrosine Kinase 3/*genetics, Adult ; Animals ; Cell Proliferation/drug effects ; DNA Mutational Analysis ; Enzyme Activation/drug effects ; Humans ; Leukemia, Monocytic, Acute/enzymology ; Leukemia, Monocytic, Acute/genetics ; Leukemia, Monocytic, Acute/pathology ; Mice ; Mutant Proteins/metabolism ; Phosphorylation/drug effects ; Protein Kinase Inhibitors/pharmacology ; Protein Structure, Secondary ; Signal Transduction/drug effects ; Staurosporine/analogs & derivatives ; Staurosporine/pharmacology ; fms-Like Tyrosine Kinase 3/chemistry

المؤلفون: Walters DK; Howard Hughes Medical Institute, Portland, Oregon 97239, USA., Mercher T, Gu TL, O'Hare T, Tyner JW, Loriaux M, Goss VL, Lee KA, Eide CA, Wong MJ, Stoffregen EP, McGreevey L, Nardone J, Moore SA, Crispino J, Boggon TJ, Heinrich MC, Deininger MW, Polakiewicz RD, Gilliland DG, Druker BJ

المصدر: Cancer cell [Cancer Cell] 2006 Jul; Vol. 10 (1), pp. 65-75.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101130617 Publication Model: Print Cited Medium: Print ISSN: 1535-6108 (Print) Linking ISSN: 15356108 NLM ISO Abbreviation: Cancer Cell Subsets: MEDLINE

مواضيع طبية MeSH: Leukemia, Experimental/*genetics , Leukemia, Megakaryoblastic, Acute/*genetics , Protein-Tyrosine Kinases/*genetics, Alleles ; Animals ; Apoptosis/drug effects ; Benzamides ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Humans ; Imatinib Mesylate ; Janus Kinase 2 ; Janus Kinase 3 ; K562 Cells ; Leukemia, Experimental/metabolism ; Leukemia, Experimental/pathology ; Leukemia, Megakaryoblastic, Acute/metabolism ; Leukemia, Megakaryoblastic, Acute/pathology ; Mice ; Mice, Inbred C57BL ; Models, Molecular ; Mutant Proteins/chemistry ; Mutant Proteins/genetics ; Mutant Proteins/metabolism ; Phosphorylation/drug effects ; Piperazines/pharmacology ; Protein Kinase Inhibitors/pharmacology ; Protein Structure, Tertiary/genetics ; Protein-Tyrosine Kinases/antagonists & inhibitors ; Protein-Tyrosine Kinases/metabolism ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins/metabolism ; Pyrimidines/pharmacology ; RNA, Small Interfering/genetics ; TYK2 Kinase