المؤلفون: Rana S; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, NIH, Rockville, MD 20850, USA., Dranchak P; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, NIH, Rockville, MD 20850, USA., Dahlin JL; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, NIH, Rockville, MD 20850, USA., Lamy L; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, NIH, Rockville, MD 20850, USA., Li W; Center for Cancer Research, National Cancer Institute, NIH, Frederick, MD, USA., Oliphant E; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, NIH, Rockville, MD 20850, USA., Shrimp JH; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, NIH, Rockville, MD 20850, USA., Rajacharya GH; Department of Oncology Science, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA., Tharakan R; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, NIH, Rockville, MD 20850, USA., Holland DO; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, NIH, Rockville, MD 20850, USA., Whitten AS; Department of Oncology Science, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA., Wilson KM; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, NIH, Rockville, MD 20850, USA., Singh PK; Department of Oncology Science, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA; OU Health Stephenson Center, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA., Durum SK; Center for Cancer Research, National Cancer Institute, NIH, Frederick, MD, USA., Tao D; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, NIH, Rockville, MD 20850, USA., Rai G; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, NIH, Rockville, MD 20850, USA. Electronic address: bantukallug@mail.nih.gov., Inglese J; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, NIH, Rockville, MD 20850, USA; Metabolic Medicine Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA. Electronic address: jinglese@mail.nih.gov.

المصدر: Cell chemical biology [Cell Chem Biol] 2024 Feb 15; Vol. 31 (2), pp. 221-233.e14. Date of Electronic Publication: 2023 Oct 23.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101676030 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2451-9448 (Electronic) Linking ISSN: 24519448 NLM ISO Abbreviation: Cell Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/therapeutic use , Folic Acid Antagonists*/chemistry , Folic Acid Antagonists*/metabolism , Folic Acid Antagonists*/pharmacology , Folic Acid Antagonists*/therapeutic use , Neoplasms*/drug therapy, Humans ; Carbon ; Methotrexate/pharmacology ; Methotrexate/metabolism ; Methotrexate/therapeutic use ; Proteolysis Targeting Chimera ; Tetrahydrofolate Dehydrogenase/metabolism

المؤلفون: Koren I; The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, 5290002, Israel. Electronic address: itay.koren@biu.ac.il.

المصدر: Structure (London, England : 1993) [Structure] 2022 Sep 01; Vol. 30 (9), pp. 1219-1221.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Comment

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101087697 Publication Model: Print Cited Medium: Internet ISSN: 1878-4186 (Electronic) Linking ISSN: 09692126 NLM ISO Abbreviation: Structure Subsets: MEDLINE

مواضيع طبية MeSH: Tetrahydrofolate Dehydrogenase*/chemistry , Tetrahydrofolate Dehydrogenase*/genetics , Tetrahydrofolate Dehydrogenase*/metabolism

المؤلفون: Lee IK; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA., Sharma N; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Noguera-Ortega E; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Liousia M; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Baroja ML; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Etersque JM; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA 19104, USA., Pham J; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Sarkar S; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Carreno BM; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Linette GP; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Puré E; Department of Biomedical Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA., Albelda SM; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Sellmyer MA; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: mark.sellmyer@pennmedicine.upenn.edu.

المصدر: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2023 Dec 06; Vol. 31 (12), pp. 3564-3578. Date of Electronic Publication: 2023 Nov 03.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE

مواضيع طبية MeSH: Immunotherapy, Adoptive*/methods , T-Lymphocytes*, Humans ; Tetrahydrofolate Dehydrogenase/genetics ; Tetrahydrofolate Dehydrogenase/metabolism ; Receptors, Antigen, T-Cell/genetics

المؤلفون: Suzuki S; Department of Nanopharmaceutical Sciences, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya 466-8555, Japan., Nakamura A; Quantitative Biology Research Group, Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences, 5-1 Higashiyama, Myodaiji-cho, Okazaki, Aichi 444-8787, Japan., Hatano Y; Department of Life Science and Applied Chemistry, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya 466-8555, Japan., Yoshikawa M; Department of Nanopharmaceutical Sciences, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya 466-8555, Japan., Yoshii T; Department of Life Science and Applied Chemistry, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya 466-8555, Japan; PRESTO, Japan Science and Technology Agency (JST), 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan., Sawada S; Department of Nanopharmaceutical Sciences, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya 466-8555, Japan., Atsuta-Tsunoda K; Department of Life Science and Applied Chemistry, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya 466-8555, Japan., Aoki K; Quantitative Biology Research Group, Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences, 5-1 Higashiyama, Myodaiji-cho, Okazaki, Aichi 444-8787, Japan; Division of Quantitative Biology, National Institute for Basic Biology, National Institutes of Natural Sciences, 5-1 Higashiyama, Myodaiji-cho, Okazaki, Aichi 444-8787, Japan; Department of Basic Biology, Faculty of Life Science, SOKENDAI (The Graduate University for Advanced Studies), 5-1 Higashiyama, Myodaiji-cho, Okazaki, Aichi 444-8787, Japan., Tsukiji S; Department of Nanopharmaceutical Sciences, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya 466-8555, Japan; Department of Life Science and Applied Chemistry, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya 466-8555, Japan. Electronic address: stsukiji@nitech.ac.jp.

المصدر: Cell chemical biology [Cell Chem Biol] 2022 Sep 15; Vol. 29 (9), pp. 1446-1464.e10. Date of Electronic Publication: 2022 Jul 13.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101676030 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2451-9448 (Electronic) Linking ISSN: 24519448 NLM ISO Abbreviation: Cell Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: Tetrahydrofolate Dehydrogenase*/metabolism , Trimethoprim*/pharmacology, Cell Membrane/metabolism ; Escherichia coli/metabolism ; Ligands ; Proteins ; Signal Transduction

المؤلفون: Zhao VY; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts., Rodrigues JV; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts., Lozovsky ER; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts., Hartl DL; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts., Shakhnovich EI; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts. Electronic address: shakhnovich@chemistry.harvard.edu.

المصدر: Biophysical journal [Biophys J] 2021 Nov 02; Vol. 120 (21), pp. 4738-4750. Date of Electronic Publication: 2021 Sep 25.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0370626 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1542-0086 (Electronic) Linking ISSN: 00063495 NLM ISO Abbreviation: Biophys J Subsets: MEDLINE

مواضيع طبية MeSH: Escherichia coli*/genetics , Escherichia coli*/metabolism , Tetrahydrofolate Dehydrogenase*/genetics, Catalytic Domain ; Kinetics ; Protein Conformation

المؤلفون: Fenwick RB; Department of Integrative Structural and Computational Biology and Skaggs Institute of Chemical Biology, The Scripps Research Institute, La Jolla, California. Electronic address: bryn.fenwick@gmail.com., Oyen D; Department of Integrative Structural and Computational Biology and Skaggs Institute of Chemical Biology, The Scripps Research Institute, La Jolla, California., van den Bedem H; SLAC National Accelerator Laboratory, Stanford University, Menlo Park, California, and Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, California., Dyson HJ; Department of Integrative Structural and Computational Biology and Skaggs Institute of Chemical Biology, The Scripps Research Institute, La Jolla, California., Wright PE; Department of Integrative Structural and Computational Biology and Skaggs Institute of Chemical Biology, The Scripps Research Institute, La Jolla, California. Electronic address: wright@scripps.edu.

المصدر: Biophysical journal [Biophys J] 2021 Jan 19; Vol. 120 (2), pp. 296-305. Date of Electronic Publication: 2020 Dec 08.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0370626 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1542-0086 (Electronic) Linking ISSN: 00063495 NLM ISO Abbreviation: Biophys J Subsets: MEDLINE

مواضيع طبية MeSH: Escherichia coli*/metabolism , Tetrahydrofolate Dehydrogenase*/genetics, Magnetic Resonance Spectroscopy ; Nuclear Magnetic Resonance, Biomolecular ; Protein Conformation

المؤلفون: Ramadurgum P; Department of Ophthalmology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX, USA., Woodard DR; Department of Ophthalmology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX, USA., Daniel S; Department of Ophthalmology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX, USA., Peng H; Department of Ophthalmology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX, USA., Mallipeddi PL; Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX, USA., Niederstrasser H; Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX, USA., Mihelakis M; Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX, USA., Chau VQ; Department of Ophthalmology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX, USA., Douglas PM; Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX, USA., Posner BA; Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX, USA., Hulleman JD; Department of Ophthalmology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX, USA; Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX, USA. Electronic address: john.hulleman@utsouthwestern.edu.

المصدر: Cell chemical biology [Cell Chem Biol] 2020 May 21; Vol. 27 (5), pp. 622-634.e6. Date of Electronic Publication: 2020 Apr 23.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101676030 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2451-9448 (Electronic) Linking ISSN: 24519448 NLM ISO Abbreviation: Cell Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: Anti-Bacterial Agents/*pharmacology , Enzyme Stability/*drug effects , Folic Acid Antagonists/*pharmacology , Pyrimidines/*pharmacology , Tetrahydrofolate Dehydrogenase/*metabolism, Animals ; Anti-Bacterial Agents/chemistry ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/pharmacology ; Escherichia coli/enzymology ; Female ; Folic Acid Antagonists/chemistry ; HeLa Cells ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Pyrimidines/chemistry ; Tetrahydrofolate Dehydrogenase/chemistry ; Triazines/chemistry ; Triazines/pharmacology ; Trimethoprim/analogs & derivatives ; Trimethoprim/pharmacology

المؤلفون: Sellmyer MA; Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: mark.sellmyer@pennmedicine.upenn.edu., Richman SA; Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA., Lohith K; Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA., Hou C; Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA., Weng CC; Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan 33302, Taiwan., Mach RH; Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA., O'Connor RS; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Milone MC; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Farwell MD; Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: michael.farwell@pennmedicine.upenn.edu.

المصدر: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2020 Jan 08; Vol. 28 (1), pp. 42-51. Date of Electronic Publication: 2019 Oct 15.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE

مواضيع طبية MeSH: Genes, Reporter*, CD8-Positive T-Lymphocytes/*immunology , Escherichia coli/*enzymology , Positron Emission Tomography Computed Tomography/*methods , Receptors, Chimeric Antigen/*metabolism , Tetrahydrofolate Dehydrogenase/*genetics, Animals ; CD8-Positive T-Lymphocytes/metabolism ; Female ; Fluorine Radioisotopes ; Gangliosides/metabolism ; HCT116 Cells ; Healthy Volunteers ; Heterografts/diagnostic imaging ; Humans ; Interleukin Receptor Common gamma Subunit/genetics ; Mice ; Mice, Inbred NOD ; Mice, Knockout ; Mice, Nude ; Mice, SCID ; Spleen/diagnostic imaging ; Spleen/metabolism ; Tetrahydrofolate Dehydrogenase/metabolism ; Trimethoprim

المؤلفون: Clancy B; Biodesy, Inc., South San Francisco, California. Electronic address: bason.clancy@biodesy.com., Moree B; Biodesy, Inc., South San Francisco, California., Salafsky J; Biodesy, Inc., South San Francisco, California. Electronic address: joshua.salafsky@ucsf.edu.

المصدر: Biophysical journal [Biophys J] 2019 Aug 06; Vol. 117 (3), pp. 500-508. Date of Electronic Publication: 2019 Jul 11.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0370626 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1542-0086 (Electronic) Linking ISSN: 00063495 NLM ISO Abbreviation: Biophys J Subsets: MEDLINE

مواضيع طبية MeSH: Nonlinear Dynamics* , Optical Imaging*, Tetrahydrofolate Dehydrogenase/*chemistry, Catalytic Domain ; Mutation/genetics ; Point Mutation/genetics ; Tetrahydrofolate Dehydrogenase/genetics

المؤلفون: Schober AF; The Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Mathis AD; The Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Ingle C; The Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Park JO; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA; Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, USA., Chen L; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA; Department of Chemistry, Princeton University, Princeton, NJ 08544, USA., Rabinowitz JD; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA; Department of Chemistry, Princeton University, Princeton, NJ 08544, USA., Junier I; Centre National de la Recherche Scientifique, Université Grenoble Alpes, TIMC-IMAG, F-38000 Grenoble, France., Rivoire O; Center for Interdisciplinary Research in Biology (CIRB), Collège de France, CNRS, INSERM, PSL Research University, F-75005 Paris, France., Reynolds KA; The Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: kimberly.reynolds@utsouthwestern.edu.

المصدر: Cell reports [Cell Rep] 2019 Jun 11; Vol. 27 (11), pp. 3359-3370.e7.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE

مواضيع طبية MeSH: Adaptation, Physiological* , Evolution, Molecular*, Escherichia coli Proteins/*genetics , Folic Acid/*metabolism , Tetrahydrofolate Dehydrogenase/*genetics , Thymidylate Synthase/*genetics, Escherichia coli ; Escherichia coli Proteins/metabolism ; Folic Acid/genetics ; Stress, Physiological ; Synteny ; Tetrahydrofolate Dehydrogenase/metabolism ; Thymidylate Synthase/metabolism