المؤلفون: Mollazadeh M; School of Chemistry, College of Science, University of Tehran, Tehran, Iran., Mohammadi-Khanaposhtani M; Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran., Zonouzi A; School of Chemistry, College of Science, University of Tehran, Tehran, Iran. Electronic address: zonouzi@khayam.ut.ac.ir., Nadri H; Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran., Najafi Z; Department of Medicinal Chemistry, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran; Medicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, Iran., Larijani B; Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran., Mahdavi M; Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: momahdavi@tums.ac.ir.

المصدر: Bioorganic chemistry [Bioorg Chem] 2019 Jun; Vol. 87, pp. 506-515. Date of Electronic Publication: 2019 Mar 06.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

مواضيع طبية MeSH: Drug Design*, Alzheimer Disease/*drug therapy , Benzyl Compounds/*pharmacology , Cholinesterase Inhibitors/*pharmacology , Chromans/*pharmacology , Neuroprotective Agents/*pharmacology , Pyridinium Compounds/*pharmacology, Acetylcholinesterase/metabolism ; Alzheimer Disease/metabolism ; Amyloid beta-Peptides/antagonists & inhibitors ; Amyloid beta-Peptides/metabolism ; Animals ; Benzyl Compounds/chemical synthesis ; Benzyl Compounds/chemistry ; Butyrylcholinesterase/metabolism ; Cell Death/drug effects ; Cholinesterase Inhibitors/chemical synthesis ; Cholinesterase Inhibitors/chemistry ; Chromans/chemistry ; Dose-Response Relationship, Drug ; Humans ; Hydrogen Peroxide/antagonists & inhibitors ; Hydrogen Peroxide/pharmacology ; Molecular Docking Simulation ; Molecular Structure ; Neuroprotective Agents/chemical synthesis ; Neuroprotective Agents/chemistry ; PC12 Cells ; Pyridinium Compounds/chemical synthesis ; Pyridinium Compounds/chemistry ; Rats ; Structure-Activity Relationship

المؤلفون: Rastegari A; Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran., Nadri H; Department of Medicinal Chemistry, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran., Mahdavi M; Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran., Moradi A; Department of Medicinal Chemistry, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran., Mirfazli SS; Department of Medicinal Chemistry, School of Pharmacy-International Campus, Iran University of Medical Sciences, Tehran, Iran., Edraki N; Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran., Moghadam FH; Department of Cellular Biotechnology at Cell Science Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran., Larijani B; Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran., Akbarzadeh T; Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran; Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran., Saeedi M; Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran; Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: m-saeedi@tums.ac.ir.

المصدر: Bioorganic chemistry [Bioorg Chem] 2019 Mar; Vol. 83, pp. 391-401. Date of Electronic Publication: 2018 Oct 30.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

مواضيع طبية MeSH: Coumarins/*pharmacology , Neuroprotective Agents/*pharmacology , Triazoles/*pharmacology, Acetylcholinesterase/chemistry ; Acetylcholinesterase/metabolism ; Alzheimer Disease/drug therapy ; Amyloid Precursor Protein Secretases/antagonists & inhibitors ; Animals ; Apoptosis/drug effects ; Catalytic Domain ; Chelating Agents/chemical synthesis ; Chelating Agents/chemistry ; Chelating Agents/metabolism ; Chelating Agents/pharmacology ; Cholinesterase Inhibitors/chemical synthesis ; Cholinesterase Inhibitors/chemistry ; Cholinesterase Inhibitors/metabolism ; Cholinesterase Inhibitors/pharmacology ; Coumarins/chemical synthesis ; Coumarins/chemistry ; Coumarins/metabolism ; Drug Design ; Hydrogen Peroxide/pharmacology ; Metals, Heavy/chemistry ; Molecular Docking Simulation ; Neuroprotective Agents/chemical synthesis ; Neuroprotective Agents/chemistry ; Neuroprotective Agents/metabolism ; PC12 Cells ; Rats ; Torpedo ; Triazoles/chemical synthesis ; Triazoles/chemistry ; Triazoles/metabolism