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المؤلفون: Lin S; Department of Pharmacology, State Key Laboratory of Natural and Biomimetic Drugs, School of Basic Medical Sciences, Peking University, Beijing, China., Wang L; Department of Pharmacology, State Key Laboratory of Natural and Biomimetic Drugs, School of Basic Medical Sciences, Peking University, Beijing, China., Jia Y; Department of Pharmacology, State Key Laboratory of Natural and Biomimetic Drugs, School of Basic Medical Sciences, Peking University, Beijing, China., Sun Y; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, China., Qiao P; Department of Pharmacology, State Key Laboratory of Natural and Biomimetic Drugs, School of Basic Medical Sciences, Peking University, Beijing, China., Quan Y; Department of Pharmacology, State Key Laboratory of Natural and Biomimetic Drugs, School of Basic Medical Sciences, Peking University, Beijing, China., Liu J; Department of Pharmacology, State Key Laboratory of Natural and Biomimetic Drugs, School of Basic Medical Sciences, Peking University, Beijing, China., Hu H; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Fujian, China., Yang B; Department of Pharmacology, State Key Laboratory of Natural and Biomimetic Drugs, School of Basic Medical Sciences, Peking University, Beijing, China; Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing, China., Zhou H; Department of Pharmacology, State Key Laboratory of Natural and Biomimetic Drugs, School of Basic Medical Sciences, Peking University, Beijing, China; Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing, China. Electronic address: rainbow_zhou@126.com.

المصدر: Translational research : the journal of laboratory and clinical medicine [Transl Res] 2024 Apr; Vol. 266, pp. 1-15. Date of Electronic Publication: 2023 Jul 09.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 101280339 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1810 (Electronic) Linking ISSN: 18781810 NLM ISO Abbreviation: Transl Res Subsets: MEDLINE

مواضيع طبية MeSH: Diabetic Nephropathies*/metabolism , Metabolic Diseases*/pathology , Diabetes Mellitus*/pathology, Mice ; Animals ; Kidney/pathology ; Disease Models, Animal ; Lipids ; Fatty Acids ; Organic Chemicals

المؤلفون: Zhang Y; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China., Huang H; Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Kong Y; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China., Xu C; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China., Dai L; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China., Geng X; Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, China., Deng Y; Guangzhou Laboratory, Guangzhou, China., Wang Y; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China., Liu Y; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China; Department of Nephrology, Center of Nephrology and Urology, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China., Meng C; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China., Zhang X; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China., Li J; Department of Nephrology, Center of Nephrology and Urology, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China., Qin J; The Key Laboratory of Model Animal for Disease Study of Ministry of Education, Model Animal Research Center, Nanjing University, Nanjing, China., Feng B; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China., Mak KK; Department of Biomedical Sciences, City University of Hong Kong, Hong Kong, China., Wang L; Department of Biomedical Sciences, City University of Hong Kong, Hong Kong, China., Huang Y; Department of Biomedical Sciences, City University of Hong Kong, Hong Kong, China., Wang W; Department of Pathophysiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China., Lan HY; Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China; Guangdong-Hong Kong Joint Laboratory for Immune and Genetic Kidney Disease, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangzhou, and The Chinese University of Hong Kong, Hong Kong, China., Yang B; Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, China., Lu HAJ; Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Xia Y; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China; Guangdong-Hong Kong Joint Laboratory for Immune and Genetic Kidney Disease, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangzhou, and The Chinese University of Hong Kong, Hong Kong, China; Key Laboratory for Regenerative Medicine, Ministry of Education, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China. Electronic address: Xia.Yin@cuhk.edu.hk.

المصدر: Kidney international [Kidney Int] 2023 Mar; Vol. 103 (3), pp. 501-513. Date of Electronic Publication: 2022 Nov 01.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 0323470 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-1755 (Electronic) Linking ISSN: 00852538 NLM ISO Abbreviation: Kidney Int Subsets: MEDLINE

مواضيع طبية MeSH: Aquaporin 2*/metabolism , Kidney Tubules, Collecting*/metabolism, Mice ; Animals ; YAP-Signaling Proteins ; Kidney/metabolism ; Adaptor Proteins, Signal Transducing/metabolism ; Transcription Factors/metabolism ; Mice, Knockout ; Water/metabolism ; Homeostasis

المؤلفون: Zhang S; Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.; State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China.; Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing 100191, China., Zhao Y; State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China.; School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.; College of Pharmacy, Inner Mongolia Medical University, Hohhot 010110, China., Wang S; State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China.; Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing 100191, China., Li M; State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China.; Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing 100191, China., Xu Y; State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China.; Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing 100191, China., Ran J; Department of Anatomy and Neuroscience Center, Chongqing Medical University, Chongqing 400016, China., Geng X; State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China., He J; State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China.; Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing 100191, China., Meng J; State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China.; Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing 100191, China., Shao G; State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China.; Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing 100191, China., Zhou H; State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China.; Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing 100191, China., Ge Z; State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China.; School of Pharmaceutical Sciences, Peking University, Beijing 100191, China., Chen G; Department of Physiology, Emory University School of Medicine, Atlanta, GA 30322, USA., Li R; State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China.; School of Pharmaceutical Sciences, Peking University, Beijing 100191, China., Yang B; Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.; State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China.; Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing 100191, China.

المصدر: Acta pharmaceutica Sinica. B [Acta Pharm Sin B] 2021 Jan; Vol. 11 (1), pp. 181-202. Date of Electronic Publication: 2020 Jun 14.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101600560 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2211-3835 (Print) Linking ISSN: 22113835 NLM ISO Abbreviation: Acta Pharm Sin B Subsets: PubMed not MEDLINE

المؤلفون: He J; State Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China., Zhou H; State Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China; Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing, 100191, China., Meng J; State Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China., Zhang S; State Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China., Li X; State Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China., Wang S; State Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China., Shao G; State Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China., Jin W; Division of Graduate Medical Sciences, Boston University School of Medicine, Boston, MA 02118, USA., Geng X; State Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China., Zhu S; State Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China., Yang B; State Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China; Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing, 100191, China. Electronic address: baoxue@bjmu.edu.cn.

المصدر: Pharmacological research [Pharmacol Res] 2020 May; Vol. 155, pp. 104751. Date of Electronic Publication: 2020 Mar 06.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8907422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-1186 (Electronic) Linking ISSN: 10436618 NLM ISO Abbreviation: Pharmacol Res Subsets: MEDLINE

مواضيع طبية MeSH: Chalcones/*therapeutic use , Cysts/*drug therapy , Polycystic Kidney, Autosomal Dominant/*drug therapy, Animals ; Chalcones/pharmacology ; Cysts/metabolism ; Cysts/pathology ; Dogs ; Female ; Fibrosis ; Kidney/drug effects ; Kidney/embryology ; Kidney/pathology ; Madin Darby Canine Kidney Cells ; Mice, Inbred ICR ; Mice, Transgenic ; Mitogen-Activated Protein Kinases/metabolism ; Polycystic Kidney, Autosomal Dominant/metabolism ; Polycystic Kidney, Autosomal Dominant/pathology ; Signal Transduction/drug effects ; Smad2 Protein/metabolism ; Smad3 Protein/metabolism ; TOR Serine-Threonine Kinases/metabolism ; Transforming Growth Factor beta/metabolism

المؤلفون: Su L; State Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China., Liu L; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China., Jia Y; State Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China., Lei L; State Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China., Liu J; State Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China., Zhu S; State Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China., Zhou H; State Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China., Chen R; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China., Lu HAJ; Center for Systems Biology, Program in Membrane Biology, Division of Nephrology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA. Electronic address: halu@partners.org., Yang B; State Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China; Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing, 100191, China. Electronic address: baoxue@bjmu.edu.cn.

المصدر: Kidney international [Kidney Int] 2017 Dec; Vol. 92 (6), pp. 1404-1418. Date of Electronic Publication: 2017 Jul 12.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 0323470 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-1755 (Electronic) Linking ISSN: 00852538 NLM ISO Abbreviation: Kidney Int Subsets: MEDLINE

مواضيع طبية MeSH: Cell Differentiation/*drug effects , Ganoderma/*chemistry , MAP Kinase Signaling System/*drug effects , Polycystic Kidney, Autosomal Dominant/*drug therapy , Triterpenes/*pharmacology, 8-Bromo Cyclic Adenosine Monophosphate/analogs & derivatives ; Animals ; Cell Line ; Cell Proliferation/drug effects ; Colforsin/pharmacology ; Cysts/drug therapy ; Disease Models, Animal ; Down-Regulation ; Epithelial Cells/drug effects ; Humans ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Polycystic Kidney, Autosomal Dominant/genetics ; Signal Transduction ; TOR Serine-Threonine Kinases/metabolism ; TRPP Cation Channels/genetics ; Triterpenes/isolation & purification ; Triterpenes/therapeutic use ; ras Proteins/metabolism