المؤلفون: Julius Lukeš, Ambar Kachale, Jan Votýpka, Anzhelika Butenko, Mark C. Field

المصدر: Trends in Parasitology. 38:724-736

مصطلحات موضوعية: Trypanosoma, Trypanosomiasis, African, Infectious Diseases, Trypanosomiasis, Trypanosoma brucei brucei, Animals, Humans, Parasitology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c60858e2bdf6ffce3d36df48752554c
https://doi.org/10.1016/j.pt.2022.05.011

المؤلفون: Atata, J.A., Enam, S.J., Ogbuagu, N.E., Balogun, E.O., Adamu, S., Esievo, K.A.N.

المصدر: Res Vet Sci

مصطلحات موضوعية: Swine Diseases, Erythrocytes, Trypanosomiasis, African, General Veterinary, Swine, Trypanosoma brucei brucei, Animals, Anemia, Article, Sialyltransferases, Up-Regulation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fd36a0c7cb0d1c6594b279846d9517b
https://doi.org/10.1016/j.rvsc.2022.02.012

المؤلفون: Dietmar Steverding, Daniel Strand, Adam Huczyński

المصدر: Experimental Parasitology. 243:108414

مصطلحات موضوعية: Infectious Diseases, Trypanosoma brucei brucei, Immunology, Humans, HL-60 Cells, Parasitology, General Medicine, Trypanocidal Agents

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08d9d07fa229cb6aeed3c7498a58774b
https://doi.org/10.1016/j.exppara.2022.108414

المؤلفون: Saulo Fehelberg Pinto Braga, Viviane Corrêa Santos, Rafael Pinto Vieira, Elany Barbosa da Silva, Ludovica Monti, Susann H. Krake, Pablo D.G. Martinez, Luiz Carlos Dias, Conor R. Caffrey, Jair L. Siqueira-Neto, Renata Barbosa de Oliveira, Rafaela Salgado Ferreira

المصدر: European Journal of Medicinal Chemistry. 244:114876

مصطلحات موضوعية: Thiosemicarbazones, Pharmacology, Structure-Activity Relationship, Trypanosoma cruzi, Trypanosoma brucei brucei, Organic Chemistry, Drug Discovery, Humans, Chagas Disease, General Medicine, Cysteine Proteinase Inhibitors, Trypanocidal Agents

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d7aca1f71a1510dad5e970a2f1ef430
https://doi.org/10.1016/j.ejmech.2022.114876

المؤلفون: Charles Schaub, Russell Thomson, Joseph Verdi, Jayne Raper, Nada Terra, Penny Lee, Gina Limon

المصدر: J Biol Chem

مصطلحات موضوعية: 0301 basic medicine, Endosome, Trypanosoma brucei brucei, Endocytic recycling, Gating, Endocytosis, Biochemistry, 03 medical and health sciences, Animals, Humans, Editors' Picks, Lipid bilayer, Molecular Biology, Ion channel, chemistry.chemical_classification, 030102 biochemistry & molecular biology, Helix-Loop-Helix Motifs, Cell Biology, Hydrogen-Ion Concentration, Apolipoprotein L1, Immunity, Innate, Amino acid, 030104 developmental biology, chemistry, Colicin, Biophysics, Papio hamadryas

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d3b860e30de0f1a5cfabe77943ded42
https://doi.org/10.1074/jbc.ra120.014201

المؤلفون: Katherine M. McKenney, Achim Schnaufer, Juan D. Alfonzo, Aleš Horák, Anita Bär, Julius Lukeš, Drahomíra Faktorová, Hassan Hashimi, Mary Anne T. Rubio

المصدر: Faktorová, D, Bär, A, Hashimi, H, McKenney, K, Horák, A, Schnaufer, A, Rubio, M A T, Alfonzo, J D & Lukeš, J 2018, ' TbUTP10, a protein involved in early stages of pre-18S rRNA processing in Trypanosoma brucei ', Molecular and Biochemical Parasitology, vol. 225, pp. 84-93 . https://doi.org/10.1016/j.molbiopara.2018.09.003

مصطلحات موضوعية: 0301 basic medicine, Trypanosoma brucei brucei/enzymology, Nucleolus, Trypanosoma brucei brucei, Protozoan Proteins, Biology, Ribosome, Article, Ribosome assembly, 03 medical and health sciences, 0302 clinical medicine, Large ribosomal subunit, RNA, Ribosomal, 18S, RNA, Small Nucleolar, Eukaryotic Small Ribosomal Subunit, Gene Silencing, RNA Processing, Post-Transcriptional, RRNA processing, Molecular Biology, RNA, Small Nucleolar/metabolism, Genes, Essential, Eukaryotic Large Ribosomal Subunit, RNA, Ribosomal, 18S/metabolism, RNA-Binding Proteins, Ribosomal RNA, RNA-Binding Proteins/genetics, Cell biology, 030104 developmental biology, Protozoan Proteins/genetics, Parasitology, 030217 neurology & neurosurgery

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::678723c204ca7797fa530b10c605956a
https://doi.org/10.1016/j.molbiopara.2018.09.003

المؤلفون: David Terán

المصدر: Drug Discovery Today. 25:1043-1053

مصطلحات موضوعية: 0301 basic medicine, Drug, Purine, media_common.quotation_subject, Trypanosoma brucei brucei, Organophosphonates, Trypanosoma brucei, Antimalarials, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Catalytic Domain, Drug Discovery, medicine, Animals, Humans, Prodrugs, African trypanosomiasis, Nucleotide, Enzyme Inhibitors, media_common, Pharmacology, chemistry.chemical_classification, biology, Chemistry, Acyclic nucleoside, Active site, Nucleosides, biology.organism_classification, medicine.disease, 030104 developmental biology, Biochemistry, 030220 oncology & carcinogenesis, biology.protein, DNA

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6179bbf0d4d82d7d24b3749571e76cf5
https://doi.org/10.1016/j.drudis.2020.02.008

المؤلفون: Keith R. Matthews, Federico Rojas

المصدر: Rojas, F & Matthews, K 2019, ' Quorum sensing in African Trypanosomes ', Current Opinion in Microbiology, vol. 52, pp. 124-129 . https://doi.org/10.1016/j.mib.2019.07.001

مصطلحات موضوعية: Microbiology (medical), Trypanosoma brucei brucei, Context (language use), Computational biology, Biology, Microbiology, 03 medical and health sciences, Animals, Humans, Africa South of the Sahara, 030304 developmental biology, 0303 health sciences, Coinfection, 030306 microbiology, Mechanism (biology), Host (biology), Animal disease, Quorum Sensing, biology.organism_classification, Quorum sensing, Trypanosomiasis, African, Infectious Diseases, Protozoa, Signal transduction, Bacteria, Signal Transduction

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec695de7b834c0bd8ac3236012b2cbbd
https://doi.org/10.1016/j.mib.2019.07.001

المؤلفون: Gowdham Manivel, Ruban Durairaj D, Arun Meyyazhagan, Shanmughavel Piramanayagam

المصدر: Genomics. 111:1124-1133

مصطلحات موضوعية: 0106 biological sciences, Proteome, Trypanosoma brucei brucei, Protozoan Proteins, Genome wide analysis, Computational biology, Disease, Biology, Trypanosoma brucei, 01 natural sciences, Exocytosis, Epitope, Epitopes, 03 medical and health sciences, Databases, Genetic, parasitic diseases, Genetics, medicine, African trypanosomiasis, 030304 developmental biology, 0303 health sciences, Secretory Pathway, Computational Biology, Molecular Sequence Annotation, Excretory secretory, biology.organism_classification, medicine.disease, Identification (biology), 010606 plant biology & botany

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bf875d881644934d2629fe242372b45
https://doi.org/10.1016/j.ygeno.2018.07.007

المؤلفون: Erik de Heuvel, Abhimanyu K. Singh, Ewald Edink, Tiffany van der Meer, Melanie van der Woude, Payman Sadek, Mikkel P. Krell-Jørgensen, Toine van den Bergh, Johan Veerman, Guy Caljon, Titilola D. Kalejaiye, Maikel Wijtmans, Louis Maes, Harry P. de Koning, Geert Jan Sterk, Marco Siderius, Iwan J.P. de Esch, David G. Brown, Rob Leurs

المساهمون: Medicinal chemistry, AIMMS

المصدر: Bioorganic and Medicinal Chemistry, 27(18), 3998-4012. Elsevier Limited
de Heuvel, E, Singh, A K, Edink, E, van der Meer, T, van der Woude, M, Sadek, P, Krell-Jørgensen, M P, van den Bergh, T, Veerman, J, Caljon, G, Kalejaiye, T D, Wijtmans, M, Maes, L, de Koning, H P, Jan Sterk, G, Siderius, M, de Esch, I J P, Brown, D G & Leurs, R 2019, ' Alkynamide phthalazinones as a new class of TbrPDEB1 inhibitors ', Bioorganic and Medicinal Chemistry, vol. 27, no. 18, pp. 3998-4012 . https://doi.org/10.1016/j.bmc.2019.06.027

مصطلحات موضوعية: Biochemistry & Molecular Biology, Phosphodiesterase Inhibitors, Trypanosoma brucei brucei, Neglected tropical disease, Clinical Biochemistry, Chemistry, Organic, Pharmaceutical Science, Chemistry, Medicinal, ROFLUMILAST, Trypanosoma brucei phosphodiesterase B1, 01 natural sciences, Biochemistry, Structure-Activity Relationship, DESIGN, SDG 3 - Good Health and Well-being, PHOSPHODIESTERASE INHIBITORS, Drug Discovery, Humans, DRUGS, Pharmacology & Pharmacy, Molecular Biology, Science & Technology, ANALOGS, 010405 organic chemistry, Crystal structure, Tetrahydrophthalazinone, Human African trypanosomiasis, Organic Chemistry, CHEMOTHERAPY, 0104 chemical sciences, 3. Good health, Chemistry, Structure-based drug discovery, 010404 medicinal & biomolecular chemistry, Physical Sciences, Molecular Medicine, Life Sciences & Biomedicine, SELECTIVE PDE4 INHIBITORS, ENZYMES, GENERATION

وصف الملف: Print-Electronic; application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7977de212c1b702b8e7a0a91b90f42f3
https://doi.org/10.1016/j.bmc.2019.06.027