المؤلفون: Lévesque S; Shire BioChem Inc., 275 Armand-Frappier Blvd., Laval, H7V 4A7, Québec, Canada. slevesque@ca.shire.com, St-Denis Y, Bachand B, Préville P, Leblond L, Winocour PD, Edmunds JJ, Rubin JR, Siddiqui MA

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2001 Dec 17; Vol. 11 (24), pp. 3161-4.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print Cited Medium: Print ISSN: 0960-894X (Print) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Antithrombins/*pharmacology , Lactams/*pharmacology , Thrombin/*antagonists & inhibitors, Animals ; Antithrombins/chemistry ; Arteries/drug effects ; In Vitro Techniques ; Lactams/chemistry ; Rats

المؤلفون: Bachand B; BioChem Pharma Inc., Laval, Québec, Canada. bachandb@biochempharma.com, Tarazi M, St-Denis Y, Edmunds JJ, Winocour PD, Leblond L, Siddiqui MA

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2001 Feb 12; Vol. 11 (3), pp. 287-90.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print Cited Medium: Print ISSN: 0960-894X (Print) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Fibrinolytic Agents/*chemical synthesis , Lactams/*pharmacology , Thrombin/*antagonists & inhibitors, Animals ; Blood Coagulation Tests ; Bridged Bicyclo Compounds, Heterocyclic/chemical synthesis ; Bridged Bicyclo Compounds, Heterocyclic/pharmacology ; Combinatorial Chemistry Techniques ; Crystallography, X-Ray ; Disease Models, Animal ; Fibrinolytic Agents/pharmacology ; Lactams/chemical synthesis ; Models, Molecular ; Rats ; Structure-Activity Relationship ; Thrombosis/drug therapy ; Trypsin Inhibitors/pharmacology

المؤلفون: Cody WL; Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Company, Ann Arbor, MI 48105, USA., Cai C, Doherty AM, Edmunds JJ, He JX, Narasimhan LS, Plummer JS, Rapundalo ST, Rubin JR, Van Huis CA, St-Denis Y, Winocour PD, Siddiqui MA

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 1999 Sep 06; Vol. 9 (17), pp. 2497-502.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print Cited Medium: Print ISSN: 0960-894X (Print) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Drug Design*, Antithrombins/*chemical synthesis , Piperazines/*chemistry, Antithrombins/chemistry ; Antithrombins/pharmacology ; Crystallography, X-Ray ; Models, Molecular

المؤلفون: Cody WL; Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Company, Ann Arbor, MI 48105, USA., Augelli-Szafran CE, Berryman KA, Cai C, Doherty AM, Edmunds JJ, He JX, Narasimhan LS, Penvose-Yi J, Plummer JS, Rapundalo ST, Rubin JR, Van Huis CA, Leblond L, Winocour PD, Siddiqui MA

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 1999 Sep 06; Vol. 9 (17), pp. 2503-8.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print Cited Medium: Print ISSN: 0960-894X (Print) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Drug Design*, Antithrombins/*chemical synthesis , Piperazines/*chemical synthesis, Antithrombins/chemistry ; Antithrombins/pharmacology ; Crystallography, X-Ray ; Molecular Structure ; Piperazines/chemistry ; Piperazines/pharmacology ; Structure-Activity Relationship

المؤلفون: Plummer JS; Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Company, Ann Arbor, MI 48105, USA., Berryman KA, Cai C, Cody WL, DiMaio J, Doherty AM, Eaton S, Edmunds JJ, Holland DR, Lafleur D, Levesque S, Narasimhan LS, Rubin JR, Rapundalo ST, Siddiqui MA, Susser A, St-Denis Y, Winocour P

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 1999 Mar 22; Vol. 9 (6), pp. 835-40.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print Cited Medium: Print ISSN: 0960-894X (Print) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Lactams/*pharmacology , Thrombin/*antagonists & inhibitors, Animals ; Disease Models, Animal ; Heterocyclic Compounds/chemistry ; Inhibitory Concentration 50 ; Kinetics ; Models, Chemical ; Models, Molecular ; Rats ; Thrombosis/drug therapy

المؤلفون: Plummer JS; Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Company, Ann Arbor, MI 48105, USA., Berryman KA, Cai C, Cody WL, DiMaio J, Doherty AM, Edmunds JJ, He JX, Holland DR, Levesque S, Kent DR, Narasimhan LS, Rubin JR, Rapundalo ST, Siddiqui MA, Susser AJ, St-Denis Y, Winocour PD

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 1998 Dec 01; Vol. 8 (23), pp. 3409-14.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print Cited Medium: Print ISSN: 0960-894X (Print) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Fibrinolytic Agents/*chemical synthesis , Lactams/*chemical synthesis , Serine Proteinase Inhibitors/*chemical synthesis , Thrombin/*antagonists & inhibitors, Animals ; Fibrinolytic Agents/pharmacology ; Lactams/pharmacology ; Rats ; Serine Proteinase Inhibitors/pharmacology ; Structure-Activity Relationship

المؤلفون: St-Denis Y; BioChem Therapeutic Inc., Laval, Québec, Canada., Augelli-Szafran CE, Bachand B, Berryman KA, DiMaio J, Doherty AM, Edmunds JJ, Leblond L, Lévesque S, Narasimhan LS, Penvose-Yi JR, Rubin JR, Tarazi M, Winocour PD, Siddiqui MA

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 1998 Nov 17; Vol. 8 (22), pp. 3193-8.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print Cited Medium: Print ISSN: 0960-894X (Print) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Fibrinolytic Agents/*chemical synthesis , Lactams/*chemical synthesis , Serine Proteinase Inhibitors/*chemical synthesis , Thrombin/*antagonists & inhibitors, Animals ; Crystallography, X-Ray ; Fibrinolytic Agents/pharmacology ; Lactams/pharmacology ; Rats ; Serine Proteinase Inhibitors/pharmacology ; Structure-Activity Relationship