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المؤلفون: Sopheaktra Ros, Richard J. Webby, Trushar Jeevan, A. E. Metlin, Songha Tok, Paul F. Horwood, Sareth Rith, Phalla Y, Thomas P. Fabrizio, Erik A. Karlsson, Philippe Buchy, Annika Suttie, Patrick Seiler, Philippe Dussart, Srey Viseth Horm
المساهمون: Unité de Virologie / Virology Unit [Phnom Penh], Institut Pasteur du Cambodge, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), James Cook University (JCU), St Jude Children's Research Hospital, Federation University [Churchill, Australia], GlaxoSmithKline Vaccines [Singapore], GlaxoSmithKline [Headquarters, London, UK] (GSK), The study was partially funded by the US Agency for International Development [grant number AID-442-G-14-00005]. This work was also partially supported by the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, under CEIRS contract no. HHSN272201400006C.
المصدر: Emerging microbes & infections
Emerging microbes & infections, Earliest : Springer-Nature ; Latest : Taylor & Francis, 2020, 9 (1), pp.1702-1711. ⟨10.1080/22221751.2020.1792353⟩
Emerging Microbes & Infections
article-version (VoR) Version of Recordمصطلحات موضوعية: 0301 basic medicine, Epidemiology, viruses, MESH: Virulence, medicine.disease_cause, MESH: Ferrets, Drug Discovery, ducks, MESH: Ducks, MESH: Animals, Clade, MESH: Phylogeny, MESH: Orthomyxoviridae Infections, Phylogeny, Virulence, Transmission (medicine), poultry, MESH: Influenza, Human, transmission, MESH: Chickens, virus diseases, General Medicine, H5N1, Infectious Diseases, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Enzootic, Original Article, Cambodia, Research Article, MESH: Influenza A Virus, H5N1 Subtype, 030106 microbiology, Immunology, Biology, Microbiology, Virus, 03 medical and health sciences, Orthomyxoviridae Infections, Species Specificity, MESH: Influenza in Birds, Virology, Influenza, Human, medicine, Animals, Humans, MESH: Species Specificity, MESH: Humans, Influenza A Virus, H5N1 Subtype, avian, MESH: Cambodia, Influenza A/H5N1, Pathogenicity, Influenza A virus subtype H5N1, Influenza, 030104 developmental biology, Influenza in Birds, Parasitology, Chickens, ferrets
الوصف: International audience; Influenza A/H5N1 has circulated in Asia since 2003 and is now enzootic in many countries in that region. In Cambodia, the virus has circulated since 2004 and has intermittently infected humans. During this period, we have noted differences in the rate of infections in humans, potentially associated with the circulation of different viral clades. In particular, a reassortant clade 1.1.2 virus emerged in early 2013 and was associated with a dramatic increase in infections of humans (34 cases) until it was replaced by a clade 2.3.2.1c virus in early 2014. In contrast, only one infection of a human has been reported in the 6 years since the clade 2.3.2.1c virus became the dominant circulating virus. We selected three viruses to represent the main viral clades that have circulated in Cambodia (clade 1.1.2, clade 1.1.2 reassortant, and clade 2.3.2.1c), and we conducted experiments to assess the virulence and transmissibility of these viruses in avian (chicken, duck) and mammalian (ferret) models. Our results suggest that the clade 2.3.2.1c virus is more "avian-like," with high virulence in both ducks and chickens, but there is no evidence of aerosol transmission of the virus from ducks to ferrets. In contrast, the two clade 1 viruses were less virulent in experimentally infected and contact ducks. However, evidence of chicken-to-ferret aerosol transmission was observed for both clade 1 viruses. The transmission experiments provide insights into clade-level differences that might explain the variation in A/H5N1 infections of humans observed in Cambodia and other settings.
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2High doses of highly pathogenic avian influenza virus in chicken meat are required to infect ferrets
المؤلفون: Kateri Bertran, David E. Swayne
المصدر: Veterinary Research
Veterinary Research, BioMed Central, 2014, 45 (1), pp.60. ⟨10.1186/1297-9716-45-60⟩مصطلحات موضوعية: Meat, animal diseases, [SDV]Life Sciences [q-bio], Short Report, Influenza A Virus, H7N7 Subtype, Biology, medicine.disease_cause, Virus, Microbiology, Influenza A Virus, H7N3 Subtype, Orthomyxoviridae Infections, Virus strain, Bacteriology, High doses, medicine, Animals, Influenza A Virus, H5N1 Subtype, General Veterinary, Ferrets, food and beverages, virus diseases, Pathogenicity, Virology, veterinary(all), Influenza A virus subtype H5N1, 3. Good health, Titer, Highly Pathogenic Avian Influenza Virus, Influenza in Birds, Chickens
الوصف: International audience; High pathogenicity avian influenza viruses (HPAIV) have caused fatal infections in mammals through consumption of infected bird carcasses or meat, but scarce information exists on the dose of virus required and the diversity of HPAIV subtypes involved. Ferrets were exposed to different HPAIV (H5 and H7 subtypes) through consumption of infected chicken meat. The dose of virus needed to infect ferrets through consumption was much higher than via respiratory exposure and varied with the virus strain. In addition, H5N1 HPAIV produced higher titers in the meat of infected chickens and more easily infected ferrets than the H7N3 or H7N7 HPAIV.
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55c9689df3cae45bf9fa15d45d27786a
https://hal.archives-ouvertes.fr/hal-01290641/document -
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المؤلفون: Stella E. Vogelzang-van Trierum, Vuong Ba Lê, Bruno Lina, Peter Carmeliet, Roger Lijnen, Fatima Berri, Michel Hanss, Eric Camerer, Guus F. Rimmelzwaan, Emmanuel Albina, Marie-Laure Foucault-Grunenwald, Dominique Martinez, Patricia Gil, Béatrice Riteau
المساهمون: Virpath-Grippe, de l'émergence au contrôle -- Virpath-Influenza, from emergence to control (Virpath), Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Dept Virol, Erasmus University Medical Center [Rotterdam] (Erasmus MC), Hospices Civils de Lyon (HCL), Contrôle des maladies animales exotiques et émergentes (UMR CMAEE), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA), Paris-Centre de Recherche Cardiovasculaire (PARCC - UMR-S U970), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris Descartes - Paris 5 (UPD5), Université Catholique de Louvain = Catholic University of Louvain (UCL), Flanders Institute for Biotechnology, Département Santé Animale (DEPT SA), Institut National de la Recherche Agronomique (INRA), Agence Nationale de la Recherche (ANR), Long term Structural funding - Methusalem by the Flemish Government, INSERM avenir, Centre International de Recherche en Infectiologie - UMR (CIRI), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), ProdInra, Migration, Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Virology
المصدر: PLoS Pathogens
PLoS Pathogens, 2013, 9 (3), ⟨10.1371/journal.ppat.1003229⟩
Plos Pathogens 3 (9), . (2013)
PLoS Pathogens, Public Library of Science, 2013, 9 (3), ⟨10.1371/journal.ppat.1003229⟩
PLoS Pathogens (print), 9(3). Public Library of Science
PLoS Pathogens, Vol 9, Iss 3, p e1003229 (2013)مصطلحات موضوعية: Male, Pulmonology, medicine.medical_treatment, [SDV]Life Sciences [q-bio], 030204 cardiovascular system & hematology, medicine.disease_cause, L73 - Maladies des animaux, Virus Replication, Fibrinogène, Pathogenesis, Pathogénèse, Mice, 0302 clinical medicine, Influenza A Virus, H1N1 Subtype, Influenza A virus, Coagulation sanguine, Biology (General), Mice, Knockout, 0303 health sciences, Fibrinolysis, Hematology, 3. Good health, Host-Pathogen Interaction, [SDV] Life Sciences [q-bio], Cytokine, Expérimentation en laboratoire, Host-Pathogen Interactions, Medicine, Female, medicine.symptom, Infection, Fibrin Clot Lysis Time, Research Article, Souris, QH301-705.5, Immunology, Pneumonia, Viral, Inflammation, Immunopathology, Biology, Microbiology, Antiviral Agents, Virus, Immunomodulation, 03 medical and health sciences, Fibrinolytic Agents, Orthomyxoviridae Infections, Virology, Genetics, medicine, Animals, Influenzavirus aviaire, Molecular Biology, 030304 developmental biology, Fibrin, Influenza A Virus, H5N1 Subtype, Fibrinogen, Plasminogen, RC581-607, Influenza A virus subtype H5N1, Mice, Inbred C57BL, Poumon, Parasitology, Immunologic diseases. Allergy, Fibrinolytic agent
الوصف: Detrimental inflammation of the lungs is a hallmark of severe influenza virus infections. Endothelial cells are the source of cytokine amplification, although mechanisms underlying this process are unknown. Here, using combined pharmacological and gene-deletion approaches, we show that plasminogen controls lung inflammation and pathogenesis of infections with influenza A/PR/8/34, highly pathogenic H5N1 and 2009 pandemic H1N1 viruses. Reduction of virus replication was not responsible for the observed effect. However, pharmacological depletion of fibrinogen, the main target of plasminogen reversed disease resistance of plasminogen-deficient mice or mice treated with an inhibitor of plasminogen-mediated fibrinolysis. Therefore, plasminogen contributes to the deleterious inflammation of the lungs and local fibrin clot formation may be implicated in host defense against influenza virus infections. Our studies suggest that the hemostatic system might be explored for novel treatments against influenza.
Author Summary Influenza viruses, including H5N1 bird influenza viruses continue to form a major threat for public health. Available antiviral drugs for the treatment of influenza are effective to a limited extent and the emergence of resistant viruses may further undermine their use. The symptoms associated with influenza are caused by replication of the virus in the respiratory tract and the host immune response. Here, we report that a molecule of the fibrinolytic system, plasminogen, contributes to inflammation caused by influenza. Inhibiting the action of plasminogen protected mice from severe influenza infections, including those caused by H5N1 and H1N1 pandemic 2009 viruses and may be a promising novel strategy to treat influenza.وصف الملف: application/pdf
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