المؤلفون: Pierre Denise, Gudrun Schiffl, Nicholas Luxa, Stephane Besnard, Andrew H. Clarke, Michele Salanova, Dieter Blottner, Martina Gutsmann

المصدر: Journal of Vestibular Research. 23:187-193

مصطلحات موضوعية: medicine.medical_specialty, Muscle Fibers, Skeletal, Chromosomal translocation, Biology, Rats, Sprague-Dawley, Atrophy, Internal medicine, medicine, Animals, Myocyte, Muscle, Skeletal, Weightlessness Simulation, Cell Size, Vestibular system, Soleus muscle, Anatomy, Cross-Sectional, Weightlessness, General Neuroscience, Skeletal muscle, medicine.disease, Denervation, Immunohistochemistry, Phenotype, Sensory Systems, Muscle atrophy, Rats, Endocrinology, medicine.anatomical_structure, Otorhinolaryngology, Ear, Inner, Female, Vestibule, Labyrinth, Neurology (clinical), medicine.symptom, Biomarkers, Signal Transduction, Transcription Factors

الوصف: BACKGROUND: The vestibular system undergoes considerable modification during spaceflight [5]. This is paralleled bymicrogravity-induced muscle atrophy [6]. However, the possibility of vestibulo-autonomic regulatory mechanisms affectingskeletal muscle structure and function have not yet been addressed.OBJECTIVE: We hypothesise that the vestibular system affects anti-gravitational skeletal muscle phenotype composition, sizeand the transcriptional factor called nuclear factor of activated T cells (NFATc1).METHODS: In a laboratory study, we examined the morphological and histochemical properties including intramyocellularNFATc1 changes in slow-type soleus muscle of chemically labyrinthectomized rats (VLx; n = 8) compared to a control group(Sham; n = 6) after a period of one month.RESULTSANDCONCLUSION:Neurochemicalvestibulardeafferentationresultedinsmallermyofibresizes,alteredmyofibrephenotype composition, high yields of hybrid fibre formation, and reduced myonuclear NFATc1 accumulation as signs of slow-type myofibre atrophy, myofibre type remodelling, and altered nuclear transcriptional activity in the postural soleus muscle ofrats. We propose that vestibulo-autonomic modification of skeletal muscles occurs during prolonged microgravity. Our findingsare likely to have implications for vestibular rehabilitation in clinical settings.Keywords: Labyrinthectomy (vestibular lesion), skeletal muscle soleus, NFATc1 (NFAT2)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cceba6fd11e3c274ef4c6c3e3095f150
https://doi.org/10.3233/ves-130499