المؤلفون: Villa V; Department of Experimental Medicine, Section of General Pathology, School of Medical and Pharmaceutical Sciences, University of Genoa, Genoa, Italy., Montalto G; Department of Experimental Medicine, Section of General Pathology, School of Medical and Pharmaceutical Sciences, University of Genoa, Genoa, Italy., Caudano F; Department of Experimental Medicine, Section of General Pathology, School of Medical and Pharmaceutical Sciences, University of Genoa, Genoa, Italy., Fedele E; Department of Pharmacy, Section of Pharmacology and Toxicology, School of Medical and Pharmaceutical Sciences, University of Genoa, Genoa, Italy.; IRCCS Ospedale Policlinico San Martino, Genoa, Italy., Ricciarelli R; Department of Experimental Medicine, Section of General Pathology, School of Medical and Pharmaceutical Sciences, University of Genoa, Genoa, Italy.; IRCCS Ospedale Policlinico San Martino, Genoa, Italy.

المصدر: BioFactors (Oxford, England) [Biofactors] 2022 Sep; Vol. 48 (5), pp. 1111-1117. Date of Electronic Publication: 2022 May 13.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Ios Press Country of Publication: Netherlands NLM ID: 8807441 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8081 (Electronic) Linking ISSN: 09516433 NLM ISO Abbreviation: Biofactors Subsets: MEDLINE

مواضيع طبية MeSH: Alzheimer Disease*/drug therapy , Alzheimer Disease*/metabolism , Cyclic Nucleotide Phosphodiesterases, Type 4*/genetics , Cyclic Nucleotide Phosphodiesterases, Type 4*/metabolism , Cyclic Nucleotide Phosphodiesterases, Type 4*/therapeutic use, Adenylyl Cyclases/metabolism ; Animals ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Cyclic AMP-Dependent Protein Kinases/therapeutic use ; Phosphorylation ; Rats

المؤلفون: Zhang C; Department of Pharmacology, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China Departments of Behavioral Medicine & Psychiatry and Physiology & Pharmacology, West Virginia University Health Sciences Center, Morgantown, WV, USA., Cheng Y, Wang H, Wang C, Wilson SP, Xu J, Zhang HT

المصدر: Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2014; Vol. 38 (2), pp. 269-80.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: IOS Press Country of Publication: Netherlands NLM ID: 9814863 Publication Model: Print Cited Medium: Internet ISSN: 1875-8908 (Electronic) Linking ISSN: 13872877 NLM ISO Abbreviation: J Alzheimers Dis Subsets: MEDLINE

مواضيع طبية MeSH: Memory Disorders*/chemically induced , Memory Disorders*/enzymology , Memory Disorders*/therapy, Amyloid beta-Peptides/*pharmacology , Cyclic Nucleotide Phosphodiesterases, Type 4/*deficiency , Gene Expression Regulation/*physiology , Peptide Fragments/*pharmacology , RNA Interference/*physiology, Animals ; Cyclic AMP/metabolism ; Cyclic Nucleotide Phosphodiesterases, Type 4/genetics ; Disease Models, Animal ; Exploratory Behavior/drug effects ; Exploratory Behavior/physiology ; Gene Expression Regulation/drug effects ; Gene Expression Regulation/genetics ; Hippocampus/drug effects ; Hippocampus/metabolism ; Male ; Maze Learning/drug effects ; Maze Learning/physiology ; Mice ; Mice, Inbred ICR ; Reaction Time/drug effects ; Reaction Time/genetics ; Recognition, Psychology/drug effects ; Recognition, Psychology/physiology

المؤلفون: Nikitidou E; Department of Public Health and Caring Sciences, Molecular Geriatrics, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden., Khoonsari PE; Department of Medical Sciences, Clinical Chemistry, Uppsala University Academic Hospital, Uppsala, Sweden., Shevchenko G; Department of Chemistry-BMC, AnalyticalChemistry, Uppsala University, Uppsala, Sweden., Ingelsson M; Department of Public Health and Caring Sciences, Molecular Geriatrics, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden., Kultima K; Department of Medical Sciences, Clinical Chemistry, Uppsala University Academic Hospital, Uppsala, Sweden., Erlandsson A; Department of Public Health and Caring Sciences, Molecular Geriatrics, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.

المصدر: Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2017; Vol. 60 (1), pp. 305-321.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: IOS Press Country of Publication: Netherlands NLM ID: 9814863 Publication Model: Print Cited Medium: Internet ISSN: 1875-8908 (Electronic) Linking ISSN: 13872877 NLM ISO Abbreviation: J Alzheimers Dis Subsets: MEDLINE

مواضيع طبية MeSH: Amyloid beta-Peptides/*pharmacology , Apolipoproteins E/*metabolism , Extracellular Vesicles/*drug effects , Extracellular Vesicles/*metabolism , Neuroglia/*cytology , Neurons/*cytology , Peptide Fragments/*pharmacology, 2',3'-Cyclic-Nucleotide Phosphodiesterases/metabolism ; Animals ; Cell Count ; Cells, Cultured ; Coculture Techniques ; Embryo, Mammalian ; Extracellular Vesicles/ultrastructure ; Mass Spectrometry ; Mice ; Mice, Inbred C57BL ; Microscopy, Electron, Transmission ; Nerve Tissue Proteins/metabolism ; Neurons/ultrastructure ; Proteins/metabolism ; Time Factors ; Tubulin/metabolism

المؤلفون: Yu R; Liver Research Center, Divisions of Rhode Island Hospital and the Warren Alpert Medical School of Brown University, Providence, RI, USA.; Gastroenterology and Rhode Island Hospital and the Warren Alpert Medical School of Brown University, Providence, RI, USA.; Medicine, Rhode Island Hospital and the Warren Alpert Medical School of Brown University, Providence, RI, USA., Deochand C; Liver Research Center, Divisions of Rhode Island Hospital and the Warren Alpert Medical School of Brown University, Providence, RI, USA.; Gastroenterology and Rhode Island Hospital and the Warren Alpert Medical School of Brown University, Providence, RI, USA.; Medicine, Rhode Island Hospital and the Warren Alpert Medical School of Brown University, Providence, RI, USA.; Molecular Pharmacology and Physiology Graduate Program at Brown University, Providence, RI, USA., Krotow A; Molecular Pharmacology and Physiology Graduate Program at Brown University, Providence, RI, USA., Leão R; Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., Tong M; Liver Research Center, Divisions of Rhode Island Hospital and the Warren Alpert Medical School of Brown University, Providence, RI, USA.; Gastroenterology and Rhode Island Hospital and the Warren Alpert Medical School of Brown University, Providence, RI, USA.; Medicine, Rhode Island Hospital and the Warren Alpert Medical School of Brown University, Providence, RI, USA., Agarwal AR; Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, USA., Cadenas E; Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, USA., de la Monte SM; Liver Research Center, Divisions of Rhode Island Hospital and the Warren Alpert Medical School of Brown University, Providence, RI, USA.; Gastroenterology and Rhode Island Hospital and the Warren Alpert Medical School of Brown University, Providence, RI, USA.; Neuropathology, and Departments of Rhode Island Hospital and the Warren Alpert Medical School of Brown University, Providence, RI, USA.; Medicine, Rhode Island Hospital and the Warren Alpert Medical School of Brown University, Providence, RI, USA.; Pathology, Rhode Island Hospital and the Warren Alpert Medical School of Brown University, Providence, RI, USA.; Neurology, Rhode Island Hospital and the Warren Alpert Medical School of Brown University, Providence, RI, USA.; Neurosurgery, Rhode Island Hospital and the Warren Alpert Medical School of Brown University, Providence, RI, USA.

المصدر: Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2016; Vol. 50 (1), pp. 133-48.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: IOS Press Country of Publication: Netherlands NLM ID: 9814863 Publication Model: Print Cited Medium: Internet ISSN: 1875-8908 (Electronic) Linking ISSN: 13872877 NLM ISO Abbreviation: J Alzheimers Dis Subsets: MEDLINE

مواضيع طبية MeSH: Smoking*, Brain/*pathology , Leukoencephalopathies/*chemically induced , Leukoencephalopathies/*pathology , Nerve Degeneration/*etiology , Nicotiana/*toxicity, 2',3'-Cyclic-Nucleotide Phosphodiesterases/genetics ; 2',3'-Cyclic-Nucleotide Phosphodiesterases/metabolism ; AC133 Antigen ; Animals ; Antigens, CD/genetics ; Antigens, CD/metabolism ; Disease Models, Animal ; Galactosylceramides/genetics ; Galactosylceramides/metabolism ; Gene Expression Regulation/drug effects ; Glycoproteins/genetics ; Glycoproteins/metabolism ; Leukoencephalopathies/metabolism ; Male ; Mice ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; Neuroglia/metabolism ; Neurons/metabolism ; Oligodendroglia/metabolism ; Peptides/genetics ; Peptides/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism

المؤلفون: Granger MW; Neural Regeneration Laboratory, Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON, Canada., Franko B; Neural Regeneration Laboratory, Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON, Canada., Taylor MW; Neural Regeneration Laboratory, Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON, Canada., Messier C; School of Psychology, University of Ottawa, Ottawa, ON, Canada., George-Hyslop PS; Department of Clinical Neurosciences, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK and Tanz Centre for Research in Neurodegenerative Diseases University of Toronto, Toronto, ON, Canada., Bennett SA; Neural Regeneration Laboratory, Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON, Canada.

المصدر: Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2016; Vol. 51 (3), pp. 757-73.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: IOS Press Country of Publication: Netherlands NLM ID: 9814863 Publication Model: Print Cited Medium: Internet ISSN: 1875-8908 (Electronic) Linking ISSN: 13872877 NLM ISO Abbreviation: J Alzheimers Dis Subsets: MEDLINE

مواضيع طبية MeSH: Cognitive Reserve* , Disease Models, Animal* , Sex Characteristics*, Alzheimer Disease/*physiopathology , Alzheimer Disease/*psychology, Alzheimer Disease/genetics ; Alzheimer Disease/pathology ; Amyloid beta-Protein Precursor/genetics ; Amyloid beta-Protein Precursor/metabolism ; Animals ; Brain/pathology ; Brain/physiopathology ; Cyclic Nucleotide Phosphodiesterases, Type 6/genetics ; Cyclic Nucleotide Phosphodiesterases, Type 6/metabolism ; Female ; Humans ; Male ; Maze Learning/physiology ; Mice, Inbred C3H ; Mice, Inbred C57BL ; Mice, Transgenic ; Plaque, Amyloid/genetics ; Plaque, Amyloid/pathology ; Plaque, Amyloid/physiopathology ; Plaque, Amyloid/psychology ; Psychomotor Performance/physiology ; Spatial Memory/physiology ; Spatial Navigation/physiology ; Survival Analysis

المؤلفون: Teich AF; Department of Pathology and Cell Biology, Columbia University, New York, NY, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA., Sakurai M; Department of Pathology and Cell Biology, Columbia University, New York, NY, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA., Patel M; Department of Pathology and Cell Biology, Columbia University, New York, NY, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA., Holman C; Department of Pathology and Cell Biology, Columbia University, New York, NY, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA., Saeed F; Department of Pathology and Cell Biology, Columbia University, New York, NY, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA., Fiorito J; Department of Pathology and Cell Biology, Columbia University, New York, NY, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA., Arancio O; Department of Pathology and Cell Biology, Columbia University, New York, NY, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.

المصدر: Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2016; Vol. 52 (1), pp. 295-302.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: IOS Press Country of Publication: Netherlands NLM ID: 9814863 Publication Model: Print Cited Medium: Internet ISSN: 1875-8908 (Electronic) Linking ISSN: 13872877 NLM ISO Abbreviation: J Alzheimers Dis Subsets: MEDLINE

مواضيع طبية MeSH: Brain/*enzymology , Cyclic Nucleotide Phosphodiesterases, Type 5/*metabolism , Neurons/*enzymology, Blotting, Western ; DNA Primers ; Enzyme-Linked Immunosorbent Assay ; Humans ; Immunohistochemistry ; Nervous System Diseases/drug therapy ; Phosphodiesterase 5 Inhibitors/therapeutic use ; Polymerase Chain Reaction ; RNA, Messenger/metabolism

المؤلفون: Sun J; CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China University of Chinese Academy of Sciences, Beijing, China., Song F; CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China University of Chinese Academy of Sciences, Beijing, China., Wang J; CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China University of Chinese Academy of Sciences, Beijing, China., Han G; CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China University of Chinese Academy of Sciences, Beijing, China., Bai Z; CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China University of Chinese Academy of Sciences, Beijing, China., Xie B; CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China University of Chinese Academy of Sciences, Beijing, China., Feng X; CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China., Jia J; Center of Alzheimer's disease, Beijing Institute for Brain Disorders, Beijing, China Department of Neurology, Xuanwu hospital, Beijing, China., Duan Y; UC Davis Genome Center and Department of Biomedical Engineering, Davis, CA, USA., Lei H; CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China Center of Alzheimer's disease, Beijing Institute for Brain Disorders, Beijing, China UC Davis Genome Center and Department of Biomedical Engineering, Davis, CA, USA.

المصدر: Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2014; Vol. 41 (4), pp. 1039-56.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: IOS Press Country of Publication: Netherlands NLM ID: 9814863 Publication Model: Print Cited Medium: Internet ISSN: 1875-8908 (Electronic) Linking ISSN: 13872877 NLM ISO Abbreviation: J Alzheimers Dis Subsets: MEDLINE

مواضيع طبية MeSH: Epistasis, Genetic*, Alzheimer Disease/*genetics , Genetic Predisposition to Disease/*genetics , Polymorphism, Single Nucleotide/*genetics, Aged ; Aged, 80 and over ; Apolipoproteins E/genetics ; Carrier Proteins/genetics ; Cyclic Nucleotide Phosphodiesterases, Type 1/genetics ; Female ; Genetic Association Studies ; Humans ; Male ; Membrane Proteins/genetics ; Mitochondrial Membrane Transport Proteins/genetics ; Nerve Tissue Proteins/genetics ; Protein Tyrosine Phosphatases, Non-Receptor/genetics ; Receptors, FSH/genetics ; Receptors, Mineralocorticoid/genetics ; Ryanodine Receptor Calcium Release Channel/genetics ; Ubiquitin-Protein Ligases/genetics

المؤلفون: Taher A; Department of Urology, Faculty of Medicine, University of Indonesia, Jakarta., Birowo P, Kamil ST, Shahab N

المصدر: Clinical hemorheology and microcirculation [Clin Hemorheol Microcirc] 2000; Vol. 23 (2-4), pp. 277-81.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Ios Press Country of Publication: Netherlands NLM ID: 9709206 Publication Model: Print Cited Medium: Print ISSN: 1386-0291 (Print) Linking ISSN: 13860291 NLM ISO Abbreviation: Clin Hemorheol Microcirc Subsets: MEDLINE

مواضيع طبية MeSH: Diabetes Mellitus, Experimental/*complications , Erectile Dysfunction/*physiopathology , Muscle, Smooth/*drug effects , Nitric Oxide Donors/*pharmacology , Penicillamine/*pharmacology , Penis/*drug effects , Phosphodiesterase Inhibitors/*pharmacology , Piperazines/*pharmacology , Vasodilator Agents/*pharmacology, 3',5'-Cyclic-GMP Phosphodiesterases ; Alloxan ; Animals ; Cyclic GMP/metabolism ; Cyclic Nucleotide Phosphodiesterases, Type 5 ; Drug Evaluation, Preclinical ; Drug Interactions ; Macaca fascicularis ; Male ; Muscle, Smooth, Vascular/drug effects ; Nitric Oxide/physiology ; Norepinephrine/pharmacology ; Penicillamine/analogs & derivatives ; Penis/blood supply ; Penis/pathology ; Phenylephrine/pharmacology ; Phosphoric Diester Hydrolases/metabolism ; Purines ; Sildenafil Citrate ; Sulfones

المؤلفون: Heinle H; Institute of Physiology, University of Tuebingen, Tuebingen, Germany., Tober C, Zhang D, Jäggi R, Kuebler WM

المصدر: Clinical hemorheology and microcirculation [Clin Hemorheol Microcirc] 2010; Vol. 46 (1), pp. 23-35.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Ios Press Country of Publication: Netherlands NLM ID: 9709206 Publication Model: Print Cited Medium: Internet ISSN: 1875-8622 (Electronic) Linking ISSN: 13860291 NLM ISO Abbreviation: Clin Hemorheol Microcirc Subsets: MEDLINE

مواضيع طبية MeSH: Minerals/*pharmacology , Nucleotides, Cyclic/*metabolism , Picrotoxin/*pharmacology , Plant Extracts/*pharmacology , Vasodilation/*drug effects , Vasodilator Agents/*pharmacology, Adenylyl Cyclases/metabolism ; Animals ; CHO Cells ; Carotid Arteries/drug effects ; Conium/metabolism ; Cricetinae ; Cricetulus ; Cyclic Nucleotide Phosphodiesterases, Type 5/metabolism ; Drug Combinations ; Female ; Humans ; Male ; Rats ; Rats, Sprague-Dawley

المؤلفون: Park JW; Department of Internal Medicine, Division of Cardiology, Angiology, Nephrology, Hoyerswerda Hospital, Germany., Mrowietz C, Chung N, Jung F

المصدر: Clinical hemorheology and microcirculation [Clin Hemorheol Microcirc] 2004; Vol. 31 (3), pp. 173-83.

نوع المنشور: Clinical Trial; Journal Article; Randomized Controlled Trial

بيانات الدورية: Publisher: Ios Press Country of Publication: Netherlands NLM ID: 9709206 Publication Model: Print Cited Medium: Print ISSN: 1386-0291 (Print) Linking ISSN: 13860291 NLM ISO Abbreviation: Clin Hemorheol Microcirc Subsets: MEDLINE

مواضيع طبية MeSH: Coronary Artery Disease/*drug therapy , Microcirculation/*drug effects , Piperazines/*pharmacology, 3',5'-Cyclic-GMP Phosphodiesterases/antagonists & inhibitors ; Adult ; Aged ; Blood Flow Velocity/drug effects ; Coronary Artery Disease/blood ; Cross-Over Studies ; Double-Blind Method ; Enzyme Inhibitors/therapeutic use ; Humans ; Ischemia/blood ; Male ; Microscopy, Video ; Middle Aged ; Piperazines/administration & dosage ; Piperazines/therapeutic use ; Placebos ; Purines ; Sildenafil Citrate ; Skin/blood supply ; Sulfones