المؤلفون: Pineda S; Development, Aging & Regeneration Program, Sanford-Burnham Prebys Medical Discovery Institute, La Jolla, CA (S.P., S.K., K.B., R.B., G.V., K.O.)., Nikolova-Krstevski V; Victor Chang Cardiac Research Institute, Darlinghurst (V.N.-K., C.L., A.-K.A., C.D.C., A.J., I.G.H., M.S., M.O., G.T., R.J., R.P.H., A.P.H., D.F.).; Faculty of Medicine, UNSW Sydney, Kensington (V.N.-K., I.G.H., R.J., R.P.H., A.P.H., D.F.)., Leimena C; Victor Chang Cardiac Research Institute, Darlinghurst (V.N.-K., C.L., A.-K.A., C.D.C., A.J., I.G.H., M.S., M.O., G.T., R.J., R.P.H., A.P.H., D.F.)., Atkinson AJ; Institute of Cardiovascular Sciences, University of Manchester, United Kingdom (A.J.A., H.D.)., Altekoester AK; Victor Chang Cardiac Research Institute, Darlinghurst (V.N.-K., C.L., A.-K.A., C.D.C., A.J., I.G.H., M.S., M.O., G.T., R.J., R.P.H., A.P.H., D.F.)., Cox CD; Victor Chang Cardiac Research Institute, Darlinghurst (V.N.-K., C.L., A.-K.A., C.D.C., A.J., I.G.H., M.S., M.O., G.T., R.J., R.P.H., A.P.H., D.F.)., Jacoby A; Victor Chang Cardiac Research Institute, Darlinghurst (V.N.-K., C.L., A.-K.A., C.D.C., A.J., I.G.H., M.S., M.O., G.T., R.J., R.P.H., A.P.H., D.F.)., Huttner IG; Victor Chang Cardiac Research Institute, Darlinghurst (V.N.-K., C.L., A.-K.A., C.D.C., A.J., I.G.H., M.S., M.O., G.T., R.J., R.P.H., A.P.H., D.F.).; Faculty of Medicine, UNSW Sydney, Kensington (V.N.-K., I.G.H., R.J., R.P.H., A.P.H., D.F.)., Ju YK; Bosch Institute, University of Sydney, Camperdown (Y.-K.J., D.G.A.)., Soka M; Victor Chang Cardiac Research Institute, Darlinghurst (V.N.-K., C.L., A.-K.A., C.D.C., A.J., I.G.H., M.S., M.O., G.T., R.J., R.P.H., A.P.H., D.F.)., Ohanian M; Victor Chang Cardiac Research Institute, Darlinghurst (V.N.-K., C.L., A.-K.A., C.D.C., A.J., I.G.H., M.S., M.O., G.T., R.J., R.P.H., A.P.H., D.F.)., Trivedi G; Victor Chang Cardiac Research Institute, Darlinghurst (V.N.-K., C.L., A.-K.A., C.D.C., A.J., I.G.H., M.S., M.O., G.T., R.J., R.P.H., A.P.H., D.F.)., Kalvakuri S; Development, Aging & Regeneration Program, Sanford-Burnham Prebys Medical Discovery Institute, La Jolla, CA (S.P., S.K., K.B., R.B., G.V., K.O.)., Birker K; Development, Aging & Regeneration Program, Sanford-Burnham Prebys Medical Discovery Institute, La Jolla, CA (S.P., S.K., K.B., R.B., G.V., K.O.)., Johnson R; Victor Chang Cardiac Research Institute, Darlinghurst (V.N.-K., C.L., A.-K.A., C.D.C., A.J., I.G.H., M.S., M.O., G.T., R.J., R.P.H., A.P.H., D.F.).; Faculty of Medicine, UNSW Sydney, Kensington (V.N.-K., I.G.H., R.J., R.P.H., A.P.H., D.F.)., Molenaar P; Faculty of Health, Queensland University of Technology (P.M.).; School of Medicine, University of Queensland, Prince Charles Hospital, Brisbane, Queensland, Australia (P.M.)., Kuchar D; Cardiology Department, St Vincent's Hospital, Darlinghurst (D.K., D.F.)., Allen DG; Bosch Institute, University of Sydney, Camperdown (Y.-K.J., D.G.A.)., van Helden DF; University of Newcastle and Hunter Medical Research Institute, NSW, Australia (D.F.v.H.)., Harvey RP; Victor Chang Cardiac Research Institute, Darlinghurst (V.N.-K., C.L., A.-K.A., C.D.C., A.J., I.G.H., M.S., M.O., G.T., R.J., R.P.H., A.P.H., D.F.).; Faculty of Medicine, UNSW Sydney, Kensington (V.N.-K., I.G.H., R.J., R.P.H., A.P.H., D.F.)., Hill AP; Victor Chang Cardiac Research Institute, Darlinghurst (V.N.-K., C.L., A.-K.A., C.D.C., A.J., I.G.H., M.S., M.O., G.T., R.J., R.P.H., A.P.H., D.F.).; Faculty of Medicine, UNSW Sydney, Kensington (V.N.-K., I.G.H., R.J., R.P.H., A.P.H., D.F.)., Bodmer R; Development, Aging & Regeneration Program, Sanford-Burnham Prebys Medical Discovery Institute, La Jolla, CA (S.P., S.K., K.B., R.B., G.V., K.O.)., Vogler G; Development, Aging & Regeneration Program, Sanford-Burnham Prebys Medical Discovery Institute, La Jolla, CA (S.P., S.K., K.B., R.B., G.V., K.O.)., Dobrzynski H; Institute of Cardiovascular Sciences, University of Manchester, United Kingdom (A.J.A., H.D.).; Jagiellonian University Medical College, Cracow, Poland (H.D.)., Ocorr K; Development, Aging & Regeneration Program, Sanford-Burnham Prebys Medical Discovery Institute, La Jolla, CA (S.P., S.K., K.B., R.B., G.V., K.O.)., Fatkin D; Victor Chang Cardiac Research Institute, Darlinghurst (V.N.-K., C.L., A.-K.A., C.D.C., A.J., I.G.H., M.S., M.O., G.T., R.J., R.P.H., A.P.H., D.F.).; Faculty of Medicine, UNSW Sydney, Kensington (V.N.-K., I.G.H., R.J., R.P.H., A.P.H., D.F.).; Cardiology Department, St Vincent's Hospital, Darlinghurst (D.K., D.F.).

المصدر: Circulation. Genomic and precision medicine [Circ Genom Precis Med] 2021 Apr; Vol. 14 (2), pp. e003144. Date of Electronic Publication: 2021 Feb 25.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 101714113 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2574-8300 (Electronic) Linking ISSN: 25748300 NLM ISO Abbreviation: Circ Genom Precis Med Subsets: MEDLINE

مواضيع طبية MeSH: Atrial Fibrillation/*pathology , Large-Conductance Calcium-Activated Potassium Channel alpha Subunits/*genetics , Sinoatrial Node/*metabolism, Action Potentials/drug effects ; Animals ; Atrial Fibrillation/genetics ; Atrial Function/drug effects ; Atrial Function/physiology ; Embryo, Nonmammalian/metabolism ; Heart Atria/metabolism ; Heart Atria/pathology ; Humans ; Indoles/chemistry ; Indoles/metabolism ; Indoles/pharmacology ; Large-Conductance Calcium-Activated Potassium Channel alpha Subunits/antagonists & inhibitors ; Large-Conductance Calcium-Activated Potassium Channel alpha Subunits/metabolism ; Mice ; Myocardial Contraction ; Pedigree ; Polymorphism, Genetic ; RNA Interference ; RNA, Small Interfering/metabolism ; RNA, Small Interfering/pharmacology ; Zebrafish ; Zebrafish Proteins/antagonists & inhibitors ; Zebrafish Proteins/genetics ; Zebrafish Proteins/metabolism

المؤلفون: Huttner IG; Molecular Cardiology and Biophysics Division (I.G.H., L.W.W., C.F.S., C.H., R.J., T.J.B., G.T., D.F.).; Victor Chang Cardiac Research Institute, Darlinghurst, NSW, Australia. St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Kensington (I.G.H., L.W.W., C.F.S., D.H., C.S.H., M.P.F., D.F.)., Wang LW; Molecular Cardiology and Biophysics Division (I.G.H., L.W.W., C.F.S., C.H., R.J., T.J.B., G.T., D.F.).; Victor Chang Cardiac Research Institute, Darlinghurst, NSW, Australia. St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Kensington (I.G.H., L.W.W., C.F.S., D.H., C.S.H., M.P.F., D.F.).; Cardiology Department, St Vincent's Hospital, Darlinghurst, NSW, Australia (L.W.W., C.S.H., M.P.F., D.F.)., Santiago CF; Molecular Cardiology and Biophysics Division (I.G.H., L.W.W., C.F.S., C.H., R.J., T.J.B., G.T., D.F.).; Victor Chang Cardiac Research Institute, Darlinghurst, NSW, Australia. St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Kensington (I.G.H., L.W.W., C.F.S., D.H., C.S.H., M.P.F., D.F.)., Horvat C; Molecular Cardiology and Biophysics Division (I.G.H., L.W.W., C.F.S., C.H., R.J., T.J.B., G.T., D.F.)., Johnson R; Molecular Cardiology and Biophysics Division (I.G.H., L.W.W., C.F.S., C.H., R.J., T.J.B., G.T., D.F.)., Cheng D; School of Medical Sciences, Bosch Institute, University of Sydney, Camperdown, NSW, Australia (D.C., F.B.)., von Frieling-Salewsky M; Institute of Physiology II, University of Muenster, Germany (M.v.F.-S., W.A.L.)., Hillcoat K; Kevin Alford Cardiology, Port Macquarie, NSW Australia (K.H., K.A.)., Bemand TJ; Molecular Cardiology and Biophysics Division (I.G.H., L.W.W., C.F.S., C.H., R.J., T.J.B., G.T., D.F.)., Trivedi G; Molecular Cardiology and Biophysics Division (I.G.H., L.W.W., C.F.S., C.H., R.J., T.J.B., G.T., D.F.)., Braet F; School of Medical Sciences, Bosch Institute, University of Sydney, Camperdown, NSW, Australia (D.C., F.B.).; Cellular Imaging Facility, Charles Perkins Centre (F.B.).; Australian Centre for Microscopy and Microanalysis (F.B.)., Hesselson D; Victor Chang Cardiac Research Institute, Darlinghurst, NSW, Australia. St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Kensington (I.G.H., L.W.W., C.F.S., D.H., C.S.H., M.P.F., D.F.).; University of Sydney, Camperdown, NSW, Australia. Diabetes and Metabolism Division, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia (D.H.)., Alford K; Kevin Alford Cardiology, Port Macquarie, NSW Australia (K.H., K.A.)., Hayward CS; Cardiac Physiology and Transplantation Division (C.S.H., M.P.F.).; Victor Chang Cardiac Research Institute, Darlinghurst, NSW, Australia. St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Kensington (I.G.H., L.W.W., C.F.S., D.H., C.S.H., M.P.F., D.F.).; Cardiology Department, St Vincent's Hospital, Darlinghurst, NSW, Australia (L.W.W., C.S.H., M.P.F., D.F.)., Seidman JG; Howard Hughes Medical Institute, MD (J.G.S.).; Department of Genetics, Harvard Medical School (J.G.S., C.E.S.)., Seidman CE; Department of Genetics, Harvard Medical School (J.G.S., C.E.S.).; Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (C.E.S.)., Feneley MP; Cardiac Physiology and Transplantation Division (C.S.H., M.P.F.).; Victor Chang Cardiac Research Institute, Darlinghurst, NSW, Australia. St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Kensington (I.G.H., L.W.W., C.F.S., D.H., C.S.H., M.P.F., D.F.).; Cardiology Department, St Vincent's Hospital, Darlinghurst, NSW, Australia (L.W.W., C.S.H., M.P.F., D.F.)., Linke WA; Institute of Physiology II, University of Muenster, Germany (M.v.F.-S., W.A.L.)., Fatkin D; Molecular Cardiology and Biophysics Division (I.G.H., L.W.W., C.F.S., C.H., R.J., T.J.B., G.T., D.F.).; Victor Chang Cardiac Research Institute, Darlinghurst, NSW, Australia. St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Kensington (I.G.H., L.W.W., C.F.S., D.H., C.S.H., M.P.F., D.F.).; Cardiology Department, St Vincent's Hospital, Darlinghurst, NSW, Australia (L.W.W., C.S.H., M.P.F., D.F.).

المصدر: Circulation. Genomic and precision medicine [Circ Genom Precis Med] 2018 Aug; Vol. 11 (8), pp. e002135.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 101714113 Publication Model: Print Cited Medium: Internet ISSN: 2574-8300 (Electronic) Linking ISSN: 25748300 NLM ISO Abbreviation: Circ Genom Precis Med Subsets: MEDLINE

مواضيع طبية MeSH: Cardiomyopathy, Dilated/*genetics , Connectin/*genetics , Hemodynamics/*genetics , Stress, Physiological/*genetics, Adaptation, Biological/genetics ; Adolescent ; Adult ; Aged ; Animals ; Animals, Genetically Modified ; Cardiomyopathy, Dilated/pathology ; Cardiomyopathy, Dilated/physiopathology ; Embryo, Nonmammalian ; Female ; Genetic Association Studies ; Heart/embryology ; Heart/growth & development ; Heart Defects, Congenital/genetics ; Heart Defects, Congenital/pathology ; Humans ; Male ; Middle Aged ; Pedigree ; Sarcomeres/pathology ; Sequence Deletion ; Stroke Volume/genetics ; Young Adult ; Zebrafish

SCR Disease Name: Familial dilated cardiomyopathy