المؤلفون: Kasner SE; University of Pennsylvania, Philadelphia, PA kasner@mail.med.upenn.edu., Rhodes JF; Medical University of South Carolina, Charleston, SC., Andersen G; Aarhus University, Aarhus, Denmark., Iversen HK; Rigshospitalet, Copenhagen, Denmark., Nielsen-Kudsk JE; Aarhus University Hospital, Aarhus, Denmark., Settergren M; Karolinska Institutet, Stockholm, Sweden., Sjöstrand C; Karolinska Institutet, Stockholm, Sweden., Roine RO; Turku University Hospital, Turku, Finland., Hildick-Smith D; Sussex Cardiac Centre, Brighton, United Kingdom., Spence JD; Western University, London, ON, Canada., Søndergaard L; Rigshospitalet, Copenhagen, Denmark.

مؤلفون مشاركون: Gore REDUCE Clinical Study Investigators

المصدر: The New England journal of medicine [N Engl J Med] 2021 Mar 11; Vol. 384 (10), pp. 970-971.

نوع المنشور: Comparative Study; Letter; Randomized Controlled Trial

بيانات الدورية: Publisher: Massachusetts Medical Society Country of Publication: United States NLM ID: 0255562 Publication Model: Print Cited Medium: Internet ISSN: 1533-4406 (Electronic) Linking ISSN: 00284793 NLM ISO Abbreviation: N Engl J Med Subsets: MEDLINE

مواضيع طبية MeSH: Septal Occluder Device*/adverse effects, Foramen Ovale, Patent/*therapy , Ischemic Stroke/*prevention & control , Platelet Aggregation Inhibitors/*therapeutic use, Follow-Up Studies ; Foramen Ovale, Patent/complications ; Humans ; Ischemic Stroke/etiology ; Platelet Aggregation Inhibitors/adverse effects ; Secondary Prevention

المؤلفون: Søndergaard L; From the Departments of Cardiology (L.S.) and Neurology (H.K.I.) Rigshospitalet, University of Copenhagen, Copenhagen, and the Departments of Neurology (G.A.) and Cardiology (J.E.N.-K.) and the Faculty of Health (G.A.), Aarhus University, Aarhus - both in Denmark; the Department of Neurology, University of Pennsylvania, Philadelphia (S.E.K.); the Department of Cardiology, Nicklaus Children's Hospital, Miami (J.F.R.); Heart and Vascular Theme (M.S.) and Department of Neurology (C.S.), Karolinska University Hospital, and Departments of Medicine (M.S.) and Clinical Neuroscience (C.S.), Karolinska Institutet - both in Stockholm; the Department of Clinical Neurosciences, Turku University Hospital and University of Turku, Turku, Finland (R.O.R.); the Department of Cardiology, Sussex Cardiac Centre, Brighton and Sussex University Hospitals, Brighton, United Kingdom (D.H.-S.); the Division of Neurology, Western University, London, ON, Canada (J.D.S.); and the Department of Neurology, Haukeland University Hospital, Bergen, Norway (L.T.)., Kasner SE; From the Departments of Cardiology (L.S.) and Neurology (H.K.I.) Rigshospitalet, University of Copenhagen, Copenhagen, and the Departments of Neurology (G.A.) and Cardiology (J.E.N.-K.) and the Faculty of Health (G.A.), Aarhus University, Aarhus - both in Denmark; the Department of Neurology, University of Pennsylvania, Philadelphia (S.E.K.); the Department of Cardiology, Nicklaus Children's Hospital, Miami (J.F.R.); Heart and Vascular Theme (M.S.) and Department of Neurology (C.S.), Karolinska University Hospital, and Departments of Medicine (M.S.) and Clinical Neuroscience (C.S.), Karolinska Institutet - both in Stockholm; the Department of Clinical Neurosciences, Turku University Hospital and University of Turku, Turku, Finland (R.O.R.); the Department of Cardiology, Sussex Cardiac Centre, Brighton and Sussex University Hospitals, Brighton, United Kingdom (D.H.-S.); the Division of Neurology, Western University, London, ON, Canada (J.D.S.); and the Department of Neurology, Haukeland University Hospital, Bergen, Norway (L.T.)., Rhodes JF; From the Departments of Cardiology (L.S.) and Neurology (H.K.I.) Rigshospitalet, University of Copenhagen, Copenhagen, and the Departments of Neurology (G.A.) and Cardiology (J.E.N.-K.) and the Faculty of Health (G.A.), Aarhus University, Aarhus - both in Denmark; the Department of Neurology, University of Pennsylvania, Philadelphia (S.E.K.); the Department of Cardiology, Nicklaus Children's Hospital, Miami (J.F.R.); Heart and Vascular Theme (M.S.) and Department of Neurology (C.S.), Karolinska University Hospital, and Departments of Medicine (M.S.) and Clinical Neuroscience (C.S.), Karolinska Institutet - both in Stockholm; the Department of Clinical Neurosciences, Turku University Hospital and University of Turku, Turku, Finland (R.O.R.); the Department of Cardiology, Sussex Cardiac Centre, Brighton and Sussex University Hospitals, Brighton, United Kingdom (D.H.-S.); the Division of Neurology, Western University, London, ON, Canada (J.D.S.); and the Department of Neurology, Haukeland University Hospital, Bergen, Norway (L.T.)., Andersen G; From the Departments of Cardiology (L.S.) and Neurology (H.K.I.) Rigshospitalet, University of Copenhagen, Copenhagen, and the Departments of Neurology (G.A.) and Cardiology (J.E.N.-K.) and the Faculty of Health (G.A.), Aarhus University, Aarhus - both in Denmark; the Department of Neurology, University of Pennsylvania, Philadelphia (S.E.K.); the Department of Cardiology, Nicklaus Children's Hospital, Miami (J.F.R.); Heart and Vascular Theme (M.S.) and Department of Neurology (C.S.), Karolinska University Hospital, and Departments of Medicine (M.S.) and Clinical Neuroscience (C.S.), Karolinska Institutet - both in Stockholm; the Department of Clinical Neurosciences, Turku University Hospital and University of Turku, Turku, Finland (R.O.R.); the Department of Cardiology, Sussex Cardiac Centre, Brighton and Sussex University Hospitals, Brighton, United Kingdom (D.H.-S.); the Division of Neurology, Western University, London, ON, Canada (J.D.S.); and the Department of Neurology, Haukeland University Hospital, Bergen, Norway (L.T.)., Iversen HK; From the Departments of Cardiology (L.S.) and Neurology (H.K.I.) Rigshospitalet, University of Copenhagen, Copenhagen, and the Departments of Neurology (G.A.) and Cardiology (J.E.N.-K.) and the Faculty of Health (G.A.), Aarhus University, Aarhus - both in Denmark; the Department of Neurology, University of Pennsylvania, Philadelphia (S.E.K.); the Department of Cardiology, Nicklaus Children's Hospital, Miami (J.F.R.); Heart and Vascular Theme (M.S.) and Department of Neurology (C.S.), Karolinska University Hospital, and Departments of Medicine (M.S.) and Clinical Neuroscience (C.S.), Karolinska Institutet - both in Stockholm; the Department of Clinical Neurosciences, Turku University Hospital and University of Turku, Turku, Finland (R.O.R.); the Department of Cardiology, Sussex Cardiac Centre, Brighton and Sussex University Hospitals, Brighton, United Kingdom (D.H.-S.); the Division of Neurology, Western University, London, ON, Canada (J.D.S.); and the Department of Neurology, Haukeland University Hospital, Bergen, Norway (L.T.)., Nielsen-Kudsk JE; From the Departments of Cardiology (L.S.) and Neurology (H.K.I.) Rigshospitalet, University of Copenhagen, Copenhagen, and the Departments of Neurology (G.A.) and Cardiology (J.E.N.-K.) and the Faculty of Health (G.A.), Aarhus University, Aarhus - both in Denmark; the Department of Neurology, University of Pennsylvania, Philadelphia (S.E.K.); the Department of Cardiology, Nicklaus Children's Hospital, Miami (J.F.R.); Heart and Vascular Theme (M.S.) and Department of Neurology (C.S.), Karolinska University Hospital, and Departments of Medicine (M.S.) and Clinical Neuroscience (C.S.), Karolinska Institutet - both in Stockholm; the Department of Clinical Neurosciences, Turku University Hospital and University of Turku, Turku, Finland (R.O.R.); the Department of Cardiology, Sussex Cardiac Centre, Brighton and Sussex University Hospitals, Brighton, United Kingdom (D.H.-S.); the Division of Neurology, Western University, London, ON, Canada (J.D.S.); and the Department of Neurology, Haukeland University Hospital, Bergen, Norway (L.T.)., Settergren M; From the Departments of Cardiology (L.S.) and Neurology (H.K.I.) Rigshospitalet, University of Copenhagen, Copenhagen, and the Departments of Neurology (G.A.) and Cardiology (J.E.N.-K.) and the Faculty of Health (G.A.), Aarhus University, Aarhus - both in Denmark; the Department of Neurology, University of Pennsylvania, Philadelphia (S.E.K.); the Department of Cardiology, Nicklaus Children's Hospital, Miami (J.F.R.); Heart and Vascular Theme (M.S.) and Department of Neurology (C.S.), Karolinska University Hospital, and Departments of Medicine (M.S.) and Clinical Neuroscience (C.S.), Karolinska Institutet - both in Stockholm; the Department of Clinical Neurosciences, Turku University Hospital and University of Turku, Turku, Finland (R.O.R.); the Department of Cardiology, Sussex Cardiac Centre, Brighton and Sussex University Hospitals, Brighton, United Kingdom (D.H.-S.); the Division of Neurology, Western University, London, ON, Canada (J.D.S.); and the Department of Neurology, Haukeland University Hospital, Bergen, Norway (L.T.)., Sjöstrand C; From the Departments of Cardiology (L.S.) and Neurology (H.K.I.) Rigshospitalet, University of Copenhagen, Copenhagen, and the Departments of Neurology (G.A.) and Cardiology (J.E.N.-K.) and the Faculty of Health (G.A.), Aarhus University, Aarhus - both in Denmark; the Department of Neurology, University of Pennsylvania, Philadelphia (S.E.K.); the Department of Cardiology, Nicklaus Children's Hospital, Miami (J.F.R.); Heart and Vascular Theme (M.S.) and Department of Neurology (C.S.), Karolinska University Hospital, and Departments of Medicine (M.S.) and Clinical Neuroscience (C.S.), Karolinska Institutet - both in Stockholm; the Department of Clinical Neurosciences, Turku University Hospital and University of Turku, Turku, Finland (R.O.R.); the Department of Cardiology, Sussex Cardiac Centre, Brighton and Sussex University Hospitals, Brighton, United Kingdom (D.H.-S.); the Division of Neurology, Western University, London, ON, Canada (J.D.S.); and the Department of Neurology, Haukeland University Hospital, Bergen, Norway (L.T.)., Roine RO; From the Departments of Cardiology (L.S.) and Neurology (H.K.I.) Rigshospitalet, University of Copenhagen, Copenhagen, and the Departments of Neurology (G.A.) and Cardiology (J.E.N.-K.) and the Faculty of Health (G.A.), Aarhus University, Aarhus - both in Denmark; the Department of Neurology, University of Pennsylvania, Philadelphia (S.E.K.); the Department of Cardiology, Nicklaus Children's Hospital, Miami (J.F.R.); Heart and Vascular Theme (M.S.) and Department of Neurology (C.S.), Karolinska University Hospital, and Departments of Medicine (M.S.) and Clinical Neuroscience (C.S.), Karolinska Institutet - both in Stockholm; the Department of Clinical Neurosciences, Turku University Hospital and University of Turku, Turku, Finland (R.O.R.); the Department of Cardiology, Sussex Cardiac Centre, Brighton and Sussex University Hospitals, Brighton, United Kingdom (D.H.-S.); the Division of Neurology, Western University, London, ON, Canada (J.D.S.); and the Department of Neurology, Haukeland University Hospital, Bergen, Norway (L.T.)., Hildick-Smith D; From the Departments of Cardiology (L.S.) and Neurology (H.K.I.) Rigshospitalet, University of Copenhagen, Copenhagen, and the Departments of Neurology (G.A.) and Cardiology (J.E.N.-K.) and the Faculty of Health (G.A.), Aarhus University, Aarhus - both in Denmark; the Department of Neurology, University of Pennsylvania, Philadelphia (S.E.K.); the Department of Cardiology, Nicklaus Children's Hospital, Miami (J.F.R.); Heart and Vascular Theme (M.S.) and Department of Neurology (C.S.), Karolinska University Hospital, and Departments of Medicine (M.S.) and Clinical Neuroscience (C.S.), Karolinska Institutet - both in Stockholm; the Department of Clinical Neurosciences, Turku University Hospital and University of Turku, Turku, Finland (R.O.R.); the Department of Cardiology, Sussex Cardiac Centre, Brighton and Sussex University Hospitals, Brighton, United Kingdom (D.H.-S.); the Division of Neurology, Western University, London, ON, Canada (J.D.S.); and the Department of Neurology, Haukeland University Hospital, Bergen, Norway (L.T.)., Spence JD; From the Departments of Cardiology (L.S.) and Neurology (H.K.I.) Rigshospitalet, University of Copenhagen, Copenhagen, and the Departments of Neurology (G.A.) and Cardiology (J.E.N.-K.) and the Faculty of Health (G.A.), Aarhus University, Aarhus - both in Denmark; the Department of Neurology, University of Pennsylvania, Philadelphia (S.E.K.); the Department of Cardiology, Nicklaus Children's Hospital, Miami (J.F.R.); Heart and Vascular Theme (M.S.) and Department of Neurology (C.S.), Karolinska University Hospital, and Departments of Medicine (M.S.) and Clinical Neuroscience (C.S.), Karolinska Institutet - both in Stockholm; the Department of Clinical Neurosciences, Turku University Hospital and University of Turku, Turku, Finland (R.O.R.); the Department of Cardiology, Sussex Cardiac Centre, Brighton and Sussex University Hospitals, Brighton, United Kingdom (D.H.-S.); the Division of Neurology, Western University, London, ON, Canada (J.D.S.); and the Department of Neurology, Haukeland University Hospital, Bergen, Norway (L.T.)., Thomassen L; From the Departments of Cardiology (L.S.) and Neurology (H.K.I.) Rigshospitalet, University of Copenhagen, Copenhagen, and the Departments of Neurology (G.A.) and Cardiology (J.E.N.-K.) and the Faculty of Health (G.A.), Aarhus University, Aarhus - both in Denmark; the Department of Neurology, University of Pennsylvania, Philadelphia (S.E.K.); the Department of Cardiology, Nicklaus Children's Hospital, Miami (J.F.R.); Heart and Vascular Theme (M.S.) and Department of Neurology (C.S.), Karolinska University Hospital, and Departments of Medicine (M.S.) and Clinical Neuroscience (C.S.), Karolinska Institutet - both in Stockholm; the Department of Clinical Neurosciences, Turku University Hospital and University of Turku, Turku, Finland (R.O.R.); the Department of Cardiology, Sussex Cardiac Centre, Brighton and Sussex University Hospitals, Brighton, United Kingdom (D.H.-S.); the Division of Neurology, Western University, London, ON, Canada (J.D.S.); and the Department of Neurology, Haukeland University Hospital, Bergen, Norway (L.T.).

مؤلفون مشاركون: Gore REDUCE Clinical Study Investigators

المصدر: The New England journal of medicine [N Engl J Med] 2017 Sep 14; Vol. 377 (11), pp. 1033-1042.

نوع المنشور: Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Massachusetts Medical Society Country of Publication: United States NLM ID: 0255562 Publication Model: Print Cited Medium: Internet ISSN: 1533-4406 (Electronic) Linking ISSN: 00284793 NLM ISO Abbreviation: N Engl J Med Subsets: MEDLINE

مواضيع طبية MeSH: Septal Occluder Device*/adverse effects, Foramen Ovale, Patent/*drug therapy , Foramen Ovale, Patent/*therapy , Platelet Aggregation Inhibitors/*therapeutic use , Secondary Prevention/*methods , Stroke/*prevention & control, Adolescent ; Adult ; Atrial Fibrillation/etiology ; Combined Modality Therapy ; Female ; Follow-Up Studies ; Foramen Ovale, Patent/complications ; Humans ; Intention to Treat Analysis ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Platelet Aggregation Inhibitors/adverse effects ; Recurrence ; Single-Blind Method ; Stroke/epidemiology ; Stroke/etiology ; Young Adult