المؤلفون: Wang S; Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Biomedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029., Zhang Y; Division of Pharmaceutics & Pharmacology, College of Pharmacy, The Ohio State University, Columbus, OH 43210., Zhong Y; Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Biomedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029., Xue Y; Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Biomedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029., Liu Z; Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Biomedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029., Wang C; Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Biomedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029., Kang DD; Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Biomedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Division of Pharmaceutics & Pharmacology, College of Pharmacy, The Ohio State University, Columbus, OH 43210., Li H; Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Biomedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029., Hou X; Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Biomedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029., Tian M; Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Biomedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029., Cao D; Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Biomedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029., Wang L; Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Biomedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029., Guo K; Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Biomedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029., Deng B; Center for Electron Microscopy and Analysis, The Ohio State University, Columbus, OH 43210., McComb DW; Center for Electron Microscopy and Analysis, The Ohio State University, Columbus, OH 43210.; Department of Materials Science and Engineering, The Ohio State University, Columbus, OH 43210., Merad M; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Division of Hematology/Oncology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Center for Thoracic Oncology, Icahn School of Medicine at Mount Sinai, New York, NY 10029., Brown BD; Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029., Dong Y; Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Biomedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 May 28; Vol. 121 (22), pp. e2322935121. Date of Electronic Publication: 2024 May 21.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Wound Healing*/drug effects , Nanoparticles*/chemistry , RNA, Messenger*/genetics , RNA, Messenger*/metabolism , Reactive Oxygen Species*/metabolism, Animals ; Mice ; Macrophages/metabolism ; Macrophages/drug effects ; Interleukin-4/metabolism ; Diabetes Mellitus, Experimental ; Humans ; Lipids/chemistry ; Disease Models, Animal ; Male ; Liposomes

المؤلفون: Louzada RA; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Miami, Miller School of Medicine, Miami, FL 33136., Blandino-Rosano M; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Miami, Miller School of Medicine, Miami, FL 33136., Flores S; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Miami, Miller School of Medicine, Miami, FL 33136., Lubaczeuski C; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Miami, Miller School of Medicine, Miami, FL 33136., Cui T; Interdisciplinary Stem Cell Institute, Miller School of Medicine, University of Miami, Miami, FL 33136.; Endocrine, Polypeptide, and Cancer Institute, Veterans Affairs Medical Center, Miami, FL 33125.; South Florida Veterans Affairs Foundation for Research and Education, Miami, FL 33125., Sha W; Interdisciplinary Stem Cell Institute, Miller School of Medicine, University of Miami, Miami, FL 33136.; Endocrine, Polypeptide, and Cancer Institute, Veterans Affairs Medical Center, Miami, FL 33125.; South Florida Veterans Affairs Foundation for Research and Education, Miami, FL 33125., Cai R; Endocrine, Polypeptide, and Cancer Institute, Veterans Affairs Medical Center, Miami, FL 33125.; South Florida Veterans Affairs Foundation for Research and Education, Miami, FL 33125., Schally AV; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Miami, Miller School of Medicine, Miami, FL 33136.; Endocrine, Polypeptide, and Cancer Institute, Veterans Affairs Medical Center, Miami, FL 33125.; South Florida Veterans Affairs Foundation for Research and Education, Miami, FL 33125.; Department of Pathology, Miller School of Medicine, University of Miami, Miami, FL 33136.; Division of Hematology and Oncology, Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL 33136.; Veterans Affairs Medical Center, Miami, FL 33136., Bernal-Mizrachi E; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Miami, Miller School of Medicine, Miami, FL 33136.; Veterans Affairs Medical Center, Miami, FL 33136.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Jun 20; Vol. 120 (25), pp. e2209810120. Date of Electronic Publication: 2023 Jun 12.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Diabetes Mellitus, Type 1* , Diabetes Mellitus, Experimental* , Pancreatic Neoplasms*, Humans ; Animals ; Mice ; Streptozocin ; Cytokines ; Insulin

المؤلفون: Liang W; Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104.; Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, NC 27157., Huang L; Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, NC 27157.; Department of Ophthalmology, Fujian Medical University Union Hospital, Fuzhou 350000, China., Whelchel A; Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104., Yuan T; Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, NC 27157., Ma X; Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104.; Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, NC 27157., Cheng R; Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, NC 27157., Takahashi Y; Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, NC 27157., Karamichos D; Division of Research and Innovation, North Texas Eye Research Institute, University of North Texas Health Science Center, Fort Worth, TX 76107.; Department of Pharmaceutical Sciences, University of North Texas Health Science Center, Fort Worth, TX 76107.; Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107., Ma JX; Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, NC 27157.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Mar 28; Vol. 120 (13), pp. e2217576120. Date of Electronic Publication: 2023 Mar 21.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: PPAR alpha*/genetics , PPAR alpha*/metabolism , Diabetes Mellitus, Experimental*/genetics , Diabetes Mellitus, Experimental*/metabolism, Mice ; Humans ; Animals ; Cornea/metabolism ; Wound Healing/physiology ; Mice, Knockout ; Mitochondria/metabolism

المؤلفون: Wang MY; Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX 75390-8549.; Medical Service, Veterans Administration North Texas Health Care System, Dallas, TX 75216., Dean ED; Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, TN 37232.; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232., Quittner-Strom E; Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX 75390-8549.; Department of Nutrition and Integrative Physiology, University of Utah College of Health, Salt Lake City, UT 84112., Zhu Y; Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX 75390-8549.; Diabetes and Complications, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285.; Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030., Chowdhury KH; Department of Nutrition and Integrative Physiology, University of Utah College of Health, Salt Lake City, UT 84112., Zhang Z; Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX 75390-8549., Zhao S; Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX 75390-8549., Li N; Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX 75390-8549., Ye R; Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX 75390-8549., Lee Y; Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX 75390-8549.; Medical Service, Veterans Administration North Texas Health Care System, Dallas, TX 75216., Zhang Y; Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX 75390-8549., Chen S; Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX 75390-8549., Yu X; Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX 75390-8549.; Medical Service, Veterans Administration North Texas Health Care System, Dallas, TX 75216., Leonard DC; Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX 75390-8549., Poffenberger G; Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, TN 37232., Von Deylen A; Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, TN 37232., McCorkle SK; Medical Service, Veterans Administration North Texas Health Care System, Dallas, TX 75216., Schlegel A; Department of Nutrition and Integrative Physiology, University of Utah College of Health, Salt Lake City, UT 84112.; Division of Endocrinology, Metabolism, and Diabetes, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT 84112.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112., Sloop KW; Diabetes and Complications, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285., Efanov AM; Diabetes and Complications, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285., Gimeno RE; Diabetes and Complications, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285., Scherer PE; Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX 75390-8549., Powers AC; Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, TN 37232.; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232.; Veterans Administration, Tennessee Valley Healthcare System, Nashville, TN 37212., Unger RH; Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX 75390-8549.; Medical Service, Veterans Administration North Texas Health Care System, Dallas, TX 75216., Holland WL; Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX 75390-8549; will.holland@hsc.utah.edu.; Department of Nutrition and Integrative Physiology, University of Utah College of Health, Salt Lake City, UT 84112.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Mar 02; Vol. 118 (9).

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Antibodies, Monoclonal/*pharmacology , Diabetes Mellitus, Experimental/*therapy , Glucagon-Secreting Cells/*drug effects , Hypoglycemic Agents/*pharmacology , Insulin-Secreting Cells/*drug effects , Receptors, Glucagon/*antagonists & inhibitors, Animals ; Blood Glucose/metabolism ; C-Peptide/metabolism ; Cell Lineage/drug effects ; Cell Transdifferentiation/drug effects ; Diabetes Mellitus, Experimental/genetics ; Diabetes Mellitus, Experimental/immunology ; Diabetes Mellitus, Experimental/pathology ; Diabetes Mellitus, Type 1/genetics ; Diabetes Mellitus, Type 1/immunology ; Diabetes Mellitus, Type 1/pathology ; Diabetes Mellitus, Type 1/therapy ; Gene Expression ; Glucagon/antagonists & inhibitors ; Glucagon/metabolism ; Glucagon-Secreting Cells/metabolism ; Glucagon-Secreting Cells/pathology ; Humans ; Insulin/metabolism ; Insulin-Secreting Cells/metabolism ; Insulin-Secreting Cells/pathology ; Islets of Langerhans/metabolism ; Islets of Langerhans/physiology ; Islets of Langerhans Transplantation ; Mice ; Mice, Inbred NOD ; Organ Size/drug effects ; Receptors, Glucagon/genetics ; Receptors, Glucagon/metabolism ; Treatment Outcome

المؤلفون: Wang Z; Department of Bioengineering, University of California, Los Angeles, CA 90095.; California NanoSystems Institute, University of California, Los Angeles, CA 90095., Wang J; Department of Bioengineering, University of California, Los Angeles, CA 90095.; California NanoSystems Institute, University of California, Los Angeles, CA 90095.; College of Pharmaceutical Sciences, Zhejiang University, 310058 Hangzhou, China., Li H; Department of Bioengineering, University of California, Los Angeles, CA 90095.; California NanoSystems Institute, University of California, Los Angeles, CA 90095.; College of Pharmaceutical Sciences, Zhejiang University, 310058 Hangzhou, China., Yu J; Zenomics Inc., Los Angeles, CA 90095., Chen G; Department of Bioengineering, University of California, Los Angeles, CA 90095.; California NanoSystems Institute, University of California, Los Angeles, CA 90095., Kahkoska AR; Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599., Wu V; Department of Bioengineering, University of California, Los Angeles, CA 90095.; California NanoSystems Institute, University of California, Los Angeles, CA 90095., Zeng Y; Department of Bioengineering, University of California, Los Angeles, CA 90095.; California NanoSystems Institute, University of California, Los Angeles, CA 90095., Wen D; Department of Bioengineering, University of California, Los Angeles, CA 90095.; California NanoSystems Institute, University of California, Los Angeles, CA 90095., Miedema JR; Department of Dermatology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516.; Department of Pathology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516., Buse JB; Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599., Gu Z; Department of Bioengineering, University of California, Los Angeles, CA 90095; guzhen@zju.edu.cn.; California NanoSystems Institute, University of California, Los Angeles, CA 90095.; College of Pharmaceutical Sciences, Zhejiang University, 310058 Hangzhou, China.; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Nov 24; Vol. 117 (47), pp. 29512-29517. Date of Electronic Publication: 2020 Nov 11.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Diabetes Mellitus, Experimental/*drug therapy , Diabetes Mellitus, Type 1/*drug therapy , Drug Delivery Systems/*methods , Glucagon/*administration & dosage , Hypoglycemic Agents/*administration & dosage , Insulin/*administration & dosage, Animals ; Blood Glucose/analysis ; Blood Glucose/drug effects ; Blood Glucose/metabolism ; Delayed-Action Preparations/administration & dosage ; Delayed-Action Preparations/chemistry ; Delayed-Action Preparations/pharmacokinetics ; Diabetes Mellitus, Experimental/blood ; Diabetes Mellitus, Experimental/chemically induced ; Diabetes Mellitus, Experimental/diagnosis ; Diabetes Mellitus, Type 1/blood ; Diabetes Mellitus, Type 1/chemically induced ; Diabetes Mellitus, Type 1/diagnosis ; Drug Combinations ; Drug Compounding/methods ; Drug Liberation ; Drug Overdose/prevention & control ; Glucagon/chemistry ; Glucagon/pharmacokinetics ; Humans ; Hypoglycemic Agents/chemistry ; Hypoglycemic Agents/pharmacokinetics ; Insulin/chemistry ; Insulin/pharmacokinetics ; Male ; Mice ; Polymerization ; Solubility ; Streptozocin ; Transdermal Patch

المؤلفون: Hu H; Division of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine in St. Louis, St. Louis, MO 63110., Zakharov PN; Division of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine in St. Louis, St. Louis, MO 63110., Peterson OJ; Division of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine in St. Louis, St. Louis, MO 63110., Unanue ER; Division of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine in St. Louis, St. Louis, MO 63110 unanue@wustl.edu.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Dec 08; Vol. 117 (49), pp. 31319-31330. Date of Electronic Publication: 2020 Nov 23.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Symbiosis*, CD4-Positive T-Lymphocytes/*immunology , CD8-Positive T-Lymphocytes/*immunology , Diabetes Mellitus, Experimental/*immunology , Macrophages/*immunology , Programmed Cell Death 1 Receptor/*antagonists & inhibitors, Acute Disease ; Animals ; Cell Line, Tumor ; Diabetes Mellitus, Experimental/pathology ; Female ; Immune Checkpoint Inhibitors/pharmacology ; Insulin-Secreting Cells/pathology ; Macrophages/pathology ; Mice, Inbred NOD ; Programmed Cell Death 1 Receptor/metabolism

المؤلفون: Polina I; Department of Physiology and Biophysics, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada, B3H 4R2., Jansen HJ; Department of Physiology and Biophysics, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada, B3H 4R2.; Libin Cardiovascular Institute of Alberta, Department of Cardiac Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, T2N 4Z6.; Libin Cardiovascular Institute of Alberta, Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, T2N 4Z6., Li T; Department of Physiology and Biophysics, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada, B3H 4R2., Moghtadaei M; Department of Physiology and Biophysics, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada, B3H 4R2.; Libin Cardiovascular Institute of Alberta, Department of Cardiac Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, T2N 4Z6.; Libin Cardiovascular Institute of Alberta, Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, T2N 4Z6., Bohne LJ; Libin Cardiovascular Institute of Alberta, Department of Cardiac Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, T2N 4Z6.; Libin Cardiovascular Institute of Alberta, Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, T2N 4Z6., Liu Y; Libin Cardiovascular Institute of Alberta, Department of Cardiac Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, T2N 4Z6.; Libin Cardiovascular Institute of Alberta, Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, T2N 4Z6., Krishnaswamy P; Department of Physiology and Biophysics, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada, B3H 4R2., Egom EE; Department of Physiology and Biophysics, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada, B3H 4R2., Belke DD; Libin Cardiovascular Institute of Alberta, Department of Cardiac Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, T2N 4Z6.; Libin Cardiovascular Institute of Alberta, Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, T2N 4Z6., Rafferty SA; Department of Physiology and Biophysics, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada, B3H 4R2., Ezeani M; Department of Physiology and Biophysics, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada, B3H 4R2., Gillis AM; Libin Cardiovascular Institute of Alberta, Department of Cardiac Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, T2N 4Z6.; Libin Cardiovascular Institute of Alberta, Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, T2N 4Z6., Rose RA; Department of Physiology and Biophysics, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada, B3H 4R2; robert.rose@ucalgary.ca.; Libin Cardiovascular Institute of Alberta, Department of Cardiac Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, T2N 4Z6.; Libin Cardiovascular Institute of Alberta, Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, T2N 4Z6.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Apr 07; Vol. 117 (14), pp. 7990-8000. Date of Electronic Publication: 2020 Mar 20.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Atrial Fibrillation/*metabolism , Atrial Remodeling/*physiology , Diabetes Mellitus, Experimental/*complications , Diabetes Mellitus, Type 1/*complications , Insulin/*metabolism, Action Potentials/drug effects ; Action Potentials/physiology ; Animals ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/etiology ; Atrial Fibrillation/physiopathology ; Atrial Remodeling/immunology ; Cells, Cultured ; Diabetes Mellitus, Experimental/chemically induced ; Diabetes Mellitus, Experimental/metabolism ; Diabetes Mellitus, Type 1/genetics ; Diabetes Mellitus, Type 1/metabolism ; Disease Models, Animal ; Echocardiography ; Electrocardiography ; Heart Atria/cytology ; Heart Atria/metabolism ; Heart Atria/pathology ; Heart Atria/physiopathology ; Humans ; Insulin/administration & dosage ; Insulin/genetics ; Kv1.5 Potassium Channel/metabolism ; Male ; Mice ; Mice, Transgenic ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/pathology ; Myocytes, Cardiac/physiology ; NAV1.5 Voltage-Gated Sodium Channel/metabolism ; Patch-Clamp Techniques ; Potassium/metabolism ; Primary Cell Culture ; Sodium/metabolism ; Streptozocin/toxicity

المؤلفون: Yu J; The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, SE-171 76 Stockholm, Sweden; Jia.Yu@ki.se Shao-Nian.Yang@ki.se Per-Olof.Berggren@ki.se., Shi Y; The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, SE-171 76 Stockholm, Sweden., Zhao K; The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, SE-171 76 Stockholm, Sweden., Yang G; The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, SE-171 76 Stockholm, Sweden.; Institute of Pharmacology, Jilin Academy of Traditional Chinese Medicine, Changchun 130021, China., Yu L; The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, SE-171 76 Stockholm, Sweden., Li Y; National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, China., Andersson EM; Bioscience, Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, 431 38 Mölndal, Gothenburg, Sweden., Ämmälä C; Bioscience, Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, 431 38 Mölndal, Gothenburg, Sweden., Yang SN; The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, SE-171 76 Stockholm, Sweden; Jia.Yu@ki.se Shao-Nian.Yang@ki.se Per-Olof.Berggren@ki.se.; National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, China., Berggren PO; The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, SE-171 76 Stockholm, Sweden; Jia.Yu@ki.se Shao-Nian.Yang@ki.se Per-Olof.Berggren@ki.se.; Department of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu 610041, China.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Jan 07; Vol. 117 (1), pp. 448-453. Date of Electronic Publication: 2019 Dec 23.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Calcium Channels, T-Type/*metabolism , Diabetes Mellitus, Experimental/*metabolism , Insulin Secretion/*drug effects , Insulin-Secreting Cells/*metabolism , Nerve Tissue Proteins/*metabolism, Adolescent ; Adult ; Animals ; COS Cells ; Calcium Channel Blockers/pharmacology ; Calcium Channel Blockers/therapeutic use ; Calcium Channels, T-Type/genetics ; Cell Nucleus/metabolism ; Chlorocebus aethiops ; Cytosol/metabolism ; Diabetes Mellitus, Experimental/chemically induced ; Diabetes Mellitus, Experimental/drug therapy ; Exocytosis/drug effects ; Feasibility Studies ; Female ; Green Fluorescent Proteins/genetics ; HEK293 Cells ; Humans ; Insulin/metabolism ; Insulin-Secreting Cells/drug effects ; Insulin-Secreting Cells/transplantation ; Male ; Middle Aged ; Phosphorylation ; Primary Cell Culture ; Rats ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Streptozocin/toxicity ; Vesicular Transport Proteins/metabolism ; Young Adult

المؤلفون: Pozo M; Neuronal Control of Metabolism Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain., Milà-Guasch M; Neuronal Control of Metabolism Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain., Haddad-Tóvolli R; Neuronal Control of Metabolism Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain., Boudjadja MB; Faculty of Biology, Medicine and Health, School of Medical Sciences, University of Manchester, M13 9PT Manchester, United Kingdom., Chivite I; Neuronal Control of Metabolism Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain., Toledo M; Neuronal Control of Metabolism Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain., Gómez-Valadés AG; Neuronal Control of Metabolism Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain., Eyre E; Neuronal Control of Metabolism Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain., Ramírez S; Neuronal Control of Metabolism Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain., Obri A; Neuronal Control of Metabolism Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain., Ben-Ami Bartal I; School of Psychological Sciences, Tel-Aviv University, 6997801 Tel Aviv, Israel.; Sagol School of Neuroscience, Tel-Aviv University, 6997801 Tel Aviv, Israel., D'Agostino G; Faculty of Biology, Medicine and Health, School of Medical Sciences, University of Manchester, M13 9PT Manchester, United Kingdom., Costa-Font J; Department of Health Policy, London School of Economics and Political Science, WC2A 2AE London, United Kingdom., Claret M; Neuronal Control of Metabolism Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Spain.; School of Medicine, Universitat de Barcelona, 08036 Barcelona, Spain.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Apr 11; Vol. 120 (15), pp. e2218142120. Date of Electronic Publication: 2023 Apr 06.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Energy Metabolism* , Helping Behavior*, Animals ; Mice ; Blood Glucose/metabolism ; Adenosine Triphosphate/metabolism ; Adenosine Diphosphate/metabolism ; Prosencephalon/metabolism ; Hunger ; Glycated Hemoglobin/analysis ; Hypothalamus/metabolism ; Glycemic Control ; Mice, Inbred C57BL ; Male ; Humans ; Charities ; Diabetes Mellitus, Type 2/metabolism ; Diabetes Mellitus, Experimental/metabolism ; Streptozocin

المؤلفون: Wang X; Joint Center of Translational Precision Medicine, Guangzhou Institute of Pediatrics, Guangzhou Women and Children Medical Center, 510623 Guangzhou, China., Lu J; Department of Child Psychiatry, Kangning Hospital of Shenzhen, 518020 Shenzhen, People's Republic of China., Xie W; Institute of Rehabilitation Center, Tongren Hospital of Wuhan University, 430060 Wuhan, People's Republic of China., Lu X; Joint Center of Translational Precision Medicine, Guangzhou Institute of Pediatrics, Guangzhou Women and Children Medical Center, 510623 Guangzhou, China., Liang Y; Department of Child Psychiatry, Kangning Hospital of Shenzhen, 518020 Shenzhen, People's Republic of China., Li M; Institute of Rehabilitation Center, Tongren Hospital of Wuhan University, 430060 Wuhan, People's Republic of China., Wang Z; Department of Child Psychiatry, Kangning Hospital of Shenzhen, 518020 Shenzhen, People's Republic of China., Huang X; Institute of Rehabilitation Center, Tongren Hospital of Wuhan University, 430060 Wuhan, People's Republic of China., Tang M; Department of Pathology, Affiliated Hospital of Southwest Medical University, Luzhou, 646000 Sichuan, China., Pfaff DW; Joint Center of Translational Precision Medicine, Guangzhou Institute of Pediatrics, Guangzhou Women and Children Medical Center, 510623 Guangzhou, China; pfaff@rockefeller.edu yptang12@126.com vasilis112@yahoo.com.; Laboratory of Neurobiology and Behavior, The Rockefeller University, New York, NY 10065., Tang YP; Joint Center of Translational Precision Medicine, Guangzhou Institute of Pediatrics, Guangzhou Women and Children Medical Center, 510623 Guangzhou, China; pfaff@rockefeller.edu yptang12@126.com vasilis112@yahoo.com.; Department of Pathology, Affiliated Hospital of Southwest Medical University, Luzhou, 646000 Sichuan, China.; Department of Imaging, Affiliated Hospital 3, Zhengzhou University, 450052 Zhengzhou, China., Yao P; Joint Center of Translational Precision Medicine, Guangzhou Institute of Pediatrics, Guangzhou Women and Children Medical Center, 510623 Guangzhou, China; pfaff@rockefeller.edu yptang12@126.com vasilis112@yahoo.com.; Department of Child Psychiatry, Kangning Hospital of Shenzhen, 518020 Shenzhen, People's Republic of China.; Institute of Rehabilitation Center, Tongren Hospital of Wuhan University, 430060 Wuhan, People's Republic of China.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2019 Nov 19; Vol. 116 (47), pp. 23743-23752. Date of Electronic Publication: 2019 Nov 04.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Oxidative Stress*, Autistic Disorder/*etiology , Diabetes Mellitus, Experimental/*complications , Diabetes, Gestational/*metabolism , Hyperglycemia/*complications, Amygdala/enzymology ; Animals ; Autistic Disorder/metabolism ; Blood-Brain Barrier ; Diabetes Mellitus, Experimental/metabolism ; Early Growth Response Protein 1/metabolism ; Female ; Gene Knockdown Techniques ; Histones/metabolism ; Methylation ; Pregnancy ; Promoter Regions, Genetic ; Rats ; Reactive Oxygen Species/metabolism ; Resveratrol/administration & dosage ; Resveratrol/pharmacokinetics ; Superoxide Dismutase/genetics ; Superoxide Dismutase/metabolism