المؤلفون: Bellenguez C; Université de Lille, INSERM, CHU Lille, Institut Pasteur Lille, U1167-RID-AGE, Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France. celine.bellenguez@pasteur-lille.fr., Küçükali F; Complex Genetics of Alzheimer's Disease Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.; Laboratory of Neurogenetics, Institute Born - Bunge, Antwerp, Belgium.; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium., Jansen IE; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije University, Amsterdam, the Netherlands., Kleineidam L; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, Cologne, Germany.; German Center for Neurodegenerative Diseases (DZNE Bonn), Bonn, Germany., Moreno-Grau S; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Amin N; Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.; Nuffield Department of Population Health, Oxford University, Oxford, UK., Naj AC; Department of Biostatistics, Epidemiology, and Informatics, Penn Neurodegeneration Genomics Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Campos-Martin R; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, Cologne, Germany., Grenier-Boley B; Université de Lille, INSERM, CHU Lille, Institut Pasteur Lille, U1167-RID-AGE, Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France., Andrade V; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, Cologne, Germany., Holmans PA; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff, UK., Boland A; CEA, Centre National de Recherche en Génomique Humaine, Université Paris-Saclay, Evry, France., Damotte V; Université de Lille, INSERM, CHU Lille, Institut Pasteur Lille, U1167-RID-AGE, Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France., van der Lee SJ; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.; Section Genomics of Neurodegenerative Diseases and Aging, Department of Human Genetics Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands., Costa MR; Université de Lille, INSERM, CHU Lille, Institut Pasteur Lille, U1167-RID-AGE, Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France.; Brain Institute, Federal University of Rio Grande do Norte, Natal, Brazil., Kuulasmaa T; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland., Yang Q; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; Framingham Heart Study, Framingham, MA, USA., de Rojas I; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Yaqub A; Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands., Prokic I; Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands., Chapuis J; Université de Lille, INSERM, CHU Lille, Institut Pasteur Lille, U1167-RID-AGE, Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France., Ahmad S; Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.; LACDR, Leiden, the Netherlands., Giedraitis V; Department of Public Health and Carins Sciences/Geriatrics, Uppsala University, Uppsala, Sweden., Aarsland D; Centre of Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway.; Institute of Psychiatry, Psychology & Neuroscience, London, UK., Garcia-Gonzalez P; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Abdelnour C; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Alarcón-Martín E; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; Department of Surgery, Biochemistry and Molecular Biology, School of Medicine, University of Málaga, Málaga, Spain., Alcolea D; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Department of Neurology, II B Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain., Alegret M; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Alvarez I; Fundació Docència i Recerca MútuaTerrassa and Movement Disorders Unit, Department of Neurology, University Hospital MútuaTerrassa, Terrassa, Spain.; Memory Disorders Unit, Department of Neurology, Hospital Universitari Mutua de Terrassa, Terrassa, Spain., Álvarez V; Laboratorio de Genética, Hospital Universitario Central de Asturias, Oviedo, Spain.; Servicio de Neurología, Hospital Universitario Central de Asturias- Oviedo and Instituto de Investigación Biosanitaria del Principado de Asturias, Oviedo, Spain., Armstrong NJ; Centre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia., Tsolaki A; First Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.; Alzheimer Hellas, Thessaloniki, Greece., Antúnez C; Unidad de Demencias, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain., Appollonio I; School of Medicine and Surgery, University of Milano-Bicocca, Milano, Italy.; Neurology Unit, San Gerardo Hospital, Monza, Italy., Arcaro M; Fondazione IRCCS Ca'Granda, Ospedale Policlinico, Milan, Italy., Archetti S; Department of Laboratory Diagnostics, III Laboratory of Analysis, Brescia Hospital, Brescia, Italy., Pastor AA; Unitat Trastorns Cognitius, Hospital Universitari Santa Maria de Lleida, Lleida, Spain.; Institut de Recerca Biomedica de Lleida (IRBLLeida), Lleida, Spain., Arosio B; Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.; Geriatic Unit, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy., Athanasiu L; NORMENT Centre, University of Oslo, Oslo, Norway., Bailly H; EA 4468, Université de Paris, APHP, Hôpital Broca, Paris, France., Banaj N; Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy., Baquero M; Servei de Neurologia, Hospital Universitari i Politècnic La Fe, Valencia, Spain., Barral S; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.; Unit of Neurology, University of Parma and AOU, Parma, Italy.; Clinic of Neurology, UH 'Alexandrovska', Medical University - Sofia, Sofia, Bulgaria., Beiser A; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.; Boston University and the NHLBI's Framingham Heart Study, Boston, MA, USA., Pastor AB; CIEN Foundation/Queen Sofia Foundation Alzheimer Center, Madrid, Spain., Below JE; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA., Benchek P; Cleveland Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, USA.; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Benussi L; Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy., Berr C; Neuropsychiatry: Epidemiological and Clinical Research, PSNREC, Université de Montpellier, INSERM U1061, Montpellier, France., Besse C; CEA, Centre National de Recherche en Génomique Humaine, Université Paris-Saclay, Evry, France., Bessi V; Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.; Azienda Ospedaliero-Universitaria Careggi, Florence, Italy., Binetti G; Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.; MAC - Memory Clinic, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy., Bizarro A; Geriatrics Unit, Fondazione Policlinico A. Gemelli IRCCS, Rome, Italy., Blesa R; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Department of Neurology, II B Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain., Boada M; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Boerwinkle E; Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA., Borroni B; Centre for Neurodegenerative Disorders, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy., Boschi S; Department of Neuroscience 'Rita Levi Montalcini', University of Torino, Torino, Italy., Bossù P; Experimental Neuro-psychobiology Laboratory, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy., Bråthen G; Department of Neurology and Clinical Neurophysiology, University Hospital of Trondheim, Trondheim, Norway.; Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway., Bressler J; Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.; School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA., Bresner C; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff, UK., Brodaty H; Centre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia.; Dementia Centre for Research Collaboration, School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia., Brookes KJ; Biosciences, School of Science and Technology, Nottingham Trent University, Nottingham, UK., Brusco LI; Centro de Neuropsiquiatría y Neurología de la Conducta (CENECON), Facultad de Medicina, Universidad de Buenos Aires (UBA), C.A.B.A., Buenos Aires, Argentina.; Departamento Ciencias Fisiológicas UAII, Facultad de Medicina, UBA, C.A.B.A., Buenos Aires, Argentina.; Hospital Interzonal General de Agudos Eva Perón, San Martín, Buenos Aires, Argentina., Buiza-Rueda D; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Department of Neurology, Erasmus MC, Rotterdam, the Netherlands., Bûrger K; Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig Maximilians Universität (LMU), Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE, Munich), Munich, Germany., Burholt V; Faculty of Medical & Health Sciences, University of Auckland, Auckland, New Zealand.; Wales Centre for Ageing & Dementia Research, Swansea University, Wales, New Zealand., Bush WS; Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Calero M; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; CIEN Foundation/Queen Sofia Foundation Alzheimer Center, Madrid, Spain.; UFIEC, Instituto de Salud Carlos III, Madrid, Spain., Cantwell LB; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA., Chene G; INSERM, Bordeaux Population Health Research Center, UMR 1219, ISPED, CIC 1401-EC, Université de Bordeaux, Bordeaux, France.; Pole Santé Publique, CHU de Bordeaux, Bordeaux, France., Chung J; Medicine Biomedical Genetics Boston University School of Medicine, Boston, MA, USA., Cuccaro ML; Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL, USA., Carracedo Á; Grupo de Medicina Xenómica, Centro Nacional de Genotipado (CEGEN-PRB3-ISCIII), Universidade de Santiago de Compostela, Santiago de Compostela, Spain.; Fundación Pública Galega de Medicina Xenómica- CIBERER-IDIS, University of Santiago de Compostela, Santiago de Compostela, Spain., Cecchetti R; Institute of Gerontology and Geriatrics, Department of Medicine and Surgery, University of Perugia, Perugia, Italy., Cervera-Carles L; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Department of Neurology, II B Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain., Charbonnier C; Department of Genetics and CNR-MAJ, Normandie University, UNIROUEN, INSERM U1245, CHU Rouen, Rouen, France., Chen HH; Division of Genetic Medicine, Vanderbilt University, Nashville, TN, USA., Chillotti C; Unit of Clinical Pharmacology, University Hospital of Cagliari, Cagliari, Italy., Ciccone S; Geriatic Unit, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy., Claassen JAHR; Radboudumc Alzheimer Center, Department of Geriatrics, Radboud University Medical Center, Nijmegen, the Netherlands., Clark C; Institute for Regenerative Medicine, University of Zürich, Schlieren, Switzerland., Conti E; School of Medicine and Surgery, University of Milano-Bicocca, Milano, Italy., Corma-Gómez A; Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain., Costantini E; Department of Neuroscience, Catholic University of Sacred Heart, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Custodero C; University of Bari, 'A. Moro', Bary, Italy., Daian D; CEA, Centre National de Recherche en Génomique Humaine, Université Paris-Saclay, Evry, France., Dalmasso MC; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, Cologne, Germany., Daniele A; Department of Neuroscience, Catholic University of Sacred Heart, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Dardiotis E; School of Medicine, University of Thessaly, Larissa, Greece., Dartigues JF; Bordeaux Population Health Research Center, University Bordeaux, INSERM, Bordeaux, France., de Deyn PP; Department of Neurology, University Medical Center Groningen, Groningen, the Netherlands., de Paiva Lopes K; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences & Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Estelle and Daniel Maggin Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA., de Witte LD; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Debette S; Bordeaux Population Health Research Center, University Bordeaux, INSERM, Bordeaux, France., Deckert J; Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital, Wuerzburg, Germany., Del Ser T; CIEN Foundation/Queen Sofia Foundation Alzheimer Center, Madrid, Spain., Denning N; UKDRI@ Cardiff, School of Medicine, Cardiff University, Cardiff, UK., DeStefano A; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA., Dichgans M; Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig Maximilians Universität (LMU), Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Diehl-Schmid J; Klinikum rechts der Isar, Department of Psychiatry and Psychotherapy, Technical University of Munich, School of Medicine, Munich, Germany., Diez-Fairen M; Fundació Docència i Recerca MútuaTerrassa and Movement Disorders Unit, Department of Neurology, University Hospital MútuaTerrassa, Terrassa, Spain.; Memory Disorders Unit, Department of Neurology, Hospital Universitari Mutua de Terrassa, Terrassa, Spain., Rossi PD; Geriatic Unit, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy., Djurovic S; NORMENT Centre, University of Oslo, Oslo, Norway., Duron E; EA 4468, Université de Paris, APHP, Hôpital Broca, Paris, France., Düzel E; Institute of Cognitive Neurology and Dementia Research (IKND), Otto-Von-Guericke University, Magdeburg, Germany.; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany., Dufouil C; INSERM, Bordeaux Population Health Research Center, UMR 1219, ISPED, CIC 1401-EC, Université de Bordeaux, Bordeaux, France.; Pole Santé Publique, CHU de Bordeaux, Bordeaux, France., Eiriksdottir G; Icelandic Heart Association, Kopovagur, Iceland., Engelborghs S; Center for Neurosciences, Vrije Universiteit Brussel (VUB), Brussels, Belgium.; Reference Center for Biological Markers of Dementia (BIODEM), Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.; Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.; Department of Neurology, UZ Brussel, Brussels, Belgium., Escott-Price V; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; UKDRI@ Cardiff, School of Medicine, Cardiff University, Cardiff, UK., Espinosa A; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Ewers M; Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig Maximilians Universität (LMU), Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE, Munich), Munich, Germany., Faber KM; Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA., Fabrizio T; Fondazione IRCCS, Istituto Neurologico Carlo Besta, Milan, Italy., Nielsen SF; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Herlev, Denmark., Fardo DW; Sanders-Brown Center on Aging, Department of Biostatistics, University of Kentucky, Lexington, KY, USA., Farotti L; Centre for Memory Disturbances, Lab of Clinical Neurochemistry, Section of Neurology, University of Perugia, Perugia, Italy., Fenoglio C; University of Milan, Milan, Italy., Fernández-Fuertes M; Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain., Ferrari R; Laboratory of Neurogenetics, Department of Internal Medicine, Texas Tech University Health Science Center, Lubbock, TX, USA.; Reta Lila Weston Research Laboratories, Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK., Ferreira CB; Faculty of Medicine, University of Lisbon, Lisbon, Portugal., Ferri E; Geriatic Unit, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy., Fin B; CEA, Centre National de Recherche en Génomique Humaine, Université Paris-Saclay, Evry, France., Fischer P; Department of Psychiatry, Social Medicine Center East- Donauspital, Vienna, Austria., Fladby T; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Fließbach K; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, Cologne, Germany.; German Center for Neurodegenerative Diseases (DZNE Bonn), Bonn, Germany., Fongang B; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA., Fornage M; Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway.; School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA., Fortea J; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Department of Neurology, II B Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain., Foroud TM; Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA., Fostinelli S; Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy., Fox NC; Dementia Research Centre, UCL Queen Square Institute of Neurology, London, UK., Franco-Macías E; Unidad de Demencias, Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain., Bullido MJ; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Instituto de Investigacion Sanitaria 'Hospital la Paz' (IdIPaz), Madrid, Spain.; Centro de Biología Molecular Severo Ochoa (UAM-CSIC), Madrid, Spain., Frank-García A; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Instituto de Investigacion Sanitaria 'Hospital la Paz' (IdIPaz), Madrid, Spain.; Hospital Universitario la Paz, Madrid, Spain., Froelich L; Department of Geriatric Psychiatry, Central Institute for Mental Health, Mannheim, University of Heidelberg, Heidelberg, Germany., Fulton-Howard B; Department of Genetics and Genomic Sciences, Ronald M. Loeb Center for Alzheimer's Disease Icahn School of Medicine at Mount Sinai, New York, NY, USA., Galimberti D; Fondazione IRCCS Ca'Granda, Ospedale Policlinico, Milan, Italy.; University of Milan, Milan, Italy., García-Alberca JM; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Alzheimer Research Center & Memory Clinic, Andalusian Institute for Neuroscience, Málaga, Spain., García-González P; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain., Garcia-Madrona S; Hospital Universitario Ramon y Cajal, IRYCIS, Madrid, Spain., Garcia-Ribas G; Hospital Universitario Ramon y Cajal, IRYCIS, Madrid, Spain., Ghidoni R; Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy., Giegling I; Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria., Giorgio G; Fondazione IRCCS, Istituto Neurologico Carlo Besta, Milan, Italy., Goate AM; Department of Genetics and Genomic Sciences, Ronald M. Loeb Center for Alzheimer's Disease Icahn School of Medicine at Mount Sinai, New York, NY, USA., Goldhardt O; Klinikum rechts der Isar, Department of Psychiatry and Psychotherapy, Technical University of Munich, School of Medicine, Munich, Germany., Gomez-Fonseca D; Department of Biostatistics, Epidemiology, and Informatics Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., González-Pérez A; CAEBI, Centro Andaluz de Estudios Bioinformáticos, Sevilla, Spain., Graff C; Center for Alzheimer Research, Department NVS, Division of Neurogeriatrics, Karolinska Institutet, Stockholm, Sweden.; Unit for Hereditary Dementias, Karolinska University Hospital-Solna, Stockholm, Sweden., Grande G; Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden., Green E; Institute of Public Health, University of Cambridge, Cambridge, UK., Grimmer T; Klinikum rechts der Isar, Department of Psychiatry and Psychotherapy, Technical University of Munich, School of Medicine, Munich, Germany., Grünblatt E; Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich, Zurich, Switzerland.; Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland.; Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland., Grunin M; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Gudnason V; Icelandic Heart Association, Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Guetta-Baranes T; Human Genetics, School of Life Sciences, Life Sciences Building, University Park, University of Nottingham, Nottingham, UK., Haapasalo A; AI Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland., Hadjigeorgiou G; Department of Neurology, Medical School, University of Cyprus, Nicosia, Cyprus., Haines JL; Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Hamilton-Nelson KL; The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA., Hampel H; GRC 21, Alzheimer Precision Medicine Initiative (APMI), Sorbonne University, AP-HP, Pitié-Salpêtrière Hospital, Paris, France., Hanon O; EA 4468, Université de Paris, APHP, Hôpital Broca, Paris, France., Hardy J; Reta Lila Weston Research Laboratories, Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK., Hartmann AM; Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria., Hausner L; Department of Geriatric Psychiatry, Central Institute for Mental Health, Mannheim, University of Heidelberg, Heidelberg, Germany., Harwood J; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff, UK., Heilmann-Heimbach S; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany., Helisalmi S; Institute of Clinical Medicine, Neurology, University of Eastern, Kuopio, Finland.; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland., Heneka MT; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.; German Center for Neurodegenerative Diseases (DZNE Bonn), Bonn, Germany., Hernández I; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Herrmann MJ; Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital, Wuerzburg, Germany., Hoffmann P; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany., Holmes C; Clinical and Experimental Science, Faculty of Medicine, University of Southampton, Southampton, UK., Holstege H; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.; Section Genomics of Neurodegenerative Diseases and Aging, Department of Human Genetics Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands., Vilas RH; Unitat Trastorns Cognitius, Hospital Universitari Santa Maria de Lleida, Lleida, Spain.; Institut de Recerca Biomedica de Lleida (IRBLLeida), Lleida, Spain., Hulsman M; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.; Section Genomics of Neurodegenerative Diseases and Aging, Department of Human Genetics Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands., Humphrey J; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences & Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Estelle and Daniel Maggin Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience & Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Biessels GJ; Department of Neurology, UMC Utrecht Brain Center, Utrecht, the Netherlands., Jian X; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA., Johansson C; Center for Alzheimer Research, Department NVS, Division of Neurogeriatrics, Karolinska Institutet, Stockholm, Sweden., Jun GR; Medicine Biomedical Genetics Boston University School of Medicine, Boston, MA, USA., Kastumata Y; Biostatistics, University of Kentucky College of Public Health, Lexington, KY, USA., Kauwe J; Department of Biology, Brigham Young University, Provo, UT, USA., Kehoe PG; Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Kilander L; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Ståhlbom AK; Center for Alzheimer Research, Department NVS, Division of Neurogeriatrics, Karolinska Institutet, Stockholm, Sweden., Kivipelto M; Division of Clinical Geriatrics, Center for Alzheimer Research, Care Sciences and Society (NVS), Karolinska Institutet, Stockholm, Sweden.; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.; Neuroepidemiology and Ageing Research Unit, School of Public Health, Imperial College London, London, UK.; Research & Development, UnitStockholms Sjukhem, Stockholm, Sweden., Koivisto A; Institute of Clinical Medicine, Neurology, University of Eastern, Kuopio, Finland.; Department of Neurology, Kuopio University Hospital, Kuopio, Finland.; Department of Neurosciences, University of Helsinki and Department of Geriatrics, Helsinki University Hospital, Helsinki, Finland., Kornhuber J; Department of Psychiatry and Psychotherapy, Universitätsklinikum Erlangen, and Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany., Kosmidis MH; Laboratory of Cognitive Neuroscience, School of Psychology, Aristotle University of Thessaloniki, Thessaloniki, Greece., Kukull WA; Department of Epidemiology, University of Washington, Seattle, WA, USA., Kuksa PP; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Kunkle BW; Department of Neurology, Medical School, University of Cyprus, Nicosia, Cyprus., Kuzma AB; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA., Lage C; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Neurology Service, Marqués de Valdecilla University Hospital (University of Cantabria and IDIVAL), Santander, Spain., Laukka EJ; Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.; Stockholm Gerontology Research Center, Stockholm, Sweden., Launer L; Laboratory of Epidemiology, Demography, and Biometry, National Institute of Aging, The National Institutes of Health, Bethesda, MD, USA.; Intramural Research Program/National Institute on Aging/National Institutes of Health, Bethesda, MD, USA., Lauria A; Geriatrics Unit, Fondazione Policlinico A. Gemelli IRCCS, Rome, Italy., Lee CY; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Lehtisalo J; Institute of Clinical Medicine, Neurology, University of Eastern, Kuopio, Finland.; Public Health Promotion Unit, Finnish Institute for Health and Welfare, Helsinki, Finland., Lerch O; Memory Clinic, Department of Neurology, Charles University, 2nd Faculty of Medicine and Motol University Hospital, Praha, Czechia.; International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czechia., Lleó A; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Department of Neurology, II B Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain., Longstreth W Jr; Departments of Neurology and Epidemiology, University of Washington, Seattle, WA, USA., Lopez O; Framingham Heart Study, Framingham, MA, USA., de Munain AL; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Department of Neurology, Hospital Universitario Donostia, OSAKIDETZA-Servicio Vasco de Salud, San Sebastian, Spain., Love S; Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Löwemark M; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Luckcuck L; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff, UK., Lunetta KL; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland., Ma Y; Section Genomics of Neurodegenerative Diseases and Aging, Department of Human Genetics Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.; Department of Neurology, Columbia University, New York, NY, USA., Macías J; Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain., MacLeod CA; School of Health Sciences, Bangor University, Bangor, UK., Maier W; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.; German Center for Neurodegenerative Diseases (DZNE Bonn), Bonn, Germany., Mangialasche F; Division of Clinical Geriatrics, Center for Alzheimer Research, Care Sciences and Society (NVS), Karolinska Institutet, Stockholm, Sweden., Spallazzi M; Unit of Neurology, University of Parma and AOU, Parma, Italy., Marquié M; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Marshall R; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff, UK., Martin ER; The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA., Montes AM; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Instituto de Investigacion Sanitaria 'Hospital la Paz' (IdIPaz), Madrid, Spain.; Hospital Universitario la Paz, Madrid, Spain., Rodríguez CM; Servicio de Neurología, Hospital Universitario Central de Asturias- Oviedo and Instituto de Investigación Biosanitaria del Principado de Asturias, Oviedo, Spain., Masullo C; Institute of Neurology, Catholic University of the Sacred Heart, Rome, Italy., Mayeux R; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.; Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA., Mead S; MRC Prion Unit at UCL, UCL Institute of Prion Diseases, London, UK., Mecocci P; Institute of Gerontology and Geriatrics, Department of Medicine and Surgery, University of Perugia, Perugia, Italy., Medina M; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; CIEN Foundation/Queen Sofia Foundation Alzheimer Center, Madrid, Spain., Meggy A; UKDRI@ Cardiff, School of Medicine, Cardiff University, Cardiff, UK., Mehrabian S; Clinic of Neurology, UH 'Alexandrovska', Medical University - Sofia, Sofia, Bulgaria., Mendoza S; Alzheimer Research Center & Memory Clinic, Andalusian Institute for Neuroscience, Málaga, Spain., Menéndez-González M; Servicio de Neurología, Hospital Universitario Central de Asturias- Oviedo and Instituto de Investigación Biosanitaria del Principado de Asturias, Oviedo, Spain., Mir P; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain., Moebus S; Institute for Urban Public Health, University Hospital of University Duisburg-Essen, Essen, Germany., Mol M; Department of Neurology, Erasmus MC, Rotterdam, the Netherlands., Molina-Porcel L; Neurological Tissue Bank of the Biobanc-Hospital Clinic-IDIBAPS, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.; Alzheimer's Disease and Other Cognitive Disorders Unit, Neurology Department, Hospital Clinic, Barcelona, Spain., Montrreal L; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain., Morelli L; Laboratory of Brain Aging and Neurodegeneration, FIL-CONICET, Buenos Aires, Argentina., Moreno F; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Department of Neurology, Hospital Universitario Donostia, OSAKIDETZA-Servicio Vasco de Salud, San Sebastian, Spain., Morgan K; Human Genetics, School of Life Sciences, University of Nottingham, Nottingham, UK., Mosley T; Memory Impairment and Neurodegenerative Dementia (MIND) Center, University of Mississippi Medical Center, Jackson, MS, USA., Nöthen MM; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany., Muchnik C; Centro de Neuropsiquiatría y Neurología de la Conducta (CENECON), Facultad de Medicina, Universidad de Buenos Aires (UBA), C.A.B.A., Buenos Aires, Argentina.; Laboratorio de Bioquímica Molecular, Facultad de Medicina, Instituto de Investigaciones Médicas A. Lanari, UBA, C.A.B.A, Buenos Aires, Argentina., Mukherjee S; Department of Medicine, University of Washington, Seattle, WA, USA., Nacmias B; Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.; IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy., Ngandu T; Public Health Promotion Unit, Finnish Institute for Health and Welfare, Helsinki, Finland., Nicolas G; Department of Genetics and CNR-MAJ, Normandie University, UNIROUEN, INSERM U1245, CHU Rouen, Rouen, France., Nordestgaard BG; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Herlev, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Olaso R; CEA, Centre National de Recherche en Génomique Humaine, Université Paris-Saclay, Evry, France., Orellana A; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Orsini M; Department of Neuroscience, Catholic University of Sacred Heart, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Ortega G; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Padovani A; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA., Paolo C; DIMEC, University of Parma, Parma, Italy., Papenberg G; Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden., Parnetti L; Centre for Memory Disturbances, Lab of Clinical Neurochemistry, Section of Neurology, University of Perugia, Perugia, Italy., Pasquier F; Resources and Research Memory Center (MRRC) of Distalz, LicendUniversity of Lille, INSERM, CHU Lille, UMR1172, Lille, France., Pastor P; Fundació Docència i Recerca MútuaTerrassa and Movement Disorders Unit, Department of Neurology, University Hospital MútuaTerrassa, Terrassa, Spain.; Memory Disorders Unit, Department of Neurology, Hospital Universitari Mutua de Terrassa, Terrassa, Spain., Peloso G; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.; Boston University and the NHLBI's Framingham Heart Study, Boston, MA, USA., Pérez-Cordón A; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain., Pérez-Tur J; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Institut de Biomedicina de València-CSIC CIBERNED, València, Spain.; Unitat Mixta de de Neurología y Genética, Institut d'Investigació Sanitària La Fe, València, Spain., Pericard P; US 41-UMS 2014-PLBS, bilille, Université de Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, Lille, France., Peters O; Institute of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health, Berlin, Germany.; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany., Pijnenburg YAL; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands., Pineda JA; Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain., Piñol-Ripoll G; Unitat Trastorns Cognitius, Hospital Universitari Santa Maria de Lleida, Lleida, Spain.; Institut de Recerca Biomedica de Lleida (IRBLLeida), Lleida, Spain., Pisanu C; Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy., Polak T; Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital, Wuerzburg, Germany., Popp J; CHUV, Old Age Psychiatry, Department of Psychiatry, Lausanne, Switzerland.; Old Age Psychiatry, Department of Psychiatry, Lausanne University Hospital, Lausanne, Switzerland.; Department of Geriatric Psychiatry, University Hospital of Psychiatry Zürich, Zürich, Switzerland., Posthuma D; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije University, Amsterdam, the Netherlands., Priller J; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Department of Neuropsychiatry and Laboratory of Molecular Psychiatry, Charité, Charitéplatz 1, Berlin, Germany., Puerta R; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain., Quenez O; Department of Genetics and CNR-MAJ, Normandie University, UNIROUEN, INSERM U1245, CHU Rouen, Rouen, France., Quintela I; Grupo de Medicina Xenómica, Centro Nacional de Genotipado (CEGEN-PRB3-ISCIII), Universidade de Santiago de Compostela, Santiago de Compostela, Spain., Thomassen JQ; Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark., Rábano A; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; CIEN Foundation/Queen Sofia Foundation Alzheimer Center, Madrid, Spain., Rainero I; Centre for Neurodegenerative Disorders, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy., Rajabli F; The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA., Ramakers I; Department of Psychiatry & Neuropsychologie, Maastricht University, Alzheimer Center Limburg, Maastricht, the Netherlands., Real LM; Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain.; Depatamento de Especialidades Quirúrgicas Bioquímica e Inmunología, Facultad de Medicina, Universidad de Málaga, Málaga, Spain., Reinders MJT; Delft Bioinformatics Lab, Delft University of Technology, Delft, the Netherlands., Reitz C; Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA.; Delft Bioinformatics Lab, Delft University of Technology, Delft, the Netherlands.; Taub Institute, Columbia University, New York, NY, USA., Reyes-Dumeyer D; Department of Neurology, Columbia University, New York, NY, USA.; Taub Institute, Columbia University, New York, NY, USA., Ridge P; Bioinformatics, College of Life Sciences, Brigham Young University, Provo, UT, USA., Riedel-Heller S; Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Leipzig, Germany., Riederer P; Center of Mental Health, Clinic and Policlinic of Psychiatry, Psychosomatics and Psychotherapy, University Hospital of Würzburg, Wuerzburg, Germany., Roberto N; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain., Rodriguez-Rodriguez E; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Neurology Service, Marqués de Valdecilla University Hospital (University of Cantabria and IDIVAL), Santander, Spain., Rongve A; Department of Research and Innovation, Helse Fonna, Haugesund Hospital, Haugesund, Norway.; Institute of Clinical Medicine (K1), The University of Bergen, Bergen, Norway., Allende IR; Laboratorio de Genética, Hospital Universitario Central de Asturias, Oviedo, Spain.; Servicio de Neurología, Hospital Universitario Central de Asturias- Oviedo and Instituto de Investigación Biosanitaria del Principado de Asturias, Oviedo, Spain., Rosende-Roca M; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Royo JL; Departamento de Especialidades Quirúrgicas, Bioquímicas e Inmunología, School of Medicine, University of Málaga, Málaga, Spain., Rubino E; Department of Neuroscience and Mental Health, AOU Città della Salute e della Scienza di Torino, Torino, Italy., Rujescu D; Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria., Sáez ME; CAEBI, Centro Andaluz de Estudios Bioinformáticos, Sevilla, Spain., Sakka P; Athens Association of Alzheimer's Disease and Related Disorders, Athens, Greece., Saltvedt I; Department of Neurology and Clinical Neurophysiology, University Hospital of Trondheim, Trondheim, Norway.; Department of Geriatrics, St. Olav's Hospital, Trondheim University Hospital, Trondheim, Norway., Sanabria Á; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Sánchez-Arjona MB; Unidad de Demencias, Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain., Sanchez-Garcia F; Department of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Las Palmas, Spain., Juan PS; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Neurology Service, Marqués de Valdecilla University Hospital (University of Cantabria and IDIVAL), Santander, Spain., Sánchez-Valle R; Neurology Department-Hospital Clínic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain., Sando SB; Experimental Neuro-psychobiology Laboratory, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy.; Department of Neurology and Clinical Neurophysiology, University Hospital of Trondheim, Trondheim, Norway., Sarnowski C; Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA., Satizabal CL; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA., Scamosci M; Institute of Gerontology and Geriatrics, Department of Medicine and Surgery, University of Perugia, Perugia, Italy., Scarmeas N; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.; First Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece., Scarpini E; Fondazione IRCCS Ca'Granda, Ospedale Policlinico, Milan, Italy.; University of Milan, Milan, Italy., Scheltens P; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands., Scherbaum N; LVR-Hospital Essen, Department of Psychiatry and Psychotherapy, Medical Faculty, University of Duisburg-Essen, Essen, Germany., Scherer M; Department of Primary Medical Care, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany., Schmid M; German Center for Neurodegenerative Diseases (DZNE Bonn), Bonn, Germany.; Institute of Medical Biometry, Informatics and Epidemiology, University Hospital of Bonn, Bonn, Germany., Schneider A; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.; German Center for Neurodegenerative Diseases (DZNE Bonn), Bonn, Germany., Schott JM; Dementia Research Centre, UCL Queen Square Institute of Neurology, London, UK., Selbæk G; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Geriatric Medicine, Oslo University Hospital, Oslo, Norway., Seripa D; Laboratory for Advanced Hematological Diagnostics, Department of Hematology and Stem Cell Transplant, Vito Fazzi Hospital, Lecce, Italy., Serrano M; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas, CIBERDEM, Hospital Clínico San Carlos, Madrid, Spain., Sha J; Department of Biostatistics, Epidemiology, and Informatics, Penn Neurodegeneration Genomics Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Shadrin AA; NORMENT Centre, University of Oslo, Oslo, Norway., Skrobot O; Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Slifer S; The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA., Snijders GJL; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Soininen H; Institute of Clinical Medicine, Neurology, University of Eastern, Kuopio, Finland., Solfrizzi V; University of Bari, 'A. Moro', Bary, Italy., Solomon A; Institute of Clinical Medicine, Neurology, University of Eastern, Kuopio, Finland.; Division of Clinical Geriatrics, Center for Alzheimer Research, Care Sciences and Society (NVS), Karolinska Institutet, Stockholm, Sweden., Song Y; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Sorbi S; Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.; IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy., Sotolongo-Grau O; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain., Spalletta G; Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy., Spottke A; German Center for Neurodegenerative Diseases (DZNE Bonn), Bonn, Germany.; Department of Neurology, University of Bonn, Bonn, Germany., Squassina A; Department of Biomedical Sciences, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, Cagliari, Italy., Stordal E; Department of Psychiatry, Namsos Hospital, Namsos, Norway., Tartan JP; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain., Tárraga L; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Tesí N; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.; Section Genomics of Neurodegenerative Diseases and Aging, Department of Human Genetics Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands., Thalamuthu A; Centre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia., Thomas T; First Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.; Alzheimer Hellas, Thessaloniki, Greece., Tosto G; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.; Department of Neurology, Columbia University, New York, NY, USA., Traykov L; Clinic of Neurology, UH 'Alexandrovska', Medical University - Sofia, Sofia, Bulgaria., Tremolizzo L; School of Medicine and Surgery, University of Milano-Bicocca, Milano, Italy.; Neurology Unit, San Gerardo Hospital, Monza, Italy., Tybjærg-Hansen A; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark., Uitterlinden A; Department of Internal Medicine and Biostatistics, Erasmus MC, Rotterdam, the Netherlands., Ullgren A; Center for Alzheimer Research, Department NVS, Division of Neurogeriatrics, Karolinska Institutet, Stockholm, Sweden., Ulstein I; Department of Geriatric Medicine, Oslo University Hospital, Oslo, Norway., Valero S; Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Valladares O; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Broeckhoven CV; Complex Genetics of Alzheimer's Disease Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.; Laboratory of Neurogenetics, Institute Born - Bunge, Antwerp, Belgium.; Neurodegenerative Brain Diseases Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium., Vance J; Dr. John T. 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Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences & Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Estelle and Daniel Maggin Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience & Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Sachdev P; Centre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia., Mather K; Centre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia., Jessen F; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.; German Center for Neurodegenerative Diseases (DZNE Bonn), Bonn, Germany., Ikram MA; Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands., de Mendonça A; Faculty of Medicine, University of Lisbon, Lisbon, Portugal., Hort J; Intramural Research Program/National Institute on Aging/National Institutes of Health, Bethesda, MD, USA.; Memory Clinic, Department of Neurology, Charles University, 2nd Faculty of Medicine and Motol University Hospital, Praha, Czechia., Tsolaki M; First Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.; Alzheimer Hellas, Thessaloniki, Greece., Pericak-Vance MA; AI Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland., Amouyel P; Université de Lille, INSERM, CHU Lille, Institut Pasteur Lille, U1167-RID-AGE, Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France., Williams J; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff, UK.; 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Université de Lille, INSERM, CHU Lille, Institut Pasteur Lille, U1167-RID-AGE, Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France. Jean-Charles.Lambert@pasteur-lille.fr.

مؤلفون مشاركون: EADB, GR@ACE, DEGESCO, EADI, GERAD, Demgene, FinnGen, ADGC, CHARGE

المصدر: Nature genetics [Nat Genet] 2022 Apr; Vol. 54 (4), pp. 412-436. Date of Electronic Publication: 2022 Apr 04.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE

مواضيع طبية MeSH: Alzheimer Disease*/genetics , Alzheimer Disease*/pathology , Cognitive Dysfunction*/psychology, Genome-Wide Association Study ; Humans ; tau Proteins/genetics

المؤلفون: Kunkle BW; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA. bkunkle@miami.edu., Grenier-Boley B; Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.; Institut Pasteur de Lille, Lille, France.; Univ. Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France., Sims R; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.; UK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, UK., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Damotte V; Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.; Institut Pasteur de Lille, Lille, France.; Univ. Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France., Naj AC; Department of Biostatistics and Epidemiology/Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Boland A; Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France., Vronskaya M; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., van der Lee SJ; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Amlie-Wolf A; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Bellenguez C; Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.; Institut Pasteur de Lille, Lille, France.; Univ. Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France., Frizatti A; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Chouraki V; Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.; Institut Pasteur de Lille, Lille, France.; Univ. Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France.; Framingham Heart Study, Framingham, MA, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA., Martin ER; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Sleegers K; Neurodegenerative Brain Diseases Group, Center for Molecular Neurology, VIB, Antwerp, Belgium.; Laboratory for Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium., Badarinarayan N; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Jakobsdottir J; Icelandic Heart Association, Kopavogur, Iceland., Hamilton-Nelson KL; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Moreno-Grau S; Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain., Olaso R; Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France., Raybould R; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.; UK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, UK., Chen Y; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Kuzma AB; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Hiltunen M; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.; Department of Neurology, Kuopio University Hospital, Kuopio, Finland., Morgan T; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Ahmad S; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Vardarajan BN; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.; Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA.; Department of Neurology, Columbia University, New York, NY, USA., Epelbaum J; UMR 894, Center for Psychiatry and Neuroscience, Inserm, Université Paris Descartes, Paris, France., Hoffmann P; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.; Division of Medical Genetics, University Hospital and Department of Biomedicine, University of Basel, Basel, Switzerland., Boada M; Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain., Beecham GW; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Garnier JG; Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France., Harold D; School of Biotechnology, Dublin City University, Dublin, Ireland., Fitzpatrick AL; Department of Family Medicine, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA., Valladares O; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Moutet ML; Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France., Gerrish A; Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK., Smith AV; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Qu L; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Bacq D; Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France., Denning N; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.; UK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, UK., Jian X; Brown Foundation Institute of Molecular Medicine, University of Texas Health Sciences Center at Houston, Houston, TX, USA., Zhao Y; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Del Zompo M; Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy., Fox NC; Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.; UK Dementia Research Institute at UCL, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK., Choi SH; Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain., Mateo I; Neurology Service and CIBERNED, 'Marqués de Valdecilla' University Hospital (University of Cantabria and IDIVAL), Santander, Spain., Hughes JT; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Adams HH; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Malamon J; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Sanchez-Garcia F; Department of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain., Patel Y; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Brody JA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Dombroski BA; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Naranjo MCD; Department of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain., Daniilidou M; Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece., Eiriksdottir G; Icelandic Heart Association, Kopavogur, Iceland., Mukherjee S; Department of Medicine, University of Washington, Seattle, WA, USA., Wallon D; Normandie University, UNIROUEN, Inserm U1245, and Rouen University Hospital, Department of Neurology, Department of Genetics and CNR-MAJ, Normandy Center for Genomic and Personalized Medicine, Rouen, France., Uphill J; Department of Neurodegenerative Disease, MRC Prion Unit at UCL, Institute of Prion Diseases, London, UK., Aspelund T; Icelandic Heart Association, Kopavogur, Iceland.; Centre for Public Health, University of Iceland, Reykjavik, Iceland., Cantwell LB; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Garzia F; Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France., Galimberti D; Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Neurodegenerative Diseases Unit, Milan, Italy.; University of Milan, Centro Dino Ferrari, Milan, Italy., Hofer E; Clinical Division of Neurogeriatrics, Department of Neurology, Medical University Graz, Graz, Austria.; Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria., Butkiewicz M; Institute for Computational Biology, Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Fin B; Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France., Scarpini E; Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Neurodegenerative Diseases Unit, Milan, Italy.; University of Milan, Centro Dino Ferrari, Milan, Italy., Sarnowski C; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Bush WS; Institute for Computational Biology, Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Meslage S; Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France., Kornhuber J; Department of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Erlangen, Germany., White CC; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA., Song Y; Institute for Computational Biology, Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Barber RC; Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA., Engelborghs S; Laboratory for Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.; Department of Neurology and Memory Clinic, Hospital Network Antwerp, Antwerp, Belgium., Sordon S; Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany., Voijnovic D; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Adams PM; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA., Vandenberghe R; Laboratory for Cognitive Neurology, Department of Neurology, University Hospital and University of Leuven, Leuven, Belgium., Mayhaus M; Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany., Cupples LA; Framingham Heart Study, Framingham, MA, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Albert MS; Department of Neurology, Johns Hopkins University, Baltimore, MD, USA., De Deyn PP; Laboratory for Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.; Department of Neurology and Memory Clinic, Hospital Network Antwerp, Antwerp, Belgium., Gu W; Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany., Himali JJ; Framingham Heart Study, Framingham, MA, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Beekly D; National Alzheimer's Coordinating Center, University of Washington, Seattle, WA, USA., Squassina A; Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy., Hartmann AM; Department of Psychiatry, Martin Luther University Halle-Wittenberg, Halle, Germany., Orellana A; Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain., Blacker D; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.; Department of Psychiatry, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA., Rodriguez-Rodriguez E; Neurology Service and CIBERNED, 'Marqués de Valdecilla' University Hospital (University of Cantabria and IDIVAL), Santander, Spain., Lovestone S; Department of Psychiatry, University of Oxford, Oxford, UK., Garcia ME; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD, USA., Doody RS; Alzheimer's Disease and Memory Disorders Center, Baylor College of Medicine, Houston, TX, USA., Munoz-Fernadez C; Department of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain., Sussams R; Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, UK., Lin H; Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA., Fairchild TJ; Office of Strategy and Measurement, University of North Texas Health Science Center, Fort Worth, TX, USA., Benito YA; Department of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain., Holmes C; Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, UK., Karamujić-Čomić H; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Frosch MP; C.S. Kubik Laboratory for Neuropathology, Massachusetts General Hospital, Charlestown, MA, USA., Thonberg H; Theme Aging, Unit for Hereditary Dementias, Karolinska University Hospital-Solna, Stockholm, Sweden.; Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Alzheimer Research Center, Division of Neurogeriatrics, Solna, Sweden., Maier W; German Center for Neurodegenerative Diseases, Bonn, Germany.; Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany., Roshchupkin G; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Ghetti B; Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, IN, USA., Giedraitis V; Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden., Kawalia A; Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany., Li S; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Huebinger RM; Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA., Kilander L; Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden., Moebus S; Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany., Hernández I; Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain., Kamboh MI; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA.; Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA, USA., Brundin R; Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden., Turton J; Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK., Yang Q; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Katz MJ; Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA., Concari L; Section of Neuroscience, DIMEC-University of Parma, Parma, Italy.; FERB-Alzheimer Center, Gazzaniga (Bergamo), Italy., Lord J; Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK., Beiser AS; Framingham Heart Study, Framingham, MA, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Keene CD; Department of Pathology, University of Washington, Seattle, WA, USA., Helisalmi S; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.; Department of Neurology, Kuopio University Hospital, Kuopio, Finland., Kloszewska I; Elderly and Psychiatric Disorders Department, Medical University of Lodz, Lodz, Poland., Kukull WA; Department of Epidemiology, University of Washington, Seattle, WA, USA., Koivisto AM; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.; Department of Neurology, Kuopio University Hospital, Kuopio, Finland., Lynch A; Mercer's Institute for Research on Aging, St. James's Hospital and Trinity College, Dublin, Ireland.; St. James's Hospital and Trinity College, Dublin, Ireland., Tarraga L; Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain., Larson EB; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA., Haapasalo A; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland., Lawlor B; Mercer's Institute for Research on Aging, St. James's Hospital and Trinity College, Dublin, Ireland.; St. James's Hospital and Trinity College, Dublin, Ireland., Mosley TH; Departments of Medicine, Geriatrics, Gerontology and Neurology, University of Mississippi Medical Center, Jackson, MS, USA., Lipton RB; Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA., Solfrizzi V; Interdisciplinary Department of Medicine, Geriatric Medicine and Memory Unity, University of Bari, Bari, Italy., Gill M; Mercer's Institute for Research on Aging, St. James's Hospital and Trinity College, Dublin, Ireland.; St. James's Hospital and Trinity College, Dublin, Ireland., Longstreth WT Jr; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Neurology, University of Washington, Seattle, WA, USA., Montine TJ; Department of Pathology, University of Washington, Seattle, WA, USA., Frisardi V; Department of Geriatrics, Center for Aging Brain, University of Bari, Bari, Italy., Diez-Fairen M; Fundació per la Recerca Biomèdica i Social Mútua Terrassa, Terrassa, Barcelona, Spain.; Memory Disorders Unit, Department of Neurology, Hospital Universitari Mutua de Terrassa, Terrassa, Barcelona, Spain., Rivadeneira F; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Department of Internal Medicine, Erasmus University Medical Center, Rotterdamt, the Netherlands.; Netherlands Consortium on Health Aging and National Genomics Initiative, Leiden, the Netherlands., Petersen RC; Department of Neurology, Mayo Clinic, Rochester, MN, USA., Deramecourt V; CHU Lille, Memory Center of Lille (Centre Mémoire de Ressources et de Recherche), Lille, France., Alvarez I; Fundació per la Recerca Biomèdica i Social Mútua Terrassa, Terrassa, Barcelona, Spain.; Memory Disorders Unit, Department of Neurology, Hospital Universitari Mutua de Terrassa, Terrassa, Barcelona, Spain., Salani F; Department of Clinical and Behavioral Neurology, Experimental Neuropsychobiology Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy., Ciaramella A; Department of Clinical and Behavioral Neurology, Experimental Neuropsychobiology Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy., Boerwinkle E; School of Public Health, Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA., Reiman EM; Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, USA.; Arizona Alzheimer's Consortium, Phoenix, AZ, USA.; Banner Alzheimer's Institute, Phoenix, AZ, USA.; Department of Psychiatry, University of Arizona, Phoenix, AZ, USA., Fievet N; Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.; Institut Pasteur de Lille, Lille, France.; Univ. Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France., Rotter JI; Institute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA., Reisch JS; Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA., Hanon O; University Paris Descartes, EA 4468, AP-HP, Geriatrics Department, Hôpital Broca, Paris, France., Cupidi C; Regional Neurogenetic Centre (CRN), ASP Catanzaro, Lamezia Terme, Italy., Uitterlinden AGA; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Department of Internal Medicine, Erasmus University Medical Center, Rotterdamt, the Netherlands.; Netherlands Consortium on Health Aging and National Genomics Initiative, Leiden, the Netherlands., Royall DR; Departments of Psychiatry, Medicine, Family & Community Medicine, South Texas Veterans Health Administration Geriatric Research Education & Clinical Center (GRECC), UT Health Science Center at San Antonio, San Antonio, TX, USA., Dufouil C; University of Bordeaux, Inserm 1219, Bordeaux, France.; Department of Neurology, Bordeaux University Hospital / CHU de Bordeaux, Bordeaux, France., Maletta RG; Regional Neurogenetic Centre (CRN), ASP Catanzaro, Lamezia Terme, Italy., de Rojas I; Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain., Sano M; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Brice A; Inserm U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Université Paris 06, UMRS 1127, Institut du Cerveau et de la Moelle Épinière, Paris, France.; AP-HP, Department of Genetics, Pitié-Salpêtrière Hospital, Paris, France., Cecchetti R; Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy., George-Hyslop PS; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.; Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada., Ritchie K; Inserm U1061 Neuropsychiatry, La Colombière Hospital, Montpellier, France.; Montpellier University, Montpellier, France.; Department of Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK., Tsolaki M; Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece., Tsuang DW; VA Puget Sound Health Care System/>GRECC, Seattle, WA, USA.; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA., Dubois B; Institut de la Mémoire et de la Maladie d'Alzheimer and Institut du Cerveau et de la Moelle Épinière, Département de Neurologie, Hôpital de la Pitié-Salpêtrière, Paris, France.; Institut des Neurosciences Translationnelles de Paris, Institut du Cerveau et de la Moelle Épinière, Paris, France.; Inserm, CNRS, UMR-S975, Institut du Cerveau et de la Moelle Epinière, Paris, France.; Sorbonne Universités, Université Pierre et Marie Curie, Hôpital de la Pitié-Salpêtrière, AP-HP, Paris, France., Craig D; Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK., Wu CK; Departments of Neurology, Pharmacology & Neuroscience, Texas Tech University Health Science Center, Lubbock, TX, USA., Soininen H; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.; Department of Neurology, Kuopio University Hospital, Kuopio, Finland., Avramidou D; Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece., Albin RL; Department of Neurology, University of Michigan, Ann Arbor, MI, USA.; Geriatric Research, Education and Clinical Center (GRECC), VA Ann Arbor Healthcare System (VAAAHS), Ann Arbor, MI, USA.; Michigan Alzheimer Disease Center, Ann Arbor, MI, USA., Fratiglioni L; Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden., Germanou A; Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece., Apostolova LG; Indiana Alzheimer's Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA.; Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA.; Department of Neurology, Indiana University, Indianapolis, IN, USA.; Department of Radiology and Imaging Sciences, Indiana University, Indianapolis, IN, USA., Keller L; Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden., Koutroumani M; Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece., Arnold SE; Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Panza F; Department of Geriatrics, Center for Aging Brain, University of Bari, Bari, Italy., Gkatzima O; Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece., Asthana S; Geriatric Research, Education and Clinical Center (GRECC), University of Wisconsin, Madison, WI, USA.; Department of Medicine, University of Wisconsin, Madison, WI, USA.; Wisconsin Alzheimer's Disease Research Center, Madison, WI, USA., Hannequin D; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Whitehead P; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Atwood CS; Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA.; Department of Neurology, Indiana University, Indianapolis, IN, USA.; Department of Radiology and Imaging Sciences, Indiana University, Indianapolis, IN, USA., Caffarra P; Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA, USA.; Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK., Hampel H; AXA Research Fund & Sorbonne University Chair, Paris, France.; Sorbonne University, GRC n° 21, Alzheimer Precision Medicine (APM), AP-HP, Pitié-Salpêtrière Hospital, Paris, France.; Brain & Spine Institute, Inserm U 1127, CNRS UMR 7225, Paris, France.; Institute of Memory and Alzheimer's Disease, Department of Neurology, Pitié-Salpêtrière Hospital, AP-HP, Paris, France., Quintela I; Grupo de Medicina Xenomica, Universidade de Santiago de Compostela, Centro Nacional de Genotipado, Centro de Investigación Biomédica en Red de Enfermedades Raras, Santiago de Compostela, Spain., Carracedo Á; Grupo de Medicina Xenomica, Universidade de Santiago de Compostela, Centro Nacional de Genotipado, Centro de Investigación Biomédica en Red de Enfermedades Raras, Santiago de Compostela, Spain., Lannfelt L; Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden., Rubinsztein DC; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.; UK Dementia Research Institute, University of Cambridge, Cambridge, UK., Barnes LL; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.; Department of Behavioral Sciences, Rush University Medical Center, Chicago, IL, USA.; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA., Pasquier F; CHU Lille, Memory Center of Lille (Centre Mémoire de Ressources et de Recherche), Lille, France., Frölich L; Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany., Barral S; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.; Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA.; Department of Neurology, Columbia University, New York, NY, USA., McGuinness B; Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK., Beach TG; Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Phoenix, AZ, USA., Johnston JA; Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK., Becker JT; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Psychology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Passmore P; Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK., Bigio EH; Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Schott JM; Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK., Bird TD; Department of Neurology, University of Washington, Seattle, WA, USA.; VA Puget Sound Health Care System/>GRECC, Seattle, WA, USA., Warren JD; Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK., Boeve BF; Department of Neurology, Mayo Clinic, Rochester, MN, USA., Lupton MK; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia., Bowen JD; Swedish Medical Center, Seattle, WA, USA., Proitsi P; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Boxer A; Department of Neurology, University of California, San Francisco, San Francisco, CA, USA., Powell JF; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Burke JR; Department of Neurology, Duke University, Durham, NC, USA., Kauwe JSK; Departments of Biology, Brigham Young University, Provo, UT, USA., Burns JM; University of Kansas Alzheimer's Disease Center, University of Kansas Medical Center, Kansas City, KS, USA., Mancuso M; Department of Experimental and Clinical Medicine, Neurological Institute, University of Pisa, Pisa, Italy., Buxbaum JD; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Bonuccelli U; Department of Experimental and Clinical Medicine, Neurological Institute, University of Pisa, Pisa, Italy., Cairns NJ; Department of Pathology and Immunology, Washington University, St. Louis, MO, USA., McQuillin A; Division of Psychiatry, University College London, London, UK., Cao C; USF Health Byrd Alzheimer's Institute, University of South Florida, Tampa, FL, USA., Livingston G; Division of Psychiatry, University College London, London, UK., Carlson CS; Department of Medicine, University of Wisconsin, Madison, WI, USA.; Wisconsin Alzheimer's Disease Research Center, Madison, WI, USA., Bass NJ; Division of Psychiatry, University College London, London, UK., Carlsson CM; Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Hardy J; Department of Molecular Neuroscience, UCL, Institute of Neurology, London, UK., Carney RM; Mental Health & Behavioral Science Service, Bruce W. Carter VA Medical Center, Miami, FL, USA., Bras J; UK Dementia Research Institute at UCL, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK., Carrasquillo MM; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Guerreiro R; UK Dementia Research Institute at UCL, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK., Allen M; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Chui HC; Department of Neurology, University of Southern California, Los Angeles, CA, USA., Fisher E; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK., Masullo C; Department of Neurology, Catholic University of Rome, Rome, Italy., Crocco EA; Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, FL, USA., DeCarli C; Department of Neurology, University of California, Davis, Sacramento, CA, USA., Bisceglio G; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Dick M; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA., Ma L; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Duara R; Wien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL, USA., Graff-Radford NR; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Evans DA; Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA., Hodges A; Department of Old Age Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Faber KM; Indiana Alzheimer's Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA., Scherer M; Department of Primary Medical Care, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany., Fallon KB; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA., Riemenschneider M; Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany., Fardo DW; Sanders-Brown Center on Aging, Department of Biostatistics, University of Kentucky, Lexington, KY, USA., Heun R; Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany., Farlow MR; Department of Neurology, Indiana University, Indianapolis, IN, USA., Kölsch H; Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany., Ferris S; Department of Psychiatry, New York University, New York, NY, USA., Leber M; Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany., Foroud TM; Indiana Alzheimer's Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA., Heuser I; Department of Psychiatry and Psychotherapy, Charité University Medicine, Berlin, Germany., Galasko DR; Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA., Giegling I; Department of Psychiatry, Martin Luther University Halle-Wittenberg, Halle, Germany., Gearing M; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA.; Emory Alzheimer's Disease Center, Emory University, Atlanta, GA, USA., Hüll M; Department of Psychiatry, University of Freiburg, Freiburg, Germany., Geschwind DH; Neurogenetics Program, University of California, Los Angeles, Los Angeles, CA, USA., Gilbert JR; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Morris J; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.; Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, MO, USA., Green RC; Division of Genetics, Department of Medicine and Partners Center for Personalized Genetic Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Mayo K; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.; Department of Neurology, Washington University, St. Louis, MO, USA.; Department of Genetics, Washington University, St. Louis, MO, USA., Growdon JH; Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA., Feulner T; Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany., Hamilton RL; Department of Pathology (Neuropathology), University of Pittsburgh, Pittsburgh, PA, USA., Harrell LE; Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA., Drichel D; Cologne Center for Genomics, University of Cologne, Cologne, Germany., Honig LS; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA., Cushion TD; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.; UK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, UK., Huentelman MJ; Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, USA., Hollingworth P; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Hulette CM; Department of Pathology, Duke University, Durham, NC, USA., Hyman BT; Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA., Marshall R; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Jarvik GP; Department of Genome Sciences, University of Washington, Seattle, WA, USA.; Department of Medicine (Medical Genetics), University of Washington, Seattle, WA, USA., Meggy A; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Abner E; Sanders-Brown Center on Aging, College of Public Health, Department of Epidemiology, University of Kentucky, Lexington, KY, USA., Menzies GE; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.; UK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, UK., Jin LW; Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain., Leonenko G; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Real LM; Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain., Jun GR; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA., Baldwin CT; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA., Grozeva D; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Karydas A; Swedish Medical Center, Seattle, WA, USA., Russo G; Functional Genomics Center Zurich, ETH/University of Zurich, Zurich, Switzerland., Kaye JA; Department of Neurology, Oregon Health &Science University, Portland, OR, USA.; Department of Neurology, Portland Veterans Affairs Medical Center, Portland, OR, USA., Kim R; Department of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, CA, USA., Jessen F; German Center for Neurodegenerative Diseases, Bonn, Germany.; Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.; Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany., Kowall NW; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; Department of Pathology, Boston University School of Medicine, Boston University, Boston, MA, USA., Vellas B; Inserm U558, University of Toulouse, Toulouse, France., Kramer JH; Department of Neuropsychology, University of California San Francisco, San Francisco, CA, USA., Vardy E; Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK., LaFerla FM; Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA, USA., Jöckel KH; Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany., Lah JJ; Department of Neurology, Emory University, Atlanta, GA, USA., Dichgans M; Institute for Stroke and Dementia Research, Klinikum der Universität München, Munich, Germany.; German Center for Neurodegenerative Diseases, Munich, Germany., Leverenz JB; Cleveland Clinic Lou Ruvo Center for Brain Health, Cleveland Clinic, Cleveland, OH, USA., Mann D; Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK., Levey AI; Department of Neurology, Emory University, Atlanta, GA, USA., Pickering-Brown S; Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK., Lieberman AP; Department of Pathology, University of Michigan, Ann Arbor, MI, USA., Klopp N; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Munich, Germany., Lunetta KL; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Wichmann HE; Helmholtz Center Munich, Institute of Epidemiology, Neuherberg, Munich, Germany.; Ludwig-Maximilians University Chair of Epidemiology, Munich, Germany.; Joint Biobank Munich and KORA Biobank, Baltimore, MD, USA., Lyketsos CG; Department of Psychiatry, Johns Hopkins University, Baltimore, MD, USA., Morgan K; Human Genetics, Schools of Life Sciences and Medicine, University of Nottingham, Nottingham, UK., Marson DC; Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA., Brown K; Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK., Martiniuk F; Department of Medicine-Pulmonary, New York University, New York, NY, USA., Medway C; Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK., Mash DC; Department of Neurology, University of Miami, Miami, FL, USA., Nöthen MM; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany., Masliah E; Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.; Department of Pathology, University of California, San Diego, La Jolla, CA, USA., Hooper NM; Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK., McCormick WC; Department of Medicine, University of Washington, Seattle, WA, USA., Daniele A; Institute of Neurology, Catholic University of Sacred Hearth, Rome, Italy., McCurry SM; School of Nursing Northwest Research Group on Aging, University of Washington, Seattle, WA, USA., Bayer A; Institute of Primary Care and Public Health, Cardiff University, University Hospital of Wales, Cardiff, UK., McDavid AN; USF Health Byrd Alzheimer's Institute, University of South Florida, Tampa, FL, USA., Gallacher J; Department of Psychiatry, University of Oxford, Oxford, UK., McKee AC; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; Department of Pathology, Boston University School of Medicine, Boston University, Boston, MA, USA., van den Bussche H; 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The Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK., Cruchaga C; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.; Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, MO, USA., Graff C; Theme Aging, Unit for Hereditary Dementias, Karolinska University Hospital-Solna, Stockholm, Sweden.; Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Alzheimer Research Center, Division of Neurogeriatrics, Solna, Sweden., Gwilliam R; The Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK., Fornage M; Brown Foundation Institute of Molecular Medicine, University of Texas Health Sciences Center at Houston, Houston, TX, USA., Goate AM; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Ronald M. 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Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD, USA., Younkin SG; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.; Department of Neurology, Mayo Clinic, Jacksonville, FL, USA., Dartigues JF; Memory Research and Resources Center, CMRR de Bordeaux, Bordeaux, France., Corcoran C; Utah State University, Logan, UT, USA., Ikram MA; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Department of Neurology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.; Departments of Radiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands., Dickson DW; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Nicolas G; Normandie University, UNIROUEN, Inserm U1245, and Rouen University Hospital, Department of Neurology, Department of Genetics and CNR-MAJ, Normandy Center for Genomic and Personalized Medicine, Rouen, France., Campion D; Normandie University, UNIROUEN, Inserm U1245, and Rouen University Hospital, Department of Neurology, Department of Genetics and CNR-MAJ, Normandy Center for Genomic and Personalized Medicine, Rouen, France.; Department of Research Rouvray Psychiatric Hospital, Sotteville-lès-Rouen, France., Tschanz J; Utah State University, Logan, UT, USA., Schmidt H; Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Division of Molecular Biology and Biochemistry, Medical University Graz, Graz, Austria.; Department of Neurology, Medical University Graz, Graz, Austria., Hakonarson H; Center for Applied Genomics, Children's Hospital of Philadelphia, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Division of Human Genetics, Department of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Clarimon J; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain.; Memory Unit, Neurology Department and Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Autonomous University Barcelona, Barcelona, Spain., Munger R; Utah State University, Logan, UT, USA., Schmidt R; 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Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Jones L; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.; UK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, UK., Haines JL; Institute for Computational Biology, Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Deleuze JF; Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France., Owen MJ; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Gudnason V; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Mayeux R; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.; 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Sergievsky Center, Columbia University, New York, NY, USA.; Department of Neurology, Columbia University, New York, NY, USA., Escott-Price V; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.; UK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, UK., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Health Services, University of Washington, Seattle, WA, USA.; Kaiser Permanente, Washington Health Research Institute, Seattle, WA, USA., Ramirez A; Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.; Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany., Wang LS; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Ruiz A; Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain., van Duijn CM; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Holmans PA; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Seshadri S; Framingham Heart Study, Framingham, MA, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX, USA., Williams J; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.; UK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, UK., Amouyel P; Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.; Institut Pasteur de Lille, Lille, France.; Univ. Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France.; Centre Hospitalier Universitaire de Lille, Lille, France., Schellenberg GD; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Lambert JC; Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France. jean-charles.lambert@pasteur-lille.fr.; Institut Pasteur de Lille, Lille, France. jean-charles.lambert@pasteur-lille.fr.; Univ. Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France. jean-charles.lambert@pasteur-lille.fr., Pericak-Vance MA; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA. mpericak@miami.edu.

مؤلفون مشاركون: Alzheimer Disease Genetics Consortium (ADGC), European Alzheimer’s Disease Initiative (EADI), Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE), Genetic and Environmental Risk in AD/Defining Genetic, Polygenic and Environmental Risk for Alzheimer’s Disease Consortium (GERAD/PERADES)

المصدر: Nature genetics [Nat Genet] 2019 Sep; Vol. 51 (9), pp. 1423-1424.

نوع المنشور: Published Erratum

بيانات الدورية: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: PubMed not MEDLINE; MEDLINE

المؤلفون: Kunkle BW; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA. bkunkle@miami.edu., Grenier-Boley B; Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.; Institut Pasteur de Lille, Lille, France.; Univ. Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France., Sims R; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.; UK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, UK., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Damotte V; Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.; Institut Pasteur de Lille, Lille, France.; Univ. Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France., Naj AC; Department of Biostatistics and Epidemiology/Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Boland A; Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France., Vronskaya M; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., van der Lee SJ; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Amlie-Wolf A; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Bellenguez C; Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.; Institut Pasteur de Lille, Lille, France.; Univ. Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France., Frizatti A; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Chouraki V; Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.; Institut Pasteur de Lille, Lille, France.; Univ. Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France.; Framingham Heart Study, Framingham, MA, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA., Martin ER; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Sleegers K; Neurodegenerative Brain Diseases Group, Center for Molecular Neurology, VIB, Antwerp, Belgium.; Laboratory for Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium., Badarinarayan N; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Jakobsdottir J; Icelandic Heart Association, Kopavogur, Iceland., Hamilton-Nelson KL; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Moreno-Grau S; Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain., Olaso R; Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France., Raybould R; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.; UK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, UK., Chen Y; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Kuzma AB; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Hiltunen M; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.; Department of Neurology, Kuopio University Hospital, Kuopio, Finland., Morgan T; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Ahmad S; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Vardarajan BN; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.; Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA.; Department of Neurology, Columbia University, New York, NY, USA., Epelbaum J; UMR 894, Center for Psychiatry and Neuroscience, Inserm, Université Paris Descartes, Paris, France., Hoffmann P; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.; Division of Medical Genetics, University Hospital and Department of Biomedicine, University of Basel, Basel, Switzerland., Boada M; Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain., Beecham GW; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Garnier JG; Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France., Harold D; School of Biotechnology, Dublin City University, Dublin, Ireland., Fitzpatrick AL; Department of Family Medicine, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA., Valladares O; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Moutet ML; Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France., Gerrish A; Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK., Smith AV; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Qu L; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Bacq D; Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France., Denning N; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.; UK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, UK., Jian X; Brown Foundation Institute of Molecular Medicine, University of Texas Health Sciences Center at Houston, Houston, TX, USA., Zhao Y; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Del Zompo M; Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy., Fox NC; Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.; UK Dementia Research Institute at UCL, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK., Choi SH; Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain., Mateo I; Neurology Service and CIBERNED, 'Marqués de Valdecilla' University Hospital (University of Cantabria and IDIVAL), Santander, Spain., Hughes JT; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Adams HH; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Malamon J; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Sanchez-Garcia F; Department of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain., Patel Y; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Brody JA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Dombroski BA; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Naranjo MCD; Department of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain., Daniilidou M; Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece., Eiriksdottir G; Icelandic Heart Association, Kopavogur, Iceland., Mukherjee S; Department of Medicine, University of Washington, Seattle, WA, USA., Wallon D; Normandie University, UNIROUEN, Inserm U1245, and Rouen University Hospital, Department of Neurology, Department of Genetics and CNR-MAJ, Normandy Center for Genomic and Personalized Medicine, Rouen, France., Uphill J; Department of Neurodegenerative Disease, MRC Prion Unit at UCL, Institute of Prion Diseases, London, UK., Aspelund T; Icelandic Heart Association, Kopavogur, Iceland.; Centre for Public Health, University of Iceland, Reykjavik, Iceland., Cantwell LB; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Garzia F; Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France., Galimberti D; Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Neurodegenerative Diseases Unit, Milan, Italy.; University of Milan, Centro Dino Ferrari, Milan, Italy., Hofer E; Clinical Division of Neurogeriatrics, Department of Neurology, Medical University Graz, Graz, Austria.; Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria., Butkiewicz M; Institute for Computational Biology, Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Fin B; Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France., Scarpini E; Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Neurodegenerative Diseases Unit, Milan, Italy.; University of Milan, Centro Dino Ferrari, Milan, Italy., Sarnowski C; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Bush WS; Institute for Computational Biology, Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Meslage S; Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France., Kornhuber J; Department of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Erlangen, Germany., White CC; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA., Song Y; Institute for Computational Biology, Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Barber RC; Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA., Engelborghs S; Laboratory for Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.; Department of Neurology and Memory Clinic, Hospital Network Antwerp, Antwerp, Belgium., Sordon S; Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany., Voijnovic D; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Adams PM; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA., Vandenberghe R; Laboratory for Cognitive Neurology, Department of Neurology, University Hospital and University of Leuven, Leuven, Belgium., Mayhaus M; Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany., Cupples LA; Framingham Heart Study, Framingham, MA, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Albert MS; Department of Neurology, Johns Hopkins University, Baltimore, MD, USA., De Deyn PP; Laboratory for Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.; Department of Neurology and Memory Clinic, Hospital Network Antwerp, Antwerp, Belgium., Gu W; Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany., Himali JJ; Framingham Heart Study, Framingham, MA, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Beekly D; National Alzheimer's Coordinating Center, University of Washington, Seattle, WA, USA., Squassina A; Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy., Hartmann AM; Department of Psychiatry, Martin Luther University Halle-Wittenberg, Halle, Germany., Orellana A; Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain., Blacker D; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.; Department of Psychiatry, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA., Rodriguez-Rodriguez E; Neurology Service and CIBERNED, 'Marqués de Valdecilla' University Hospital (University of Cantabria and IDIVAL), Santander, Spain., Lovestone S; Department of Psychiatry, University of Oxford, Oxford, UK., Garcia ME; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD, USA., Doody RS; Alzheimer's Disease and Memory Disorders Center, Baylor College of Medicine, Houston, TX, USA., Munoz-Fernadez C; Department of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain., Sussams R; Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, UK., Lin H; Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA., Fairchild TJ; Office of Strategy and Measurement, University of North Texas Health Science Center, Fort Worth, TX, USA., Benito YA; Department of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain., Holmes C; Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, UK., Karamujić-Čomić H; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Frosch MP; C.S. Kubik Laboratory for Neuropathology, Massachusetts General Hospital, Charlestown, MA, USA., Thonberg H; Theme Aging, Unit for Hereditary Dementias, Karolinska University Hospital-Solna, Stockholm, Sweden.; Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Alzheimer Research Center, Division of Neurogeriatrics, Solna, Sweden., Maier W; German Center for Neurodegenerative Diseases, Bonn, Germany.; Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany., Roshchupkin G; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Ghetti B; Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, IN, USA., Giedraitis V; Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden., Kawalia A; Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany., Li S; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Huebinger RM; Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA., Kilander L; Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden., Moebus S; Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany., Hernández I; Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain., Kamboh MI; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA.; Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA, USA., Brundin R; Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden., Turton J; Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK., Yang Q; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Katz MJ; Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA., Concari L; Section of Neuroscience, DIMEC-University of Parma, Parma, Italy.; FERB-Alzheimer Center, Gazzaniga (Bergamo), Italy., Lord J; Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK., Beiser AS; Framingham Heart Study, Framingham, MA, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Keene CD; Department of Pathology, University of Washington, Seattle, WA, USA., Helisalmi S; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.; Department of Neurology, Kuopio University Hospital, Kuopio, Finland., Kloszewska I; Elderly and Psychiatric Disorders Department, Medical University of Lodz, Lodz, Poland., Kukull WA; Department of Epidemiology, University of Washington, Seattle, WA, USA., Koivisto AM; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.; Department of Neurology, Kuopio University Hospital, Kuopio, Finland., Lynch A; Mercer's Institute for Research on Aging, St. James's Hospital and Trinity College, Dublin, Ireland.; St. James's Hospital and Trinity College, Dublin, Ireland., Tarraga L; Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain., Larson EB; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA., Haapasalo A; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland., Lawlor B; Mercer's Institute for Research on Aging, St. James's Hospital and Trinity College, Dublin, Ireland.; St. James's Hospital and Trinity College, Dublin, Ireland., Mosley TH; Departments of Medicine, Geriatrics, Gerontology and Neurology, University of Mississippi Medical Center, Jackson, MS, USA., Lipton RB; Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA., Solfrizzi V; Interdisciplinary Department of Medicine, Geriatric Medicine and Memory Unity, University of Bari, Bari, Italy., Gill M; Mercer's Institute for Research on Aging, St. James's Hospital and Trinity College, Dublin, Ireland.; St. James's Hospital and Trinity College, Dublin, Ireland., Longstreth WT Jr; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Neurology, University of Washington, Seattle, WA, USA., Montine TJ; Department of Pathology, University of Washington, Seattle, WA, USA., Frisardi V; Department of Geriatrics, Center for Aging Brain, University of Bari, Bari, Italy., Diez-Fairen M; Fundació per la Recerca Biomèdica i Social Mútua Terrassa, Terrassa, Barcelona, Spain.; Memory Disorders Unit, Department of Neurology, Hospital Universitari Mutua de Terrassa, Terrassa, Barcelona, Spain., Rivadeneira F; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Department of Internal Medicine, Erasmus University Medical Center, Rotterdamt, the Netherlands.; Netherlands Consortium on Health Aging and National Genomics Initiative, Leiden, the Netherlands., Petersen RC; Department of Neurology, Mayo Clinic, Rochester, MN, USA., Deramecourt V; CHU Lille, Memory Center of Lille (Centre Mémoire de Ressources et de Recherche), Lille, France., Alvarez I; Fundació per la Recerca Biomèdica i Social Mútua Terrassa, Terrassa, Barcelona, Spain.; Memory Disorders Unit, Department of Neurology, Hospital Universitari Mutua de Terrassa, Terrassa, Barcelona, Spain., Salani F; Department of Clinical and Behavioral Neurology, Experimental Neuropsychobiology Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy., Ciaramella A; Department of Clinical and Behavioral Neurology, Experimental Neuropsychobiology Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy., Boerwinkle E; School of Public Health, Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA., Reiman EM; Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, USA.; Arizona Alzheimer's Consortium, Phoenix, AZ, USA.; Banner Alzheimer's Institute, Phoenix, AZ, USA.; Department of Psychiatry, University of Arizona, Phoenix, AZ, USA., Fievet N; Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.; Institut Pasteur de Lille, Lille, France.; Univ. Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France., Rotter JI; Institute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA., Reisch JS; Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA., Hanon O; University Paris Descartes, EA 4468, AP-HP, Geriatrics Department, Hôpital Broca, Paris, France., Cupidi C; Regional Neurogenetic Centre (CRN), ASP Catanzaro, Lamezia Terme, Italy., Andre Uitterlinden AG; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Department of Internal Medicine, Erasmus University Medical Center, Rotterdamt, the Netherlands.; Netherlands Consortium on Health Aging and National Genomics Initiative, Leiden, the Netherlands., Royall DR; Departments of Psychiatry, Medicine, Family & Community Medicine, South Texas Veterans Health Administration Geriatric Research Education & Clinical Center (GRECC), UT Health Science Center at San Antonio, San Antonio, TX, USA., Dufouil C; University of Bordeaux, Inserm 1219, Bordeaux, France.; Department of Neurology, Bordeaux University Hospital / CHU de Bordeaux, Bordeaux, France., Maletta RG; Regional Neurogenetic Centre (CRN), ASP Catanzaro, Lamezia Terme, Italy., de Rojas I; Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain., Sano M; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Brice A; Inserm U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Université Paris 06, UMRS 1127, Institut du Cerveau et de la Moelle Épinière, Paris, France.; AP-HP, Department of Genetics, Pitié-Salpêtrière Hospital, Paris, France., Cecchetti R; Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy., George-Hyslop PS; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.; Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada., Ritchie K; Inserm U1061 Neuropsychiatry, La Colombière Hospital, Montpellier, France.; Montpellier University, Montpellier, France.; Department of Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK., Tsolaki M; Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece., Tsuang DW; VA Puget Sound Health Care System/>GRECC, Seattle, WA, USA.; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA., Dubois B; Institut de la Mémoire et de la Maladie d'Alzheimer and Institut du Cerveau et de la Moelle Épinière, Département de Neurologie, Hôpital de la Pitié-Salpêtrière, Paris, France.; Institut des Neurosciences Translationnelles de Paris, Institut du Cerveau et de la Moelle Épinière, Paris, France.; Inserm, CNRS, UMR-S975, Institut du Cerveau et de la Moelle Epinière, Paris, France.; Sorbonne Universités, Université Pierre et Marie Curie, Hôpital de la Pitié-Salpêtrière, AP-HP, Paris, France., Craig D; Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK., Wu CK; Departments of Neurology, Pharmacology & Neuroscience, Texas Tech University Health Science Center, Lubbock, TX, USA., Soininen H; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.; Department of Neurology, Kuopio University Hospital, Kuopio, Finland., Avramidou D; Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece., Albin RL; Department of Neurology, University of Michigan, Ann Arbor, MI, USA.; Geriatric Research, Education and Clinical Center (GRECC), VA Ann Arbor Healthcare System (VAAAHS), Ann Arbor, MI, USA.; Michigan Alzheimer Disease Center, Ann Arbor, MI, USA., Fratiglioni L; Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden., Germanou A; Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece., Apostolova LG; Indiana Alzheimer's Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA.; Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA.; Department of Neurology, Indiana University, Indianapolis, IN, USA.; Department of Radiology and Imaging Sciences, Indiana University, Indianapolis, IN, USA., Keller L; Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden., Koutroumani M; Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece., Arnold SE; Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Panza F; Department of Geriatrics, Center for Aging Brain, University of Bari, Bari, Italy., Gkatzima O; Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece., Asthana S; Geriatric Research, Education and Clinical Center (GRECC), University of Wisconsin, Madison, WI, USA.; Department of Medicine, University of Wisconsin, Madison, WI, USA.; Wisconsin Alzheimer's Disease Research Center, Madison, WI, USA., Hannequin D; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Whitehead P; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Atwood CS; Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA.; Department of Neurology, Indiana University, Indianapolis, IN, USA.; Department of Radiology and Imaging Sciences, Indiana University, Indianapolis, IN, USA., Caffarra P; Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA, USA.; Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK., Hampel H; AXA Research Fund & Sorbonne University Chair, Paris, France.; Sorbonne University, GRC n° 21, Alzheimer Precision Medicine (APM), AP-HP, Pitié-Salpêtrière Hospital, Paris, France.; Brain & Spine Institute, Inserm U 1127, CNRS UMR 7225, Paris, France.; Institute of Memory and Alzheimer's Disease, Department of Neurology, Pitié-Salpêtrière Hospital, AP-HP, Paris, France., Quintela I; Grupo de Medicina Xenomica, Universidade de Santiago de Compostela, Centro Nacional de Genotipado, Centro de Investigación Biomédica en Red de Enfermedades Raras, Santiago de Compostela, Spain., Carracedo Á; Grupo de Medicina Xenomica, Universidade de Santiago de Compostela, Centro Nacional de Genotipado, Centro de Investigación Biomédica en Red de Enfermedades Raras, Santiago de Compostela, Spain., Lannfelt L; Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden., Rubinsztein DC; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.; UK Dementia Research Institute, University of Cambridge, Cambridge, UK., Barnes LL; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.; Department of Behavioral Sciences, Rush University Medical Center, Chicago, IL, USA.; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA., Pasquier F; CHU Lille, Memory Center of Lille (Centre Mémoire de Ressources et de Recherche), Lille, France., Frölich L; Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany., Barral S; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.; Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA.; Department of Neurology, Columbia University, New York, NY, USA., McGuinness B; Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK., Beach TG; Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Phoenix, AZ, USA., Johnston JA; Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK., Becker JT; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Psychology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Passmore P; Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK., Bigio EH; Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Schott JM; Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK., Bird TD; Department of Neurology, University of Washington, Seattle, WA, USA.; VA Puget Sound Health Care System/>GRECC, Seattle, WA, USA., Warren JD; Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK., Boeve BF; Department of Neurology, Mayo Clinic, Rochester, MN, USA., Lupton MK; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia., Bowen JD; Swedish Medical Center, Seattle, WA, USA., Proitsi P; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Boxer A; Department of Neurology, University of California, San Francisco, San Francisco, CA, USA., Powell JF; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Burke JR; Department of Neurology, Duke University, Durham, NC, USA., Kauwe JSK; Departments of Biology, Brigham Young University, Provo, UT, USA., Burns JM; University of Kansas Alzheimer's Disease Center, University of Kansas Medical Center, Kansas City, KS, USA., Mancuso M; Department of Experimental and Clinical Medicine, Neurological Institute, University of Pisa, Pisa, Italy., Buxbaum JD; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Bonuccelli U; Department of Experimental and Clinical Medicine, Neurological Institute, University of Pisa, Pisa, Italy., Cairns NJ; Department of Pathology and Immunology, Washington University, St. Louis, MO, USA., McQuillin A; Division of Psychiatry, University College London, London, UK., Cao C; USF Health Byrd Alzheimer's Institute, University of South Florida, Tampa, FL, USA., Livingston G; Division of Psychiatry, University College London, London, UK., Carlson CS; Department of Medicine, University of Wisconsin, Madison, WI, USA.; Wisconsin Alzheimer's Disease Research Center, Madison, WI, USA., Bass NJ; Division of Psychiatry, University College London, London, UK., Carlsson CM; Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Hardy J; Department of Molecular Neuroscience, UCL, Institute of Neurology, London, UK., Carney RM; Mental Health & Behavioral Science Service, Bruce W. Carter VA Medical Center, Miami, FL, USA., Bras J; UK Dementia Research Institute at UCL, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK., Carrasquillo MM; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Guerreiro R; UK Dementia Research Institute at UCL, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK., Allen M; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Chui HC; Department of Neurology, University of Southern California, Los Angeles, CA, USA., Fisher E; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK., Masullo C; Department of Neurology, Catholic University of Rome, Rome, Italy., Crocco EA; Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, FL, USA., DeCarli C; Department of Neurology, University of California, Davis, Sacramento, CA, USA., Bisceglio G; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Dick M; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA., Ma L; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Duara R; Wien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL, USA., Graff-Radford NR; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Evans DA; Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA., Hodges A; Department of Old Age Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Faber KM; Indiana Alzheimer's Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA., Scherer M; Department of Primary Medical Care, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany., Fallon KB; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA., Riemenschneider M; Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany., Fardo DW; Sanders-Brown Center on Aging, Department of Biostatistics, University of Kentucky, Lexington, KY, USA., Heun R; Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany., Farlow MR; Department of Neurology, Indiana University, Indianapolis, IN, USA., Kölsch H; Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany., Ferris S; Department of Psychiatry, New York University, New York, NY, USA., Leber M; Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany., Foroud TM; Indiana Alzheimer's Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA., Heuser I; Department of Psychiatry and Psychotherapy, Charité University Medicine, Berlin, Germany., Galasko DR; Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA., Giegling I; Department of Psychiatry, Martin Luther University Halle-Wittenberg, Halle, Germany., Gearing M; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA.; Emory Alzheimer's Disease Center, Emory University, Atlanta, GA, USA., Hüll M; Department of Psychiatry, University of Freiburg, Freiburg, Germany., Geschwind DH; Neurogenetics Program, University of California, Los Angeles, Los Angeles, CA, USA., Gilbert JR; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Morris J; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.; Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, MO, USA., Green RC; Division of Genetics, Department of Medicine and Partners Center for Personalized Genetic Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Mayo K; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.; Department of Neurology, Washington University, St. Louis, MO, USA.; Department of Genetics, Washington University, St. Louis, MO, USA., Growdon JH; Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA., Feulner T; Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany., Hamilton RL; Department of Pathology (Neuropathology), University of Pittsburgh, Pittsburgh, PA, USA., Harrell LE; Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA., Drichel D; Cologne Center for Genomics, University of Cologne, Cologne, Germany., Honig LS; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA., Cushion TD; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.; UK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, UK., Huentelman MJ; Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, USA., Hollingworth P; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Hulette CM; Department of Pathology, Duke University, Durham, NC, USA., Hyman BT; Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA., Marshall R; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Jarvik GP; Department of Genome Sciences, University of Washington, Seattle, WA, USA.; Department of Medicine (Medical Genetics), University of Washington, Seattle, WA, USA., Meggy A; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Abner E; Sanders-Brown Center on Aging, College of Public Health, Department of Epidemiology, University of Kentucky, Lexington, KY, USA., Menzies GE; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.; UK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, UK., Jin LW; Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain., Leonenko G; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Real LM; Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain., Jun GR; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA., Baldwin CT; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA., Grozeva D; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Karydas A; Swedish Medical Center, Seattle, WA, USA., Russo G; Functional Genomics Center Zurich, ETH/University of Zurich, Zurich, Switzerland., Kaye JA; Department of Neurology, Oregon Health &Science University, Portland, OR, USA.; Department of Neurology, Portland Veterans Affairs Medical Center, Portland, OR, USA., Kim R; Department of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, CA, USA., Jessen F; German Center for Neurodegenerative Diseases, Bonn, Germany.; Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.; Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany., Kowall NW; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; Department of Pathology, Boston University School of Medicine, Boston University, Boston, MA, USA., Vellas B; Inserm U558, University of Toulouse, Toulouse, France., Kramer JH; Department of Neuropsychology, University of California San Francisco, San Francisco, CA, USA., Vardy E; Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK., LaFerla FM; Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA, USA., Jöckel KH; Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany., Lah JJ; Department of Neurology, Emory University, Atlanta, GA, USA., Dichgans M; Institute for Stroke and Dementia Research, Klinikum der Universität München, Munich, Germany.; German Center for Neurodegenerative Diseases, Munich, Germany., Leverenz JB; Cleveland Clinic Lou Ruvo Center for Brain Health, Cleveland Clinic, Cleveland, OH, USA., Mann D; Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK., Levey AI; Department of Neurology, Emory University, Atlanta, GA, USA., Pickering-Brown S; Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK., Lieberman AP; Department of Pathology, University of Michigan, Ann Arbor, MI, USA., Klopp N; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Munich, Germany., Lunetta KL; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Wichmann HE; Helmholtz Center Munich, Institute of Epidemiology, Neuherberg, Munich, Germany.; Ludwig-Maximilians University Chair of Epidemiology, Munich, Germany.; Joint Biobank Munich and KORA Biobank, Baltimore, MD, USA., Lyketsos CG; Department of Psychiatry, Johns Hopkins University, Baltimore, MD, USA., Morgan K; Human Genetics, Schools of Life Sciences and Medicine, University of Nottingham, Nottingham, UK., Marson DC; Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA., Brown K; Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK., Martiniuk F; Department of Medicine-Pulmonary, New York University, New York, NY, USA., Medway C; Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK., Mash DC; Department of Neurology, University of Miami, Miami, FL, USA., Nöthen MM; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany., Masliah E; Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.; Department of Pathology, University of California, San Diego, La Jolla, CA, USA., Hooper NM; Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK., McCormick WC; Department of Medicine, University of Washington, Seattle, WA, USA., Daniele A; Institute of Neurology, Catholic University of Sacred Hearth, Rome, Italy., McCurry SM; School of Nursing Northwest Research Group on Aging, University of Washington, Seattle, WA, USA., Bayer A; Institute of Primary Care and Public Health, Cardiff University, University Hospital of Wales, Cardiff, UK., McDavid AN; USF Health Byrd Alzheimer's Institute, University of South Florida, Tampa, FL, USA., Gallacher J; Department of Psychiatry, University of Oxford, Oxford, UK., McKee AC; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; Department of Pathology, Boston University School of Medicine, Boston University, Boston, MA, USA., van den Bussche H; Department of Primary Medical Care, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany., Mesulam M; Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Brayne C; Cambridge Institute of Public Health, University of Cambridge School of Clinical Medicine, Cambridge, UK., Miller BL; Weill Institute for Neurosciences, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, USA., Riedel-Heller S; Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Leipzig, Germany., Miller CA; Department of Pathology, University of Southern California, Los Angeles, CA, USA., Miller JW; Department of Pathology and Laboratory Medicine, University of California, Davis, Sacramento, CA, USA., Al-Chalabi A; Institute of Psychiatry, Psychology and Neuroscienceó, King's College London, London, UK., Morris JC; Department of Pathology and Immunology, Washington University, St. Louis, MO, USA.; Department of Neurology, Washington University, St. Louis, MO, USA., Shaw CE; Institute of Psychiatry, Psychology and Neuroscienceó, King's College London, London, UK.; UK Dementia Research Institute, King's College London, London, UK., Myers AJ; Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, FL, USA., Wiltfang J; Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, Goettingen, Germany.; German Center for Neurodegenerative Diseases, Goettingen, Germany.; IBiMED, Medical Sciences Department, University of Aveiro, Aveiro, Portugal., O'Bryant S; Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA., Olichney JM; Department of Neurology, University of California, Davis, Sacramento, CA, USA., Alvarez V; Molecular Genetics Laboratory-Hospital, University of Central Asturias, Oviedo, Spain., Parisi JE; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA., Singleton AB; Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA., Paulson HL; Department of Neurology, University of Michigan, Ann Arbor, MI, USA.; Michigan Alzheimer Disease Center, Ann Arbor, MI, USA., Collinge J; Department of Neurodegenerative Disease, MRC Prion Unit at UCL, Institute of Prion Diseases, London, UK., Perry WR; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Mead S; Department of Neurodegenerative Disease, MRC Prion Unit at UCL, Institute of Prion Diseases, London, UK., Peskind E; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA., Cribbs DH; Department of Neurology, University of California, Irvine, Irvine, CA, USA., Rossor M; Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK., Pierce A; Department of Neurology, University of California, Irvine, Irvine, CA, USA., Ryan NS; Department of Neurodegenerative Disease, MRC Prion Unit at UCL, Institute of Prion Diseases, London, UK., Poon WW; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA., Nacmias B; Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.; Centro di Ricerca, Trasferimento e Alta Formazione DENOTHE, University of Florence, Florence, Italy., Potter H; Department of Neurology, University of Colorado School of Medicine, Aurora, CO, USA., Sorbi S; Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.; IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy., Quinn JF; Department of Primary Medical Care, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA., Sacchinelli E; Department of Clinical and Behavioral Neurology, Experimental Neuropsychobiology Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy., Raj A; USF Health Byrd Alzheimer's Institute, University of South Florida, Tampa, FL, USA., Spalletta G; Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy.; Division of Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA., Raskind M; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA., Caltagirone C; Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy., Bossù P; Department of Clinical and Behavioral Neurology, Experimental Neuropsychobiology Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy., Orfei MD; Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy., Reisberg B; Department of Psychiatry, New York University, New York, NY, USA.; Alzheimer's Disease Center, New York University, New York, NY, USA., Clarke R; Oxford Healthy Aging Project, Clinical Trial Service Unit, University of Oxford, Oxford, UK., Reitz C; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.; Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA.; Department of Epidemiology, Columbia University, New York, NY, USA., Smith AD; Oxford Project to Investigate Memory and Ageing, University of Oxford, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK., Ringman JM; Department of Neurology, Keck School of Medicine at the University of Southern California, Los Angeles, Los Angeles, CA, USA., Warden D; Oxford Project to Investigate Memory and Ageing, University of Oxford, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK., Roberson ED; Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA., Wilcock G; Oxford Project to Investigate Memory and Ageing, University of Oxford, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK., Rogaeva E; Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada., Bruni AC; Regional Neurogenetic Centre (CRN), ASP Catanzaro, Lamezia Terme, Italy., Rosen HJ; Department of Neurology, University of California, San Francisco, San Francisco, CA, USA., Gallo M; Regional Neurogenetic Centre (CRN), ASP Catanzaro, Lamezia Terme, Italy., Rosenberg RN; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, USA., Ben-Shlomo Y; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Sager MA; Department of Medicine, University of Wisconsin, Madison, WI, USA., Mecocci P; Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy., Saykin AJ; Indiana Alzheimer's Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA.; Department of Neurology, Indiana University, Indianapolis, IN, USA., Pastor P; Fundació per la Recerca Biomèdica i Social Mútua Terrassa, Terrassa, Barcelona, Spain.; Memory Disorders Unit, Department of Neurology, Hospital Universitari Mutua de Terrassa, Terrassa, Barcelona, Spain., Cuccaro ML; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Vance JM; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Schneider JA; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.; Department of Pathology (Neuropathology), Rush University Medical Center, Chicago, IL, USA., Schneider LS; Department of Neurology, University of Southern California, Los Angeles, CA, USA.; Department of Psychiatry, University of Southern California, Los Angeles, CA, USA., Slifer S; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Seeley WW; Department of Neurology, University of California, San Francisco, San Francisco, CA, USA., Smith AG; USF Health Byrd Alzheimer's Institute, University of South Florida, Tampa, FL, USA., Sonnen JA; Department of Pathology, University of Washington, Seattle, WA, USA., Spina S; Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, IN, USA., Stern RA; Department of Neurology, Boston University School of Medicine, Boston, MA, USA., Swerdlow RH; University of Kansas Alzheimer's Disease Center, University of Kansas Medical Center, Kansas City, KS, USA., Tang M; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Tanzi RE; Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA., Trojanowski JQ; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Troncoso JC; Department of Pathology, Johns Hopkins University, Baltimore, MD, USA., Van Deerlin VM; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Van Eldik LJ; Sanders-Brown Center on Aging, Department of Neuroscience, University of Kentucky, Lexington, KY, USA., Vinters HV; Department of Neurology, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Vonsattel JP; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Pathology, Columbia University, New York, NY, USA., Weintraub S; Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Welsh-Bohmer KA; Department of Neurology, Duke University, Durham, NC, USA.; Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA., Wilhelmsen KC; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Williamson J; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA., Wingo TS; Department of Neurology, Emory University, Atlanta, GA, USA.; Department of Human Genetics, Emory University, Atlanta, GA, USA., Woltjer RL; Department of Pathology, Oregon Health & Science University, Portland, OR, USA., Wright CB; National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA., Yu CE; Department of Medicine, University of Washington, Seattle, WA, USA., Yu L; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA., Saba Y; Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Division of Molecular Biology and Biochemistry, Medical University Graz, Graz, Austria., Pilotto A; Gerontology and Geriatrics Research Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy.; Department Geriatric Care, Orthogeriatrics and Rehabilitation, Galliera Hospital, Genova, Italy., Bullido MJ; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain.; IdiPAZ, Instituto de Investigación Sanitaria la Paz, Madrid, Spain.; Centro de Biologia Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain., Peters O; Department of Psychiatry and Psychotherapy, Charité University Medicine, Berlin, Germany.; German Center for Neurodegenerative Diseases, Berlin, Germany., Crane PK; Department of Medicine, University of Washington, Seattle, WA, USA., Bennett D; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA., Bosco P; Instituto di Ricovero e Cura a Carattere Scientifico, Associazione Oasi Maria Santissima Srl, Troina, Italy., Coto E; Molecular Genetics Laboratory-Hospital, University of Central Asturias, Oviedo, Spain., Boccardi V; Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy., De Jager PL; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, NY, USA., Lleo A; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain.; Memory Unit, Neurology Department and Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Autonomous University Barcelona, Barcelona, Spain., Warner N; Somerset Partnership NHS Trust, Somerset, UK., Lopez OL; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.; Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA., Ingelsson M; Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden., Deloukas P; The Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK., Cruchaga C; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.; Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, MO, USA., Graff C; Theme Aging, Unit for Hereditary Dementias, Karolinska University Hospital-Solna, Stockholm, Sweden.; Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Alzheimer Research Center, Division of Neurogeriatrics, Solna, Sweden., Gwilliam R; The Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK., Fornage M; Brown Foundation Institute of Molecular Medicine, University of Texas Health Sciences Center at Houston, Houston, TX, USA., Goate AM; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Ronald M. Loeb Center for Alzheimer's Disease, Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Sanchez-Juan P; Neurology Service and CIBERNED, 'Marqués de Valdecilla' University Hospital (University of Cantabria and IDIVAL), Santander, Spain., Kehoe PG; University of Bristol Medical School, Learning & Research level 2, Southmead Hospital, Bristol, UK., Amin N; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Ertekin-Taner N; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.; Department of Neurology, Mayo Clinic, Jacksonville, FL, USA., Berr C; Inserm U1061 Neuropsychiatry, La Colombière Hospital, Montpellier, France.; Montpellier University, Montpellier, France., Debette S; Inserm U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Université Paris 06, UMRS 1127, Institut du Cerveau et de la Moelle Épinière, Paris, France.; AP-HP, Department of Genetics, Pitié-Salpêtrière Hospital, Paris, France., Love S; University of Bristol Medical School, Learning & Research level 2, Southmead Hospital, Bristol, UK., Launer LJ; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD, USA., Younkin SG; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.; Department of Neurology, Mayo Clinic, Jacksonville, FL, USA., Dartigues JF; Memory Research and Resources Center, CMRR de Bordeaux, Bordeaux, France., Corcoran C; Utah State University, Logan, UT, USA., Ikram MA; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Department of Neurology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.; Departments of Radiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands., Dickson DW; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Nicolas G; Normandie University, UNIROUEN, Inserm U1245, and Rouen University Hospital, Department of Neurology, Department of Genetics and CNR-MAJ, Normandy Center for Genomic and Personalized Medicine, Rouen, France., Campion D; Normandie University, UNIROUEN, Inserm U1245, and Rouen University Hospital, Department of Neurology, Department of Genetics and CNR-MAJ, Normandy Center for Genomic and Personalized Medicine, Rouen, France.; Department of Research Rouvray Psychiatric Hospital, Sotteville-lès-Rouen, France., Tschanz J; Utah State University, Logan, UT, USA., Schmidt H; Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Division of Molecular Biology and Biochemistry, Medical University Graz, Graz, Austria.; Department of Neurology, Medical University Graz, Graz, Austria., Hakonarson H; Center for Applied Genomics, Children's Hospital of Philadelphia, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Division of Human Genetics, Department of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Clarimon J; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain.; Memory Unit, Neurology Department and Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Autonomous University Barcelona, Barcelona, Spain., Munger R; Utah State University, Logan, UT, USA., Schmidt R; 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Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France.; Centre Hospitalier Universitaire de Lille, Lille, France., Schellenberg GD; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Lambert JC; Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France. jean-charles.lambert@pasteur-lille.fr.; Institut Pasteur de Lille, Lille, France. jean-charles.lambert@pasteur-lille.fr.; Univ. Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France. jean-charles.lambert@pasteur-lille.fr., Pericak-Vance MA; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA. mpericak@miami.edu.

مؤلفون مشاركون: Alzheimer Disease Genetics Consortium (ADGC),, European Alzheimer’s Disease Initiative (EADI),, Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE),, Genetic and Environmental Risk in AD/Defining Genetic, Polygenic and Environmental Risk for Alzheimer’s Disease Consortium (GERAD/PERADES),

المصدر: Nature genetics [Nat Genet] 2019 Mar; Vol. 51 (3), pp. 414-430. Date of Electronic Publication: 2019 Feb 28.

نوع المنشور: Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE

مواضيع طبية MeSH: Alzheimer Disease/*genetics , Amyloid beta-Peptides/*genetics , Genetic Loci/*genetics , Genetic Predisposition to Disease/*genetics , Immunity/*genetics , Lipids/*genetics , tau Proteins/*genetics, Aged ; Case-Control Studies ; Female ; Genetic Testing/methods ; Genome-Wide Association Study/methods ; Haplotypes/genetics ; Humans ; Lipid Metabolism/genetics ; Male

المؤلفون: Sims R; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., van der Lee SJ; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Naj AC; Department of Biostatistics and Epidemiology/Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Bellenguez C; INSERM, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.; Institut Pasteur de Lille, Lille, France.; University Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France., Badarinarayan N; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Jakobsdottir J; Icelandic Heart Association, Kopavogur, Iceland., Kunkle BW; John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA., Boland A; CEA/Institut de Génomique, Centre National de Génotypage, Evry, France., Raybould R; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA., Martin ER; John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.; Dr. John T. Macdonald Foundation, Department of Human Genetics, University of Miami, Miami, Florida, USA., Grenier-Boley B; INSERM, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.; Institut Pasteur de Lille, Lille, France.; University Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France., Heilmann-Heimbach S; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Department of Genomics, Life &Brain Center, University of Bonn, Bonn, Germany., Chouraki V; Boston University School of Medicine, Boston, Massachusetts, USA.; Framingham Heart Study, Framingham, Massachusetts, USA., Kuzma AB; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Sleegers K; Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium.; Institute Born-Bunge, University of Antwerp, Antwerp, Belgium., Vronskaya M; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Ruiz A; Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades, Barcelona, Spain., Graham RR; Immunology Biomarkers Group, Genentech, South San Francisco, California, USA., Olaso R; CEA/Institut de Génomique, Centre National de Génotypage, Evry, France., Hoffmann P; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Department of Genomics, Life &Brain Center, University of Bonn, Bonn, Germany.; Division of Medical Genetics, University Hospital and Department of Biomedicine, University of Basel, Basel, Switzerland., Grove ML; School of Public Health, Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, USA., Vardarajan BN; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, New York, USA.; Gertrude H. Sergievsky Center, Columbia University, New York, New York, USA.; Department of Neurology, Columbia University, New York, New York, USA., Hiltunen M; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.; Department of Neurology, Kuopio University Hospital, Kuopio, Finland., Nöthen MM; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Department of Genomics, Life &Brain Center, University of Bonn, Bonn, Germany., White CC; Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Departments of Neurology and Psychiatry, Brigham and Women's Hospital, Boston, Massachusetts, USA., Hamilton-Nelson KL; John P. 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Department of Pathophysiology and Transplantation, University of Milan, Fondazione Ca' Granda, IRCCS Ospedale Policlinico, Milan, Italy., Caltagirone C; Experimental Neuropsychiatry Laboratory, IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Rome, Italy., Orfei MD; Experimental Neuropsychiatry Laboratory, IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Rome, Italy., Ciaramella A; Experimental Neuropsychiatry Laboratory, IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Rome, Italy., Pichler S; Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany., Mayhaus M; Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany., Gu W; Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany., Lleó A; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Memory Unit, Neurology Department and Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain., Fortea J; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Memory Unit, Neurology Department and Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain., Blesa R; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Memory Unit, Neurology Department and Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain., Barber IS; Schools of Life Sciences and Medicine, University of Nottingham, Nottingham, UK., Brookes K; Schools of Life Sciences and Medicine, University of Nottingham, Nottingham, UK., Cupidi C; Regional Neurogenetic Centre (CRN), ASP Catanzaro, Lamezia Terme, Italy., Maletta RG; Regional Neurogenetic Centre (CRN), ASP Catanzaro, Lamezia Terme, Italy., Carrell D; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington, USA., Sorbi S; NEUROFARBA (Department of Neuroscience, Psychology, Drug Research and Child Health), University of Florence, Florence, Italy.; IRCCS 'Don Carlo Gnocchi', Florence, Italy., Moebus S; Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany., Urbano M; Geriatric Unit and Gerontology-Geriatrics Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy., Pilotto A; Geriatric Unit and Gerontology-Geriatrics Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy., Kornhuber J; Department of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Erlangen, Germany., Bosco P; Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Associazione Oasi Maria Santissima Srl, Troina, Italy., Todd S; Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University, Belfast, UK., Craig D; Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University, Belfast, UK., Johnston J; Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University, Belfast, UK., Gill M; Mercers Institute for Research on Aging, St. James Hospital and Trinity College, Dublin, Ireland., Lawlor B; Mercers Institute for Research on Aging, St. James Hospital and Trinity College, Dublin, Ireland., Lynch A; Mercers Institute for Research on Aging, St. James Hospital and Trinity College, Dublin, Ireland., Fox NC; Department of Molecular Neuroscience, UCL, Institute of Neurology, London, UK., Hardy J; Department of Molecular Neuroscience, UCL, Institute of Neurology, London, UK., Albin RL; Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA.; Geriatric Research, Education and Clinical Center (GRECC), VA Ann Arbor Healthcare System (VAAAHS), Ann Arbor, Michigan, USA.; Michigan Alzheimer Disease Center, Ann Arbor, Michigan, USA., Apostolova LG; Indiana Alzheimer's Disease Center, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, USA.; Department of Neurology, Indiana University, Indianapolis, Indiana, USA.; Department of Radiology and Imaging Sciences, Indiana University, Indianapolis, Indiana, USA., Arnold SE; Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Asthana S; Geriatric Research, Education and Clinical Center (GRECC), University of Wisconsin, Madison, Wisconsin, USA.; Department of Medicine, University of Wisconsin, Madison, Wisconsin, USA.; Wisconsin Alzheimer's Disease Research Center, Madison, Wisconsin, USA., Atwood CS; Geriatric Research, Education and Clinical Center (GRECC), University of Wisconsin, Madison, Wisconsin, USA.; Department of Medicine, University of Wisconsin, Madison, Wisconsin, USA.; Wisconsin Alzheimer's Disease Research Center, Madison, Wisconsin, USA., Baldwin CT; Department of Medicine (Genetics Program), Boston University, Boston, Massachusetts, USA., Barnes LL; Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.; Department of Behavioral Sciences, Rush University Medical Center, Chicago, Illinois, USA.; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA., Barral S; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, New York, USA.; Gertrude H. Sergievsky Center, Columbia University, New York, New York, USA.; Department of Neurology, Columbia University, New York, New York, USA., Beach TG; Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Phoenix, Arizona, USA., Becker JT; Departments of Psychiatry, Neurology, and Psychology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Bigio EH; Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Cognitive Neurology and Alzheimer's Disease Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Bird TD; Department of Neurology, University of Washington, Seattle, Washington, USA.; VA Puget Sound Health Care System/GRECC, Seattle, Washington, USA., Boeve BF; Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA., Bowen JD; Swedish Medical Center, Seattle, Washington, USA., Boxer A; Department of Neurology, University of California, San Francisco, San Francisco, California, USA., Burke JR; Department of Medicine, Duke University, Durham, North Carolina, USA., Burns JM; University of Kansas Alzheimer's Disease Center, University of Kansas Medical Center, Kansas City, Kansas, USA., Buxbaum JD; Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, USA.; Department of Neuroscience, Mount Sinai School of Medicine, New York, New York, USA.; Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA., Cairns NJ; Department of Pathology and Immunology, Washington University, St. Louis, Missouri, USA., Cao C; USF Health Byrd Alzheimer's Institute, University of South Florida, Tampa, Florida, USA., Carlson CS; Fred Hutchinson Cancer Research Center, Seattle, Washington, USA., Carlsson CM; Department of Medicine, University of Wisconsin, Madison, Wisconsin, USA.; Wisconsin Alzheimer's Disease Research Center, Madison, Wisconsin, USA., Carney RM; Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, Florida, USA., Carrasquillo MM; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA., Carroll SL; Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, USA., Diaz CC; Center for Translational Research in Neurodegenerative Disease, Department of Neuroscience, University of Florida, Gainesville, Florida, USA., Chui HC; Department of Neurology, University of Southern California, Los Angeles, California, USA., Clark DG; Department of Neurology, Medical University of South Carolina, Charleston, South Carolina, USA.; Department of Neurology, Ralph H. Johnson VA Medical Center, Charleston, South Carolina, USA., Cribbs DH; Department of Neurology, University of California, Irvine, Irvine, California, USA., Crocco EA; Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, Florida, USA., DeCarli C; Department of Neurology, University of California, Davis, Sacramento, California, USA., Dick M; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, California, USA., Duara R; Wien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, Florida, USA., Evans DA; Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois, USA., Faber KM; Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, USA., Fallon KB; Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA., Fardo DW; Sanders-Brown Center on Aging, Department of Biostatistics, University of Kentucky, Lexington, Kentucky, USA., Farlow MR; Department of Neurology, Indiana University, Indianapolis, Indiana, USA., Ferris S; Department of Psychiatry, New York University, New York, New York, USA., Foroud TM; Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, USA., Galasko DR; Department of Neurosciences, University of California, San Diego, La Jolla, California, USA., Gearing M; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, USA.; Emory Alzheimer's Disease Center, Emory University, Atlanta, Georgia, USA., Geschwind DH; Neurogenetics Program, University of California, Los Angeles, Los Angeles, California, USA., Gilbert JR; John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.; Dr. John T. Macdonald Foundation, Department of Human Genetics, University of Miami, Miami, Florida, USA., Graff-Radford NR; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.; Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA., Green RC; Division of Genetics, Department of Medicine and Partners Center for Personalized Genetic Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Growdon JH; Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, USA., Hamilton RL; Department of Pathology (Neuropathology), University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Harrell LE; Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA., Honig LS; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, New York, USA., Huentelman MJ; Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona, USA., Hulette CM; Department of Pathology, Duke University, Durham, North Carolina, USA., Hyman BT; Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, USA., Jarvik GP; Department of Genome Sciences, University of Washington, Seattle, Washington, USA.; Department of Medicine (Medical Genetics), University of Washington, Seattle, Washington, USA., Abner E; Sanders-Brown Center on Aging, College of Public Health, Department of Epidemiology, University of Kentucky, Lexington, Kentucky, USA., Jin LW; Department of Pathology and Laboratory Medicine, University of California, Davis, Sacramento, California, USA., Jun G; Department of Medicine (Genetics Program), Boston University, Boston, Massachusetts, USA.; Department of Biostatistics, Boston University, Boston, Massachusetts, USA.; Department of Ophthalmology, Boston University, Boston, Massachusetts, USA., Karydas A; Department of Neurology, University of California, San Francisco, San Francisco, California, USA., Kaye JA; Department of Neurology, Oregon Health &Science University, Portland, Oregon, USA.; Department of Neurology, Portland Veterans Affairs Medical Center, Portland, Oregon, USA., Kim R; Department of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, California, USA., Kowall NW; Department of Neurology, Boston University, Boston, Massachusetts, USA.; Department of Pathology, Boston University, Boston, Massachusetts, USA., Kramer JH; Department of Neuropsychology, University of California, San Francisco, San Francisco, California, USA., LaFerla FM; Department of Neurobiology and Behavior, University of California, Irvine, Irvine, California, USA., Lah JJ; Department of Neurology, Emory University, Atlanta, Georgia, USA., Leverenz JB; Cleveland Clinic Lou Ruvo Center for Brain Health, Cleveland Clinic, Cleveland, Ohio, USA., Levey AI; Department of Neurology, Emory University, Atlanta, Georgia, USA., Li G; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington, USA.; VA Puget Sound Health Care System/GRECC, Seattle, Washington, USA., Lieberman AP; Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA., Lunetta KL; Department of Biostatistics, Boston University, Boston, Massachusetts, USA., Lyketsos CG; Department of Psychiatry, Johns Hopkins University, Baltimore, Maryland, USA., Marson DC; Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA., Martiniuk F; Department of Medicine-Pulmonary, New York University, New York, New York, USA., Mash DC; Department of Neurology, University of Miami, Miami, Florida, USA., Masliah E; Department of Neurosciences, University of California, San Diego, La Jolla, California, USA.; Department of Pathology, University of California, San Diego, La Jolla, California, USA., McCormick WC; Department of Medicine, University of Washington, Seattle, Washington, USA., McCurry SM; School of Nursing Northwest Research Group on Aging, University of Washington, Seattle, Washington, USA., McDavid AN; Fred Hutchinson Cancer Research Center, Seattle, Washington, USA., McKee AC; Department of Neurology, Boston University, Boston, Massachusetts, USA.; Department of Pathology, Boston University, Boston, Massachusetts, USA., Mesulam M; Cognitive Neurology and Alzheimer's Disease Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Miller BL; Department of Neurology, University of California, San Francisco, San Francisco, California, USA., Miller CA; Department of Pathology, University of Southern California, Los Angeles, California, USA., Miller JW; Department of Pathology and Laboratory Medicine, University of California, Davis, Sacramento, California, USA., Morris JC; Department of Pathology and Immunology, Washington University, St. Louis, Missouri, USA.; Department of Neurology, Washington University, St. Louis, Missouri, USA., Murrell JR; Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, Indiana, USA.; Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, USA., Myers AJ; Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, Florida, USA., O'Bryant S; Internal Medicine, Division of Geriatrics, University of North Texas Health Science Center, Fort Worth, Texas, USA., Olichney JM; Department of Neurology, University of California, Davis, Sacramento, California, USA., Pankratz VS; Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA., Parisi JE; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA., Paulson HL; Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA.; Michigan Alzheimer Disease Center, Ann Arbor, Michigan, USA., Perry W; John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA., Peskind E; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington, USA., Pierce A; Department of Neurology, University of California, Irvine, Irvine, California, USA., Poon WW; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, California, USA., Potter H; Department of Neurology, University of Colorado School of Medicine, Aurora, Colorado, USA., Quinn JF; Department of Neurology, Oregon Health &Science University, Portland, Oregon, USA.; Department of Neurology, Portland Veterans Affairs Medical Center, Portland, Oregon, USA., Raj A; USF Health Byrd Alzheimer's Institute, University of South Florida, Tampa, Florida, USA., Raskind M; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington, USA., Reisberg B; Department of Psychiatry, New York University, New York, New York, USA.; Alzheimer's Disease Center, New York University, New York, New York, USA., Reitz C; Gertrude H. Sergievsky Center, Columbia University, New York, New York, USA.; Department of Neurology, Columbia University, New York, New York, USA.; Department of Epidemiology, Columbia University, New York, New York, USA., Ringman JM; Department of Neurology, University of California, Los Angeles, Los Angeles, California, USA., Roberson ED; Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA., Rogaeva E; Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada., Rosen HJ; Department of Neurology, University of California, San Francisco, San Francisco, California, USA., Rosenberg RN; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas, USA., Sager MA; Department of Medicine, University of Wisconsin, Madison, Wisconsin, USA., Saykin AJ; Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, USA.; Department of Radiology and Imaging Sciences, Indiana University, Indianapolis, Indiana, USA., Schneider JA; Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.; Department of Pathology (Neuropathology), Rush University Medical Center, Chicago, Illinois, USA., Schneider LS; Department of Neurology, University of Southern California, Los Angeles, California, USA.; Department of Psychiatry, University of Southern California, Los Angeles, California, USA., Seeley WW; Department of Neurology, University of California, San Francisco, San Francisco, California, USA., Smith AG; USF Health Byrd Alzheimer's Institute, University of South Florida, Tampa, Florida, USA., Sonnen JA; Department of Pathology, University of Washington, Seattle, Washington, USA., Spina S; Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, Indiana, USA., Stern RA; Department of Neurology, Boston University, Boston, Massachusetts, USA., Swerdlow RH; University of Kansas Alzheimer's Disease Center, University of Kansas Medical Center, Kansas City, Kansas, USA., Tanzi RE; Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, USA., Thornton-Wells TA; Translational Medicine, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA., Trojanowski JQ; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Troncoso JC; Department of Pathology, Johns Hopkins University, Baltimore, Maryland, USA., Van Deerlin VM; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Van Eldik LJ; Sanders-Brown Center on Aging, Department of Anatomy and Neurobiology, University of Kentucky, Lexington, Kentucky, USA., Vinters HV; Department of Neurology, University of California, Los Angeles, Los Angeles, California, USA.; Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, California, USA., Vonsattel JP; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Pathology, Columbia University, New York, New York, USA., Weintraub S; Cognitive Neurology and Alzheimer's Disease Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Department of Psychiatry, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Welsh-Bohmer KA; Department of Medicine, Duke University, Durham, North Carolina, USA.; Department of Psychiatry and Behavioral Sciences, Duke University, Durham, North Carolina, USA., Wilhelmsen KC; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Williamson J; Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, New York, USA., Wingo TS; Department of Neurology, Emory University, Atlanta, Georgia, USA., Woltjer RL; Department of Pathology, Oregon Health &Science University, Portland, Oregon, USA., Wright CB; Evelyn F. McKnight Brain Institute, Department of Neurology, Miller School of Medicine, University of Miami, Miami, Florida, USA., Yu CE; Department of Medicine, University of Washington, Seattle, Washington, USA., Yu L; Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA., Garzia F; CEA/Institut de Génomique, Centre National de Génotypage, Evry, France., Golamaully F; CEA/Institut de Génomique, Centre National de Génotypage, Evry, France., Septier G; CEA/Institut de Génomique, Centre National de Génotypage, Evry, France., Engelborghs S; Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.; Department of Neurology and Memory Clinic, Hospital Network Antwerp, Antwerp, Belgium., Vandenberghe R; Department of Neurology and Memory Clinic, Hospital Network Antwerp, Antwerp, Belgium.; Laboratory for Cognitive Neurology, Department of Neurology, University of Leuven, Leuven, Belgium., De Deyn PP; Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.; Department of Neurology and Memory Clinic, Hospital Network Antwerp, Antwerp, Belgium., Fernadez CM; Department of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain., Benito YA; Department of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain., Thonberg H; Department of Geriatric Medicine, Genetics Unit, Karolinska University Hospital Huddinge, Stockholm, Sweden.; Department of Neurobiology, Care Sciences and Society, KIADRC, Karolinska Institutet, Stockholm, Sweden., Forsell C; Department of Geriatric Medicine, Genetics Unit, Karolinska University Hospital Huddinge, Stockholm, Sweden.; Department of Neurobiology, Care Sciences and Society, KIADRC, Karolinska Institutet, Stockholm, Sweden., Lilius L; Department of Geriatric Medicine, Genetics Unit, Karolinska University Hospital Huddinge, Stockholm, Sweden.; Department of Neurobiology, Care Sciences and Society, KIADRC, Karolinska Institutet, Stockholm, Sweden., Kinhult-Stählbom A; Department of Geriatric Medicine, Genetics Unit, Karolinska University Hospital Huddinge, Stockholm, Sweden.; Department of Neurobiology, Care Sciences and Society, KIADRC, Karolinska Institutet, Stockholm, Sweden., Kilander L; Department of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden., Brundin R; Department of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden., Concari L; Department of Neuroscience, University of Parma, Parma, Italy.; Center for Cognitive Disorders AUSL, Parma, Italy., Helisalmi S; Department of Neurology, Kuopio University Hospital, Kuopio, Finland.; Institute of Clinical Medicine/Neurology, University of Eastern Finland, Kuopio, Finland., Koivisto AM; Department of Neurology, Kuopio University Hospital, Kuopio, Finland.; Institute of Clinical Medicine/Neurology, University of Eastern Finland, Kuopio, Finland., Haapasalo A; Department of Neurology, Kuopio University Hospital, Kuopio, Finland.; Institute of Clinical Medicine/Neurology, University of Eastern Finland, Kuopio, Finland., Dermecourt V; CHU Lille, Memory Center of Lille (Centre Mémoire de Ressources et de Recherche), Lille, France., Fievet N; INSERM, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.; Institut Pasteur de Lille, Lille, France.; University Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France.; University Paris Descartes, EA 4468, AP-HP, Hôpital Broca, Geriatrics Department, Paris, France., Hanon O; University Paris Descartes, EA 4468, AP-HP, Hôpital Broca, Geriatrics Department, Paris, France., Dufouil C; University of Bordeaux, Neuroepidemiology, Bordeaux, France.; INSERM, Neuroepidemiology, UMR 897, Bordeaux, France., Brice A; INSERM U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Université Paris 06, UMRS 1127, Institut du Cerveau et de la Moelle Épinière, Paris, France.; AP-HP, Department of Genetics, Pitié-Salpêtrière Hospital, Paris, France., Ritchie K; INSERM U1061, La Colombière Hospital, Montpellier, France., Dubois B; Institut de la Mémoire et de la Maladie d'Alzheimer (IM2A), Département de Neurologie, Hôpital de la Pitié-Salpêtrière, AP-HP, Paris, France.; Institut des Neurosciences Translationnelles de Paris (IHU-A-ICM), Institut du Cerveau et de la Moelle Épinière (ICM), Paris, France.; INSERM, CNRS, UMRS 975, Institut du Cerveau et de la Moelle Épinière (ICM), Paris, France.; Sorbonne Universités, Université Pierre et Marie Curie, Hôpital de la Pitié-Salpêtrière, AP-HP, Paris, France., Himali JJ; Boston University School of Medicine, Boston, Massachusetts, USA., Keene CD; Department of Pathology, University of Washington, Seattle, Washington, USA., Tschanz J; Department of Mathematics and Statistics, Utah State University, Logan, Utah, USA., Fitzpatrick AL; Department of Epidemiology, University of Washington, Seattle, Washington, USA.; Department of Family Medicine, University of Washington, Seattle, Washington, USA., Kukull WA; Department of Epidemiology, University of Washington, Seattle, Washington, USA., Norton M; Department of Mathematics and Statistics, Utah State University, Logan, Utah, USA., Aspelund T; Icelandic Heart Association, Kopavogur, Iceland.; Centre for Public Health, University of Iceland, Reykjavik, Iceland., Larson EB; Department of Medicine, University of Washington, Seattle, Washington, USA.; Group Health Research Institute, Group Health, Seattle, Washington, USA., Munger R; Department of Mathematics and Statistics, Utah State University, Logan, Utah, USA., Rotter JI; Institute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, USA., Lipton RB; Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, USA., Bullido MJ; Instituto de Investigación Sanitaria Hospital la Paz (IdiPAZ), Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain., Hofman A; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Montine TJ; Department of Pathology, University of Washington, Seattle, Washington, USA., Coto E; Molecular Genetics Laboratory-Hospital, University of Central Asturias, Oviedo, Spain., Boerwinkle E; School of Public Health, Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, USA.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, USA., Petersen RC; Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA., Alvarez V; Molecular Genetics Laboratory-Hospital, University of Central Asturias, Oviedo, Spain., Rivadeneira F; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.; Netherlands Consortium on Health Aging and National Genomics Initiative, Leiden, the Netherlands., Reiman EM; Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona, USA.; Arizona Alzheimer's Consortium, Phoenix, Arizona, USA.; Banner Alzheimer's Institute, Phoenix, Arizona, USA.; Department of Psychiatry, University of Arizona, Phoenix, Arizona, USA., Gallo M; Regional Neurogenetic Centre (CRN), ASP Catanzaro, Lamezia Terme, Italy., O'Donnell CJ; Framingham Heart Study, Framingham, Massachusetts, USA., Reisch JS; Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, Texas, USA., Bruni AC; Regional Neurogenetic Centre (CRN), ASP Catanzaro, Lamezia Terme, Italy., Royall DR; Departments of Psychiatry, Medicine, and Family and Community Medicine and South Texas Veterans Health Administration Geriatric Research Education and Clinical Center (GRECC), University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA., Dichgans M; Institute for Stroke and Dementia Research, Klinikum der Universität München, Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany., Sano M; Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA., Galimberti D; Department of Pathophysiology and Transplantation, University of Milan, Fondazione Ca' Granda, IRCCS Ospedale Policlinico, Milan, Italy., St George-Hyslop P; Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada.; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK., Scarpini E; Department of Pathophysiology and Transplantation, University of Milan, Fondazione Ca' Granda, IRCCS Ospedale Policlinico, Milan, Italy., Tsuang DW; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington, USA.; VA Puget Sound Health Care System/GRECC, Seattle, Washington, USA., Mancuso M; Department of Experimental and Clinical Medicine, Neurological Institute, University of Pisa, Pisa, Italy., Bonuccelli U; Department of Experimental and Clinical Medicine, Neurological Institute, University of Pisa, Pisa, Italy., Winslow AR; PharmaTherapeutics Clinical Research, Pfizer Worldwide Research and Development, Cambridge, Massachusetts, USA., Daniele A; Institute of Neurology, Catholic University of Sacred Hearth, Rome, Italy., Wu CK; Departments of Neurology, Pharmacology, and Neuroscience, Texas Tech University Health Science Center, Lubbock, Texas, USA., Peters O; Department of Psychiatry, Charité University Medicine, Berlin, Germany., Nacmias B; NEUROFARBA (Department of Neuroscience, Psychology, Drug Research and Child Health), University of Florence, Florence, Italy.; IRCCS 'Don Carlo Gnocchi', Florence, Italy., Riemenschneider M; Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany., Heun R; Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany., Brayne C; Institute of Public Health, University of Cambridge, Cambridge, UK., Rubinsztein DC; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK., Bras J; Department of Molecular Neuroscience, UCL, Institute of Neurology, London, UK.; Department of Medical Sciences, Institute of Biomedicine (iBiMED), University of Aveiro, Aveiro, Portugal., Guerreiro R; Department of Molecular Neuroscience, UCL, Institute of Neurology, London, UK.; Department of Medical Sciences, Institute of Biomedicine (iBiMED), University of Aveiro, Aveiro, Portugal., Al-Chalabi A; Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Shaw CE; Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Collinge J; Department of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, London, UK., Mann D; Institute of Brain, Behaviour and Mental Health, Clinical and Cognitive Neuroscience Research Group, University of Manchester, Manchester, UK., Tsolaki M; 3rd Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece., Clarimón J; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Memory Unit, Neurology Department and Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain., Sussams R; Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, UK., Lovestone S; Department of Psychiatry, University of Oxford, Oxford, UK., O'Donovan MC; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Owen MJ; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Behrens TW; Immunology Biomarkers Group, Genentech, South San Francisco, California, USA., Mead S; Department of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, London, UK., Goate AM; Department of Neuroscience, Mount Sinai School of Medicine, New York, New York, USA., Uitterlinden AG; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Department of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, London, UK.; Department of Pathophysiology and Transplantation, University of Milan, Fondazione Ca' Granda, IRCCS Ospedale Policlinico, Milan, Italy., Holmes C; 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مؤلفون مشاركون: ARUK Consortium, GERAD/PERADES, CHARGE, ADGC, EADI

المصدر: Nature genetics [Nat Genet] 2017 Sep; Vol. 49 (9), pp. 1373-1384. Date of Electronic Publication: 2017 Jul 17.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE

مواضيع طبية MeSH: Polymorphism, Single Nucleotide*, Adaptor Proteins, Signal Transducing/*genetics , Alzheimer Disease/*genetics , Immunity, Innate/*genetics , Membrane Glycoproteins/*genetics , Microglia/*metabolism , Phospholipase C gamma/*genetics , Receptors, Immunologic/*genetics, Amino Acid Sequence ; Case-Control Studies ; Exome/genetics ; Gene Expression Profiling ; Gene Frequency ; Genetic Predisposition to Disease/genetics ; Genotype ; Humans ; Linkage Disequilibrium ; Odds Ratio ; Protein Interaction Maps/genetics ; Sequence Homology, Amino Acid