المؤلفون: Morral C; Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Ayyaz A; Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.; Department of Biological Sciences, University of Calgary, Calgary, AB, Canada., Kuo HC; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Fink M; Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Verginadis II; Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Daniel AR; Department of Radiation Oncology, Duke University, Durham, NC, USA., Burner DN; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA., Driver LM; Department of Radiation Oncology, Duke University, Durham, NC, USA.; Department of Pathology, Duke University, Durham, NC, USA., Satow S; Department of Radiation Oncology, Duke University, Durham, NC, USA., Hasapis S; Department of Radiation Oncology, Duke University, Durham, NC, USA., Ghinnagow R; Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Luo L; Department of Radiation Oncology, Duke University, Durham, NC, USA., Ma Y; Department of Radiation Oncology, Duke University, Durham, NC, USA., Attardi LD; Departments of Radiation Oncology and Genetics, Stanford University, Palo Alto, CA, USA., Koumenis C; Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Minn AJ; Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Parker Institute for Cancer Immunotherapy, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Mark Foundation Center for Immunotherapy, Immune Signaling, and Radiation, University of Pennsylvania, Philadelphia, PA, USA., Wrana JL; Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada. wrana@lunenfeld.ca.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. wrana@lunenfeld.ca., Lee CL; Department of Radiation Oncology, Duke University, Durham, NC, USA. chang-lung.lee@duke.edu.; Department of Pathology, Duke University, Durham, NC, USA. chang-lung.lee@duke.edu., Kirsch DG; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA. david.kirsch@uhn.ca.; Department of Radiation Oncology, Duke University, Durham, NC, USA. david.kirsch@uhn.ca.; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada. david.kirsch@uhn.ca.; Departments of Radiation Oncology and Medical Biophysics, University of Toronto, Toronto, ON, Canada. david.kirsch@uhn.ca.

المصدر: Nature communications [Nat Commun] 2024 Apr 08; Vol. 15 (1), pp. 3018. Date of Electronic Publication: 2024 Apr 08.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Tumor Suppressor Protein p53*/genetics , Tumor Suppressor Protein p53*/metabolism , Radiation Injuries*/genetics , Radiation Injuries*/metabolism, Mice ; Animals ; Intestines ; Gastrointestinal Tract/metabolism ; Stem Cells/metabolism ; Apoptosis/genetics

المؤلفون: Rivera-Reyes A; Abramson Family Cancer Research Institute, Department of Pathology & Laboratory Medicine, Penn Sarcoma Program, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Ye S; Abramson Family Cancer Research Institute, Department of Pathology & Laboratory Medicine, Penn Sarcoma Program, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., E Marino G; Abramson Family Cancer Research Institute, Department of Pathology & Laboratory Medicine, Penn Sarcoma Program, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Egolf S; Abramson Family Cancer Research Institute, Department of Pathology & Laboratory Medicine, Penn Sarcoma Program, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., E Ciotti G; Abramson Family Cancer Research Institute, Department of Pathology & Laboratory Medicine, Penn Sarcoma Program, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Chor S; Abramson Family Cancer Research Institute, Department of Pathology & Laboratory Medicine, Penn Sarcoma Program, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Liu Y; Abramson Family Cancer Research Institute, Department of Pathology & Laboratory Medicine, Penn Sarcoma Program, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Posimo JM; Abramson Family Cancer Research Institute, Department of Pathology & Laboratory Medicine, Penn Sarcoma Program, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Department of Cancer Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Park PMC; Department of Medicine, Harvard Medical School, Boston, MA, 02115, USA., Pak K; Abramson Family Cancer Research Institute, Department of Pathology & Laboratory Medicine, Penn Sarcoma Program, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Babichev Y; Department of Surgery and Institute of Medical Science, University of Toronto, Toronto, ON, Canada.; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada., Sostre-Colón J; Abramson Family Cancer Research Institute, Department of Pathology & Laboratory Medicine, Penn Sarcoma Program, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Tameire F; Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Leli NM; Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Koumenis C; Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., C Brady D; Abramson Family Cancer Research Institute, Department of Pathology & Laboratory Medicine, Penn Sarcoma Program, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Department of Cancer Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Mancuso A; Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Weber K; Department of Orthopedic Surgery, Penn Sarcoma Program, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Gladdy R; Department of Surgery and Institute of Medical Science, University of Toronto, Toronto, ON, Canada.; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada., Qi J; Department of Medicine, Harvard Medical School, Boston, MA, 02115, USA., Eisinger-Mathason TSK; Abramson Family Cancer Research Institute, Department of Pathology & Laboratory Medicine, Penn Sarcoma Program, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. karineis@pennmedicine.upenn.edu.

المصدر: Cell death & disease [Cell Death Dis] 2018 Oct 31; Vol. 9 (11), pp. 1108. Date of Electronic Publication: 2018 Oct 31.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE

مواضيع طبية MeSH: Gene Expression Regulation, Neoplastic*, Adaptor Proteins, Signal Transducing/*genetics , Autophagy/*genetics , Cell Cycle Proteins/*genetics , Muscle Neoplasms/*genetics , NF-kappa B/*genetics , Sarcoma/*genetics, Activating Transcription Factor 6/genetics ; Activating Transcription Factor 6/metabolism ; Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Autophagy/drug effects ; Azepines/pharmacology ; CLOCK Proteins/genetics ; CLOCK Proteins/metabolism ; Cell Cycle Proteins/metabolism ; Cell Differentiation ; Cell Line ; Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/metabolism ; Cell Transformation, Neoplastic/pathology ; Circadian Clocks/drug effects ; Circadian Clocks/genetics ; Humans ; Mice ; Mice, Transgenic ; Muscle Neoplasms/drug therapy ; Muscle Neoplasms/metabolism ; Muscle Neoplasms/pathology ; Muscle, Skeletal/drug effects ; Muscle, Skeletal/metabolism ; Muscle, Skeletal/pathology ; Myoblasts/drug effects ; Myoblasts/metabolism ; Myoblasts/pathology ; NF-kappa B/metabolism ; Sarcoma/drug therapy ; Sarcoma/metabolism ; Sarcoma/pathology ; Signal Transduction ; Stem Cells/drug effects ; Stem Cells/metabolism ; Stem Cells/pathology ; Triazoles/pharmacology ; Unfolded Protein Response/drug effects ; Vorinostat/pharmacology ; YAP-Signaling Proteins ; eIF-2 Kinase/genetics ; eIF-2 Kinase/metabolism

المؤلفون: Xu Z; Department of Biochemistry, Hollings Cancer Center, Medical University of South Carolina, 86 Jonathan Lucas Street, 3400, Charleston, South Carolina 29425, USA., Bu Y; Department of Biochemistry, Hollings Cancer Center, Medical University of South Carolina, 86 Jonathan Lucas Street, 3400, Charleston, South Carolina 29425, USA., Chitnis N; Department of Biochemistry, Hollings Cancer Center, Medical University of South Carolina, 86 Jonathan Lucas Street, 3400, Charleston, South Carolina 29425, USA., Koumenis C; Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA., Fuchs SY; Department of Animal Biology, School of Veterinary Medicine, 380 S. University Avenue, Philadelphia, Pennsylvania 19104, USA., Diehl JA; Department of Biochemistry, Hollings Cancer Center, Medical University of South Carolina, 86 Jonathan Lucas Street, 3400, Charleston, South Carolina 29425, USA.

المصدر: Nature communications [Nat Commun] 2016 May 13; Vol. 7, pp. 11422. Date of Electronic Publication: 2016 May 13.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Apoptosis*, MicroRNAs/*metabolism , Proto-Oncogene Proteins c-jun/*metabolism , Transcription Factor CHOP/*metabolism, Animals ; Cell Line ; Cell Line, Tumor ; Cell Survival ; Endoplasmic Reticulum Stress ; Endoribonucleases/genetics ; Endoribonucleases/metabolism ; Humans ; Mice ; MicroRNAs/genetics ; Protein Serine-Threonine Kinases/genetics ; Protein Serine-Threonine Kinases/metabolism ; Proto-Oncogene Proteins c-jun/genetics ; Transcription Factor CHOP/genetics ; Unfolded Protein Response ; eIF-2 Kinase/genetics ; eIF-2 Kinase/metabolism