المؤلفون: Barmada SJ; 1] Gladstone Institute of Neurologic Disease, San Francisco, California, USA. [2] Department of Neurology, University of California-San Francisco Medical Center, San Francisco, California, USA. [3] Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA., Serio A; 1] Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Edinburgh, Scotland, UK. [2] Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, Scotland, UK. [3] Departments of Materials and Bioengineering, and Institute for Biomedical Engineering, Imperial College, London, UK., Arjun A; Gladstone Institute of Neurologic Disease, San Francisco, California, USA., Bilican B; 1] Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Edinburgh, Scotland, UK. [2] Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, Scotland, UK., Daub A; Gladstone Institute of Neurologic Disease, San Francisco, California, USA., Ando DM; 1] Gladstone Institute of Neurologic Disease, San Francisco, California, USA. [2] Biomedical Sciences Graduate Program, University of California-San Francisco, San Francisco, California, USA., Tsvetkov A; 1] Gladstone Institute of Neurologic Disease, San Francisco, California, USA. [2] Department of Neurobiology and Anatomy, University of Texas Medical School, Houston, Texas, USA., Pleiss M; Keck Program in Brain Cell Engineering, Gladstone Institutes, San Francisco, California, USA., Li X; Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA., Peisach D; Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA., Shaw C; Institute of Psychiatry, King's College London, London, UK., Chandran S; 1] Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Edinburgh, Scotland, UK. [2] Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, Scotland, UK., Finkbeiner S; 1] Gladstone Institute of Neurologic Disease, San Francisco, California, USA. [2] Department of Neurology, University of California-San Francisco Medical Center, San Francisco, California, USA. [3] Biomedical Sciences Graduate Program, University of California-San Francisco, San Francisco, California, USA. [4] Keck Program in Brain Cell Engineering, Gladstone Institutes, San Francisco, California, USA. [5] Department of Physiology, University of California-San Francisco, San Francisco, California, USA. [6] Taube-Koret Center for Neurodegenerative Disease Research, San Francisco, California, USA. [7] Hellman Family Foundation Alzheimer's Disease Research Program, San Francisco, California, USA. [8] Roddenberry Stem Cell Program, San Francisco, California, USA.

المصدر: Nature chemical biology [Nat Chem Biol] 2014 Aug; Vol. 10 (8), pp. 677-85. Date of Electronic Publication: 2014 Jun 29.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: Autophagy*/drug effects, Amyotrophic Lateral Sclerosis/*metabolism , DNA-Binding Proteins/*metabolism , Neurons/*metabolism, Amino Acid Sequence ; Amyotrophic Lateral Sclerosis/pathology ; Animals ; Astrocytes/metabolism ; Cell Survival ; Cells, Cultured ; DNA-Binding Proteins/genetics ; Fluphenazine/pharmacology ; Half-Life ; Humans ; Induced Pluripotent Stem Cells/physiology ; Methotrimeprazine/pharmacology ; Mice ; Microtubule-Associated Proteins/genetics ; Microtubule-Associated Proteins/metabolism ; Molecular Sequence Data ; Mutation ; Rats ; Reproducibility of Results ; Single-Cell Analysis/methods ; Small Molecule Libraries/pharmacology ; Stem Cells/metabolism