المؤلفون: Tylawsky DE; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Pharmacology, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA., Kiguchi H; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Vaynshteyn J; Departments of Neurology and Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Gerwin J; Departments of Neurology and Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Shah J; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Islam T; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Boyer JA; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Boué DR; Departments of Pathology & Laboratory Medicine, Nationwide Children's Hospital and The Ohio State University, Columbus, OH, USA., Snuderl M; Division of Neuropathology, Department of Pathology, NYU Langone Medical Center, New York, NY, USA., Greenblatt MB; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, & Research Division, Hospital for Special Surgery, New York, NY, USA., Shamay Y; Faculty of Biomedical Engineering, Technion Israel Institute of Technology, Haifa, Israel., Raju GP; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA. praveen.raju@mssm.edu.; Departments of Neurology and Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA. praveen.raju@mssm.edu.; Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA. praveen.raju@mssm.edu., Heller DA; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. hellerd@mskcc.org.; Department of Pharmacology, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA. hellerd@mskcc.org.

المصدر: Nature materials [Nat Mater] 2023 Mar; Vol. 22 (3), pp. 391-399. Date of Electronic Publication: 2023 Mar 02.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101155473 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4660 (Electronic) Linking ISSN: 14761122 NLM ISO Abbreviation: Nat Mater Subsets: MEDLINE

مواضيع طبية MeSH: Medulloblastoma* , Cerebellar Neoplasms*, Animals ; Hedgehog Proteins ; Blood-Brain Barrier ; Caveolin 1 ; P-Selectin ; Transcytosis ; Tumor Microenvironment

المؤلفون: Shamay Y; Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Faculty of Biomedical Engineering, Technion-Israel Institute of Technology, Haifa, Israel., Shah J; Memorial Sloan Kettering Cancer Center, New York, NY, USA., Işık M; Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Tri-Institutional PhD Program in Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Mizrachi A; Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Otolaryngology Head and Neck Surgery, Rabin Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Leibold J; Memorial Sloan Kettering Cancer Center, New York, NY, USA., Tschaharganeh DF; Helmholtz-University Group 'Cell Plasticity and Epigenetic Remodeling', German Cancer Research Center (DKFZ) & Institute of Pathology University Hospital, Heidelberg, Germany., Roxbury D; Department of Chemical Engineering, University of Rhode Island, Kingston, RI, 02881, USA., Budhathoki-Uprety J; Memorial Sloan Kettering Cancer Center, New York, NY, USA., Nawaly K; Memorial Sloan Kettering Cancer Center, New York, NY, USA., Sugarman JL; Memorial Sloan Kettering Cancer Center, New York, NY, USA., Baut E; Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Weill Cornell Medical College, Cornell University, New York, NY, USA., Neiman MR; Memorial Sloan Kettering Cancer Center, New York, NY, USA., Dacek M; Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Weill Cornell Medical College, Cornell University, New York, NY, USA., Ganesh KS; Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Weill Cornell Medical College, Cornell University, New York, NY, USA., Johnson DC; Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Tri-Institutional PhD Program in Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Sridharan R; Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Weill Cornell Medical College, Cornell University, New York, NY, USA., Chu KL; Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Weill Cornell Medical College, Cornell University, New York, NY, USA., Rajasekhar VK; Memorial Sloan Kettering Cancer Center, New York, NY, USA., Lowe SW; Memorial Sloan Kettering Cancer Center, New York, NY, USA., Chodera JD; Memorial Sloan Kettering Cancer Center, New York, NY, USA., Heller DA; Memorial Sloan Kettering Cancer Center, New York, NY, USA. hellerd@mskcc.org.; Weill Cornell Medical College, Cornell University, New York, NY, USA. hellerd@mskcc.org.

المصدر: Nature materials [Nat Mater] 2018 Apr; Vol. 17 (4), pp. 361-368. Date of Electronic Publication: 2018 Feb 05.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101155473 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4660 (Electronic) Linking ISSN: 14761122 NLM ISO Abbreviation: Nat Mater Subsets: MEDLINE

مواضيع طبية MeSH: Drug Carriers/*chemistry , Nanomedicine/*methods, Animals ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Drug Carriers/metabolism ; Drug Carriers/pharmacokinetics ; Endocytosis ; Indoles/chemistry ; Mice ; Nanoparticles/chemistry ; Particle Size ; Tissue Distribution

المؤلفون: Mizrachi A; Head and Neck Service, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA., Shamay Y; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA., Shah J; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA., Brook S; Human Oncology &Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA., Soong J; Human Oncology &Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA., Rajasekhar VK; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA., Humm JL; Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA., Healey JH; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA., Powell SN; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA., Baselga J; Human Oncology &Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA., Heller DA; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.; Department of Pharmacology, Weill Cornell Medical College, New York, New York 10065, USA., Haimovitz-Friedman A; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA., Scaltriti M; Human Oncology &Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.

المصدر: Nature communications [Nat Commun] 2017 Feb 13; Vol. 8, pp. 14292. Date of Electronic Publication: 2017 Feb 13.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Xenograft Model Antitumor Assays*, Carcinoma, Squamous Cell/*drug therapy , Class I Phosphatidylinositol 3-Kinases/*antagonists & inhibitors , Head and Neck Neoplasms/*drug therapy , Nanoparticles/*chemistry , Thiazoles/*pharmacology, Animals ; Carcinoma, Squamous Cell/metabolism ; Cell Line, Tumor ; Class I Phosphatidylinositol 3-Kinases/metabolism ; Drug Delivery Systems/methods ; Head and Neck Neoplasms/metabolism ; Humans ; Mice, Nude ; Microscopy, Electron, Scanning ; Nanoparticles/ultrastructure ; Protein Kinase Inhibitors/administration & dosage ; Protein Kinase Inhibitors/chemistry ; Protein Kinase Inhibitors/pharmacology ; Thiazoles/administration & dosage ; Thiazoles/chemistry ; Treatment Outcome