المؤلفون: Kennedy RJ; Breast, Endocrine and Surgical Oncology Unit and Department of Surgery, University of Adelaide, Royal Adelaide Hospital, Adelaide, South Australia, Australia. rk103@btopenworld.com, Kollias J, Gill PG, Bochner M, Coventry BJ, Farshid G

المصدر: The British journal of surgery [Br J Surg] 2003 Nov; Vol. 90 (11), pp. 1349-53.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Oxford University Press on behalf of BJS Foundation Ltd Country of Publication: England NLM ID: 0372553 Publication Model: Print Cited Medium: Print ISSN: 0007-1323 (Print) Linking ISSN: 00071323 NLM ISO Abbreviation: Br J Surg Subsets: MEDLINE

مواضيع طبية MeSH: Breast Neoplasms/*pathology , Neoplasm Staging/*standards , Sentinel Lymph Node Biopsy/*standards, Adult ; Aged ; Axilla ; Breast Neoplasms/surgery ; False Negative Reactions ; Female ; Humans ; Lymph Node Excision/methods ; Lymphatic Metastasis/pathology ; Middle Aged ; Neoplasm Staging/methods ; Prospective Studies ; Sensitivity and Specificity ; Sentinel Lymph Node Biopsy/methods

مستخلص: Background: Assessment of lymph node status in breast cancer is still necessary for staging. Sentinel lymph node biopsy (SNB) may provide accurate staging with less morbidity than axillary clearance. The aim of this study was to assess the effect of the number of sentinel nodes removed on the false-negative rate.
Methods: Data were collected prospectively from 395 women undergoing SNB for breast cancer, between June 1995 and December 2001. All nodes that were hot and/or blue were removed and analysed.
Results: During this interval 136 patients who had SNB were lymph node positive. The median number of sentinel nodes removed was two (range one to five). The overall false-negative rate of SNB in these women was 7.1 per cent. If only one sentinel node had been removed, the false-negative rate would have been 16.5 per cent. The removal of more than two nodes had no effect on axillary staging in all but two women.
Conclusion: In early breast cancer, when there were multiple sentinel nodes, removal of two sentinel nodes significantly reduced the false-negative rate compared with removal of one node. Removing more than two sentinel nodes did not significantly reduce the false-negative rate further.
(Copyright 2003 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.)

المؤلفون: Nano MT; Breast Unit and Women's Health Centre, Royal Adelaide Hospital Cancer Centre, South Australia, Australia., Kollias J, Farshid G, Gill PG, Bochner M

المصدر: The British journal of surgery [Br J Surg] 2002 Nov; Vol. 89 (11), pp. 1430-4.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Oxford University Press on behalf of BJS Foundation Ltd Country of Publication: England NLM ID: 0372553 Publication Model: Print Cited Medium: Print ISSN: 0007-1323 (Print) Linking ISSN: 00071323 NLM ISO Abbreviation: Br J Surg Subsets: MEDLINE

مواضيع طبية MeSH: Breast Neoplasms/*pathology , Carcinoma, Ductal, Breast/*secondary , Carcinoma, Lobular/*secondary, Aged ; Breast Neoplasms/diagnostic imaging ; Carcinoma, Ductal, Breast/diagnostic imaging ; Carcinoma, Lobular/diagnostic imaging ; False Negative Reactions ; Female ; Humans ; Lymphatic Metastasis/diagnostic imaging ; Lymphatic Metastasis/pathology ; Middle Aged ; Radionuclide Imaging ; Sensitivity and Specificity ; Sentinel Lymph Node Biopsy/methods ; Sentinel Lymph Node Biopsy/standards

مستخلص: Background: The aim was to assess the false-negative sentinel node biopsy rate in women with early breast cancer and its implications in patient treatment.
Methods: Between January 1995 and March 2001, 328 consecutive patients with clinically lymph node-negative primary operable breast cancer underwent lymphatic mapping and sentinel node biopsy using a combination of preoperative lymphoscintigraphy and/or blue dye. All underwent immediate axillary dissection. The intraoperative success rate in sentinel node identification, false-negative rate, predictive value of negative sentinel node status and overall accuracy were assessed. The clinical features and primary tumour characteristics for each false-negative case were reviewed.
Results: The sentinel node was identified in 285 (86.9 per cent) of 328 women. The false-negative rate was 7.9 per cent (eight of 101). Most members of the breast multidisciplinary team would have instituted adjuvant systemic therapy for six false-negative cases based on clinical features and primary tumour histology. In all, only two (0.7 per cent) of 285 women who had sentinel node biopsy may have had their management and survival prospects potentially jeopardized owing to a false-negative sentinel node.
Conclusion: The results of this study suggest that the clinical impact of a false-negative sentinel node is low.

المؤلفون: Gill PG; Department of Surgery, University of Adelaide, South Australia., Jamieson GG, Denham J, Devitt PG, Ahmad A, Yeoh E, Jones AM

المصدر: The British journal of surgery [Br J Surg] 1990 Sep; Vol. 77 (9), pp. 1020-3.

نوع المنشور: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Oxford University Press on behalf of BJS Foundation Ltd Country of Publication: England NLM ID: 0372553 Publication Model: Print Cited Medium: Print ISSN: 0007-1323 (Print) Linking ISSN: 00071323 NLM ISO Abbreviation: Br J Surg Subsets: MEDLINE

مواضيع طبية MeSH: Adenocarcinoma/*drug therapy , Antineoplastic Combined Chemotherapy Protocols/*therapeutic use , Stomach Neoplasms/*drug therapy, Adenocarcinoma/pathology ; Adenocarcinoma/radiotherapy ; Adenocarcinoma/surgery ; Cardia ; Cisplatin/administration & dosage ; Combined Modality Therapy ; Fluorouracil/administration & dosage ; Humans ; Palliative Care ; Prognosis ; Stomach Neoplasms/pathology ; Stomach Neoplasms/radiotherapy ; Stomach Neoplasms/surgery

مستخلص: Twenty-nine evaluable patients with adenocarcinoma of the cardia were treated with synchronously administered chemotherapy (two cycles of 5-fluouracil and cisplatin and 30-36 Gy of radiation to determine whether these tumours are responsive to such treatment. Complete regression of tumour was observed endoscopically in 19 patients, and partial regression in four. Fourteen patients had their tumours resected and in six no microscopic tumour was found in the specimen. Nine patients received additional radiotherapy to a total dose of 54-60 Gy instead of surgery. Tumour response was associated with rapid reversal of dysphagia. Only one patient required subsequent intervention for relief of dysphagia due to fibrous stricture. Enhanced survival was associated with a complete endoscopic response to initial chemotherapy and radiotherapy, and a tumour of less than 5 cm in length. The median survival of responding patients was 15 months. Synchronous chemotherapy and radiotherapy was of major palliative benefit in this series and merits further evaluation.

المؤلفون: Gill PG, Souter RG, Morris PG

المصدر: The British journal of surgery [Br J Surg] 1980 Jul; Vol. 67 (7), pp. 478-81.

نوع المنشور: Comparative Study; Journal Article

بيانات الدورية: Publisher: Oxford University Press on behalf of BJS Foundation Ltd Country of Publication: England NLM ID: 0372553 Publication Model: Print Cited Medium: Print ISSN: 0007-1323 (Print) Linking ISSN: 00071323 NLM ISO Abbreviation: Br J Surg Subsets: MEDLINE

مواضيع طبية MeSH: Hodgkin Disease/*pathology , Neoplasm Staging/*methods, Adolescent ; Child ; Hodgkin Disease/diagnostic imaging ; Humans ; Lymph Nodes/pathology ; Lymphography ; Spleen/pathology ; Splenectomy

مستخلص: The results of surgical staging in Hodgkin's disease in 107 patients under the care of one surgeon over an 8-year period are presented. The inaccuracy of clinical staging is re-emphasized as 43 per cent of patients had their disease stage altered by surgical staging. Lymphangiography correctly predicted the presence of intra-abdominal disease in only 70 per cent of patients. Spleen size was not an indication of involvement, and furthermore the spleen was involved by disease in the absence of nodal involvement in 6 patients. In 2 cases mesenteric nodes were involved in the absence of pancreatic or coeliac nodal involvement. As a consequence of surgical staging many patients received a more extensive field of radiotherapy, and 18 per cent of patients were treated by combination chemotherapy instead of radiotherapy. There was no hospital mortality and a low operative morbidity following surgical staging. At present surgical staging is an essential part of the overall strategy of management of patients with Hodgkin's disease.

المؤلفون: Gill PG, Morris PJ

المصدر: The British journal of surgery [Br J Surg] 1978 Jan; Vol. 65 (1), pp. 17-20.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Oxford University Press on behalf of BJS Foundation Ltd Country of Publication: England NLM ID: 0372553 Publication Model: Print Cited Medium: Print ISSN: 0007-1323 (Print) Linking ISSN: 00071323 NLM ISO Abbreviation: Br J Surg Subsets: MEDLINE

مواضيع طبية MeSH: Colonic Neoplasms/*mortality , Rectal Neoplasms/*mortality, Adult ; Age Factors ; Colonic Neoplasms/pathology ; Colonic Neoplasms/surgery ; Female ; Humans ; Male ; Middle Aged ; Neoplasm Staging ; Prognosis ; Rectal Neoplasms/pathology ; Rectal Neoplasms/surgery

المؤلفون: Gill PG, Souter RG, Morris PJ

المصدر: The British journal of surgery [Br J Surg] 1981 Jan; Vol. 68 (1), pp. 29-33.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Oxford University Press on behalf of BJS Foundation Ltd Country of Publication: England NLM ID: 0372553 Publication Model: Print Cited Medium: Print ISSN: 0007-1323 (Print) Linking ISSN: 00071323 NLM ISO Abbreviation: Br J Surg Subsets: MEDLINE

مواضيع طبية MeSH: Hypersplenism/*surgery , Lymphoma/*surgery, Adolescent ; Adult ; Aged ; Female ; Hematologic Diseases/etiology ; Hodgkin Disease/mortality ; Hodgkin Disease/surgery ; Humans ; Hypersplenism/etiology ; Lymphoma/complications ; Lymphoma/mortality ; Middle Aged ; Postoperative Complications ; Splenectomy

مستخلص: Splenectomy has been performed in advanced malignant lymphomas in an effect to correct haematological cytopaenias in 41 patients since 1975. In both Hodgkin's disease and a variety of non-Hodgkin's lymphomas the operation has been associated with a high percentage of haematological correction (90 per cent overall). In many of these patients the haematological defect had prevented or led to the cessation of treatment and in those cases where chemotherapy was resumed after splenectomy worthwhile remission was achieved in 87.5 per cent of patients. There was no postoperative deaths and morbidity was considered acceptably low. We conclude that splenectomy is a valuable adjunct to treatment in advanced malignant lymphomas and should be considered at the first suggestion of splenic overactivity and reduced bone marrow reserves.

المؤلفون: Dehn TC, Jamieson GG, Gill PG

المصدر: The British journal of surgery [Br J Surg] 1988 Jun; Vol. 75 (6), pp. 621.

نوع المنشور: Letter

بيانات الدورية: Publisher: Oxford University Press on behalf of BJS Foundation Ltd Country of Publication: England NLM ID: 0372553 Publication Model: Print Cited Medium: Print ISSN: 0007-1323 (Print) Linking ISSN: 00071323 NLM ISO Abbreviation: Br J Surg Subsets: MEDLINE

مواضيع طبية MeSH: Adenocarcinoma/*therapy , Carcinoma, Squamous Cell/*therapy , Esophageal Neoplasms/*therapy, Combined Modality Therapy ; Humans