المؤلفون: Yongqiang Tang, Yi Huan, Mengqi Wei, Jing Ren, Guangwen Zhang, Qi Pan, Zhiwei Han, Na Li, Wanling Ma

المصدر: Oncology Letters

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Pancreatic ductal adenocarcinoma, pancreatic neuroendocrine neoplasms, business.industry, pancreatic ductal adenocarcinoma, Cancer, Diagnostic accuracy, Articles, medicine.disease, fast apparent diffusion coefficient, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, intravoxel incoherent motion diffusion weighted imaging, Oncology, 030220 oncology & carcinogenesis, Medicine, Effective diffusion coefficient, slow apparent diffusion coefficient, business, Nuclear medicine, Intravoxel incoherent motion, Diffusion MRI

الوصف: The aim of the present study was to investigate the potential significance of intravoxel incoherent motion (IVIM)-diffusion weighted imaging (DWI) in differentiating high-grade pancreatic neuroendocrine neoplasms (pNENs) from pancreatic ductal adenocarcinoma (PDAC). A total of 50 patients, including 37 patients with PDAC and 13 patients with high-grade pNENs, underwent pancreatic multiple b-values DWI with 15 b-values including 0, 10, 20, 40, 60, 80, 100, 150, 200, 400, 800, 1,000, 1,200, 1,500 and 2,000 sec/mm2. Standard apparent diffusion coefficient (ADCstandard) and IVIM parameter [slow apparent diffusion coefficient (Dslow), fast apparent diffusion coefficient (Dfast), fraction of fast apparent diffusion coefficient (ƒ)] values of PDAC and pNENs were compared. P9.58×10−3 mm2/sec were 91.9 and 69.2%, respectively, for differentiating high-grade pNENs from PDAC. When Dslow and Dfast were combined, the specificity and sensitivity for differentiating high-grade pNENs from PDAC were 76.9 and 100%, respectively. Taken together, these results indicated that the diffusion-associated parameter Dslow and the perfusion-associated parameter Dfast of IVIM-DWI may differentiate high-grade pNENs from PDAC with high diagnostic accuracy, and that IVIM-DWI may be a valuable biomarker in differentiating pancreatic neoplasms.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ead5b0c574682154c4d66b26c74db1a7
https://doi.org/10.3892/ol.2019.10863

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