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تسجيل الدخول للوصول الكامل.

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تسجيل الدخول للوصول الكامل.

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المؤلفون: Bui KM, Garcia-Gonzalez JM, Patel SS, Lin AY, Edward DP, Goldstein DA; University of Illinois Eye and Ear Infirmary, Chicago, IL 60612, USA. debrgold@yahoo.com.

المصدر: Journal of ophthalmic inflammation and infection [J Ophthalmic Inflamm Infect] 2014 Mar 18; Vol. 4 (1), pp. 8. Date of Electronic Publication: 2014 Mar 18.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Country of Publication: Germany NLM ID: 101553216 Publication Model: Electronic Cited Medium: Print ISSN: 1869-5760 (Print) Linking ISSN: 18695760 NLM ISO Abbreviation: J Ophthalmic Inflamm Infect Subsets: PubMed not MEDLINE

مستخلص: Background: Sarcoidosis is an idiopathic, multi-system, granulomatous disease with well-described ocular manifestations. However, other uveitic etiologies can manifest in a similar fashion, and ocular disease may precede systemic manifestations. Definitive diagnosis requires histologic confirmation of non-caseating granulomatous inflammation. This study reports the diagnostic yield of directed biopsy of conjunctival follicles in patients with uveitis suspected to be secondary to sarcoidosis, and compares an institutional standard tissue sectioning method to a multi-plane technique.
Results: A retrospective analysis was performed of all patients who underwent directed conjunctival biopsy for suspected ocular sarcoidosis. A total of eight patients were identified; all were females. Directed conjunctival biopsy was positive in three of seven patients using standard histologic processing method, a yield of 43%. Using the multi-plane technique increased the cumulative yield to 63%.
Conclusions: Directed conjunctival biopsy is a minimally invasive, cost-effective, and moderately high yield method of diagnosing ocular sarcoidosis. Using a multi-plane sectioning method may increase biopsy yield when standard sectioning techniques are negative.