المؤلفون: Wallesch, C.-W.^Aff4, Bak, T.^Aff4

المساهمون: Hartmann, Alexander, editor^Aff1, Kuschinsky, Wolfgang, editor^Aff2, Hoyer, Siegfried, editor^Aff3

المصدر: Cerebral Ischemia and Dementia. :234-243

المؤلفون: Rapoport, S. I.

المساهمون: Christen, Yves, editor^{Aff1, Aff4}, Rapoport, Stanley I., editor^Aff2, Petit, Henri, editor^Aff3, Leys, Didier, editor^Aff3

المصدر: Imaging, Cerebral Topography and Alzheimer’s Disease. :167-171

Degree: M.D.
Ph.D.

المؤلفون: Krick, C.M., Backens, M., Pützer, M., Reith, W.

المصدر: Der Radiologe: Zeitschrift für diagnostische und interventionelle Radiologie, Radioonkologie, Nuklearmedizin. July 2013 53(7):592-597

المؤلفون: Tsuda, Yoshiyasu^{Aff4, Aff5}, Kitadai, M.^Aff4, Satoh, K.^Aff4, Nagatsuka, K.^Aff4, Ayada, Y.^Aff4, Ohnishi, Y.^Aff4, Kawasaki, S.^Aff6, Matsuo, H.^Aff4

المساهمون: du Boulay, George, editor^Aff1, Molyneux, Andrew, editor^Aff2, Moseley, Ivan, editor^Aff3

المصدر: Proceedings of the XIV Symposium Neuroradiologicum : London, 17–23 June 1990. :621-623

Degree: CBE

المؤلفون: Kamen A. Tsvetanov, Alexander G Murley, Julie Wiggins, Ian Coyle Gilchrist, P. Simon Jones, Lucy Bowns, James B. Rowe

المساهمون: Murley, Alexander G. [0000-0003-0813-0670], Apollo - University of Cambridge Repository, Murley, Alexander G [0000-0003-0813-0670]

المصدر: Journal of Neurology

مصطلحات موضوعية: 0301 basic medicine, Pathology, medicine.medical_specialty, Neurology, Disease, Frontotemporal lobar degeneration, Progressive supranuclear palsy, Primary progressive aphasia, 03 medical and health sciences, 0302 clinical medicine, Metabolomics, medicine, Humans, Neuroradiology, 030304 developmental biology, 0303 health sciences, Original Communication, business.industry, Hazard ratio, Neurodegenerative Diseases, Syndrome, Disease monitoring, medicine.disease, Corticobasal syndrome, 3. Good health, 030104 developmental biology, Supranuclear Palsy, Progressive, Neurology (clinical), business, 030217 neurology & neurosurgery, Frontotemporal dementia

الوصف: Objective Widespread metabolic changes are seen in neurodegenerative disease and could be used as biomarkers for diagnosis and disease monitoring. They may also reveal disease mechanisms that could be a target for therapy. In this study we looked for blood-based biomarkers in syndromes associated with frontotemporal lobar degeneration. Methods Plasma metabolomic profiles were measured from 134 patients with a syndrome associated with frontotemporal lobar degeneration (behavioural variant frontotemporal dementia n = 30, non fluent variant primary progressive aphasia n = 26, progressive supranuclear palsy n = 45, corticobasal syndrome n = 33) and 32 healthy controls. Results Forty-nine of 842 metabolites were significantly altered in frontotemporal lobar degeneration syndromes (after false-discovery rate correction for multiple comparisons). These were distributed across a wide range of metabolic pathways including amino acids, energy and carbohydrate, cofactor and vitamin, lipid and nucleotide pathways. The metabolomic profile supported classification between frontotemporal lobar degeneration syndromes and controls with high accuracy (88.1–96.6%) while classification accuracy was lower between the frontotemporal lobar degeneration syndromes (72.1–83.3%). One metabolic profile, comprising a range of different pathways, was consistently identified as a feature of each disease versus controls: the degree to which a patient expressed this metabolomic profile was associated with their subsequent survival (hazard ratio 0.74 [0.59–0.93], p = 0.0018). Conclusions The metabolic changes in FTLD are promising diagnostic and prognostic biomarkers. Further work is required to replicate these findings, examine longitudinal change, and test their utility in differentiating between FTLD syndromes that are pathologically distinct but phenotypically similar.

وصف الملف: application/pdf; text/xml; application/vnd.openxmlformats-officedocument.wordprocessingml.document; image/tiff

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc0c667006ef5c16a208f457e5d861c4
https://www.repository.cam.ac.uk/handle/1810/307940

المؤلفون: James B. Rowe, Karalyn Patterson, Katie A. Peterson

المساهمون: Peterson, Katie A. [0000-0001-8217-8918], Rowe, James B. [0000-0001-7216-8679], Apollo - University of Cambridge Repository, Peterson, Katie A [0000-0001-8217-8918], Rowe, James B [0000-0001-7216-8679]

المصدر: Journal of Neurology

مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, Neurology, Movement disorders, Review, Apraxia, Progressive supranuclear palsy, Primary progressive aphasia, 03 medical and health sciences, 0302 clinical medicine, Physical medicine and rehabilitation, Language assessment, medicine, Humans, Speech, Language Development Disorders, Neuroradiology, Language, business.industry, Syndrome, medicine.disease, Corticobasal syndrome, eye diseases, 030104 developmental biology, Neurology (clinical), Supranuclear Palsy, Progressive, Differential diagnosis, medicine.symptom, business, 030217 neurology & neurosurgery

الوصف: Although commonly known as movement disorders, progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS) may present with changes in speech and language alongside or even before motor symptoms. The differential diagnosis of these two disorders can be challenging, especially in the early stages. Here we review their impact on speech and language. We discuss the neurobiological and clinical-phenomenological overlap of PSP and CBS with each other, and with other disorders including non-fluent agrammatic primary progressive aphasia and primary progressive apraxia of speech. Because language impairment is often an early and persistent problem in CBS and PSP, there is a need for improved methods for language screening in primary and secondary care, and more detailed language assessments in tertiary healthcare settings. Improved language assessment may aid differential diagnosis as well as inform clinical management decisions.

وصف الملف: application/pdf; text/xml

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8d0f04850f544489ff0fe57fe53405b
https://www.repository.cam.ac.uk/handle/1810/318216

المؤلفون: Sagerman, Robert H.^Aff8

المساهمون: Baert, A. L., editor^Aff1, Brady, L. W., editor^Aff2, Heilmann, H.-P., editor^Aff3, Heuck, F. H. W., editor^Aff4, Youker, J. E., editor^Aff5, Kagan, A. Robert, editor^Aff6, Steckel, Richard J., editor^Aff7

المصدر: Practical Approaches to Cancer Invasion and Metastases : A Compendium of Radiation Oncologists’ Responses to 40 Histories. :130-131

Degree: MD

المؤلفون: Kohlmeyer, K.

المساهمون: Langfitt, Thomas W., editor^Aff1, McHenry, Lawrence C., Jr., editor^Aff2, Reivich, Martin, editor^Aff3, Wollman, Harry, editor^Aff4

المصدر: Cerebral Circulation and Metabolism. :269-271

المؤلفون: Schumacher, H.-W.^Aff4, Wassmann, H.^Aff4, Linke, D. B.^Aff4

المساهمون: Wüllenweber, Rolf, editor^Aff1, Klinger, Margareta, editor^Aff2, Brock, Mario, editor^Aff3

المصدر: Regulation of Cerebral Blood Flow and Metabolism Neurosurgical Treatment of Epilepsy Rehabilitation in Neurosurgery. 15:302-305

المؤلفون: Lechner, H., Ott, E., Ladurner, G., Bertha, G.

المساهمون: Hoffmeister, Friedrich, editor^Aff1, Müller, Christian, editor^Aff2

المصدر: Brain Function in Old Age : Evaluation of Changes and Disorders. 7:259-267