المؤلفون: Sechaud R; Novartis Pharma AG, 4002, Basel, Switzerland. romain.sechaud@novartis.com., Gu H; Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA., Rahmanzadeh G; Novartis Pharma AG, 4002, Basel, Switzerland., Taylor A; Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA., Chiparus O; Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA., Sharma GK; Novartis Healthcare Pvt. Ltd., Hyderabad, Telangana, 50081, India., Breitschaft A; Parexel International GmbH, 14059, Berlin, Germany., Menssen HD; Novartis Pharma AG, 4002, Basel, Switzerland.

المصدر: Cancer chemotherapy and pharmacology [Cancer Chemother Pharmacol] 2024 May; Vol. 93 (5), pp. 439-453. Date of Electronic Publication: 2024 Jan 25.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 7806519 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0843 (Electronic) Linking ISSN: 03445704 NLM ISO Abbreviation: Cancer Chemother Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Bupropion*/pharmacokinetics , Bupropion*/administration & dosage , Cytochrome P-450 CYP2B6*/metabolism , Cytochrome P-450 CYP2B6*/genetics , Cytochrome P-450 CYP2C8*/metabolism , Cytochrome P-450 CYP3A*/metabolism , Drug Interactions* , Midazolam*/pharmacokinetics , Midazolam*/administration & dosage , Staurosporine*/analogs & derivatives , Staurosporine*/pharmacology , Staurosporine*/pharmacokinetics , Staurosporine*/administration & dosage, Humans ; Area Under Curve ; Contraceptives, Oral/administration & dosage ; Contraceptives, Oral/pharmacology ; Contraceptives, Oral/pharmacokinetics ; Drug Combinations ; Ethinyl Estradiol/pharmacokinetics ; Ethinyl Estradiol/administration & dosage ; Ethinyl Estradiol/pharmacology ; Healthy Volunteers ; Levonorgestrel/pharmacokinetics ; Levonorgestrel/administration & dosage ; Levonorgestrel/pharmacology ; Pioglitazone/pharmacology ; Pioglitazone/administration & dosage ; Pioglitazone/pharmacokinetics ; Male ; Female ; Adolescent ; Young Adult ; Adult ; Middle Aged

المؤلفون: Nakagawa J; Department of Pharmacy, Hirosaki University Hospital, 53 Hon-cho, Hirosaki, Aomori, 036-8563, Japan., Takahata T; Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori, Japan., Chen Y; Department of Medical Oncology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori, Japan., Saito K; Department of Medical Oncology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori, Japan., Kamata K; Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori, Japan., Tachita T; Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori, Japan., Yamashita S; Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori, Japan., Saito K; Department of Pharmacy, Hirosaki University Hospital, 53 Hon-cho, Hirosaki, Aomori, 036-8563, Japan., Ueno K; Department of Pharmacy, Hirosaki University Hospital, 53 Hon-cho, Hirosaki, Aomori, 036-8563, Japan., Sato A; Department of Medical Oncology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori, Japan., Sakuraba H; Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori, Japan., Niioka T; Department of Pharmacy, Hirosaki University Hospital, 53 Hon-cho, Hirosaki, Aomori, 036-8563, Japan. t-niioka@hirosaki-u.ac.jp.; Department of Pharmaceutical Science, Hirosaki University Graduate School of Medicine, 53 Hon-cho, Hirosaki, Aomori, Japan. t-niioka@hirosaki-u.ac.jp.

المصدر: Cancer chemotherapy and pharmacology [Cancer Chemother Pharmacol] 2023 Nov; Vol. 92 (5), pp. 391-398. Date of Electronic Publication: 2023 Aug 23.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 7806519 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0843 (Electronic) Linking ISSN: 03445704 NLM ISO Abbreviation: Cancer Chemother Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Cytochrome P-450 CYP3A*/genetics, Adult ; Humans ; ATP Binding Cassette Transporter, Subfamily B/genetics ; Genotype ; Half-Life ; Ubiquitin-Protein Ligases ; Vincristine

المؤلفون: Jing J; Clinical Pharmacology, Genentech, Inc., South San Francisco, CA, USA., Chen Y; Clinical Pharmacology, Genentech, Inc., South San Francisco, CA, USA.; Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, CA, USA., Musib L; Clinical Pharmacology, Genentech, Inc., South San Francisco, CA, USA., Jin JY; Clinical Pharmacology, Genentech, Inc., South San Francisco, CA, USA., Cheung KWK; Clinical Pharmacology, Genentech, Inc., South San Francisco, CA, USA., Yoshida K; Clinical Pharmacology, Genentech, Inc., South San Francisco, CA, USA. yoshida.kenta@gene.com., Sane R; Clinical Pharmacology, Genentech, Inc., South San Francisco, CA, USA. saner@gene.com.

المصدر: Cancer chemotherapy and pharmacology [Cancer Chemother Pharmacol] 2022 May; Vol. 89 (5), pp. 707-720. Date of Electronic Publication: 2022 Apr 15.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 7806519 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0843 (Electronic) Linking ISSN: 03445704 NLM ISO Abbreviation: Cancer Chemother Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Cytochrome P-450 CYP3A* , Cytochrome P-450 CYP3A Inhibitors*, Computer Simulation ; Cytochrome P-450 CYP3A Inducers ; Drug Interactions ; Humans ; Models, Biological ; Piperazines ; Pyrimidines

المؤلفون: Malhi V; Clinical Pharmacology, Genentech, Inc., 1 DNA Way, South San Francisco, CA, USA. malhi.vikram@gene.com., Budha N; Clinical Pharmacology, BeiGene, San Mateo, CA, USA., Sane R; Clinical Pharmacology, Genentech, Inc., 1 DNA Way, South San Francisco, CA, USA., Huang J; Safety Science, Genentech, Inc., South San Francisco, CA, USA., Liederer B; Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, CA, USA., Meng R; Clinical Science, Genentech, Inc., South San Francisco, CA, USA., Patel P; eFFECTOR Therapeutics, Inc., San Diego, CA, USA., Deng Y; Safety Science, Genentech, Inc., South San Francisco, CA, USA., Cervantes A; INCLIVA, University of Valencia, Valencia, Spain., Tabernero J; Vall d'Hebron Hospital Campus and Institute of Oncology (VHIO), IOB-Quiron, UVic-UCC, Barcelona, Spain., Musib L; Clinical Pharmacology, Genentech, Inc., 1 DNA Way, South San Francisco, CA, USA.

المصدر: Cancer chemotherapy and pharmacology [Cancer Chemother Pharmacol] 2021 Dec; Vol. 88 (6), pp. 921-930. Date of Electronic Publication: 2021 Sep 01.

نوع المنشور: Clinical Trial, Phase I; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 7806519 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0843 (Electronic) Linking ISSN: 03445704 NLM ISO Abbreviation: Cancer Chemother Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Food-Drug Interactions*, Antineoplastic Agents/*therapeutic use , Cytochrome P-450 CYP3A/*chemistry , Neoplasms/*drug therapy , Piperazines/*therapeutic use , Pyrimidines/*therapeutic use, Administration, Oral ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/pharmacokinetics ; Case-Control Studies ; Cytochrome P-450 CYP3A Inhibitors/metabolism ; Cytochrome P-450 CYP3A Inhibitors/pharmacokinetics ; Cytochrome P-450 CYP3A Inhibitors/therapeutic use ; Eating ; Female ; Follow-Up Studies ; Healthy Volunteers ; Humans ; Male ; Neoplasms/metabolism ; Neoplasms/pathology ; Piperazines/administration & dosage ; Piperazines/pharmacokinetics ; Prognosis ; Pyrimidines/administration & dosage ; Pyrimidines/pharmacokinetics ; Tissue Distribution

المؤلفون: Sun H; Seagen Inc, 21823 30th Dr SE, Bothell, WA, 98021, USA. hsun@seagen.com., Cardinal KA; Seagen Inc, 21823 30th Dr SE, Bothell, WA, 98021, USA., Wienkers L; Seagen Inc, 21823 30th Dr SE, Bothell, WA, 98021, USA., Chin A; Seagen Inc, 21823 30th Dr SE, Bothell, WA, 98021, USA., Kumar V; Seagen Inc, 21823 30th Dr SE, Bothell, WA, 98021, USA., Neace C; Seagen Inc, 21823 30th Dr SE, Bothell, WA, 98021, USA., Henderson C; Seagen Inc, 21823 30th Dr SE, Bothell, WA, 98021, USA., Endres CJ; Seagen Inc, 21823 30th Dr SE, Bothell, WA, 98021, USA., Topletz-Erickson A; Seagen Inc, 21823 30th Dr SE, Bothell, WA, 98021, USA., Regal K; Array Biopharma, Boulder, CO, USA.; ProPharma Services, Superior, CO, USA., Vo A; Seagen Inc, 21823 30th Dr SE, Bothell, WA, 98021, USA., Alley SC; Seagen Inc, 21823 30th Dr SE, Bothell, WA, 98021, USA., Lee AJ; Seagen Inc, 21823 30th Dr SE, Bothell, WA, 98021, USA.

المصدر: Cancer chemotherapy and pharmacology [Cancer Chemother Pharmacol] 2022 Jun; Vol. 89 (6), pp. 737-750. Date of Electronic Publication: 2022 Apr 18.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 7806519 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0843 (Electronic) Linking ISSN: 03445704 NLM ISO Abbreviation: Cancer Chemother Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents*/metabolism , Cytochrome P-450 CYP3A*/metabolism, Cytochrome P-450 CYP2C8/metabolism ; Humans ; Microsomes, Liver/metabolism ; Oxazoles ; Protein Kinase Inhibitors/metabolism ; Pyridines ; Quinazolines ; Stereoisomerism

المؤلفون: Chen Y; Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine and Simmons Cancer Institute, Springfield, IL, 62794-9626, USA., Tang Y; Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine and Simmons Cancer Institute, Springfield, IL, 62794-9626, USA., Nie JZ; Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine and Simmons Cancer Institute, Springfield, IL, 62794-9626, USA., Zhang Y; Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine and Simmons Cancer Institute, Springfield, IL, 62794-9626, USA., Nie D; Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine and Simmons Cancer Institute, Springfield, IL, 62794-9626, USA. dnie@siumed.edu.

المصدر: Cancer chemotherapy and pharmacology [Cancer Chemother Pharmacol] 2021 Dec; Vol. 88 (6), pp. 985-996. Date of Electronic Publication: 2021 Sep 15.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 7806519 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0843 (Electronic) Linking ISSN: 03445704 NLM ISO Abbreviation: Cancer Chemother Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Drug Interactions*, Cytochrome P-450 CYP3A/*metabolism , Cytochrome P-450 CYP3A Inducers/*pharmacology , Hepatocytes/*drug effects , Megestrol Acetate/*pharmacology , Pregnane X Receptor/*metabolism, Antineoplastic Agents, Hormonal/pharmacology ; Cytochrome P-450 CYP3A/chemistry ; Hep G2 Cells ; Hepatocytes/metabolism ; Humans ; Pregnane X Receptor/genetics

المؤلفون: Hurtado FK; Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA. felipe.kellermann_hurtado@novartis.com., de Braud F; Fondazione IRCCS-Istituto Nazionale Dei Tumori, Milano, Italy., De Castro Carpeño J; Medical Oncology Department, Hospital Universitario La Paz, IdiPAZ, Madrid, Spain., de Miguel Luken MJ; CIOCC-Grupo Hospitalario de Madrid, Hosp. de Sanchinarro, Madrid, Spain., Wang D; Henry Ford Cancer Institute, Detroit, MI, USA., Scott J; Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA., Lau YY; Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA., McCulloch T; Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA., Mau-Sorensen M; Department of Oncology, Rigshospitalet, Copenhagen, Denmark.

المصدر: Cancer chemotherapy and pharmacology [Cancer Chemother Pharmacol] 2021 Apr; Vol. 87 (4), pp. 475-486. Date of Electronic Publication: 2021 Jan 04.

نوع المنشور: Clinical Trial, Phase I; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 7806519 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0843 (Electronic) Linking ISSN: 03445704 NLM ISO Abbreviation: Cancer Chemother Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Anaplastic Lymphoma Kinase/*antagonists & inhibitors , Cytochrome P-450 CYP2C9/*physiology , Cytochrome P-450 CYP3A/*physiology , Pyrimidines/*pharmacology , Sulfones/*pharmacology, Adult ; Aged ; Anaplastic Lymphoma Kinase/analysis ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Cross-Over Studies ; Drug Interactions ; Female ; Humans ; Lung Neoplasms/drug therapy ; Male ; Midazolam/pharmacokinetics ; Middle Aged ; Pyrimidines/adverse effects ; Pyrimidines/pharmacokinetics ; Sulfones/adverse effects ; Sulfones/pharmacokinetics ; Warfarin/pharmacokinetics ; Young Adult

المؤلفون: Serin I; Department of Hematology, Istanbul Training and Research Hospital, University of Health Sciences, Fatih, Istanbul, Turkey. serinistemi@hotmail.com., Pehlivan S; Department of Medical Biology, Faculty of Medicine, Istanbul University, Istanbul, Turkey., Gundes I; Department of Internal Medicine, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey., Fidan Oyaci Y; Department of Medical Biology, Faculty of Medicine, Istanbul University, Istanbul, Turkey., Pehlivan M; Department of Hematology, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey.

المصدر: Annals of hematology [Ann Hematol] 2021 Feb; Vol. 100 (2), pp. 421-427. Date of Electronic Publication: 2020 Nov 10.

نوع المنشور: Clinical Trial; Journal Article; Multicenter Study

بيانات الدورية: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 9107334 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0584 (Electronic) Linking ISSN: 09395555 NLM ISO Abbreviation: Ann Hematol Subsets: MEDLINE

مواضيع طبية MeSH: Genotype* , Polymorphism, Single Nucleotide*, Cytochrome P-450 CYP3A/*genetics , Multiple Myeloma/*enzymology , Multiple Myeloma/*genetics, Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Multiple Myeloma/drug therapy

المؤلفون: Mbatchi LC; Laboratoire de Biochimie et Biologie Moléculaire, CHU Nîmes, Hôpital Carémeau, Place du Professeur Robert Debré, 30029, Nîmes, Cedex 9, France.; IRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, 34298, Montpellier, France.; Laboratoire de Pharmacocinétique, Faculté de Pharmacie, Université de Montpellier, Montpellier, France., Gassiot M; Laboratoire de Biochimie et Biologie Moléculaire, CHU Nîmes, Hôpital Carémeau, Place du Professeur Robert Debré, 30029, Nîmes, Cedex 9, France.; IRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, 34298, Montpellier, France., Pourquier P; IRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, 34298, Montpellier, France., Goberna A; Département de Recherche Clinique et d'Epidémiologie, Institut Bergonié, Bordeaux, France., Mahammedi H; Département d'Oncologie Médicale, Centre Jean Perrin, Clermont Ferrand, France., Mourey L; Département d'Oncologie Médicale, IUCT Oncopole, Toulouse, France., Joly F; Département d'Oncologie Médicale, Centre François Baclesse, Caen, France., Lumbroso S; Laboratoire de Biochimie et Biologie Moléculaire, CHU Nîmes, Hôpital Carémeau, Place du Professeur Robert Debré, 30029, Nîmes, Cedex 9, France., Evrard A; Laboratoire de Biochimie et Biologie Moléculaire, CHU Nîmes, Hôpital Carémeau, Place du Professeur Robert Debré, 30029, Nîmes, Cedex 9, France. alexandre.evrard@umontpellier.fr.; IRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, 34298, Montpellier, France. alexandre.evrard@umontpellier.fr.; Laboratoire de Pharmacocinétique, Faculté de Pharmacie, Université de Montpellier, Montpellier, France. alexandre.evrard@umontpellier.fr., Houede N; IRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, 34298, Montpellier, France.; Département d'Oncologie Médicale, CHU Nîmes, Hôpital Carémeau, Nîmes, France.

المصدر: Cancer chemotherapy and pharmacology [Cancer Chemother Pharmacol] 2017 Sep; Vol. 80 (3), pp. 653-659. Date of Electronic Publication: 2017 Jul 04.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 7806519 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0843 (Electronic) Linking ISSN: 03445704 NLM ISO Abbreviation: Cancer Chemother Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*therapeutic use , Cytochrome P-450 CYP3A/*genetics , Sirolimus/*analogs & derivatives , Urinary Bladder Neoplasms/*genetics, Aged ; Antineoplastic Agents/pharmacokinetics ; Cytochrome P-450 CYP3A/metabolism ; Female ; Genotype ; Humans ; Male ; Middle Aged ; Polymorphism, Genetic ; Polymorphism, Single Nucleotide ; Sirolimus/pharmacokinetics ; Sirolimus/therapeutic use

المؤلفون: Reddick SJ; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105-2794, USA., Campagne O; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105-2794, USA., Huang J; Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, USA., Onar-Thomas A; Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, USA., Broniscer A; Division of Neuro-Oncology, Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA., Gajjar A; Division of Neuro-Oncology, Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA., Stewart CF; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105-2794, USA. clinton.stewart@stjude.org.

المصدر: Cancer chemotherapy and pharmacology [Cancer Chemother Pharmacol] 2019 Oct; Vol. 84 (4), pp. 829-838. Date of Electronic Publication: 2019 Aug 07.

نوع المنشور: Clinical Trial; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 7806519 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0843 (Electronic) Linking ISSN: 03445704 NLM ISO Abbreviation: Cancer Chemother Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Brain Neoplasms*/drug therapy , Brain Neoplasms*/genetics , Brain Neoplasms*/pathology , Erlotinib Hydrochloride*/administration & dosage , Erlotinib Hydrochloride*/adverse effects , Erlotinib Hydrochloride*/pharmacokinetics, ATP Binding Cassette Transporter, Subfamily G, Member 2/*genetics , Cytochrome P-450 CYP3A/*genetics , Neoplasm Proteins/*genetics , Quinazolines/*blood, ATP Binding Cassette Transporter, Subfamily B/genetics ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/adverse effects ; Antineoplastic Agents/pharmacokinetics ; Biomarkers, Pharmacological/blood ; Child, Preschool ; Drug Monitoring/methods ; ErbB Receptors/antagonists & inhibitors ; Female ; Humans ; Male ; Pharmacogenomic Variants ; Treatment Outcome