المؤلفون: Chen-Li Li, Cheng Tan, Ling Gao, Yong Chang, Wei-Min Fan

المصدر: Hematology, Vol 28, Iss 1 (2023)

مصطلحات موضوعية: Healthy reference individuals, Capillary blood, Complete blood cells, Validation, Newborns, Diseases of the blood and blood-forming organs, RC633-647.5

الوصف: ABSTRACTBackground: China lacks a standard for reference intervals (RIs) of complete blood cell (CBC) counts in newborns. This study aimed to determine local haematological RIs for newborns.Methods: This prospective study was conducted from January 2020 to December 2020 in Nanjing Maternity and Child Health Care Hospital. We collected capillary blood specimens from 497 healthy newborns aged 5–28 days. We calculated the RIs as nonparametric 2.5th to 97.5th percentiles and 90% confidence intervals following the EP28-A3c guideline. We validated the RIs in another 20 specimens from healthy newborns.Results: The RIs for the 18 CBC parameters were: white blood cell count 7.17–15.69 × 109/L; monocytes# 0.52–1.66 × 109/L; Mono% 5.7–14.1; eosinophils# 0.16–1.08 × 109/L; Eos% 1.5–8.9; Lymphocytes# 4.04–8.08 × 109/L; Lymph% 40.1–67.8; Neutrophils# 1.59–6.41 × 109/L; Neut% 18.1–46.7; Basophils# 0.00–0.04 × 109/L; Baso% 0.0–0.4; red blood cell count 3.38–5.89 × 1012/L; haemoglobin (Hb) 116–198 g/L; Hematocrit % 35.2–61.2; mean corpuscular Hb (MCH) 30.9–36.3 pg/L; MCH concentration 310–341 g/L; mean corpuscular volume 94.5–112.2 fL; and platelets 210–610 × 109/L. The RIs had a conformity rate of 90%–100% in the validation specimens.Conclusion: We established region-specific RIs for CBC parameters in healthy newborns to help diagnose haematological disease in neonates.

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1607-8454

URL الوصول: https://doaj.org/article/b862313743614e5aafa9f48fcc1c746d

المؤلفون: Jing-xin Zhou, Ling Gao, Nan Hu, Zhi-Ling Yan, Chun-ying Tian, Jing Su, Ji-Jin Qi, Jun-shuai Yue, Wen-tong Ma

المصدر: Hematology, Vol 27, Iss 1, Pp 1062-1068 (2022)

مصطلحات موضوعية: Immune thrombocytopenia, recombinant human thrombopoietin, glucocorticoid, platelet count, coagulation function, adverse effects, Diseases of the blood and blood-forming organs, RC633-647.5

الوصف: Objective: Herein, we aimed to determine the clinical efficacy of recombinant human thrombopoietin (rhTPO) combined with glucocorticoids for treating immune thrombocytopenia (ITP).Methods: Clinical data of 87 patients with ITP admitted to our hospital were retrospectively analyzed, and patients were divided into two groups according to the treatment employed: 42 patients in the control group (CG) were prescribed glucocorticoids, and 45 patients in the study group (SG) received rhTPO combined with glucocorticoids.Results: The total effective treatment rate in the SG (95.56%) was higher than that in the CG (76.19%) (P 50 × 109/L faster and required fewer PLT transfusions than the CG (P 0.05).Conclusion: rhTPO combined with glucocorticoids for treating ITP can effectively enhance the therapeutic effect, regulate the T lymphocyte subpopulation, rapidly increase the PLT level, and induce no significant effect on the coagulation function of patients, with good safety and high clinical promotion value.

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1607-8454

URL الوصول: https://doaj.org/article/5fcaf6518814418399dd20b8e8d7e72c