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1
المؤلفون: Lei Ma, Yunfei Yu, Feng Jiang, Chaoran Xu, Shengnan Wang, Qiulei Zhang, Wen-Ting Huang, Qi Zeng, Shengyuan Wang, Yuqin Cheng, Baoan Wang, Li Hao, Yi Zhang, Tianzhong Li
المصدر: Plant Pathology. 70:1467-1475
مصطلحات موضوعية: PEAR, biology, Viroid, Incidence (epidemiology), Plant Science, Horticulture, biology.organism_classification, Pyrus betulifolia, Tree (data structure), Pome, Seedling, Genetics, Agronomy and Crop Science
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2
المؤلفون: Xiaoli Ma, Chao Duan, Na Xu, Libing Fu, Tong Yu, Qi Zeng, Yan Su, Binglin Jian, Wen Zhao, Chenghao Chen
المصدر: Journal of Medical Imaging and Radiation Oncology. 65:731-734
مصطلحات موضوعية: medicine.medical_specialty, Lung, medicine.diagnostic_test, biology, Provisional diagnosis, business.industry, Cryptococcus, Magnetic resonance imaging, biology.organism_classification, medicine.disease, Mycobacterium tuberculosis, medicine.anatomical_structure, Oncology, Etiology, Medicine, Radiology, Nuclear Medicine and imaging, Radiology, Differential diagnosis, business, Rhabdomyosarcoma
الوصف: Rhabdomyosarcoma (RMS) with regional lymph node involvement has a high rate of distant metastases. Lung is the most common site, accounting for 70% of all metastases. The differential diagnosis of lung lesions due to an infectious aetiology versus metastases is usually evaluated by computed tomography (CT) or magnetic resonance imaging. However, it is rare for patients of RMS to present with infectious nodules or masses in the lung during follow-up. More importantly, infections can mimic the imaging characteristics of metastatic RMS in CT. We report two such cases where children diagnosed with head and neck embryonal RMS with lymph node metastasis, presented with pulmonary masses 0.5 and 4 years after end of treatment, without the typical signs and symptoms suggestive of an infection. Chest CT suggested a provisional diagnosis of metastases and biopsies confirmed infectious aetiology (Mycobacterium tuberculosis, Cryptococcus).
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3
المؤلفون: Yanfei Zheng, Lijuan Ma, Jing-Qi Zeng, Xingguo Huang, Yuan Liao, Junjie Cao, Jing Zhang, Zhisheng Wu, Leting Lei, Jinyuan Zhu, Haoran Shen, Zheng Zhou, Ling Lin
المصدر: Phytochemical Analysis. 32:165-171
مصطلحات موضوعية: Mean squared error, Process analytical technology, Plant Science, Residual, 01 natural sciences, Biochemistry, High-performance liquid chromatography, Analytical Chemistry, chemistry.chemical_compound, Drug Discovery, Glycyrrhiza, Glycyrrhiza uralensis, Chromatography, High Pressure Liquid, Plants, Medicinal, Chromatography, biology, Plant Extracts, Content determination, 010401 analytical chemistry, Extraction (chemistry), General Medicine, Glycyrrhizic Acid, biology.organism_classification, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Complementary and alternative medicine, chemistry, Molecular Medicine, Liquiritin, Food Science
الوصف: Introduction The on-line analysis of active pharmaceutical ingredients (APIs) during the extraction process in herbal medicine is a challenge. Establishing a reliable and robust model is a critical procedure for the industrial application of on-line near-infrared (NIR) technology. Objective To evaluate the advantages of on-line NIR model development using system optimisation strategy, Glycyrrhiza uralensis Fisch was used as a case. The content of liquiritin and glycyrrhizic acid was monitored during pilot scale extraction process of Glycyrrhiza uralensis Fisch in three batches. Methods High-performance liquid chromatography (HPLC) was used as reference method for content determination of liquiritin and glycyrrhizic acid. The quantitative models of on-line NIR were developed by system optimisation of processing trajectory. For comparison, the models were simultaneously developed by stepwise optimisation. Moreover, the modelling parameters obtained through system optimisation and stepwise optimisation were reused in three batches. Root mean square error of prediction (RMSEP) and residual predictive deviation (RPD) were used to assess the model quality. Results The average values of RMSEP and RPD of systematic model for liquiritin in three batches were 0.0361, 4.1525 (first batch), 0.0348, 4.7286 (second batch) and 0.0311, 4.9686 (third batch), respectively. In addition, the modelling parameters of systematic model for glycyrrhizic acid in three batches were same, and the average values of RMSEP and RPD were 0.0665 and 5.2751, respectively. The predictive performance and robustness of systematic models for the three batches were better than the comparison models. Conclusion The work demonstrated that system optimisation quantitative model of on-line NIR could be used to determine the contents of liquiritin and glycyrrhizic acid during Glycyrrhiza uralensis Fisch extraction process.
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المؤلفون: Qi Zeng, Linglan Yang, Jingfang Yin, Bin Cheng, Xiaoan Tao, Xi Yang
المصدر: Journal of Oral Pathology & Medicine. 45:41-47
مصطلحات موضوعية: Adult, Male, Cancer Research, CCR2, Pathology, medicine.medical_specialty, Triamcinolone acetonide, Adolescent, Receptors, CCR2, Pilot Projects, CCL2, Biology, Triamcinolone Acetonide, Pathology and Forensic Medicine, Pathogenesis, Young Adult, 03 medical and health sciences, 0302 clinical medicine, parasitic diseases, medicine, Humans, Receptor, Chemokine CCL2, Aged, Mouth Mucosa, 030206 dentistry, Middle Aged, medicine.disease, Immunohistochemistry, Otorhinolaryngology, Case-Control Studies, 030220 oncology & carcinogenesis, Reticular connective tissue, Periodontics, Female, Oral lichen planus, Oral Surgery, Lichen Planus, Oral, medicine.drug
الوصف: Background The important roles of CCL2 and its receptor CCR2 had been reported in a series of inflammatory disorders. However, few studies investigated the potential role of CCL2/CCR2 axis in oral lichen planus (OLP). Therefore, this study aimed to detect the expression of CCL2 and CCR2 in OLP lesions and compare their changes before and after treatment. Methods CCL2 and CCR2 expression was investigated using immunohistochemical staining and real-time RT-PCR in 32 patients with OLP and eight controls. Moreover, changes in their expression after treatment with triamcinolone acetonide were assessed in lesions from three patients. Results CCL2+ and CCR2+ cells were few in the controls and remarkably increased in the epithelial and subepithelial layers of lesions (n = 32, all P
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5
المؤلفون: Xiaodong Pan, Yuan-Gui Zhu, Jian Zhang, Xiaochun Chen, Yu-qi Zeng, Nan Lin, Hui Shen, Jianping Lu, Meng Zhou, Xiaoman Dai, Jing Zhang
المصدر: Journal of Neurochemistry. 133:38-52
مصطلحات موضوعية: Genetically modified mouse, medicine.medical_specialty, Mice, Transgenic, Biochemistry, Neuroprotection, Mice, Phosphatidylinositol 3-Kinases, Cellular and Molecular Neuroscience, Cognition, Alzheimer Disease, Internal medicine, medicine, Amyloid precursor protein, Animals, Humans, Cognitive decline, Maze Learning, Amyloid beta-Peptides, biology, TOR Serine-Threonine Kinases, P3 peptide, Phenanthrenes, Endocrinology, Synapses, Synaptic plasticity, Synaptophysin, biology.protein, Diterpenes, Signal transduction, Proto-Oncogene Proteins c-akt, Neuroscience, Immunosuppressive Agents, Psychomotor Performance
الوصف: Alzheimer's disease (AD) is characterized by early impairments in memory and progressive neurodegeneration. Disruption of synaptic plasticity processes that underlie learning and memory contribute partly to this pathophysiology. Tripchlorolide (T4 ), an extract from a traditional Chinese herbal Tripterygium wilfordii Hook F, has been shown to be neuroprotective in animal models of Parkinson's disease and to improve cognitive deficits in senescence-accelerated mouse P8. In this study, we investigated the effect of T4 on cognitive decline and synaptic plasticity in five times familial AD (5XFAD) mice co-expressing mutated amyloid precursor protein and presenilin-1. Five-month-old 5XFAD mice and wild type littermates were intraperitoneally injected with T4 , 5 μg/kg or 25 μg/kg, every other day for 60 days. T4 treatment significantly improved spatial learning and memory, alleviated synaptic ultrastructure degradation, up-regulated expression of synapse-related proteins, including synaptophysin, post-synaptic density-95, N-methyl-D-aspartate receptor subunit 1, phosphorylation of calcium/calmodulin dependent protein kinase II α, and phosphorylation of cyclic AMP-response element binding protein, and promoted activation of the phophoinositide-3-kinase-Akt-mammalian target of rapamycin signaling pathway in 5XFAD mice. Accumulation of amyloid β (Aβ) may contribute to synapse dysfunction and memory impairment in AD. We found that T4 treatment significantly reduced cerebral Aβ deposits and lowered Aβ levels in brain homogenates. These effects coincided with a reduction in cleavage of β-carboxyl-terminal amyloid precursor protein (APP) fragment, levels of soluble APPβ, and protein expression of β-site APP cleaving enzyme 1. Taken together, our findings identify T4 as a potent negative regulator of brain Aβ levels and show that it significantly ameliorates synaptic degeneration and cognitive deficits in a mouse model of AD.
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المؤلفون: Qi Zeng, Shi-Kai Yan, Jiang-Jiang Qin, Hui-Zi Jin, Weidong Zhang, Bin Guan, Rui-Jie Chang, Xiang-Rong Cheng
المصدر: Helvetica Chimica Acta. 95:606-612
مصطلحات موضوعية: biology, 010405 organic chemistry, Chemistry, Organic Chemistry, Mtt method, biology.organism_classification, 01 natural sciences, Biochemistry, Catalysis, 0104 chemical sciences, Metasequoia glyptostroboides, Inorganic Chemistry, 010404 medicinal & biomolecular chemistry, Metasequoia, Drug Discovery, Botany, Physical and Theoretical Chemistry
الوصف: Five new compounds, i.e., the three new norlignans metasequirins G–I (1–3) and the two new phenylpropanoids 7-(3-ethoxy-5-methoxyphenyl)propane-7,8,9-triol (=1-(3-ethoxy-5-methoxyphenyl)propane-1,2,3-triol; 4) and 7-(3-hydroxy-5-methoxyphenyl)propane-7,8,9-triol (=1-(3-hydroxy-5-methoxy-phenyl)propane-1,2,3-triol; 5), were isolated from the branches and stems of Metasequoia glyptostroboidesHu et Cheng. Their structures were elucidated by physical, chemical, and spectroscopic methods, including 1D- and 2D-NMR and HR-ESI-MS. The cytotoxicites of the five compounds were tested against A549 and Colo 205 cell lines by the MTT method.
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7
المؤلفون: Wei-Dong Zhang, Xiao-Jia Hu, Jiang-Jiang Qin, Ming Chen, Qi Zeng, Lan Yan, Jian-Jun Fu, Hui-Zi Jin, Jian-Hua Liu
المصدر: Chemistry & Biodiversity. 7:1911-1929
مصطلحات موضوعية: Lamiaceae, Molecular Structure, biology, Chemistry, Dracocephalum, Plant composition, Antineoplastic Agents, Bioengineering, General Chemistry, General Medicine, biology.organism_classification, Biochemistry, Antioxidants, Terpenoid, Immunomodulation, Mice, Anti-Infective Agents, Genus, Chemical constituents, Botany, Animals, Molecular Medicine, Medicinal plants, Molecular Biology
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8
المؤلفون: Qi Zeng, Ying Huang, Shi Kai Yan, Lan Yan, Hui-Zi Jin, Jian-Jun Fu, Jiang-Jiang Qin, Wei-Dong Zhang, Yan Zhu
المصدر: Helvetica Chimica Acta. 93:1418-1421
مصطلحات موضوعية: Inula, Phenylpropanoid, biology, Stereochemistry, Chemistry, Chemical structure, Plant composition, Organic Chemistry, Asteraceae, biology.organism_classification, Biochemistry, Catalysis, Inorganic Chemistry, Drug Discovery, Physical and Theoretical Chemistry, No production, Medicinal plants
الوصف: Three new phenylpropanoid compounds, named nervolans A–C (1–3, resp.), together with two other known phenylpropanoids, coniferyl diangelate and sinapyl diangelate, were isolated from the aerial parts of Inula nervosaWall. (Asteraceae), a traditional Chinese medicinal plant. The structures of 1–3 were elucidated by detailed spectroscopic analyses, including HR-ESI-MS data and 2D-NMR spectroscopy. Compounds 1–5 exhibited mild inhibitory effects against NO production in LPS-stimulated RAW264.7 cells.
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9
المؤلفون: Bor Luen Tang, Qi Zeng, Wanjin Hong, Bin Qi Gan, Ya Wang, Ke Guo, Ling Yann Foo
المصدر: Traffic. 7:216-226
مصطلحات موضوعية: integumentary system, biology, animal diseases, media_common.quotation_subject, Transferrin receptor, Cell Biology, Hair follicle, Endocytosis, environment and public health, Biochemistry, Syntaxin 3, Cell biology, medicine.anatomical_structure, nervous system, Structural Biology, Epidermal growth factor, Genetics, biology.protein, medicine, Syntaxin, heterocyclic compounds, Epidermal growth factor receptor, Internalization, Molecular Biology, media_common
الوصف: We describe a novel syntaxin family member, syntaxin 9 (Syn 9), which does not possess a typical C-terminal hydrophobic tail anchor. Syn 9 has, however, a Q-SNARE domain and an overall homology to syntaxins (with the highest overall homology with mammalian syntaxin 11). Syn 9 is enriched in some epithelial cells, particularly that of the stomach lining and the skin. At the skin, it is found in the epidermal layers as well as structures associated with hair follicles. A biochemical interaction screen revealed that Syn 9 interacts specifically with the epidermal growth factor (EGF) receptor. Overexpression of Syn 9 perturbed EGF receptor endocytosis but does not appear to affect the internalization of the transferrin receptor. Syn 9 may therefore have a role in EGF receptor transport and signaling in certain epithelial cell types.
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10
المؤلفون: Janet E. Davies, David Murphy, S. Wells, Qi Zeng, S. Waller
المصدر: Journal of Neuroendocrinology. 15:42-50
مصطلحات موضوعية: Vasopressin, Endocrine and Autonomic Systems, Suprachiasmatic nucleus, Endocrinology, Diabetes and Metabolism, Transgene, Upstream and downstream (transduction), Structural gene, biochemical phenomena, metabolism, and nutrition, Biology, Molecular biology, Cellular and Molecular Neuroscience, Exon, Endocrinology, Magnocellular cell, Gene
الوصف: We have introduced transgenes into rats with a view to defining genomic regions that mediate the cell-specific and physiological regulation of the vasopressin gene. These transgenes consist of the rat vasopressin structural gene with a reporter inserted into exon III, flanked by different lengths of upstream and downstream sequences. 11-VCAT-3 is flanked by 11 kbp of upstream sequences and 3 kbp of downstream sequences. The previously described 5-VCAT-3 is flanked by 5 kbp of upstream and 3 kbp of downstream sequences. 3-VCAT-3 has 3 kbp of upstream and 3 kbp of downstream sequences, and 3-VCAT-0.2 is flanked by 3 kbp of upstream and 0.2 kbp of downstream sequences. All four transgenes elicit the same expression patterns; low basal expression is seen in the magnocellular supraoptic and paraventricular nuclei, and is negligible in the suprachiasmatic nucleus. Expression increases markedly in vasopressin magnocellular cells following dehydration. The sequences responsible for the cell-specific expression and physiological regulation of our transgenes thus reside within the confines of the smallest construct studied, 3-VCAT-0.2.
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