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1
المصدر: ChemBioChem. 20:1382-1386
مصطلحات موضوعية: Photoisomerization, Isostere, Molecular Conformation, Dihydrofolate reductase activity, Ligands, 010402 general chemistry, 01 natural sciences, Biochemistry, Enzyme catalysis, Photochromism, Dihydrofolate reductase, Escherichia coli, Molecular Biology, chemistry.chemical_classification, Binding Sites, biology, 010405 organic chemistry, Ligand, Biomolecule, Organic Chemistry, Combinatorial chemistry, 0104 chemical sciences, Kinetics, Tetrahydrofolate Dehydrogenase, Methotrexate, chemistry, biology.protein, Folic Acid Antagonists, Molecular Medicine
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2
المؤلفون: Iñaki Tuñón, Rudolf Konrad Allemann, Louis Y. P. Luk, Vicent Moliner, Alan Scott
المصدر: Repositori Universitat Jaume I
Universitat Jaume I
Chembiochemمصطلحات موضوعية: 010402 general chemistry, Protein Engineering, 01 natural sciences, Biochemistry, Catalysis, Enzyme catalysis, isotope effects, Catalytic Domain, Dihydrofolate reductase, Molecular Biology, Alcohol dehydrogenase, chemistry.chemical_classification, alcohol dehydrogenases, Carbon Isotopes, dihydrofolate reductases, biology, Bacteria, Nitrogen Isotopes, 010405 organic chemistry, Concept, Organic Chemistry, Alcohol Dehydrogenase, Active site, Substrate (chemistry), Protein engineering, Deuterium, Combinatorial chemistry, molecular dynamics, 0104 chemical sciences, Kinetics, Tetrahydrofolate Dehydrogenase, enzyme engineering, Enzyme, chemistry, biology.protein, Biocatalysis, Molecular Medicine, Concepts
وصف الملف: application/pdf
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3
المؤلفون: Sumalee Kamchonwongpaisan, Surasak Chunsrivirot, Wanwimon Mokmak, Yongyuth Yuthavong, Sissades Tongsima, Supa Hannongbua
المصدر: Chemical Biology & Drug Design. 84:450-461
مصطلحات موضوعية: Steric effects, Stereochemistry, Plasmodium falciparum, Mutant, Drug Resistance, Molecular Dynamics Simulation, Biochemistry, chemistry.chemical_compound, parasitic diseases, Drug Discovery, Dihydrofolate reductase, medicine, Pharmacology, Binding Sites, biology, Chemistry, Hydrogen bond, fungi, Organic Chemistry, Wild type, Hydrogen Bonding, biology.organism_classification, Protein Structure, Tertiary, Tetrahydrofolate Dehydrogenase, Pyrimethamine, Mutation, Antifolate, biology.protein, Folic Acid Antagonists, Thermodynamics, Molecular Medicine, NADP, medicine.drug
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4
المؤلفون: K. Darrell Berlin, Richard A. Bunce, Baskar Nammalwar, William W. Barrow, Shankari Mylvaganam, Philip C. Bourne, Christina R. Bourne, Esther W. Barrow, Nancy Wakeham, Kal Ramnarayan
المصدر: ChemMedChem. 7:1974-1982
مصطلحات موضوعية: Models, Molecular, Staphylococcus aureus, Conformational change, Stereochemistry, Microbial Sensitivity Tests, Biochemistry, Article, Anthrax, chemistry.chemical_compound, Minimum inhibitory concentration, Bacterial Proteins, Drug Discovery, Dihydrofolate reductase, Humans, Moiety, General Pharmacology, Toxicology and Pharmaceutics, Alkyl, Pharmacology, chemistry.chemical_classification, biology, Organic Chemistry, Staphylococcal Infections, Oxidoreductase inhibitor, biology.organism_classification, Anti-Bacterial Agents, Bacillus anthracis, Tetrahydrofolate Dehydrogenase, Pyrimidines, Diaminopyrimidine, chemistry, biology.protein, Folic Acid Antagonists, Molecular Medicine
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5
المؤلفون: Pratim Kumar Chattaraj, Mekapothula Lakshmi Vasavi Devi, Venkatesan Subramanian, Ramadoss Vijayaraj
المصدر: Chemical Biology & Drug Design. 79:935-942
مصطلحات موضوعية: Pharmacology, Quantitative structure–activity relationship, biology, Pyrimidine, Stereochemistry, Organic Chemistry, Field analysis, medicine.disease_cause, Biochemistry, Trimethoprim, chemistry.chemical_compound, chemistry, Drug Discovery, Dihydrofolate reductase, biology.protein, medicine, Molecular Medicine, Potency, Tetrahydrofolate dehydrogenase, Escherichia coli, medicine.drug
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6
المؤلفون: Engin Yapici, Lawrence W. Miller, D. Rajasekhar Reddy
المصدر: ChemBioChem. 13:553-558
مصطلحات موضوعية: Lysis, High-throughput screening, Green Fluorescent Proteins, medicine.disease_cause, Biochemistry, Article, Tacrolimus, Green fluorescent protein, Protein–protein interaction, Tacrolimus Binding Proteins, Dihydrofolate reductase, Escherichia coli, Fluorescence Resonance Energy Transfer, medicine, Humans, Molecular Biology, Molecular Structure, biology, TOR Serine-Threonine Kinases, Organic Chemistry, High-Throughput Screening Assays, Tetrahydrofolate Dehydrogenase, Förster resonance energy transfer, biology.protein, Molecular Medicine, Luminescence, Protein Binding
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7
المؤلفون: Rudolf Konrad Allemann, Edric Joel Loveridge
المصدر: ChemBioChem. 12:1258-1262
مصطلحات موضوعية: chemistry.chemical_classification, Conformational change, biology, Chemistry, Hydride, Organic Chemistry, Molecular Conformation, Temperature, Hydrogen-Ion Concentration, Photochemistry, Biochemistry, Enzyme catalysis, Tetrahydrofolate Dehydrogenase, Reaction rate constant, Enzyme, Deprotonation, Dihydrofolate reductase, Kinetic isotope effect, Escherichia coli, biology.protein, Molecular Medicine, Molecular Biology, Hydrogen
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8
المؤلفون: Rudolf Konrad Allemann, E. Joel Loveridge, Rhiannon M. Evans, Lai-Hock Tey, Jiannan Guo, Enas M. Behiry
المصدر: ChemBioChem. 11:2010-2017
مصطلحات موضوعية: Circular dichroism, Stereochemistry, Enthalpy, Inorganic chemistry, Biochemistry, Catalysis, Reaction rate constant, Dihydrofolate reductase, Escherichia coli, Enzyme kinetics, Psychrophile, Molecular Biology, chemistry.chemical_classification, biology, Chemistry, Circular Dichroism, Organic Chemistry, Temperature, Hydrogen-Ion Concentration, Kinetics, Tetrahydrofolate Dehydrogenase, Enzyme, biology.protein, Thermodynamics, Molecular Medicine, Moritella
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9
المؤلفون: Legesse Adane, Prasad V. Bharatam, Dhilon S. Patel
المصدر: Chemical Biology & Drug Design. 75:115-126
مصطلحات موضوعية: Cycloguanil, Stereochemistry, Molecular Sequence Data, Plasmodium falciparum, Quantitative Structure-Activity Relationship, Biochemistry, Antimalarials, parasitic diseases, Drug Discovery, Dihydrofolate reductase, medicine, Animals, Humans, Amino Acid Sequence, Pharmacology, chemistry.chemical_classification, Virtual screening, biology, Triazines, X-Rays, Organic Chemistry, Active site, DNA, Protozoan, biology.organism_classification, Tetrahydrofolate Dehydrogenase, Pyrimethamine, Enzyme, Proguanil, chemistry, Docking (molecular), biology.protein, Folic Acid Antagonists, Molecular Medicine, Pharmacophore, Protein Binding, medicine.drug
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10
المؤلفون: Giovanni Maglia, E. Joel Loveridge, Rudolf Konrad Allemann
المصدر: ChemBioChem. 10:2624-2627
مصطلحات موضوعية: Models, Molecular, Arginine, Stereochemistry, Biochemistry, Enzyme catalysis, Residue (chemistry), Dihydrofolate reductase, Thermotoga maritima, Molecular Biology, DNA Primers, chemistry.chemical_classification, Base Sequence, biology, Organic Chemistry, Active site, biology.organism_classification, Hyperthermophile, Tetrahydrofolate Dehydrogenase, Enzyme, chemistry, Biocatalysis, biology.protein, bacteria, Molecular Medicine