المؤلفون: Falcone N; Terasaki Institute for Biomedical Innovation, 1018 Westwood Blvd, Los Angeles, CA, 90034, USA., Ermis M; Terasaki Institute for Biomedical Innovation, 1018 Westwood Blvd, Los Angeles, CA, 90034, USA.; BIOMATEN, Center of Excellence in Biomaterials and Tissue Engineering, Middle East Technical University, Ankara, 06800, Turkey., Tamay DG; BIOMATEN, Center of Excellence in Biomaterials and Tissue Engineering, Middle East Technical University, Ankara, 06800, Turkey.; Department of Biotechnology, Middle East Technical University, Ankara, 06800, Turkey., Mecwan M; Terasaki Institute for Biomedical Innovation, 1018 Westwood Blvd, Los Angeles, CA, 90034, USA., Monirizad M; Terasaki Institute for Biomedical Innovation, 1018 Westwood Blvd, Los Angeles, CA, 90034, USA., Mathes TG; Terasaki Institute for Biomedical Innovation, 1018 Westwood Blvd, Los Angeles, CA, 90034, USA., Jucaud V; Terasaki Institute for Biomedical Innovation, 1018 Westwood Blvd, Los Angeles, CA, 90034, USA., Choroomi A; Terasaki Institute for Biomedical Innovation, 1018 Westwood Blvd, Los Angeles, CA, 90034, USA., de Barros NR; Terasaki Institute for Biomedical Innovation, 1018 Westwood Blvd, Los Angeles, CA, 90034, USA., Zhu Y; Terasaki Institute for Biomedical Innovation, 1018 Westwood Blvd, Los Angeles, CA, 90034, USA., Vrana NE; SPARTHA Medical, CRBS 1 Rue Eugene Boeckel, Strasbourg, 67000, France., Kraatz HB; Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON, M5S 3E5, Canada.; Department of Physical and Environmental Sciences, University of Toronto Scarborough, Toronto, ON, M1C 1A4, Canada., Kim HJ; Terasaki Institute for Biomedical Innovation, 1018 Westwood Blvd, Los Angeles, CA, 90034, USA.; College of Pharmacy, Korea University, Sejong, 30019, Republic of Korea., Khademhosseini A; Terasaki Institute for Biomedical Innovation, 1018 Westwood Blvd, Los Angeles, CA, 90034, USA.

المصدر: Advanced healthcare materials [Adv Healthc Mater] 2023 Oct; Vol. 12 (27), pp. e2301096. Date of Electronic Publication: 2023 Jul 09.

نوع المنشور: Journal Article; Review; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101581613 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2192-2659 (Electronic) Linking ISSN: 21922640 NLM ISO Abbreviation: Adv Healthc Mater Subsets: MEDLINE

مواضيع طبية MeSH: Nanostructures*/chemistry , Neoplasms*/therapy, Humans ; Hydrogels/chemistry ; Immunotherapy ; Peptides/chemistry

مستخلص: Peptide-based hydrogel biomaterials have emerged as an excellent strategy for immune system modulation. Peptide-based hydrogels are supramolecular materials that self-assemble into various nanostructures through various interactive forces (i.e., hydrogen bonding and hydrophobic interactions) and respond to microenvironmental stimuli (i.e., pH, temperature). While they have been reported in numerous biomedical applications, they have recently been deemed promising candidates to improve the efficacy of cancer immunotherapies and treatments. Immunotherapies seek to harness the body's immune system to preemptively protect against and treat various diseases, such as cancer. However, their low efficacy rates result in limited patient responses to treatment. Here, the immunomaterial's potential to improve these efficacy rates by either functioning as immune stimulators through direct immune system interactions and/or delivering a range of immune agents is highlighted. The chemical and physical properties of these peptide-based materials that lead to immuno modulation and how one may design a system to achieve desired immune responses in a controllable manner are discussed. Works in the literature that reports peptide hydrogels as adjuvant systems and for the delivery of immunotherapies are highlighted. Finally, the future trends and possible developments based on peptide hydrogels for cancer immunotherapy applications are discussed.
(© 2023 Wiley-VCH GmbH.)

المؤلفون: Choi H; Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.; Department of Biomedical Engineering, University of Illinois at Chicago, Chicago, IL, 60607, USA., Choi B; Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA., Han JH; Department of Integrative Biotechnology, College of Biotechnology and Bioengineering, Sungkyunkwan University, Seoburo 2066, Suwon, Gyeonggi, 16419, Republic of Korea., Shin HE; Department of Integrative Biotechnology, College of Biotechnology and Bioengineering, Sungkyunkwan University, Seoburo 2066, Suwon, Gyeonggi, 16419, Republic of Korea., Park W; Department of Integrative Biotechnology, College of Biotechnology and Bioengineering, Sungkyunkwan University, Seoburo 2066, Suwon, Gyeonggi, 16419, Republic of Korea.; Department of Biomedical Engineering, McCormick School of Engineering, Evanston, IL, 60208, USA., Kim DH; Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.; Department of Biomedical Engineering, University of Illinois at Chicago, Chicago, IL, 60607, USA.; Robert H. Lurie Comprehensive Cancer Center, Chicago, IL, 60611, USA.

المصدر: Small (Weinheim an der Bergstrasse, Germany) [Small] 2022 Sep; Vol. 18 (38), pp. e2202694. Date of Electronic Publication: 2022 Aug 13.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101235338 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1613-6829 (Electronic) Linking ISSN: 16136810 NLM ISO Abbreviation: Small Subsets: MEDLINE

مواضيع طبية MeSH: Hereditary Sensory and Motor Neuropathy* , Metal Nanoparticles*/chemistry , Nanoparticles*/chemistry , Nanostructures* , Photochemotherapy*, Animals ; Cell Line, Tumor ; Cholates ; Gold/chemistry ; Hydrogen Peroxide ; Mice ; Photosensitizing Agents/chemistry ; Reactive Oxygen Species/metabolism ; Silver ; Tissue Distribution

مستخلص: A reactive oxygen species (ROS) responsive cleavable hierarchical metallic supra-nanostructure (HMSN) is reported. HMSN structured with thin branches composed of primary gold (Au) nanocrystals and silver (Ag) nano-linkers is synthesized by a one-pot aqueous synthesis with a selected ratio of Au/Ag/cholate. ROS responsive degradability of HMSN is tested in the presence of endogenous and exogeneous ROS. Significant ROS-responsive structural deformation of HMSN is observed in the ROS exposure with hydrogen peroxide (H 2 O 2 ) solution. The ROS responsiveness of HMSN is significantly comparable with negligible structural changes of conventional spherical gold nanoparticles. The demonstrated ROS responsive degradation of HMSN is further confirmed in various in vitro ROS conditions of each cellular endogenous ROS and exogeneous ROS generated by photodynamic therapy (PDT) or X-ray radiation. Then, in vivo ROS responsive degradability of HMSN is further evaluated with intratumoral injection of HMSN and exogeneous ROS generation via PDT in a mouse tumor model. Additional in vivo biodistribution and toxicity of intravenously administrated HMSN at 30-day post-injection are investigated for potential in vivo applications. The observed ROS responsive degradability of HMSN will provide a promising option for a type of ROS responsive-multifunctional nanocarriers in cancer treatment and various biomedical applications.
(© 2022 The Authors. Small published by Wiley-VCH GmbH.)

المؤلفون: Kiaee G; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, 02115, USA., Dimitrakakis N; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, 02115, USA., Sharifzadeh S; Dana-Farber Cancer Institute, Boston, MA, 02115, USA., Kim HJ; Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90024, USA., Avery RK; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, 02115, USA., Moghaddam KM; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, 02115, USA., Haghniaz R; Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90024, USA., Yalcintas EP; Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90024, USA., Barros NR; Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90024, USA., Karamikamkar S; Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90024, USA., Libanori A; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA., Khademhosseini A; Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90024, USA., Khoshakhlagh P; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, 02115, USA.

المصدر: Advanced healthcare materials [Adv Healthc Mater] 2022 Apr; Vol. 11 (7), pp. e2102054. Date of Electronic Publication: 2022 Feb 04.

نوع المنشور: Journal Article; Review; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101581613 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2192-2659 (Electronic) Linking ISSN: 21922640 NLM ISO Abbreviation: Adv Healthc Mater Subsets: MEDLINE

مواضيع طبية MeSH: Nanoparticles*/chemistry , Nanostructures*/chemistry, Drug Delivery Systems ; Silicates/chemistry

مستخلص: Laponite is a clay-based material composed of synthetic disk-shaped crystalline nanoparticles with highly ionic, large surface area. These characteristics enable the intercalation and dissolution of biomolecules in Laponite-based drug delivery systems. Furthermore, Laponite's innate physicochemical properties and architecture enable the development of tunable pH-responsive drug delivery systems. Laponite's coagulation capacity and cation exchangeability determine its exchange capabilities, drug encapsulation efficiency, and release profile. These parameters are exploited to design highly controlled and efficacious drug delivery platforms for sustained drug release. In this review, they provide an overview of how to design efficient delivery of therapeutics by leveraging the properties and specific interactions of various Laponite-polymer composites and drug moieties.
(© 2022 Wiley-VCH GmbH.)