المؤلفون: Shi L; Department of Psychiatry, University of Oxford, Oxford, UK., Winchester LM; Department of Psychiatry, University of Oxford, Oxford, UK., Westwood S; Department of Psychiatry, University of Oxford, Oxford, UK., Baird AL; Department of Psychiatry, University of Oxford, Oxford, UK., Anand SN; Department of Psychiatry, University of Oxford, Oxford, UK., Buckley NJ; Department of Psychiatry, University of Oxford, Oxford, UK., Hye A; Maurice Wohl Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, London, UK., Ashton NJ; Maurice Wohl Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, London, UK.; Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden., Bos I; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centrum Limburg, Maastricht University, Maastricht, the Netherlands.; Alzheimer Center, VU University Medical Center, Amsterdam, the Netherlands., Vos SJB; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centrum Limburg, Maastricht University, Maastricht, the Netherlands., Kate MT; Alzheimer Center, VU University Medical Center, Amsterdam, the Netherlands., Scheltens P; Alzheimer Center, VU University Medical Center, Amsterdam, the Netherlands., Teunissen CE; Neurochemistry lab, Department of Clinical Chemistry, Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam Neuroscience, Amsterdam, the Netherlands., Vandenberghe R; University Hospital Leuven, Leuven, Belgium., Gabel S; University Hospital Leuven, Leuven, Belgium.; Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Leuven, Belgium., Meersmans K; University Hospital Leuven, Leuven, Belgium.; Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Leuven, Belgium., Engelborghs S; Reference Center for Biological Markers of Dementia (BIODEM), Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.; Department of Neurology, UZ Brussel and Center for Neurociences (C4N), Vrije Universiteit Brussel, Brussels, Belgium., De Roeck EE; Reference Center for Biological Markers of Dementia (BIODEM), Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.; Department of Neurology and Memory Clinic, Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken, Antwerp, Belgium., Sleegers K; Complex Genetics Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.; Institute Born-Bunge, Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium., Frisoni GB; University of Geneva, Geneva, Switzerland.; IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy., Blin O; AIX marseille university, INS, Ap-hm, Marseille, France., Richardson JC; Neurosciences Therapeutic Area, GlaxoSmithKline R&D, Stevenage, UK., Bordet R; Inserm, University of Lille, CHU Lille, Lille, France., Molinuevo JL; Alzheimer's Disease and Other Cognitive Disorders Unit, Hopsital Clínic-IDIBAPS, Barcelona, Spain.; Barcelona Beta Brain Research Center, Unversitat Pompeu Fabra, Barcelona, Spain., Rami L; Barcelona Beta Brain Research Center, Unversitat Pompeu Fabra, Barcelona, Spain., Wallin A; Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden., Kettunen P; Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden., Tsolaki M; 1st Department of Neurology, AHEPA University Hospital, Makedonia, Thessaloniki, Greece., Verhey F; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centrum Limburg, Maastricht University, Maastricht, the Netherlands., Lléo A; Hospital de la Santa Creu i Sant Pau, Barcelona, Spain., Sala I; Department of Neurology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain., Popp J; University Hospital of Lausanne, Lausanne, Switzerland.; Geriatric Psychiatry, Department of Mental Health and Psychiatry, Geneva University Hospitals, Geneva, Switzerland., Peyratout G; University Hospital of Lausanne, Lausanne, Switzerland., Martinez-Lage P; CITA-Alzheimer Foundation, San Sebastian, Spain., Tainta M; CITA-Alzheimer Foundation, San Sebastian, Spain., Johannsen P; Danish Dementia Research Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Freund-Levi Y; Maurice Wohl Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, London, UK.; Karolinska Institutet Center for Alzheimer Research, Division of Clinical Geriatrics, School of Medical Sciences Örebro University and Department of Neurobiology, Caring Sciences and Society (NVS), Stockholm, Sweden., Frölich L; Department of Geriatric Psychiatry, Zentralinstitut für Seelische Gesundheit, University of Heidelberg, Mannheim, Germany., Dobricic V; Lübeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics and Cardiogenetics, University of Lübeck, Lübeck, Germany., Legido-Quigley C; Kings College London, London, UK.; The Systems Medicine Group, Steno Diabetes Center, Gentofte, Denmark., Barkhof F; Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, the Netherland.; UCL Institutes of Neurology and Healthcare Engineering, London, UK., Andreasson U; Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden., Blennow K; Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden., Zetterberg H; Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.; UK Dementia Research Institute at UCL, London, UK.; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK., Streffer J; Complex Genetics Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.; UCB, Braine-l'Alleud, Belgium, formerly Janssen R&D, LLC Beerse, Beerse, Belgium., Lill CM; Section for Translational Surgical Oncology and Biobanking, Department of Surgery, University of Lübeck and University Medical Center Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.; Ageing Epidemiology Research Unit, School of Public Health, Imperial College, London, UK., Bertram L; Lübeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics and Cardiogenetics, University of Lübeck, Lübeck, Germany.; Department of Psychology, University of Oslo, Oslo, Norway., Visser PJ; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centrum Limburg, Maastricht University, Maastricht, the Netherlands.; Alzheimer Center, VU University Medical Center, Amsterdam, the Netherlands., Kolb HC; Janssen R&D, Beerse, UK., Narayan VA; Janssen R&D, Beerse, UK., Lovestone S; Department of Psychiatry, University of Oxford, Oxford, UK.; Janssen R&D, Beerse, UK., Nevado-Holgado AJ; Department of Psychiatry, University of Oxford, Oxford, UK.

المصدر: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2021 Sep; Vol. 17 (9), pp. 1452-1464. Date of Electronic Publication: 2021 Mar 31.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE

مواضيع طبية MeSH: Alzheimer Disease*/blood , Alzheimer Disease*/pathology , Blood Proteins* , Proteomics*, Amyloid beta-Peptides/*blood , Biomarkers/*blood , tau Proteins/*blood, Aged ; Apolipoprotein E4/blood ; Apolipoprotein E4/genetics ; Cognitive Dysfunction/blood ; Cognitive Dysfunction/pathology ; Europe ; Female ; Humans ; Male ; Middle Aged

المؤلفون: Westwood S; Department of Psychiatry, University of Oxford, UK., Baird AL; Department of Psychiatry, University of Oxford, UK., Anand SN; Department of Psychiatry, University of Oxford, UK., Nevado-Holgado AJ; Department of Psychiatry, University of Oxford, UK., Kormilitzin A; Department of Psychiatry, University of Oxford, UK., Shi L; Department of Psychiatry, University of Oxford, UK., Hye A; Maurice Wohl Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, London, UK., Ashton NJ; Maurice Wohl Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, London, UK.; Department of Psychiatry and Neurochemistry, University of Gothenburg, Mölndal, Sweden.; Wallenberg Centre for Molecular & Translational Medicine, University of Gothenburg, Gothenburg, Sweden., Morgan AR; Dementia Research Institute Cardiff, Cardiff University, Cardiff, UK., Bos I; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centrum Limburg, Maastricht University, Maastricht, the Netherlands., Vos SJB; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centrum Limburg, Maastricht University, Maastricht, the Netherlands., Baker S; Janssen R&D, Titusville, NJ, USA., Buckley NJ; Department of Psychiatry, University of Oxford, UK., Ten Kate M; Alzheimer Center, VU University Medical Center, Amsterdam, the Netherlands., Scheltens P; Alzheimer Center, VU University Medical Center, Amsterdam, the Netherlands., Teunissen CE; Alzheimer Center, VU University Medical Center, Amsterdam, the Netherlands., Vandenberghe R; University Hospital Leuven, Leuven, Belgium., Gabel S; University Hospital Leuven, Leuven, Belgium.; Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Belgium., Meersmans K; University Hospital Leuven, Leuven, Belgium.; Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Belgium., Engelborghs S; Department of Neurology and Memory Clinic, Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken, University of Antwerp, Antwerp, Belgium.; Center for Neurosciences, Vrije Universiteit Brussel (VUB), Brussels, Belgium., De Roeck EE; Department of Neurology and Memory Clinic, Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken, University of Antwerp, Antwerp, Belgium.; Center for Neurosciences, Vrije Universiteit Brussel (VUB), Brussels, Belgium., Sleegers K; Center for Neurosciences, Vrije Universiteit Brussel (VUB), Brussels, Belgium.; Neurodegenerative Brain Diseases Group, Center for Molecular Neurology, VIB, Belgium., Frisoni GB; University of Geneva, Geneva, Switzerland.; IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy., Blin O; AIX Marseille University, INS, Ap-Hm, Marseille, France., Richardson JC; Neurosciences Therapeutic Area, GlaxoSmithKline R&D, Stevenage, UK., Bordet R; University of Lille, Inserm, CHU Lille, France., Molinuevo JL; Alzheimer's Disease & Other Cognitive Disorders Unit, Hopsital Clínic-IDIBAPS, Barcelona, Spain.; Barcelona Beta Brain Research Center, Unversitat Pompeu Fabra, Barcelona, Spain., Rami L; Barcelona Beta Brain Research Center, Unversitat Pompeu Fabra, Barcelona, Spain., Wallin A; Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden., Kettunen P; Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden., Tsolaki M; 1st Department of Neurology, AHEPA University Hospital, Makedonia, Thessaloniki, Greece., Verhey F; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centrum Limburg, Maastricht University, Maastricht, the Netherlands., Lléo A; Hospital de la Santa Creu i Sant Pau, Barcelona, Spain., Sala I; Department of Neurology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain., Popp J; University Hospital of Lausanne, Lausanne, Switzerland.; Geriatric Psychiatry, Department of Mental Health and Psychiatry, Geneva University Hospitals, Geneva, Switzerland., Peyratout G; University Hospital of Lausanne, Lausanne, Switzerland., Martinez-Lage P; Geriatric Psychiatry, Department of Mental Health and Psychiatry, Geneva University Hospitals, Geneva, Switzerland., Tainta M; CITA-Alzheimer Foundation, San Sebastian, Spain., Johannsen P; Danish Dementia Research Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Freund-Levi Y; Department of Neurobiology, Caring Sciences and Society (NVS), Division of Clinical Geriatrics, Karolinska Institutet, and Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden.; Maurice Wohl Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, London, UK., Frölich L; Department of Geriatric Psychiatry, Zentralinstitut für Seelische Gesundheit, University of Heidelberg, Mannheim, Germany., Dobricic V; Lübeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics and Cardiogenetics, University of Lübeck, Lübeck, Germany., Legido-Quigley C; Kings College London, London, UK.; The Systems Medicine Group, Steno Diabetes Center, Gentofte, Denmark., Bertram L; Lübeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics and Cardiogenetics, University of Lübeck, Lübeck, Germany.; Department of Psychology, University of Oslo, Oslo, Norway., Barkhof F; Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherland.; UCL Institutes of Neurology and Healthcare Engineering, London, UK., Zetterberg H; Department of Psychiatry and Neurochemistry, University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.; UK Dementia Research Institute at UCL, London, UK.; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK., Morgan BP; Dementia Research Institute Cardiff, Cardiff University, Cardiff, UK., Streffer J; Center for Neurosciences, Vrije Universiteit Brussel (VUB), Brussels, Belgium.; UCB, Braine-l'Alleud, Belgium, formerly Janssen R&D, LLC. Beerse, Belgium at the Time of Study Conduct., Visser PJ; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centrum Limburg, Maastricht University, Maastricht, the Netherlands.; Alzheimer Center, VU University Medical Center, Amsterdam, the Netherlands., Lovestone S; Department of Psychiatry, University of Oxford, UK.; Janssen R&D, UK formerly affiliation (1) at the Time of the Study Conduct.

المصدر: Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2020; Vol. 74 (1), pp. 213-225.

نوع المنشور: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't; Validation Study

بيانات الدورية: Publisher: IOS Press Country of Publication: Netherlands NLM ID: 9814863 Publication Model: Print Cited Medium: Internet ISSN: 1875-8908 (Electronic) Linking ISSN: 13872877 NLM ISO Abbreviation: J Alzheimers Dis Subsets: MEDLINE

مواضيع طبية MeSH: Proteomics*, Alzheimer Disease/*blood , Biomarkers/*blood , Blood Proteins/*analysis , Cerebral Amyloid Angiopathy/*blood, Aged ; Alzheimer Disease/diagnostic imaging ; Apolipoprotein E4/genetics ; Body Burden ; Cerebral Amyloid Angiopathy/diagnostic imaging ; Cognitive Dysfunction/blood ; Cognitive Dysfunction/diagnostic imaging ; Cohort Studies ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Positron-Emission Tomography ; ROC Curve ; tau Proteins/cerebrospinal fluid