المؤلفون: Abid T; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Goodale AB; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kalani Z; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Wyatt M; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Gonzalez EM; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA., Zhou KN; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA., Qian K; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA., Novikov D; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA., Condurat AL; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA., Bandopadhayay P; Broad Institute of MIT and Harvard, Cambridge, MA, USA. Pratiti_Bandopadhayay@dfci.harvard.edu.; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA. Pratiti_Bandopadhayay@dfci.harvard.edu.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA. Pratiti_Bandopadhayay@dfci.harvard.edu., Piccioni F; Broad Institute of MIT and Harvard, Cambridge, MA, USA. piccioni.fede@gmail.com.; Merck Research Laboratories, Cambridge, MA, USA. piccioni.fede@gmail.com., Persky NS; Broad Institute of MIT and Harvard, Cambridge, MA, USA. perskyn@gmail.com.; Aera Therapeutics, Boston, MA, USA. perskyn@gmail.com., Root DE; Broad Institute of MIT and Harvard, Cambridge, MA, USA. droot@broadinstitute.org.

المصدر: Nature protocols [Nat Protoc] 2023 Jul; Vol. 18 (7), pp. 2014-2031. Date of Electronic Publication: 2023 Jun 07.

نوع المنشور: Journal Article; Review; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101284307 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1750-2799 (Electronic) Linking ISSN: 17502799 NLM ISO Abbreviation: Nat Protoc Subsets: MEDLINE

مواضيع طبية MeSH: Clustered Regularly Interspaced Short Palindromic Repeats*/genetics , Neoplasms*, Humans ; CRISPR-Cas Systems ; Genome ; Cell Line

المؤلفون: Tsai JW; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts., Cejas P; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts.; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts, Cancer Program, Broad Institute, Cambridge, Massachusetts., Wang DK; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts., Patel S; Division of Pharmaceutical Sciences, James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, Ohio.; Division of Pediatric Neurosurgery, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.; Department of Neurosurgery, University of Cincinnati College of Medicine, Cincinnati, Ohio., Wu DW; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Arounleut P; Division of Pharmaceutical Sciences, James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, Ohio., Wei X; Division of Pharmaceutical Sciences, James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, Ohio., Zhou N; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts.; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts, Cancer Program, Broad Institute, Cambridge, Massachusetts., Syamala S; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts.; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts, Cancer Program, Broad Institute, Cambridge, Massachusetts., Dubois FPB; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts., Crane A; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts., Pelton K; Department of Oncologic Pathology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts., Vogelzang J; Department of Oncologic Pathology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts., Sousa C; Department of Oncologic Pathology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts., Baguette A; Quantitative Life Sciences, McGill University, Montreal, Quebec H3A 2A7, Canada.; Lady Davis Research Institute, Jewish General Hospital, Montreal, Quebec H3T 1E2, Canada., Chen X; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee., Condurat AL; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts., Dixon-Clarke SE; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Biological Chemistry and Molecular Pharmacology, Boston, Massachusetts., Zhou KN; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts., Lu SD; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts., Gonzalez EM; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts., Chacon MS; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts., Digiacomo JJ; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts., Kumbhani R; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts., Novikov D; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts., Hunter J; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts., Tsoli M; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, Australia., Ziegler DS; Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, Australia.; School of Women's and Children's Health, University of New South Wales, Sydney, NSW, Australia.; Kids Cancer Centre, Sydney Children's Hospital, Randwick, NSW, Australia., Dirksen U; West German Cancer Center, Pediatrics III, University Hospital Essen, Essen, Germany.; German Cancer Consortium (DKTK), Essen/Düsseldorf, Germany., Jager N; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg University Hospital and German Cancer Research Center (DKFZ) Heidelberg, Germany.; Division of Pediatric Neuro-Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany., Balasubramanian GP; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg University Hospital and German Cancer Research Center (DKFZ) Heidelberg, Germany.; Division of Pediatric Neuro-Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Kramm CM; Division of Pediatric Hematology and Oncology, University Medical Center Göttingen, Göttingen, Germany., Nathrath M; Department of Pediatric Hematology and Oncology, Klinikum Kassel, Kassel, Germany.; Children's Cancer Research Centre and Department of Pediatrics, Klinikum rechts der Isar, Technische Universität München, Munich, Germany., Bielack S; University Hospital Stuttgart, Stuttgart, Germany., Baker SJ; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee., Zhang J; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee., McFarland JM; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Getz G; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Harvard Medical School, Boston, Massachusetts.; Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts.; Center for Cancer Research, Massachusetts General Hospital, Boston, Massachusetts., Aguet F; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Jabado N; Department of Human Genetics, McGill University, Montreal, H3A 0C7, Canada.; Department of Pediatrics, McGill University, and The Research Institute of the McGill University Health Centre, Montreal, H4A 3J1, Canada., Witt O; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg University Hospital and German Cancer Research Center (DKFZ) Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology, Immunology, and Pulmonology, Heidelberg University Hospital, Heidelberg, Germany.; National Center for Tumor Disease (NCT) Network, Germany., Pfister SM; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg University Hospital and German Cancer Research Center (DKFZ) Heidelberg, Germany.; Division of Pediatric Neuro-Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology, Immunology, and Pulmonology, Heidelberg University Hospital, Heidelberg, Germany.; National Center for Tumor Disease (NCT) Network, Germany., Ligon KL; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Department of Oncologic Pathology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.; Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts., Hovestadt V; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts., Kleinman CL; Lady Davis Research Institute, Jewish General Hospital, Montreal, Quebec H3T 1E2, Canada.; Department of Human Genetics, McGill University, Montreal, H3A 0C7, Canada., Long H; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts.; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts, Cancer Program, Broad Institute, Cambridge, Massachusetts., Jones DTW; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg University Hospital and German Cancer Research Center (DKFZ) Heidelberg, Germany.; Division of Pediatric Neuro-Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Bandopadhayay P; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts., Phoenix TN; Division of Pharmaceutical Sciences, James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, Ohio.

المصدر: Cancer research [Cancer Res] 2022 Sep 02; Vol. 82 (17), pp. 2980-3001.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE

مواضيع طبية MeSH: Forkhead Transcription Factors*/genetics , Neoplasms*/genetics, Adult ; Carcinogenesis/genetics ; Cell Proliferation ; Child ; Epigenesis, Genetic ; Humans ; Male ; Oncogenes/genetics ; Proto-Oncogene Proteins c-ets/genetics ; Proto-Oncogene Proteins c-ets/metabolism ; Transcriptional Activation

المؤلفون: Abou-Fadel J; Department of Molecular and Translational Medicine (MTM), Texas Tech University Health Science Center El Paso, El Paso, TX 79905, USA., Qu Y; Department of Molecular and Translational Medicine (MTM), Texas Tech University Health Science Center El Paso, El Paso, TX 79905, USA., Gonzalez EM; Department of Molecular and Translational Medicine (MTM), Texas Tech University Health Science Center El Paso, El Paso, TX 79905, USA., Smith M; Department of Molecular and Translational Medicine (MTM), Texas Tech University Health Science Center El Paso, El Paso, TX 79905, USA., Zhang J; Department of Molecular and Translational Medicine (MTM), Texas Tech University Health Science Center El Paso, El Paso, TX 79905, USA.

المصدر: Oncology reports [Oncol Rep] 2020 Jun; Vol. 43 (6), pp. 1945-1963. Date of Electronic Publication: 2020 Mar 18.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: D.A. Spandidos Country of Publication: Greece NLM ID: 9422756 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1791-2431 (Electronic) Linking ISSN: 1021335X NLM ISO Abbreviation: Oncol Rep Subsets: MEDLINE

مواضيع طبية MeSH: Apoptosis Regulatory Proteins/*genetics , Carrier Proteins/*genetics , KRIT1 Protein/*genetics , Membrane Proteins/*genetics , Neoplasms/*genetics , Proto-Oncogene Proteins/*genetics, Apoptosis Regulatory Proteins/metabolism ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Carrier Proteins/metabolism ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Gene Regulatory Networks ; Humans ; KRIT1 Protein/metabolism ; Membrane Proteins/metabolism ; Neoplasm Grading ; Neoplasms/metabolism ; Neoplasms/pathology ; Proto-Oncogene Proteins/metabolism

المؤلفون: Gonzalez EM; Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA., Mongiat M, Slater SJ, Baffa R, Iozzo RV

المصدر: The Journal of biological chemistry [J Biol Chem] 2003 Oct 03; Vol. 278 (40), pp. 38113-6. Date of Electronic Publication: 2003 Aug 04.

نوع المنشور: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.

بيانات الدورية: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Print ISSN: 0021-9258 (Print) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

مواضيع طبية MeSH: Growth Substances/*chemistry , Heparan Sulfate Proteoglycans/*chemistry , Intercellular Signaling Peptides and Proteins/*chemistry , Neoplasms/*metabolism, Angiogenesis Inhibitors/pharmacology ; Cell Division ; Cell Line ; Cell-Free System ; DNA, Complementary/metabolism ; Dose-Response Relationship, Drug ; Electrophoresis, Polyacrylamide Gel ; Growth Substances/metabolism ; Heparan Sulfate Proteoglycans/metabolism ; Humans ; Immunoblotting ; Immunohistochemistry ; Intercellular Signaling Peptides and Proteins/metabolism ; Kinetics ; Neovascularization, Pathologic ; Oligonucleotide Array Sequence Analysis ; Precipitin Tests ; Progranulins ; Protein Binding ; Protein Biosynthesis ; Protein Structure, Tertiary ; Recombinant Proteins/chemistry ; Surface Plasmon Resonance ; Transfection ; Tumor Cells, Cultured ; Two-Hybrid System Techniques