-
1دورية أكاديمية
المؤلفون: Gaëtan-Romain Joliat, David Martin, Ismail Labgaa, Emmanuel Melloul, Emilie Uldry, Nermin Halkic, Ginette Fotsing, Alessandra Cristaudi, Pietro Majno-Hurst, Dionisios Vrochides, Nicolas Demartines, Markus Schäfer
المصدر: Frontiers in Oncology, Vol 12 (2022)
مصطلحات موضوعية: pancreas cancer, pancreatoduodenectomy, malnutrition, complications, morbidity, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
الوصف: BackgroundMalnutrition has been shown to be a risk factor for postoperative complications after pancreatoduodenectomy (PD). In addition, patients needing a PD, such as patients with pancreatic cancer or chronic pancreatitis, often are malnourished. The best route of postoperative nutrition after PD remains unknown. The aim of this randomized controlled trial is to evaluate if early postoperative enteral nutrition can decrease complications after PD compared to oral nutrition.MethodsThis multicenter, open-label, randomized controlled trial will include 128 patients undergoing PD with a nutritional risk screening ≥3. Patients will be randomized 1:1 using variable block randomization stratified by center to receive either early enteral nutrition (intervention group) or oral nutrition (control group) after PD. Patients in the intervention group will receive enteral nutrition since the first night of the operation (250 ml/12 h), and enteral nutrition will be increased daily if tolerated until 1000 ml/12 h. The primary outcome will be the Comprehensive Complication Index (CCI) at 90 days after PD.DiscussionThis study with its multicentric and randomized design will permit to establish if early postoperative enteral nutrition after PD improves postoperative outcomes compared to oral nutrition in malnourished patients.Clinical trial registrationhttps://clinicaltrials.gov/(NCT05042882) Registration date: September 2021.
وصف الملف: electronic resource
إعادة تعيين المنقحات
عرض المنقحات (%%عد%%)
Full Text Finder